{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:43:37Z","timestamp":1773675817416,"version":"3.50.1"},"reference-count":0,"publisher":"Instituto Nacional de Salud Publica","issue":"2","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Salud Publica Mex"],"abstract":"<jats:p>Objective. To determine rates of drug resistance in new cases of pulmonary tuberculosis in a region with a high burden of the disease. Materials and methods. New case suspects were referred for drug susceptibility testing. Results. 28.9% of new cases were resistant to at least one first line drug; 3.9% had a multidrug-resistant strain, 15.6% a monoresistant strain and 9.4% a polyresistant strain. Conclusion.Our rate of drug resistant tuberculosis in new cases is very high; this has important clinical implications, since even monoresistance can have a negative impact on the outcome of new cases treated empirically with a six month regimen.<\/jats:p>","DOI":"10.21149\/spm.v57i2.7414","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T20:51:30Z","timestamp":1483563090000},"page":"177","source":"Crossref","is-referenced-by-count":12,"title":["Primary drug resistance in a region with high burden of tuberculosis. A critical problem"],"prefix":"10.21149","volume":"57","author":[{"given":"Cecilia","family":"Villa-Rosas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Laniado-Labor\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Oceguera-Palao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8786","published-online":{"date-parts":[[2015,3,3]]},"container-title":["Salud P\u00fablica de M\u00e9xico"],"original-title":[],"link":[{"URL":"http:\/\/www.saludpublica.mx\/index.php\/spm\/article\/viewFile\/7414\/10325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.saludpublica.mx\/index.php\/spm\/article\/viewFile\/7414\/10857","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.saludpublica.mx\/index.php\/spm\/article\/viewFile\/7414\/10857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T20:52:01Z","timestamp":1483563121000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.saludpublica.mx\/index.php\/spm\/article\/view\/7414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,3]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,3,3]]}},"URL":"https:\/\/doi.org\/10.21149\/spm.v57i2.7414","relation":{},"ISSN":["1606-7916","0036-3634"],"issn-type":[{"value":"1606-7916","type":"electronic"},{"value":"0036-3634","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3,3]]}}}