{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:33:39Z","timestamp":1758706419777},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["ANAL. SCI."],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.2116\/analsci.24.957","type":"journal-article","created":{"date-parts":[[2008,8,11]],"date-time":"2008-08-11T05:46:20Z","timestamp":1218433580000},"page":"957-962","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Development of an in vitro Batch-type Closed Gas Exposure Device with an Alveolar Epithelial Cell Line, A549, for Toxicity Evaluations of Gaseous Compounds"],"prefix":"10.1007","volume":"24","author":[{"given":"Kikuo","family":"Komori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Murai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Miyajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shino","family":"Mohri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,8,10]]},"reference":[{"key":"2408002_CR1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0041-008X(92)90329-Q","volume":"115","author":"L Y Chang","year":"1992","unstructured":"L. Y. Chang, Y. Huang, B. L. Stockstill, J. A. Graham, E. C. Grose, M. G. Menache, F. J. Miller, D. L. Costa, and J. D. Crapo, Toxicol. Appl. Pharmacol., 1992, 115, 241.","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2408002_CR2","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1080\/15287398409530506","volume":"13","author":"R E Rasmussen","year":"1984","unstructured":"R. E. Rasmussen, J. Toxicol. Environ. Health, 1984, 13, 397.","journal-title":"J. Toxicol. Environ. Health"},{"key":"2408002_CR3","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1007\/BF02628493","volume":"24","author":"M J Whittcutt","year":"1988","unstructured":"M. J. Whittcutt, K. B. Adler, and R. Wu, In Vitro Cell Develop. Biol., 1988, 24, 420.","journal-title":"In Vitro Cell Develop. Biol."},{"key":"2408002_CR4","first-page":"L560","volume":"264","author":"L G Johnson","year":"1993","unstructured":"L. G. Johnson, K. G. Dickman, K. L. Moore, L. J. Mandel, and R. C. Boucher, Am. J. Physiol., 1993, 264, L560.","journal-title":"Am. J. Physiol."},{"key":"2408002_CR5","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1289\/ehp.94102972","volume":"102","author":"E W Gabrielson","year":"1994","unstructured":"E. W. Gabrielson, W. Y. Yu, and E. W. Spannhake, Environ. Health Perspect., 1994, 102, 972.","journal-title":"Environ. Health Perspect."},{"key":"2408002_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1006\/taap.1994.1135","volume":"127","author":"D T Wright","year":"1994","unstructured":"D. T. Wright, K. B. Adler, N. J. Akley, L. A. Dailey, and M. Friedman, Toxicol. Appl. Pharmacol., 1994, 127, 27.","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2408002_CR7","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0378-4274(98)00045-9","volume":"96\/97","author":"D S Lang","year":"1998","unstructured":"D. S. Lang, R. A. Jorres, M. Mucke, W. Siegfreid, and H. Magnussen, Toxicol. Lett., 1998, 96\/97, 13.","journal-title":"Toxicol. Lett."},{"key":"2408002_CR8","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1078\/0940-2993-00187","volume":"53","author":"M Aufderheide","year":"2001","unstructured":"M. Aufderheide, J. W. Knebel, D. Ritter, and G. Scherer, Exp. Toxic. Pathol., 2001, 53, 141.","journal-title":"Exp. Toxic. Pathol."},{"key":"2408002_CR9","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1078\/0940-2993-00298","volume":"55","author":"M Aufderheide","year":"2003","unstructured":"M. Aufderheide, J. W. Knebel, and D. Ritter, Exp. Toxic. Pathol., 2003, 55, 51.","journal-title":"Exp. Toxic. Pathol."},{"key":"2408002_CR10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0887-2333(01)00110-2","volume":"16","author":"J W Knebel","year":"2002","unstructured":"J. W. Knebel, D. Ritter, and M. Aufderheide, Toxicol. in Vitro, 2002, 16, 185.","journal-title":"Toxicol. in Vitro"},{"key":"2408002_CR11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/jat.1112","volume":"26","author":"F Lestari","year":"2006","unstructured":"F. Lestari, B. Markovic, A. R. Green, G. Chattopadhyay, and A. J. Hayes, J. Appl. Toxicol., 2006, 26, 99.","journal-title":"J. Appl. Toxicol."