{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:35:25Z","timestamp":1777401325121,"version":"3.51.4"},"reference-count":0,"publisher":"Instituto Nacional de Salud Publica","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Salud Publica Mex"],"abstract":"<jats:p>Objective. To investigate the association of high-risk hu\u00adman papilloma virus (HR-HPV) and other risk factors with ocular surface squamous cell neoplasia (OSSN). Materials and methods. We obtained DNA from 22 fresh frozen OSSN tissues and 22 pterygia as controls, we used a broad-spectrum HPV DNA amplification short PCR fragment to identify HPV infection in all specimens and then genotyped HPV by a reverse hybridization line probe assay. We also obtained demographic, sun exposure, and tobacco consump\u00adtion information. Results. HR-HPV frequency was 40.9% in the OSSN group and 4.5% in the pterygia group (p=0.009). After covariate adjustment, OSSN was associated with HR-HPV (OR=16.3, 95%CI=1.2,218.1, p=0.03) and sunburn (OR=10.8, 95%CI=1.8,86.0, p=0.02). Conclusions. Ocular surface squamous cell neoplasia is a multifactorial disease. The strong association between HR-HPV and OSSN, suggests that HR-HPV could play an etiological role in OSSN development.<\/jats:p>","DOI":"10.21149\/12796","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T01:39:51Z","timestamp":1649468391000},"page":"209-217","source":"Crossref","is-referenced-by-count":6,"title":["Association of high-risk human papillomavirus with ocular surface squamous neoplasia: a case-control study in Mexico"],"prefix":"10.21149","author":[{"given":"Paola","family":"De La Parra-Colin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Pichardo-Bahena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"M\u00e9ndez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Garc\u00eda-Carranc\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonatiuh","family":"Barrientos-Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Santamar\u00eda-Olmedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Lazcano-Ponce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Hidalgo-Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8786","published-online":{"date-parts":[[2022,4,8]]},"container-title":["Salud P\u00fablica de M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/saludpublica.mx\/index.php\/spm\/article\/download\/12796\/12211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/saludpublica.mx\/index.php\/spm\/article\/download\/12796\/12211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T01:40:14Z","timestamp":1649468414000},"score":1,"resource":{"primary":{"URL":"https:\/\/saludpublica.mx\/index.php\/spm\/article\/view\/12796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.21149\/12796","relation":{},"ISSN":["1606-7916","0036-3634"],"issn-type":[{"value":"1606-7916","type":"electronic"},{"value":"0036-3634","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,8]]}}}