{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:22:53Z","timestamp":1790342573056,"version":"4.1.0"},"reference-count":228,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>\n                    <jats:list list-type=\"plain\">\n                      <jats:list-item>\n                        <jats:p>\u00bb Perioperative corticosteroids are strongly recommended for reducing the incidence and severity of postoperative nausea and vomiting following elective total hip or total knee arthroplasty.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u00bb Corticosteroids may reduce postoperative pain and opioid requirements. Similarly, corticosteroids appear to have a neutral-to-positive effect on length of stay, venous thromboembolism, mobility, delirium, acute kidney injury, and bone cement implantation syndrome (i.e., decreased length of stay).<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u00bb Perioperative corticosteroids may induce hyperglycemia among both diabetic and nondiabetic patients; however, there is no strong evidence indicating that these transient corticosteroid-induced glycemic derangements may increase the risk of postoperative infectious complications.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u00bb The dosage and frequency of perioperative corticosteroid administration play a critical role in optimizing postoperative outcomes, with higher doses showing promise in reducing opioid consumption, postoperative pain, and length of stay.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u00bb The optimal dosage and frequency of corticosteroids remain unclear; however, the perioperative administration of 8 to 16 mg dexamethasone, or equivalent steroid, appears reasonable and safe in most cases.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.2106\/jbjs.rvw.24.00107","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T14:44:26Z","timestamp":1726497866000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Perioperative Systemic Corticosteroids in Modern Total Hip and Knee Arthroplasty"],"prefix":"10.2106","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5201-7371","authenticated-orcid":false,"given":"Ryan C.","family":"Palmer","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6051-4762","authenticated-orcid":false,"given":"Ian A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology & Pain Medicine, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7050-5571","authenticated-orcid":false,"given":"Peter K.","family":"Sculco","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1579-4953","authenticated-orcid":false,"given":"Charles P.","family":"Hannon","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6626-9913","authenticated-orcid":false,"given":"Yale A.","family":"Fillingham","sequence":"additional","affiliation":[{"name":"The Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1293-1702","authenticated-orcid":false,"given":"Nathanael D.","family":"Heckmann","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9]]},"reference":[{"issue":"5 suppl 68","key":"r2-20240916","first-page":"S5","article-title":"History of the development of corticosteroid therapy","volume":"29","author":"Benedek","year":"2011","journal-title":"Clin Exp Rheumatol"},{"issue":"9","key":"r3-20240916","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1007\/s11999-013-3032-5","article-title":"Preemptive low-dose dexamethasone reduces postoperative emesis and pain after TKA: a randomized controlled study","volume":"471","author":"Koh","year":"2013","journal-title":"Clin Orthop Relat Res"},{"issue":"8 suppl","key":"r4-20240916","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.arth.2013.05.041","article-title":"Dexamethasone reduces length of hospitalization and improves postoperative pain and nausea after total joint arthroplasty: a prospective, randomized controlled trial","volume":"28","author":"Backes","year":"2013","journal-title":"J Arthroplasty"},{"issue":"3","key":"r5-20240916","doi-asserted-by":"crossref","first-page":"300060521998220","DOI":"10.1177\/0300060521998220","article-title":"The role of perioperative intravenous low-dose dexamethasone in rapid recovery after total knee arthroplasty: a meta-analysis","volume":"49","author":"Zhuo","year":"2021","journal-title":"J Int Med Res"},{"issue":"2","key":"r6-20240916","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.arth.2022.08.028","article-title":"Is intraoperative dexamethasone utilization associated with increased rates of periprosthetic joint infection following total joint arthroplasty?","volume":"38","author":"Heckmann","year":"2023","journal-title":"J Arthroplasty"},{"issue":"11","key":"r7-20240916","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1016\/j.arth.2018.07.013","article-title":"Does dexamethasone reduce hospital readiness for discharge, pain, nausea, and early patient satisfaction in hip and knee arthroplasty? 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