{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:41:39Z","timestamp":1787755299295,"version":"build-2784847793"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>\n                    <jats:list list-type=\"plain\">\n                      <jats:list-item>\n                        <jats:p>\u00bb Rotator cuff tear arthropathy (RCTA) describes a pattern of glenohumeral degenerative changes following chronic rotator cuff tears that is characterized by superior humeral head migration, erosion of the greater tuberosity of the humeral head, contouring of the coracoacromial arch to create a socket for the humeral head, and eventual glenohumeral arthritis.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u00bb Acute and chronic inflammatory changes following rotator cuff tears are thought to contribute to cartilage damage, muscle fibrosis, and fatty infiltration in the glenohumeral joint.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u00bb In vitro animal studies targeting various inflammatory modulators, including macrophages, insulin-like growth factor-I, and transforming growth factor-beta pathways, provide promising therapeutic targets to improve healing after rotator cuff tears.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u00bb The role of platelet-rich plasma in the treatment and prevention of RCTA has been investigated, with conflicting results.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.2106\/jbjs.rvw.21.00126","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T15:05:57Z","timestamp":1636556757000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Immunologic Contributions Following Rotator Cuff Injury and Development of Cuff Tear Arthropathy"],"prefix":"10.2106","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-5507","authenticated-orcid":false,"given":"Grant B.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-3390","authenticated-orcid":false,"given":"Christopher J.","family":"McMellen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3526-0078","authenticated-orcid":false,"given":"Jensen G.","family":"Kolaczko","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-3746","authenticated-orcid":false,"given":"Peter J.","family":"Millett","sequence":"additional","affiliation":[{"name":"The Steadman Clinic, Vail, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1292-8749","authenticated-orcid":false,"given":"Robert J.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-3794","authenticated-orcid":false,"given":"Charles A.","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,11]]},"reference":[{"issue":"5","key":"r1-20240731","doi-asserted-by":"crossref","first-page":"e193","DOI":"10.5435\/JAAOS-D-19-00463","article-title":"Management of Rotator Cuff Injuries","volume":"28","author":"Weber","year":"2020","journal-title":"J Am Acad Orthop Surg"},{"issue":"2","key":"r2-20240731","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1302\/0301-620X.77B2.7706351","article-title":"Rotator-cuff changes in asymptomatic adults. 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