{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:12:31Z","timestamp":1761513151470},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["ANAL. SCI."],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.2116\/analsci.28.607","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T22:43:03Z","timestamp":1340145783000},"page":"607-612","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Real-time ESI-MS of Enzymatic Conversion: Impact of Organic Solvents and Multiplexing"],"prefix":"10.1007","volume":"28","author":[{"given":"Romy K.","family":"Scheerle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Grassmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Letzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,6,10]]},"reference":[{"key":"28060012_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s00216-007-1646-8","volume":"390","author":"T Letzel","year":"2008","unstructured":"T. Letzel, Anal. Bioanal. Chem., 2008, 390, 257.","journal-title":"Anal. Bioanal. Chem."},{"key":"28060012_CR2","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.trac.2007.08.004","volume":"26","author":"A R de Boer","year":"2007","unstructured":"A. R. de Boer, H. Lingeman, W. M. A. Niessen, and H. Irth, Trac-Trends Anal. Chem., 2007, 26, 867.","journal-title":"Trac-Trends Anal. Chem."},{"key":"28060012_CR3","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1002\/mas.20127","volume":"26","author":"K D Greis","year":"2007","unstructured":"K. D. Greis, Mass Spectrom. Rev., 2007, 26, 324.","journal-title":"Mass Spectrom. Rev."},{"key":"28060012_CR4","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1007\/s00216-005-3305-2","volume":"382","author":"A Liesener","year":"2005","unstructured":"A. Liesener and U. Karst, Anal. Bioanal. Chem., 2005, 382, 1451.","journal-title":"Anal. Bioanal. Chem."},{"key":"28060012_CR5","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00216-011-5236-4","volume":"2","author":"J Grassmann","year":"2012","unstructured":"J. Grassmann, R. K. Scheerle, and T. Letzel, Anal. Bioanal. Chem., 2012, 2, 625.","journal-title":"Anal. Bioanal. Chem."},{"key":"28060012_CR6","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.carres.2011.01.012","volume":"346","author":"T Letzel","year":"2011","unstructured":"T. Letzel, E. Sahmel-Schneider, K. Skriver, T. Ohnuma, and T. Fukamizo, Carbohydr. Res., 2011, 346, 863.","journal-title":"Carbohydr. Res."},{"key":"28060012_CR7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jbiotec.2008.02.004","volume":"134","author":"N Dennhart","year":"2008","unstructured":"N. Dennhart, T. Fukamizo, R. Brzezinski, M. E. Lacombe-Harvey, and T. Letzel, J. Biotechnol., 2008, 134, 253.","journal-title":"J. Biotechnol."},{"key":"28060012_CR8","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.jbiotec.2009.08.003","volume":"143","author":"N Dennhart","year":"2009","unstructured":"N. Dennhart, L. M. M. Weigang, M. Fujiwara, T. Fukamizo, K. Skriver, and T. Letzel, J. Biotechnol., 2009, 143, 274.","journal-title":"J. Biotechnol."},{"key":"28060012_CR9","doi-asserted-by":"publisher","first-page":"5078","DOI":"10.1021\/ac0105890","volume":"73","author":"X Ge","year":"2001","unstructured":"X. Ge, T. L. Sirich, M. K. Beyer, H. Desaire, and J. A. Leary, Anal. Chem., 2001, 73, 5078.","journal-title":"Anal. Chem."},{"key":"28060012_CR10","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S0968-0896(97)00020-5","volume":"5","author":"D B Northrop","year":"1997","unstructured":"D. B. Northrop and F. B. Simpson, Bioorg. Med. Chem., 1997, 5, 641.","journal-title":"Bioorg. Med. Chem."},{"key":"28060012_CR11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0734-9750(02)00019-8","volume":"20","author":"S H Krishna","year":"2002","unstructured":"S. H. Krishna, Biotechnol. Adv., 2002, 20, 239.","journal-title":"Biotechnol. Adv."},{"key":"28060012_CR12","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/35051719","volume":"409","author":"A M Klibanov","year":"2001","unstructured":"A. M. Klibanov, Nature, 2001, 409, 241.","journal-title":"Nature"},{"key":"28060012_CR13","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S1389-1723(01)80051-7","volume":"91","author":"H Ogino","year":"2001","unstructured":"H. Ogino and H. Ishikawa, J. Biosci. Bioeng., 2001, 91, 109.","journal-title":"J. Biosci. Bioeng."