{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:48:13Z","timestamp":1789987693197,"version":"4.0.1"},"reference-count":0,"publisher":"Instituto Nacional de Salud Publica","issue":"2","license":[{"start":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T00:00:00Z","timestamp":1393977600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Salud Publica Mex"],"abstract":"<jats:p>\u00a0Objective. To assess whether in Mexican population the frequencies of ATM polymorphisms IVS24-9delT, IVS38-8\u00adT&gt;C, and 5557G&gt;A in breast cancer (BC) cases and healthy controls were different from those found in other countries. Materials and methods. Frequencies of polymorphisms conferring BC risk IVS24-9delT, IVS38-8T&gt;C, and 5557G&gt;A were analyzed by PCR-RFLP in 94 patients with familial and\/or early onset BC, and 97 healthy controls randomly selected. Allele frequencies analysis was done using \u03c72 and Hardy-Weinberg test. Results. Frequencies of heterozygous were: for 5557G&gt;A, 13% cases, 0%controls (p=0.0009); for IVS24-9delT, 21% cases, 8% controls (p=0.0122); for IVS38-8T&gt;C, only one case. 5557G&gt;A and IVS24-9delT were more frequent in cases than in controls. The allelic frequen\u00adcies found in 5557G&gt;A are similar to those described by Gonz\u00e1lez-Hormaz\u00e1bal in Chile. Conclusion. The similarity of results in this polymorphism between Chilean and Mexican populations may be due to both being crossbred with an Amerindian-Spanish component, while differences may be due to fact that Chilean population has a greater European component than Mexican\u2019s.<\/jats:p>","DOI":"10.21149\/spm.v56i2.7336","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T23:05:17Z","timestamp":1483571117000},"page":"206","source":"Crossref","is-referenced-by-count":7,"title":["ATM polymorphisms IVS24-9delT, IVS38-8T&gt;C, and 5557G&gt;A in Mexican women with familial and\/or early-onset breast cancer"],"prefix":"10.21149","volume":"56","author":[{"given":"Fabiola","family":"Del Carmen Calder\u00f3n-Z\u00fa\u00f1iga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Ocampo-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Carlos","family":"L\u00f3pez-M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Recio-Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Benjam\u00edn","family":"Serrano-Gallardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ruiz-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8786","published-online":{"date-parts":[[2014,3,5]]},"container-title":["Salud P\u00fablica de M\u00e9xico"],"original-title":[],"link":[{"URL":"http:\/\/www.saludpublica.mx\/index.php\/spm\/article\/viewFile\/7336\/9625","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.saludpublica.mx\/index.php\/spm\/article\/viewFile\/7336\/10897","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.saludpublica.mx\/index.php\/spm\/article\/viewFile\/7336\/10897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T23:05:37Z","timestamp":1483571137000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.saludpublica.mx\/index.php\/spm\/article\/view\/7336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,5]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,3,5]]}},"URL":"https:\/\/doi.org\/10.21149\/spm.v56i2.7336","relation":{},"ISSN":["1606-7916","0036-3634"],"issn-type":[{"value":"1606-7916","type":"electronic"},{"value":"0036-3634","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3,5]]}}}