{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:54:55Z","timestamp":1780606495449,"version":"3.54.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"7-12","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.2119\/2004-00027.tayebi","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T18:08:54Z","timestamp":1203617334000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Disease-Associated Prion Protein Elicits Immunoglobulin M Responses In Vivo"],"prefix":"10.1186","volume":"10","author":[{"given":"Mourad","family":"Tayebi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry","family":"Enever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahid","family":"Sattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Collinge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Hawke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,10,30]]},"reference":[{"key":"10070104_CR1","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1098\/rstb.1994.0043","volume":"343","author":"SB Prusiner","year":"1994","unstructured":"Prusiner SB. (1994) Molecular biology and genetics of prion diseases. Philos. Trans. R. Soc. Lond. B Biol. Sci. 343:447\u201363.","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10070104_CR2","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/BF00294366","volume":"88","author":"F Gray","year":"1994","unstructured":"Gray F et al. (1994) Creutzfeldt-Jakob disease and cerebral amyloid angiopathy. Acta Neuropathol. (Berl) 88:106\u201311.","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10070104_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.7589\/0090-3558-16.1.89","volume":"16","author":"ES Williams","year":"1980","unstructured":"Williams ES, Young S. (1980) Chronic wasting disease of captive mule deer: a spongiform encephalopathy. J. Wildl. Dis. 16:89\u201398.","journal-title":"J. Wildl. Dis."},{"key":"10070104_CR4","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1136\/vr.121.18.419","volume":"31","author":"GAH Wells","year":"1987","unstructured":"Wells GAH et al. (1987) A novel progressive spongiform encephalopathy in cattle. Vet. Record Oct. 31:419\u201320.","journal-title":"Vet. Record Oct."},{"key":"10070104_CR5","first-page":"638","volume":"123","author":"JW Wilesmith","year":"1988","unstructured":"Wilesmith JW, Wells GA, Cranwell MP, Ryan JB. (1988) Bovine spongiform encephalopathy: epidemiological studies. Vet. Record 123:638\u201344.","journal-title":"Vet. Record"},{"key":"10070104_CR6","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1136\/vr.146.14.391","volume":"146","author":"MM Simmons","year":"2000","unstructured":"Simmons MM et al. (2000) Scrapie surveillance in Great Britain: results of an abattoir survey, 1997\/98. Vet. Record 146:391\u20135.","journal-title":"Vet. Record"},{"key":"10070104_CR7","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/383685a0","volume":"383","author":"J Collinge","year":"1996","unstructured":"Collinge J, Sidle KCL, Meads J, Ironside J, Hill AF. (1996) Molecular analysis of prion strain variation and the etiology of \u2018new variant\u2019 CJD. Nature 383:685\u201390.","journal-title":"Nature"},{"key":"10070104_CR8","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/38925","volume":"389","author":"AF Hill","year":"1997","unstructured":"Hill AF et al. (1997) The same prion strain causes vCJD and BSE. Nature 389:448\u201350.","journal-title":"Nature"},{"key":"10070104_CR9","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/39057","volume":"389","author":"ME Bruce","year":"1997","unstructured":"Bruce ME et al. (1997) Transmissions to mice indicate that \u2018new variant\u2019 CJD is caused by the BSE agent. Nature 389:498\u2013501.","journal-title":"Nature"},{"key":"10070104_CR10","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1750-3639.1998.tb00171.x","volume":"8","author":"SB Prusiner","year":"1998","unstructured":"Prusiner SB. (1998) The prion diseases. Brain Pathol. 8:499\u2013513.","journal-title":"Brain Pathol."},{"key":"10070104_CR11","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1056\/NEJM198503143121110","volume":"312","author":"DC Gajdusek","year":"1985","unstructured":"Gajdusek DC. (1985) Hypothesis: interference with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the central nervous system. N. Engl. J. Med. 312:714\u20139.","journal-title":"N. Engl. J. Med."