{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:46:20Z","timestamp":1791146780758,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.2119\/molmed.2010.00057","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T19:54:56Z","timestamp":1289418896000},"page":"471-478","source":"Crossref","is-referenced-by-count":19,"title":["Altered mRNA Expression of Telomere-Associated Genes in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma"],"prefix":"10.1186","volume":"16","author":[{"given":"Julieta","family":"Panero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Arbelbide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorotea Beatriz","family":"Fantl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1n Garc\u00eda","family":"Rivello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Kohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Slavutsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"1611471_CR1","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1056\/NEJMra041875","volume":"351","author":"RA Kyle","year":"2004","unstructured":"Kyle RA, Rajkumar SV. (2004) Multiple myeloma. N. Engl. J. Med. 351:1860\u201373.","journal-title":"N. Engl. J. Med."},{"key":"1611471_CR2","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1056\/NEJMoa054494","volume":"354","author":"RA Kyle","year":"2006","unstructured":"Kyle RA, et al. (2006) Prevalence of monoclonal gammopathy of undetermined significance. N. Engl. J. Med. 354:1362\u20139.","journal-title":"N. Engl. J. Med."},{"key":"1611471_CR3","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1038\/leu.2008.203","volume":"22","author":"J Blad\u00e9","year":"2008","unstructured":"Blad\u00e9 J, Rosi\u00f1ol L, Cibeira MT, de Larrea CF. (2008) Pathogenesis and progression of monoclonal gammopathy of undetermined significance. Leukemia. 22:1651\u20137.","journal-title":"Leukemia"},{"key":"1611471_CR4","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/gb-2008-9-9-232","volume":"9","author":"H Xin","year":"2008","unstructured":"Xin H, Liu D, Songyang Z. (2008) The telosome\/shelterin complex and its functions. Genome Biol. 9:232.","journal-title":"Genome Biol."},{"key":"1611471_CR5","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1002\/j.1460-2075.1992.tb05245.x","volume":"11","author":"CM Counter","year":"1992","unstructured":"Counter CM, et al. (1992) Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1921\u20139.","journal-title":"EMBO J."},{"key":"1611471_CR6","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1093\/hmg\/10.7.677","volume":"10","author":"JW Shay","year":"2001","unstructured":"Shay JW, Zou Y, Hiyama E, Wright WE. (2001) Telomerase and cancer. Hum. Mol. Genet. 10:677\u201385.","journal-title":"Hum. Mol. Genet."},{"key":"1611471_CR7","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nrg2047","volume":"8","author":"MA Blasco","year":"2007","unstructured":"Blasco MA. (2007) The epigenetic regulation of mammalian telomeres. Nat. Rev. Genet. 8:299\u2013309.","journal-title":"Nat. Rev. Genet."},{"key":"1611471_CR8","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev.genet.41.110306.130350","volume":"42","author":"W Palm","year":"2008","unstructured":"Palm W, De Lange T. (2008) How shelterin protects mammalian telomeres. Ann. Rev. Genet. 42:301\u201334.","journal-title":"Ann. Rev. Genet."},{"key":"1611471_CR9","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/385740a0","volume":"385","author":"B Steensel van","year":"1997","unstructured":"van Steensel B, de Lange T. (1997) Control of telomere length by the human telomeric protein TRF1. Nature. 385:740\u20133.","journal-title":"Nature"},{"key":"1611471_CR10","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1101\/gad.1346005","volume":"19","author":"T Lange de","year":"2005","unstructured":"de Lange T. (2005) Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19:2100\u201310.","journal-title":"Genes Dev."},{"key":"1611471_CR11","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1126\/science.282.5393.1484","volume":"282","author":"S Smith","year":"1998","unstructured":"Smith S, Giriat I, Schmitt A, de Lange T. (1998) Tankyrase, a poly (ADP-ribose) polymerase at human telomeres. Science. 282:1484\u20137.","journal-title":"Science"},{"key":"1611471_CR12","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/S0960-9822(00)00752-1","volume":"10","author":"S Smith","year":"2000","unstructured":"Smith S, de Lange T. (2000) Tankyrase promotes telomere elongation in human cells. Curr. Biol. 10:1299\u2013302.","journal-title":"Curr. Biol."