{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:57:12Z","timestamp":1791248232466,"version":"4.1.0"},"reference-count":38,"publisher":"Zoological Society of Japan","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zoological Science"],"published-print":{"date-parts":[[2024,5,22]]},"abstract":"<jats:p>The circadian system comprises multiple clocks, including central and peripheral clocks. The central clock generally governs peripheral clocks to synchronize circadian rhythms throughout the animal body. However, whether the peripheral clock influences the central clock is unclear. This issue can be addressed through a system comprising a peripheral clock (compound eye clock [CE clock]) and central clock (the optic lobe [OL] clock) in the cricket Gryllus bimaculatus. We previously found that the compound eye regulates the free-running period (\u03c4) and the stability of locomotor rhythms driven by the OL clock, as measured by the daily deviation of \u03c4 at 30\u00b0C. However, the role of the CE clock in this regulation remains unexplored. In this study, we investigated the importance of the CE clock in this regulation using RNA interference (RNAi) of the period (per) gene localized to the compound eye (perCE-RNAi). The perCE-RNAi abolished the compound eye rhythms of the electroretinogram (ERG) amplitude and clock gene expression but the locomotor rhythm driven by the OL clock was maintained. The locomotor rhythm of the tested crickets showed a significantly longer \u03c4 and greater daily variation of \u03c4 than those of control crickets treated with dsDsRed2. The variation of \u03c4 was comparable with that of crickets with the optic nerve severed. The \u03c4 was considerably longer but was comparable with that of crickets with the optic nerve severed. These results suggest that the CE clock regulates the OL clock to maintain and stabilize \u03c4.<\/jats:p>","DOI":"10.2108\/zs230113","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T23:58:53Z","timestamp":1715903933000},"page":"407-415","source":"Crossref","is-referenced-by-count":0,"title":["Reciprocal Coupling of Circadian Clocks in the Compound Eye and Optic Lobe in the Cricket Gryllus bimaculatus"],"prefix":"10.2108","volume":"41","author":[{"given":"Kenji","family":"Tomioka","sequence":"first","affiliation":[{"name":"Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirai","family":"Matsuka","sequence":"additional","affiliation":[{"name":"Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Kawasaki Medical School, Kurashiki 701-0192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"848","reference":[{"key":"9","doi-asserted-by":"crossref","unstructured":"G Fleissner,  \"J Comp Physiol.\"  149, \"Isolation of an insect circadian clock.\" 311 (1982)","DOI":"10.1007\/BF00619146"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Y Moriyama, T Sakamoto, SG Karpova, et al.  \"J Biol Rhythms.\"  23, \"RNA interference of the clock gene period disrupts circadian rhythms in the cricket Gryllus bimaculatus.\" 308 (2008)","DOI":"10.1177\/0748730408320486"},{"key":"27","doi-asserted-by":"crossref","unstructured":"A Tokuoka, TQ Itoh, S Hori, et al.  \"Zool Lett.\"  3, \"cryptochrome genes form an oscillatory loop independent of the per\/tim loop in the circadian clockwork of the cricket Gryllus bimaculatus.\" 5 (2017)","DOI":"10.1186\/s40851-017-0066-7"},{"key":"31","unstructured":"K Tomioka  and Y Chiba  \"Zool Sci.\"  1, \"Effects of nymphal stage optic nerve severance or optic lobe removal on the circadian locomotor rhythm of the cricket, Gryllus bimaculatus.\" 375 (1984)"},{"key":"32","doi-asserted-by":"crossref","unstructured":"K Tomioka  and Y Chiba  \"J Comp Physiol A.\"  171, \"Characterization of an optic lobe circadian pacemaker by in situ and in vitro recording of neuronal activity in the cricket Gryllus bimaculatus.\" 1 (1992)","DOI":"10.1007\/BF00195955"},{"key":"34","doi-asserted-by":"crossref","unstructured":"K Tomioka, O Uryu, Y Kamae, et al.  \"J Comp Physiol B.\"  182, \"Peripheral circadian rhythms and their regulatory mechanism in insects and some other arthropods: a review.\" 729 (2012)","DOI":"10.1007\/s00360-012-0651-1"},{"key":"37","doi-asserted-by":"crossref","unstructured":"SA Wills, TL Page, CS Colwell,  \"J Biol Rhythms.