},{"key":"2408002_CR12","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/j.tiv.2007.04.013","volume":"21","author":"S Bakand","year":"2007","unstructured":"S. Bakand, C. Winder, and A. Hayes, Toxicol. in Vitro, 2007, 21, 1341.","journal-title":"Toxicol. in Vitro"},{"key":"2408002_CR13","first-page":"59","volume":"11","author":"Y Sakai","year":"2005","unstructured":"Y. Sakai, K. Tomita, M. Suzuki, Y. Ono, and A. Sakoda, AATEX, 2005, 11, 59.","journal-title":"AATEX"},{"key":"2408002_CR14","volume-title":"\u201cThe WHO Environmental Health Criteria Series\u201d","author":"World Health Organization","year":"1993","unstructured":"World Health Organization, \u201cThe WHO Environmental Health Criteria Series\u201d, 1993, WHO Publications, New York."},{"key":"2408002_CR15","unstructured":"S. Gangolli, \u201cThe Dictionary of Substances and Their Effect\u201d, 2nd ed., 1999, Royal Society of Chemistry."},{"key":"2408002_CR16","first-page":"L13","volume":"258","author":"J H Widdicombe","year":"1990","unstructured":"J. H. Widdicombe, Am. J. Physiology, 1990, 258, L13.","journal-title":"Am. J. Physiology"},{"key":"2408002_CR17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/BF00749057","volume":"11","author":"A Martin","year":"1993","unstructured":"A. Martin and M. Clynes, Cytotechnology, 1993, 11, 49.","journal-title":"Cytotechnology"},{"key":"2408002_CR18","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1006\/abio.1996.0383","volume":"241","author":"T T Yang","year":"1996","unstructured":"T.-T. Yang, P. Sinai, and S. R. Kain, Anal. Biochem., 1996, 241, 103.","journal-title":"Anal. Biochem."},{"key":"2408002_CR19","doi-asserted-by":"crossref","unstructured":"H. Salem and S. A. Katz, \u201cInhalation Toxicology\u201d, 2nd ed., 2006, CRC Press.","DOI":"10.1201\/9781420037302"},{"key":"2408002_CR20","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0041-008X(74)90185-9","volume":"27","author":"R T Drew","year":"1974","unstructured":"R. T. Drew and J. R. Fouts, Toxicol. Appl. Pharmacol., 1974, 27, 183.","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2408002_CR21","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/193395a0","volume":"193","author":"B Kylin","year":"1962","unstructured":"B. Kylin, H. Reichard, I. Sumegi, and S. Yllner, Nature, 1962, 193, 395.","journal-title":"Nature"},{"key":"2408002_CR22","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/0041-008X(71)90326-7","volume":"18","author":"J Siegel","year":"1971","unstructured":"J. Siegel, R. A. Jones, R. A. Coon, and J. P. Lyon, Toxicol. Appl. Pharmacol., 1971, 18, 168.","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2408002_CR23","unstructured":"NIOSH, \u201cRegistry of Toxic Effects of Chemical Substances\u201d, 1999."},{"key":"2408002_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0166-1280(02)00614-0","volume":"622","author":"T W Schultz","year":"2003","unstructured":"T. W. Schultz, M. T. D. Cronin, J. D. Walker, and A. O. Aptula, J. Mol. Struct. (Theochem), 2003, 622, 1.","journal-title":"J. Mol. Struct. (Theochem)"},{"key":"2408002_CR25","volume-title":"\u201cExploring QSAR\u201d","author":"C Hansch","year":"1995","unstructured":"C. Hansch and A. Leo, \u201cExploring QSAR\u201d, 1995, Vol. 1, American Chemical Society, Washington, D.C."},{"key":"2408002_CR26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/jps.2600840120","volume":"84","author":"W H Meylan","year":"1995","unstructured":"W. H. Meylan and P. H. Howard, J. Pharm. Sci., 1995, 84, 83.","journal-title":"J. Pharm. Sci."},{"key":"2408002_CR27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0300-483X(94)02909-E","volume":"96","author":"B Tu","year":"1995","unstructured":"B. Tu, A. Wallin, P. Mold\u00e9us, and I. A. Cotgreave, Toxicology, 1995, 96, 7.","journal-title":"Toxicology"},{"key":"2408002_CR28","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1146\/annurev.pa.30.040190.003131","volume":"30","author":"D J Reed","year":"1990","unstructured":"D. J. Reed, Annu. Rev. Pharmacol. Toxicol., 1990, 30, 603.","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2408002_CR29","first-page":"L92","volume":"266","author":"S Lannan","year":"1994","unstructured":"S. Lannan, K. Donaldson, D. Brown, and W. MacNee, Am. J. Physiol., 1994, 266, L92.","journal-title":"Am. J. Physiol."