},{"key":"28060012_CR14","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1002\/mas.20247","volume":"28","author":"P Kebarle","year":"2009","unstructured":"P. Kebarle and U. H. Verkerk, Mass Spectrom. Rev., 2009, 28, 898.","journal-title":"Mass Spectrom. Rev."},{"key":"28060012_CR15","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s00216-005-3070-2","volume":"381","author":"A R de Boer","year":"2005","unstructured":"A. R. de Boer, T. Letzel, H. Lingeman, and H. Irth, Anal. Bioanal. Chem., 2005, 381, 647.","journal-title":"Anal. Bioanal. Chem."},{"key":"28060012_CR16","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1039\/c0ay00727g","volume":"3","author":"R Scheerle","year":"2011","unstructured":"R. Scheerle, J. Grassmann, and T. Letzel, Anal. Methods, 2011, 3, 822.","journal-title":"Anal. Methods"},{"key":"28060012_CR17","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1039\/b506559c","volume":"5","author":"A R de Boer","year":"2005","unstructured":"A. R. de Boer, B. Bruyneel, J. G. Krabbe, H. Lingeman, W. M. A. Niessen, and H. Irth, Lab Chip, 2005, 5, 1286.","journal-title":"Lab Chip"},{"key":"28060012_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1432-1033.1992.tb19823.x","volume":"203","author":"M N Gupta","year":"1992","unstructured":"M. N. Gupta, Eur. J. Biochem., 1992, 203, 25.","journal-title":"Eur. J. Biochem."},{"key":"28060012_CR19","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.aca.2005.04.038","volume":"543","author":"C Hempen","year":"2005","unstructured":"C. Hempen, A. Liesener, and U. Karst, Anal. Chim. Acta, 2005, 543, 137.","journal-title":"Anal. Chim. Acta"},{"key":"28060012_CR20","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1021\/ja982878k","volume":"121","author":"S A Gerber","year":"1999","unstructured":"S. A. Gerber, C. R. Scott, F. Turecek, and M. H. Gelb, J. Am. Chem. Soc., 1999, 121, 1102.","journal-title":"J. Am. Chem. Soc."},{"key":"28060012_CR21","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1039\/b502008e","volume":"130","author":"A Liesener","year":"2005","unstructured":"A. Liesener and U. Karst, Analyst, 2005, 130, 850.","journal-title":"Analyst"},{"key":"28060012_CR22","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1002\/rcm.2136","volume":"19","author":"A Liesener","year":"2005","unstructured":"A. Liesener, A. M. Perchuc, R. Schoni, M. Wilmer, and U. Karst, Rapid Commun. Mass Spectrom., 2005, 19, 2923.","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"28060012_CR23","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/bdd.552","volume":"28","author":"V Dixit","year":"2007","unstructured":"V. Dixit, N. Hariparsad, P. Desai, and J. D. Unadkat, Biopharm. Drug Dispos., 2007, 28, 257.","journal-title":"Biopharm. Drug Dispos."},{"key":"28060012_CR24","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.chroma.2006.01.059","volume":"1112","author":"C F de Jong","year":"2006","unstructured":"C. F. de Jong, R. J. E. Derks, B. Bruyneel, W. Niessen, and H. Irth, J. Chromatogr., A, 2006, 1112, 303.","journal-title":"J. Chromatogr., A"},{"key":"28060012_CR25","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1007\/s00216-010-4406-0","volume":"399","author":"J Kool","year":"2011","unstructured":"J. Kool, M. Giera, H. Irth, and W. M. A. Niessen, Anal. Bioanal. Chem., 2011, 399, 2655.","journal-title":"Anal. Bioanal. Chem."},{"key":"28060012_CR26","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1177\/1087057103255973","volume":"8","author":"T Schenk","year":"2003","unstructured":"T. Schenk, J. Breel, P. Koevoets, S. van den Berg, A. C. Hogenboom, H. Irth, U. R. Tjaden, and J. van der Greef, J. Biomol. Screen., 2003, 8, 421.","journal-title":"J. Biomol. Screen."},{"key":"28060012_CR27","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.1021\/ac035380w","volume":"76","author":"A R de Boer","year":"2004","unstructured":"A. R. de Boer, T. Letzel, D. A. van Elswijk, H. Lingeman, W. M. A. Niessen, and H. Irth, Anal. Chem., 2004, 76, 3155.","journal-title":"Anal. Chem."