},{"key":"10070104_CR12","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1093\/infdis\/167.3.602","volume":"167","author":"SB Prusiner","year":"1993","unstructured":"Prusiner SB et al. (1993) Immunologic and molecular biologic studies of prion proteins in bovine spongiform encephalopathy. J. Infect. Dis. 167:602\u201313.","journal-title":"J. Infect. Dis."},{"key":"10070104_CR13","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/0092-8674(93)90360-3","volume":"73","author":"H Bueler","year":"1993","unstructured":"Bueler H et al. (1993) Mice devoid of PrP are resistant to scrapie. Cell 73:1339\u201347.","journal-title":"Cell"},{"key":"10070104_CR14","doi-asserted-by":"publisher","first-page":"278","DOI":"10.20506\/rst.17.1.1079","volume":"17","author":"C Weissmann","year":"1998","unstructured":"Weissmann C et al. (1998) The use of transgenic mice in the investigation of transmissible spongiform encephalopathies. Rev. Sci. Tech. 17:278\u201390.","journal-title":"Rev. Sci. Tech."},{"key":"10070104_CR15","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/77401","volume":"6","author":"NA Mabbott","year":"2000","unstructured":"Mabbott NA, Mackay F, Minns F, Bruce ME. (2000) Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie. Nat. Med. 6:719\u201320.","journal-title":"Nat. Med."},{"key":"10070104_CR16","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0140-6736(98)12075-5","volume":"353","author":"AF Hill","year":"1999","unstructured":"Hill AF et al. (1999) Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples. Lancet 353:183\u20139.","journal-title":"Lancet"},{"key":"10070104_CR17","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1128\/JCM.38.9.3254-3259.2000","volume":"38","author":"KI O\u2019Rourke","year":"2000","unstructured":"O\u2019Rourke KI et al. (2000) Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissue. J. Clin. Microbiol. 38:3254\u20139.","journal-title":"J. Clin. Microbiol."},{"key":"10070104_CR18","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1136\/vr.142.21.564","volume":"142","author":"BE Schreuder","year":"1998","unstructured":"Schreuder BE, Van Keulen LJ, Vromans ME, Langeveld JP, Smits MA. (1998) Tonsillar biopsy and PrPSc detection in the preclinical diagnosis of scrapie. Vet. Record 142:564\u20138.","journal-title":"Vet. Record"},{"key":"10070104_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0140-6736(97)24002-X","volume":"349","author":"AF Hill","year":"1997","unstructured":"Hill AF, Zeidler M, Ironside J, Collinge J. (1997) Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy. Lancet 349:99\u2013100.","journal-title":"Lancet"},{"key":"10070104_CR20","doi-asserted-by":"publisher","first-page":"10608","DOI":"10.1073\/pnas.90.22.10608","volume":"90","author":"SB Prusiner","year":"1993","unstructured":"Prusiner SB et al. (1993) Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies. Proc. Natl. Acad. Sci. U.S.A. 90:10608\u201312.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10070104_CR21","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/0092-8674(90)90134-Z","volume":"63","author":"SB Prusiner","year":"1990","unstructured":"Prusiner SB et al. (1990) Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication. Cell 63:673\u201386.","journal-title":"Cell"},{"key":"10070104_CR22","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0022-1759(96)00165-2","volume":"199","author":"S Krasemann","year":"1996","unstructured":"Krasemann S, Groschup M, Hunsmann G, Bodemer W. (1996) Induction of antibodies against human prion proteins (PrP) by DNA-mediated immunization of PrP mice. J. Immunol. Methods 199:109\u201318.","journal-title":"J. Immunol. Methods"},{"key":"10070104_CR23","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/36337","volume":"390","author":"C Korth","year":"1997","unstructured":"Korth C et al. (1997) Prion (PrPSc)-specific epitope defined by a monoclonal antibody. Nature 390:74\u20137.","journal-title":"Nature"},{"key":"10070104_CR24","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/nm883","volume":"9","author":"E Paramithiotis","year":"2003","unstructured":"Paramithiotis E et al. (2003) A prion protein epitope selective for the pathologically misfolded conformation. Nat. Med. 9:893\u20139.","journal-title":"Nat. Med."