},{"key":"2408002_CR30","first-page":"L285","volume":"269","author":"I Rahman","year":"1995","unstructured":"I. Rahman, X. Y. Li, K. Donaldson, D. J. Harrison, and W. MacNee, Am. J. Physiol., 1995, 269, L285.","journal-title":"Am. J. Physiol."},{"key":"2408002_CR31","first-page":"93","volume":"26","author":"C Clemedson","year":"1998","unstructured":"C. Clemedson, F. A. Barile, B. Ekwall, M. J. G. Lech\u00f3n, T. Hall, K. Imai, A. Kahru, P. Logemann, F. Monaco, T. Ohno, H. Segner, M. Sj\u00f6str\u00f6m, M. Valentino, E. Walum, X. Wang, and B. Ekwall, ATLA, 1998, 26, 93.","journal-title":"ATLA"},{"key":"2408002_CR32","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1128\/mr.59.2.201-222.1995","volume":"59","author":"J Sikkema","year":"1995","unstructured":"J. Sikkema, J. A. M. De Bont, and B. Poolman, Microbiol. Rev., 1995, 59, 201.","journal-title":"Microbiol. Rev."},{"key":"2408002_CR33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/toxsci\/45.1.26","volume":"45","author":"J De Jongh","year":"1998","unstructured":"J. De Jongh, H. J. M. Verhaar, and J. L. M. Hermens, Toxicol. Sci., 1998, 45, 26.","journal-title":"Toxicol. Sci."},{"key":"2408002_CR34","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/BF02713647","volume":"164","author":"A M Richter","year":"1986","unstructured":"A. M. Richter, R. T. Abboud, S. S. Johal, and T. A. Fera, Lung, 1986, 164, 233.","journal-title":"Lung"},{"key":"2408002_CR35","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/BF00172847","volume":"172","author":"K Kienast","year":"1994","unstructured":"K. Kienast, J. M\u00fcller-Quernheim, M. Knorst, S. Lubjuhn, and R. Ferlinz, Lung, 1994, 172, 335.","journal-title":"Lung"},{"key":"2408002_CR36","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1289\/ehp.8564111","volume":"64","author":"D F Church","year":"1985","unstructured":"D. F. Church and W. A. Pryor, Environ. Health Perspect., 1985, 64, 111.","journal-title":"Environ. Health Perspect."},{"key":"2408002_CR37","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1080\/08958370490476659","volume":"16","author":"D Ritter","year":"2004","unstructured":"D. Ritter, J. W. Knebel, and M. Aufderheide, Inhalation Toxicol., 2004, 16, 691.","journal-title":"Inhalation Toxicol."},{"key":"2408002_CR38","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1183\/09031936.93.03091029","volume":"3","author":"Y Uejima","year":"1990","unstructured":"Y. Uejima, Y. Fukuchi, T. Nagase, T. Matsuse, M. Yamaoka, R. Tabata, and H. Orimo, Eur. Respir. J., 1990, 3, 1029.","journal-title":"Eur. Respir. J."},{"key":"2408002_CR39","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1164\/ajrccm.149.6.8004308","volume":"149","author":"X Y Li","year":"1994","unstructured":"X. Y. Li, K. Donaldson, I. Rahman, and W. MacNee, Am. J. Respir. Crit. Care. Med., 1994, 149, 1518.","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"2408002_CR40","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0891-5849(98)00041-0","volume":"25","author":"E M Park","year":"1998","unstructured":"E. M. Park, Y. M. Park, and Y. S. Gwak, Free Radical Biol. Med., 1998, 25, 79.","journal-title":"Free Radical Biol. Med."},{"key":"2408002_CR41","doi-asserted-by":"publisher","first-page":"L509","DOI":"10.1152\/ajplung.2001.281.2.L509","volume":"281","author":"Y Hoshino","year":"2001","unstructured":"Y. Hoshino, T. Mio, S. Nagai, H. Miki, I. Ito, and T. Izumi, Am. J. Physiol. Lung Cell Mol. Physiol., 2001, 281, L509.","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."}],"container-title":["Analytical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.2116\/analsci.24.957.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.2116\/analsci.24.957\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/analsci\/24\/8\/24_8_957\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.2116\/analsci.24.957.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T14:19:46Z","timestamp":1684505986000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.2116\/analsci.24.957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["2408002"],"URL":"https:\/\/doi.org\/10.2116\/analsci.24.957","relation":{},"ISSN":["0910-6340","1348-2246"],"issn-type":[{"value":"0910-6340","type":"print"},{"value":"1348-2246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"7 April 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}