},{"key":"1611471_CR13","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.exphem.2007.03.009","volume":"35","author":"TA Widmann","year":"2007","unstructured":"Widmann TA, Herrmann M, Taha N, K\u00f6nig J, Pfreundschuh M. (2007) Short telomeres in aggressive non-Hodgkin\u2019s lymphoma as a risk factor in lymphomagenesis. Exp Hematol. 35:939\u201346.","journal-title":"Exp Hematol."},{"key":"1611471_CR14","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1093\/jnci\/djg011","volume":"95","author":"X Wu","year":"2003","unstructured":"Wu X, et al. (2003) Telomere dysfunction: a potencial cancer predisposition factor. J. Natl. Cancer Inst. 95:1211\u20138.","journal-title":"J. Natl. Cancer Inst."},{"key":"1611471_CR15","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1054\/bjoc.2000.1655","volume":"84","author":"D Xu","year":"2001","unstructured":"Xu D, et al. (2001) Telomerase activity in plasma cell dyscrasias. Br. J. Cancer. 84:621\u20135.","journal-title":"Br. J. Cancer."},{"key":"1611471_CR16","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1002\/cncr.10472","volume":"94","author":"M Shiratsuchi","year":"2002","unstructured":"Shiratsuchi M, et al. (2002) Clinical significance of telomerase activity in multiple myeloma. Cancer. 94:2232\u20138.","journal-title":"Cancer"},{"key":"1611471_CR17","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1034\/j.1600-0609.2003.00157.x","volume":"71","author":"A Cottliar","year":"2003","unstructured":"Cottliar A, et al. (2003) Telomere shortening in patients with plasma cell disorders. Eur. J. Haematol. 71:334\u201340.","journal-title":"Eur. J. Haematol."},{"key":"1611471_CR18","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.1182\/blood-2002-11-3451","volume":"101","author":"K-D Wu","year":"2003","unstructured":"Wu K-D, et al. (2003) Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival. Blood. 101:4982\u20139.","journal-title":"Blood"},{"key":"1611471_CR19","doi-asserted-by":"publisher","first-page":"4644","DOI":"10.1182\/blood-2003-12-4412","volume":"103","author":"M Ladetto","year":"2004","unstructured":"Ladetto M, et al. (2004) Telomere length correlates with histopathogenesis according to the germinal center in mature B-cell lymphoproliferative disorders. Blood. 103:4644\u20139.","journal-title":"Blood"},{"key":"1611471_CR20","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U","volume":"36","author":"BG Durie","year":"1975","unstructured":"Durie BG, Salmon E. (1975) A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 36:842\u201354.","journal-title":"Cancer"},{"key":"1611471_CR21","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1200\/JCO.2005.04.242","volume":"23","author":"P Greipp","year":"2005","unstructured":"Greipp P, et al. (2005) International staging system for multiple myeloma. J. Clin. Oncol. 23:3412\u201320.","journal-title":"J. Clin. Oncol."},{"key":"1611471_CR22","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/sj.bjc.6601112","volume":"89","author":"W Klapper","year":"2003","unstructured":"Klapper W, Krams M, Qian W, Janssen D, Parwaresch R. (2003) Telomerase activity in B-cell non-Hodgkin lymphomas is regulated by hTERT transcription and correlated with telomere-binding protein expression but uncoupled from proliferation. Br. J. Cancer. 89:713\u20139.","journal-title":"Br. J. Cancer."},{"key":"1611471_CR23","doi-asserted-by":"publisher","first-page":"3514","DOI":"10.3748\/wjg.v10.i23.3514","volume":"10","author":"LH Hu","year":"2004","unstructured":"Hu LH, Chen FH, Li YR, Wang L. (2004) Realtime determination of human telomerase reverse transcriptase mRNA in gastric cancer. World J. Gastroenterol. 10:3514\u20137.","journal-title":"World J. Gastroenterol."},{"key":"1611471_CR24","first-page":"386","volume":"86","author":"B MacNamara","year":"2001","unstructured":"MacNamara B, et al. (2001) Telomerase activity in relation to pro- and anti-apoptotic protein expression in high grade non-Hodgkin\u2019s lymphomas. Haematologica. 86:386\u201393.","journal-title":"Haematologica"},{"key":"1611471_CR25","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1002\/ijc.22026","volume":"119","author":"M Bellon","year":"2006","unstructured":"Bellon M, et al. (2006) Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia. Int. J. Cancer. 119:2090\u20137.","journal-title":"Int. J. Cancer."},{"key":"1611471_CR26","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1182\/blood-2007-09-111245","volume":"111","author":"D Poncet","year":"2008","unstructured":"Poncet D, et al. (2008) Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia. Blood. 