},{"key":"10070104_CR25","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1016\/S0140-6736(00)05110-2","volume":"357","author":"M Maissen","year":"2001","unstructured":"Maissen M, Roeckl C, Glatzel M, Goldmann W, Aguzzi A. (2001) Plasminogen binds to disease-associated prion protein of multiple species. Lancet 357:2026\u20138.","journal-title":"Lancet"},{"key":"10070104_CR26","doi-asserted-by":"crossref","first-page":"8790","DOI":"10.1128\/jvi.71.11.8790-8797.1997","volume":"71","author":"S Weiss","year":"1997","unstructured":"Weiss S et al. (1997) RNA aptamers specifically interact with the prion protein PrP. J. Virol. 71:8790\u20137.","journal-title":"J. Virol."},{"key":"10070104_CR27","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0140-6736(99)11419-3","volume":"355","author":"C Soto","year":"2000","unstructured":"Soto C et al. (2000) Reversion of prion protein conformational changes by synthetic \u03b2-sheet breaker peptides. Lancet 355:192\u20137.","journal-title":"Lancet"},{"key":"10070104_CR28","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/2654","volume":"4","author":"J Safar","year":"1998","unstructured":"Safar J et al. (1998) Eight prion strains PrPSc molecules with different conformations. Nat. Med. 4:1157\u201365.","journal-title":"Nat. Med."},{"key":"10070104_CR29","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.4049\/jimmunol.111.5.1407","volume":"111","author":"DD Porter","year":"1973","unstructured":"Porter DD, Porter HG, Cox NA. (1973) Failure to demonstrate a humoral immune response to scrapie infection in mice. J. Immunol. 111:1407\u201310.","journal-title":"J. Immunol."},{"key":"10070104_CR30","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1038\/2621","volume":"4","author":"A Aguzzi","year":"1998","unstructured":"Aguzzi A. (1998) Protein conformation dictates prion strain. Nat. Med. 4:1125\u20136.","journal-title":"Nat. Med."},{"key":"10070104_CR31","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/path.1711680412","volume":"168","author":"PA McBride","year":"1992","unstructured":"McBride PA, Eikelenboom P, Kraal G, Fraser H, Bruce ME. (1992) PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice. J. Pathol. 168:413\u20138.","journal-title":"J. Pathol."},{"key":"10070104_CR32","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1006\/jmbi.1997.1328","volume":"273","author":"D Peretz","year":"1997","unstructured":"Peretz D et al. (1997) A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform. J. Mol. Biol. 273:614\u201322.","journal-title":"J. Mol. Biol."},{"key":"10070104_CR33","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1128\/jvi.61.12.3688-3693.1987","volume":"61","author":"RJ Kascsak","year":"1987","unstructured":"Kascsak RJ et al. (1987) Mouse polyclonal and monoclonal antibody to scrapieassociated fibril proteins. J. Virol. 61:3688\u201393.","journal-title":"J. Virol."},{"key":"10070104_CR34","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1093\/brain\/awg205","volume":"126","author":"V Beringue","year":"2003","unstructured":"Beringue V et al. (2003) Regional heterogeneity of cellular prion protein isoforms in the mouse brain. Brain 126:2065\u201373.","journal-title":"Brain"},{"key":"10070104_CR35","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0952-7915(95)80109-X","volume":"7","author":"JJ Mond","year":"1995","unstructured":"Mond JJ, Vos Q, Lees A, Snapper CM. (1995) T cell independent antigens. Curr. Opin. Immunol. 7:349\u201354.","journal-title":"Curr. Opin. Immunol."},{"key":"10070104_CR36","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/356577a0","volume":"356","author":"H Bueler","year":"1992","unstructured":"Bueler H et al. (1992) Normal development and behavior of mice lacking the neuronal cell-surface PrP protein. Nature 356:577\u2013582.","journal-title":"Nature"},{"key":"10070104_CR37","doi-asserted-by":"publisher","first-page":"13148","DOI":"10.1073\/pnas.93.23.13148","volume":"93","author":"S Brandner","year":"1996","unstructured":"Brandner S et al. (1996) Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 93: 13148\u201351.