\"  1, \"Circadian rhythms in the electroretinogram of the cockroach.\" 25 (1985)","DOI":"10.1177\/074873048600100105"},{"key":"16","doi-asserted-by":"crossref","unstructured":"C Ohguro, Y Moriyama, K Tomioka,  \"Zool Sci.\"  38, \"The compound eye possesses a self-sustaining circadian oscillator in the cricket Gryllus bimaculatus.\" 82 (2020)","DOI":"10.2108\/zs200118"},{"key":"23","unstructured":"DS Saunders, CGH Steel, X Vafopoulou, et al.  \"Insect Clocks.\"  (2002)"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Y Danbara, T Sakamoto, O Uryu, et al.  \"J Insect Physiol.\"  56, \"RNA interference of timeless gene does not disrupt circadian locomotor rhythms in the cricket Gryllus bimaculatus.\" 1738 (2010)","DOI":"10.1016\/j.jinsphys.2010.07.002"},{"key":"13","doi-asserted-by":"crossref","unstructured":"JA Mohawk, CB Green, JS Takahashi,  \"Annu Rev Neurosci.\"  35, \"Central and peripheral circadian clocks in mammals.\" 445 (2012)","DOI":"10.1146\/annurev-neuro-060909-153128"},{"key":"25","doi-asserted-by":"crossref","unstructured":"B Schmid, C Helfrich-F\u00f6rster, T Yoshii,  \"J Biol Rhythms.\"  26, \"A new ImageJ plug-in \u201cActogramJ\u201d for chronobiological analyses.\" 464 (2011)","DOI":"10.1177\/0748730411414264"},{"key":"10","doi-asserted-by":"crossref","unstructured":"T Ikeno, SI Tanaka, H Numata, et al.  \"BMC Biol.\"  8, \"Photoperiodic diapause under the control of circadian clock genes in an insect.\" 116 (2010)","DOI":"10.1186\/1741-7007-8-116"},{"key":"28","doi-asserted-by":"crossref","unstructured":"K Tomioka,  \"J Comp Physiol A.\"  185, \"Light and serotonin phase-shift the circadian clock in the cricket optic lobe in vitro.\" 437 (1999)","DOI":"10.1007\/s003590050404"},{"key":"30","doi-asserted-by":"crossref","unstructured":"K Tomioka  and Y Chiba  \"Naturwissenschaften.\"  69, \"Persistence of circadian ERG rhythms in the cricket with optic tract severed.\" 355 (1982)","DOI":"10.1007\/BF00396696"},{"key":"38","doi-asserted-by":"crossref","unstructured":"S Yamazaki, V Alones, M Menaker,  \"J Biol Rhythms.\"  17, \"Interaction of the retina with suprachiasmatic pacemakers in the control of circadian behavior.\" 315 (2002)","DOI":"10.1177\/074873040201700405"},{"key":"1","doi-asserted-by":"crossref","unstructured":"H Arechiga  and L Rodriguez-Sosa  \"Proc R Soc B.\"  265, \"Circadian clock function in isolated eyestalk tissue of crayfish.\" 1819 (1998)","DOI":"10.1098\/rspb.1998.0507"},{"key":"2","doi-asserted-by":"crossref","unstructured":"RBJ Barlow,  \"J Neurosci.\"  3, \"Circaidan rhythms in the Limulus visual system.\" 856 (1983)","DOI":"10.1523\/JNEUROSCI.03-04-00856.1983"},{"key":"3","doi-asserted-by":"crossref","unstructured":"G Cao  and MN Nitabach  \"J Neurosci.\"  28, \"Circadian control of membrane excitability in Drosophila melanogaster larval ventral clock neurons.\" 6493 (2008)","DOI":"10.1523\/JNEUROSCI.1503-08.2008"},{"key":"4","doi-asserted-by":"crossref","unstructured":"M Damulewicz, JI Ispizua, MF Ceriani, et al.  \"Front Physiol.\"  11, \"Communication among photoreceptors and the central clock affects seep pofile.\" 993 (2020)","DOI":"10.3389\/fphys.2020.00993"},{"key":"6","doi-asserted-by":"crossref","unstructured":"HO de la Iglesia, J Meyer, A Carpino, et al.  \"Science.\"  290, \"Anti-phase oscillation of the left and right suprachiasmatic nuclei.\" 799 (2000)","DOI":"10.1126\/science.290.5492.799"},{"key":"7","doi-asserted-by":"crossref","unstructured":"C Dibner, U Schibler, U Albrecht,  \"Ann Rev Physiol.\"  72, \"The mammalian circadian timing system: organization and coordination of central and peripheral clocks.\" 517 (2010)","DOI":"10.1146\/annurev-physiol-021909-135821"},{"key":"8","unstructured":"JC Dunlap, J Loros, PJ DeCoursey,  \"Chronobiology: biological timekeeping.\"  (2004)"},{"key":"11","doi-asserted-by":"crossref","unstructured":"S Kiessling, G Eichele, H Oster,  \"J Clin Invest.\"  120, \"Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag.\" 2600 (2010)","DOI":"10.1172\/JCI41192"},{"key":"12","doi-asserted-by":"crossref","unstructured":"A Mizoguchi  and H Ishizaki  \"Proc Natl Acad Sci U S A.