},{"key":"28060012_CR28","doi-asserted-by":"publisher","first-page":"7894","DOI":"10.1021\/ac0510282","volume":"77","author":"A R de Boer","year":"2005","unstructured":"A. R. de Boer, J. M. Alcaide-Hidalgo, J. G. Krabbe, J. Kolkman, C. N. V. Boas, W. M. A. Niessen, H. Lingeman, and H. Irth, Anal. Chem., 2005, 77, 7894.","journal-title":"Anal. Chem."},{"key":"28060012_CR29","unstructured":"T. Teutenberg, High-Temperature Liquid Chromatography\u2014A User\u2019s Guide for Method Development, 2010, Royal Society of Chemistry."},{"key":"28060012_CR30","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00216-006-0604-1","volume":"386","author":"N Dennhart","year":"2006","unstructured":"N. Dennhart and T. Letzel, Anal. Bioanal. Chem., 2006, 386, 689.","journal-title":"Anal. Bioanal. Chem."},{"key":"28060012_CR31","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0141-0229(79)90044-9","volume":"1","author":"L G Butler","year":"1979","unstructured":"L. G. Butler, Enzyme Microb. Technol., 1979, 1, 253.","journal-title":"Enzyme Microb. Technol."},{"key":"28060012_CR32","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1002\/jms.821","volume":"40","author":"M Samalikova","year":"2005","unstructured":"M. Samalikova and R. Grandori, J. Mass Spectrom., 2005, 40, 503.","journal-title":"J. Mass Spectrom."},{"key":"28060012_CR33","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/BF01022403","volume":"16","author":"R Batra","year":"1994","unstructured":"R. Batra and M. N. Gupta, Biotechnol. Lett., 1994, 16, 1059.","journal-title":"Biotechnol. Lett."},{"key":"28060012_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/j.1432-1033.1991.tb15983.x","volume":"198","author":"Y L Khmelnitsky","year":"1991","unstructured":"Y. L. Khmelnitsky, V. V. Mozhaev, A. B. Belova, M. V. Sergeeva, and K. Martinek, Eur. J. Biochem., 1991, 198, 31.","journal-title":"Eur. J. Biochem."},{"key":"28060012_CR35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1021\/bp060252p","volume":"23","author":"H Ogino","year":"2007","unstructured":"H. Ogino, Y. Gemba, Y. Yutori, N. Doukyu, K. Ishimi, and H. Ishikawa, Biotechnol. Prog., 2007, 23, 155.","journal-title":"Biotechnol. Prog."},{"key":"28060012_CR36","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/pca.695","volume":"14","author":"I K Rhee","year":"2003","unstructured":"I. K. Rhee, N. Appels, T. Luijendijk, H. Irth, and R. Verpoorte, Phytochem. Anal., 2003, 14, 145.","journal-title":"Phytochem. Anal."},{"key":"28060012_CR37","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0021-9673(99)01292-3","volume":"872","author":"K Ingkaninan","year":"2000","unstructured":"K. Ingkaninan, C. M. de Best, R. van der Heijden, A. J. P. Hofte, B. Karabatak, H. Irth, U. R. Tjaden, J. van der Greef, and R. Verpoorte, J. Chromatogr., A, 2000, 872, 61.","journal-title":"J. Chromatogr., A"},{"key":"28060012_CR38","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1021\/bp9700263","volume":"13","author":"M N Gupta","year":"1997","unstructured":"M. N. Gupta, R. Batra, R. Tyagi, and A. Sharma, Biotechnol. Prog., 1997, 13, 284.","journal-title":"Biotechnol. Prog."},{"key":"28060012_CR39","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/bit.260300112","volume":"30","author":"C Laane","year":"1987","unstructured":"C. Laane, S. Boeren, K. Vos, and C. Veeger, Biotechnol. Bioeng., 1987, 30, 81.","journal-title":"Biotechnol. Bioeng."}],"container-title":["Analytical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.2116\/analsci.28.607.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.2116\/analsci.28.607\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/analsci\/28\/6\/28_607\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.2116\/analsci.28.607.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T01:53:44Z","timestamp":1665107624000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.2116\/analsci.28.607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["28060012"],"URL":"https:\/\/doi.org\/10.2116\/analsci.28.607","relation":{},"ISSN":["0910-6340","1348-2246"],"issn-type":[{"value":"0910-6340","type":"print"},{"value":"1348-2246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"20 February 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}