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10070104_CR38","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1126\/science.283.5409.1935","volume":"283","author":"GS Jackson","year":"1999","unstructured":"Jackson GS et al. (1999) Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations. Science 283:1935\u20137.","journal-title":"Science"},{"key":"10070104_CR39","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680\u20135.","journal-title":"Nature"},{"key":"10070104_CR40","first-page":"197","volume":"74","author":"DJ Anstee","year":"1991","unstructured":"Anstee DJ et al. (1991) New monoclonal antibodies in CD44 and CD58: their use to quantify CD44 and CD58 on normal human erythrocytes and to compare the distribution of CD44 and CD58 in human tissues. Immunology 74: 197\u2013205.","journal-title":"Immunology"},{"key":"10070104_CR41","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1099\/0022-1317-83-12-3199","volume":"83","author":"DM Taylor","year":"2002","unstructured":"Taylor DM, Fernie K, Steele PJ, McConnell I, Somerville RA. (2002) Thermostability of mouse-passaged BSE and scrapie is independent of host PrP genotype: implications for the nature of the causal agents. J. Gen. Virol. 83:3199\u2013204.","journal-title":"J. Gen. Virol."},{"key":"10070104_CR42","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1212\/WNL.40.1.110","volume":"40","author":"D Serban","year":"1990","unstructured":"Serban D, Taraboulos A, DeArmond SJ, Prusiner SB. (1990) Rapid detection of Creutzfeldt-Jakob disease and scrapie prion proteins. Neurology 40:110\u20137.","journal-title":"Neurology"},{"key":"10070104_CR43","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0168-1656(99)00115-7","volume":"73","author":"S Krasemann","year":"1999","unstructured":"Krasemann S, J\u00fcrgens T, Bodemer W. (1999) Generation of monoclonal antibodies against prion proteins with an unconventional nucleic acid-based immunization strategy. J. Biotechnol. 73:119\u201329.","journal-title":"J. Biotechnol."},{"key":"10070104_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0167-4838(99)00038-2","volume":"1431","author":"GS Jackson","year":"1999","unstructured":"Jackson GS et al. (1999) Multiple folding pathways for heterologously expressed human prion protein. Biochim. Biophys. Acta 1431:1\u201313.","journal-title":"Biochim. Biophys. Acta"},{"key":"10070104_CR45","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/0022-1759(92)90269-Y","volume":"155","author":"S Hawke","year":"1992","unstructured":"Hawke S, Willcox N, Harcourt G, Vincent A, Newsom-Davis J. (1992) Stimulation of human T cells by sparse antigens captured on immunomagnetic particles. J. Immunol. Methods 155:41\u20138.","journal-title":"J. Immunol. Methods"},{"key":"10070104_CR46","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0167-5699(96)10022-0","volume":"17","author":"S Hawke","year":"1996","unstructured":"Hawke S et al. (1996) Autoimmune T cells in myasthenia gravis: heterogeneity and potential for specific immunotargeting. Immunol. Today 17:307\u201311.","journal-title":"Immunol. Today"},{"key":"10070104_CR47","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1099\/0022-1317-79-4-937","volume":"79","author":"S Harmeyer","year":"1998","unstructured":"Harmeyer S, Pfaff E, Groschup MH. (1998) Synthetic peptide vaccines yield monoclonal antibodies to cellular and pathological prion proteins of ruminants. J. Gen. Virol. 79:937\u201345.","journal-title":"J. Gen. Virol."},{"key":"10070104_CR48","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0952-7915(95)80109-X","volume":"7","author":"JJ Mond","year":"1995","unstructured":"Mond JJ, Vos Q, Lees A, Snapper CM. (1995) T cell independent antigens. Curr. Opin. Immunol. 7:349\u201354.","journal-title":"Curr. Opin. Immunol."},{"key":"10070104_CR49","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1073\/pnas.022662599","volume":"99","author":"B O\u2019Nuallain","year":"2002","unstructured":"O\u2019Nuallain B, Wetzel R. (2002) Conformational Abs recognizing a generic amyloid fibril epitope. Proc. Natl. Acad. Sci. U.S.A. 99:1485\u201390.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.2119\/2004-00027.Tayebi.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.2119\/2004-00027.Tayebi\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.crossref.org\/2004-00027.Tayebi","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/2004-00027.Tayebi.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T11:03:44Z","timestamp":1708513424000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.2119\/2004-00027.Tayebi"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":49,"journal-issue":{"issue":"7-12","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10070104"],"URL":"https:\/\/doi.org\/10.2119\/2004-00027.tayebi","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]},"assertion":[{"value":"1 June 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}