{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:38:49Z","timestamp":1758638329793},"reference-count":34,"publisher":"Instituto Nacional de Salud Publica","issue":"1","license":[{"start":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T00:00:00Z","timestamp":1483401600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Salud Publica Mex"],"abstract":"<jats:p>Objective. To review evidence on the efficacy of HPV vaccines in the prevention of non-cancer lesions (anogenital warts [AGW], recurrent laryngeal papillomatosis and oral papillomatosis). Materials and methods. We conducted a systematic review of randomized trials. We performedrandom effect models and effects were reported as relative risks (RR) and their confidence intervals (95%CI) following both intention to treat (ITT) and per protocol (PP) analyses.Results. We included six studies (n=27 078). One study was rated as high risk of bias. One study could not be included in the meta-analysis because it provided combined results. We found that quadrivalent vaccine reduced the risk of AGW by 62% (RR: 0.38, 95%CI:0.32-0.45, I2:0%) in the ITT analysis and by 95% (RR: 0.05, 95%CI:0.01-0.25, I2:66%) in the PP analysis. Subgroup analyses of studies in women or with low-risk of bias provided similar results. Conclusion. HPV quadrivalent vaccine is efficacious in preventing AGW in men and women.<\/jats:p>","DOI":"10.21149\/7824","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T20:41:51Z","timestamp":1483562511000},"page":"84","source":"Crossref","is-referenced-by-count":11,"title":["Human papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis"],"prefix":"10.21149","volume":"59","author":[{"given":"Romina A","family":"Tejada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris G","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Benites-Zapata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Mezones-Holgu\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Bola\u00f1os-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian V","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8786","published-online":{"date-parts":[[2017,1,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1258\/0956462981921143"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2340\/0001555572185186","article-title":"Follow-up of men with genital papilloma virus infection. Psychosexual aspects.","volume":"72","author":"Voog","year":"1992","unstructured":"3. Voog E, L\u00f6whagen GB. Follow-up of men with genital papilloma virus infection. Psychosexual aspects. Acta Derm Venereol 1992;72:185-186.","journal-title":"Acta Derm Venereol","ISSN":"http:\/\/id.crossref.org\/issn\/0001-5555","issn-type":"print"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109\/01674829309084437"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-30"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2011.01.016"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-39"},{"key":"ref7","first-page":"208","article-title":"HPV 6, 11, 16, 18 vaccine in men. Inadequate assessment.","volume":"21","year":"2012","unstructured":"9. HPV 6, 11, 16, 18 vaccine in men. Inadequate assessment. Prescrire Int 2012;21:208.","journal-title":"Prescrire Int","ISSN":"http:\/\/id.crossref.org\/issn\/1167-7422","issn-type":"print"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061760"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2013.11.003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00055-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)71073-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61248-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181a3d100"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.070948"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S50365"},{"key":"ref16","first-page":"626","article-title":"FDA licensure of bivalent human papillomavirus vaccine (HPV2, Cervarix) for use in females and updated HPV vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP).","volume":"59","year":"2010","unstructured":"21. Centers for Disease Control and Prevention (CDC). FDA licensure of bivalent human papillomavirus vaccine (HPV2, Cervarix) for use in females and updated HPV vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 2010;59:626-629.","journal-title":"MMWR Morb Mortal Wkly Rep","ISSN":"http:\/\/id.crossref.org\/issn\/0149-2195","issn-type":"print"},{"key":"ref17","first-page":"1705","article-title":"Recommendations on the use of quadr.ivalent human papillomavirus vaccine in males-Advisory Committee on Immunization Practices (ACIP), 2011.","volume":"60","year":"2011","unstructured":"22. Centers for Disease Control and Prevention (CDC). Recommendations on the use of quadr.ivalent human papillomavirus vaccine in males-Advisory Committee on Immunization Practices (ACIP), 2011. MMWR Morb Mortal Wkly Rep 2011;60:1705-1708.","journal-title":"MMWR Morb Mortal Wkly Rep","ISSN":"http:\/\/id.crossref.org\/issn\/0149-2195","issn-type":"print"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000314010"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70225-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603469"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.185"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909537"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12106"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061741"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp534"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05208-11"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-6-112"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1086\/590560"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.108"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-015-0178-4"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2032"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.03.008"}],"container-title":["Salud P\u00fablica de M\u00e9xico"],"original-title":[],"link":[{"URL":"http:\/\/www.saludpublica.mx\/index.php\/spm\/article\/viewFile\/7824\/10996","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.saludpublica.mx\/index.php\/spm\/article\/viewFile\/7824\/10996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:00:39Z","timestamp":1692630039000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.saludpublica.mx\/index.php\/spm\/article\/view\/7824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,3]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,3]]}},"URL":"https:\/\/doi.org\/10.21149\/7824","relation":{},"ISSN":["1606-7916","0036-3634"],"issn-type":[{"value":"1606-7916","type":"electronic"},{"value":"0036-3634","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,3]]}}}