111:2388\u201391.","journal-title":"Blood"},{"key":"1611471_CR27","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1128\/MCB.20.5.1659-1668.2000","volume":"20","author":"A Smogorzewska","year":"2000","unstructured":"Smogorzewska A, et al. (2000) Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 20:1659\u201368.","journal-title":"Mol. Cell. Biol."},{"key":"1611471_CR28","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00432-010-0795-x","volume":"136","author":"H Hu","year":"2010","unstructured":"Hu H, Zhang Y, Zou M, Yang S, Liang XQ. (2010) Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer. J. Cancer Res. Clin. Oncol. 136:1407\u201314.","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"1611471_CR29","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1600-0609.2007.00915.x","volume":"79","author":"T Gastinne","year":"2007","unstructured":"Gastinne T, et al. (2007) Plasma cell growth fraction using Ki-67 antigen expression identifies a subgroup of multiple myeloma patients displaying short survival within the ISS stage I. Eur. J. Haematol. 79:297\u2013304.","journal-title":"Eur. J. Haematol."},{"key":"1611471_CR30","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/leu.2010.60","volume":"24","author":"RA Kyle","year":"2010","unstructured":"Kyle RA, et al. (2010) Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management. Leukemia. 24:1121\u201327.","journal-title":"Leukemia"},{"key":"1611471_CR31","doi-asserted-by":"publisher","first-page":"12683","DOI":"10.1073\/pnas.211357798","volume":"98","author":"D Gisselsson","year":"2001","unstructured":"Gisselsson D, et al. (2001) Telomere dysfunction triggers extensive DNA fragmentation and evolution to complex chromosome abnormalities in human malignant tumors. Proc. Natl. Acad. Sci. U. S. A. 98:12683\u20138.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"1611471_CR32","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/sj.bjc.6600438","volume":"87","author":"D Gisselsson","year":"2002","unstructured":"Gisselsson D, et al. (2002) Centrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres. Br. J. Cancer. 87:202\u20137.","journal-title":"Br. J. Cancer."},{"key":"1611471_CR33","first-page":"3378","volume":"63","author":"M H\u00f6glund","year":"2003","unstructured":"H\u00f6glund M, Gisselsson D, Hansen GB, S\u00e4hl T, Mitelman F. (2003) Ovarian carcinoma develops through multiple modes of chromosomal evolution. Cancer Res. 63:3378\u201385.","journal-title":"Cancer Res."},{"key":"1611471_CR34","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1182\/blood.V100.4.1417.h81602001417_1417_1424","volume":"100","author":"R Fonseca","year":"2002","unstructured":"Fonseca R, et al. (2002) Genomics abnormalities in monoclonal gammopathy of undetermined significance. Blood. 100:1417\u201324.","journal-title":"Blood"},{"key":"1611471_CR35","doi-asserted-by":"publisher","first-page":"4700","DOI":"10.1182\/blood-2007-11-122101","volume":"111","author":"T Bochtler","year":"2008","unstructured":"Bochtler T, et al. (2008) Evaluation of the cytogenetic aberration pattern in amyloid light chain amyloidosis as compared with monoclonal gammopathy of undetermined significance reveals common pathways of karyotypic instability. Blood. 111:4700\u20135.","journal-title":"Blood"},{"key":"1611471_CR36","doi-asserted-by":"publisher","first-page":"4197","DOI":"10.1200\/JCO.2008.19.1916","volume":"25","author":"A Anguiano","year":"2009","unstructured":"Anguiano A, et al. (2009) Gene expression profiles of tumor biology provide a novel approach to prognosis and may guide the selection of therapeutic targets in multiple myeloma. J. Clin. Onc. 25:4197\u2013203.","journal-title":"J. Clin. Onc."},{"key":"1611471_CR37","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/sj.bjp.0707374","volume":"152","author":"P Phatak","year":"2007","unstructured":"Phatak P, Burger AM. (2007) Telomerase and its potential for therapeutic intervention. Br. J. Pharmacol. 152:1003\u201311.","journal-title":"Br. J. Pharmacol."}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.crossref.org\/molmed.2010.00057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2010.00057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T17:56:06Z","timestamp":1592070966000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.2119\/molmed.2010.00057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":37,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["1611471"],"URL":"https:\/\/doi.org\/10.2119\/molmed.2010.00057","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}