\"  79, \"Prothoracic glands of the saturniid moth Samia cynthia ricini possess a circadian clock controlling gut purge timing.\" 2726 (1982)","DOI":"10.1073\/pnas.79.8.2726"},{"key":"15","doi-asserted-by":"crossref","unstructured":"MN Nitabach  and PH Taghert  \"Curr Biol.\"  18, \"Organization of the Drosophila circadian control circuit.\" R84 (2008)","DOI":"10.1016\/j.cub.2007.11.061"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Y Okada, K Tomioka, Y Chiba,  \"J Insect Physiol.\"  37, \"Circadian phase response curves for light in nymphal and adult crickets,\" 583 (1991)","DOI":"10.1016\/0022-1910(91)90035-X"},{"key":"18","doi-asserted-by":"crossref","unstructured":"H Oster, S Damerow, RA Hut, et al.  \"J Biol Rhythms.\"  21, \"Transcriptional profiling in the adrenal gland reveals circadian regulation of hormone biosynthesis genes and nucleosome assembly genes.\" 350 (2006)","DOI":"10.1177\/0748730406293053"},{"key":"19","doi-asserted-by":"crossref","unstructured":"TL Page  and JL Larimer  \"J Comp Physiol.\"  97, \"Neural control of circadian rhythmicity in the crayfish. I. Locomotor activity rhythm.\" 59 (1975a)","DOI":"10.1007\/BF00635649"},{"key":"20","doi-asserted-by":"crossref","unstructured":"TL Page  and JL Larimer  \"J Comp Physiol.\"  97, \"Neural control of circadian rhythmicity in the crayfish. II. The ERG amplitude rhythm.\" 81 (1975b)","DOI":"10.1007\/BF00635650"},{"key":"21","doi-asserted-by":"crossref","unstructured":"J Richards  and ML Gumz  \"FASEB J.\"  26, \"Advances in understanding the peripheral circadian clocks.\" 3602 (2012)","DOI":"10.1096\/fj.12-203554"},{"key":"22","doi-asserted-by":"crossref","unstructured":"D Rieger, R Stanewsky, C Helfrich-F\u00f6rster,  \"J Biol Rhythms.\"  18, \"Cryptochrome, compound eyes, Hofbauer-Buchner eyelets, and ocelli play different roles in the entrainment and masking pathway of the locomotor activity rhythm in the fruit fly Drosophila melanogaster.\" 377 (2003)","DOI":"10.1177\/0748730403256997"},{"key":"24","doi-asserted-by":"crossref","unstructured":"U Schibler, I Gotic, C Saini, et al.  \"Cold Spring Harbor Symposia on Quantative Biology.\"  80, \"Clock-talk: interactions between central and peripheral circadian oscillators in mammals.\" 223 (2015)","DOI":"10.1101\/sqb.2015.80.027490"},{"key":"26","doi-asserted-by":"crossref","unstructured":"M Selcho, C Mill\u00e1n, A Palacios-Mu\u00f1oz, et al.  \"Nat Commun.\"  8, \"Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila.\" 15563 (2017)","DOI":"10.1038\/ncomms15563"},{"key":"29","doi-asserted-by":"crossref","unstructured":"K Tomioka,  \"Zool Sci.\"  40, \"The compound eye regulates free-running period and stability of the circadian locomotor rhythm in the cricket Gryllus bimaculatus.\" 300 (2023)","DOI":"10.2108\/zs230005"},{"key":"33","doi-asserted-by":"crossref","unstructured":"K Tomioka, T Sakamoto, Y Moriyama,  \"Sleep Biol Rhythms.\"  7, \"RNA interference is a powerful tool for chronobiological study in the cricket.\" 144 (2009)","DOI":"10.1111\/j.1479-8425.2009.00407.x"},{"key":"35","doi-asserted-by":"crossref","unstructured":"O Uryu, Y Kamae, K Tomioka, et al.  \"J Insect Physiol.\"  59, \"Long-term effect of systemic RNA interference on circadian clock genes in hemimetabolous insects.\" 494 (2013a)","DOI":"10.1016\/j.jinsphys.2013.02.009"},{"key":"36","doi-asserted-by":"crossref","unstructured":"O Uryu, SG Karpova, K Tomioka,  \"J Insect Physiol.\"  59, \"The clock gene cycle plays an important role in the circadian clock of the cricket Gryllus bimaculatus.\" 697 (2013b)","DOI":"10.1016\/j.jinsphys.2013.04.011"}],"container-title":["Zoological Science"],"original-title":[],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:40:23Z","timestamp":1791247223000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/zoological-science\/volume-41\/issue-4\/zs230113\/Reciprocal-Coupling-of-Circadian-Clocks-in-the-Compound-Eye-and\/10.2108\/zs230113.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,8,1]]}},"URL":"https:\/\/doi.org\/10.2108\/zs230113","relation":{},"ISSN":["0289-0003","2212-3830"],"issn-type":[{"value":"0289-0003","type":"print"},{"value":"2212-3830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]}}}