{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:06:09Z","timestamp":1791216369531,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.2119\/molmed.2010.00263","type":"journal-article","created":{"date-parts":[[2011,5,26]],"date-time":"2011-05-26T14:10:54Z","timestamp":1306419054000},"page":"508-515","source":"Crossref","is-referenced-by-count":45,"title":["Peptide-Based Inhibition of NF-\u03baB Rescues Diaphragm Muscle Contractile Dysfunction in a Murine Model of Duchenne Muscular Dystrophy"],"prefix":"10.1186","volume":"17","author":[{"given":"Jennifer M","family":"Peterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Kline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D","family":"Canan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Ricca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn A","family":"Delf\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"DiRienzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula R","family":"Clemens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert S","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Flood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Kaumaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe N","family":"Kornegay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry R","family":"Mendell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill A","family":"Rafael-Fortney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis G","family":"Guttridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M L","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,1,20]]},"reference":[{"key":"1705508_CR1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1152\/physrev.00028.2001","volume":"82","author":"DJ Blake","year":"2002","unstructured":"Blake DJ, Weir A, Newey SE, Davies KE. (2002) Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol. Rev. 82:291\u2013329.","journal-title":"Physiol. Rev."},{"key":"1705508_CR2","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1172\/JCI30556","volume":"117","author":"S Acharyya","year":"2007","unstructured":"Acharyya S, et al. (2007) Interplay of IKK\/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J. Clin. Invest. 117:889\u2013901.","journal-title":"J. Clin. Invest."},{"key":"1705508_CR3","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1212\/01.WNL.0000049913.27181.51","volume":"60","author":"MC Monici","year":"2003","unstructured":"Monici MC, Aguennouz M, Mazzeo A, Messina C, Vita G. (2003) Activation of nuclear factor-kappaB in inflammatory myopathies and Duchenne muscular dystrophy. Neurology. 60:993\u20137.","journal-title":"Neurology"},{"key":"1705508_CR4","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1212\/01.wnl.0000173836.09176.c4","volume":"65","author":"YW Chen","year":"2005","unstructured":"Chen YW, et al. (2005) Early onset of inflammation and later involvement of TGFbeta in Duchenne muscular dystrophy. Neurology. 65:826\u201334.","journal-title":"Neurology"},{"key":"1705508_CR5","doi-asserted-by":"publisher","first-page":"918","DOI":"10.2353\/ajpath.2006.050673","volume":"168","author":"S Messina","year":"2006","unstructured":"Messina S, et al. (2006) Lipid peroxidation inhibition blunts nuclear factor-kappaB activation, reduces skeletal muscle degeneration, and enhances muscle function in mdx mice. Am. J. Pathol. 168:918\u201326.","journal-title":"Am. J. Pathol."},{"key":"1705508_CR6","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.expneurol.2005.11.021","volume":"198","author":"S Messina","year":"2006","unstructured":"Messina S, et al. (2006) Nuclear factor kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function in Mdx mice. Exp. Neurol. 198:234\u201341.","journal-title":"Exp. Neurol."},{"key":"1705508_CR7","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1056\/NEJM198906153202405","volume":"320","author":"JR Mendell","year":"1989","unstructured":"Mendell JR, et al. (1989) Randomized, doubleblind six-month trial of prednisone in Duchenne\u2019s muscular dystrophy. N. Engl. J. Med. 320:1592\u20137.","journal-title":"N. Engl. J. Med."},{"key":"1705508_CR8","doi-asserted-by":"publisher","first-page":"13504","DOI":"10.1073\/pnas.94.25.13504","volume":"94","author":"K Bosscher De","year":"1997","unstructured":"De Bosscher K, et al. (1997) Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation. Proc. Natl. Acad. Sci. U. S. A. 94:13504\u20139.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"1705508_CR9","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.1073\/pnas.97.8.3919","volume":"97","author":"K Bosscher De","year":"2000","unstructured":"De Bosscher K, et al. (2000) Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc. Natl. Acad. Sci. U. S. A. 97:3919\u201324.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"1705508_CR10","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","volume":"18","author":"M Karin","year":"2000","unstructured":"Karin M, Ben-Neriah Y. (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol. 18:621\u201363.","journal-title":"Annu. Rev. Immunol."},{"key":"1705508_CR11","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm2083","volume":"8","author":"ND Perkins","year":"2007","unstructured":"Perkins ND. (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat. Rev. Mol. Cell. Biol. 8:49\u201362.","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"1705508_CR12","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","volume":"132","author":"MS Hayden","year":"2008","unstructured":"Hayden MS, Ghosh S. (2008) Shared principles in NF-kappaB signaling. Cell. 132:344\u201362.","journal-title":"Cell"},{"key":"1705508_CR13","doi-asserted-by":"publisher","first-page":"13498","DOI":"10.1074\/jbc.M109.099895","volume":"285","author":"ET Baima","year":"2010","unstructured":"Baima ET, et al. (2010) Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides. J. Biol. Ghem. 285:13498\u2013506.","journal-title":"J. Biol. Ghem."},{"key":"1705508_CR14","doi-asserted-by":"publisher","first-page":"H2797","DOI":"10.1152\/ajpheart.2000.279.6.H2797","volume":"279","author":"WS Akers","year":"2000","unstructured":"Akers WS, Cross A, Speth R, Dwoskin LP, Cassis LA. (2000) Renin-angiotensin system and sympathetic nervous system in cardiac pressure-overload hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 279:H2797\u2013806.","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"1705508_CR15","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1096\/fj.05-4821fje","volume":"20","author":"JD Archer","year":"2006","unstructured":"Archer JD, Vargas CC, Anderson JE. (2006) Persistent and improved functional gain in mdx dystrophic mice after treatment with L-arginine and deflazacort. Faseb. J. 20:738\u20130.","journal-title":"Faseb. J."},{"key":"1705508_CR16","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1002\/mus.20425","volume":"32","author":"ER Barton","year":"2005","unstructured":"Barton ER, Morris L, Kawana M, Bish LT, Toursel T. (2005) Systemic administration of L-arginine benefits mdx skeletal muscle function. Muscle Nerve. 32:751\u201360.","journal-title":"Muscle Nerve."},{"key":"1705508_CR17","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.nbd.2005.05.003","volume":"20","author":"CG Carlson","year":"2005","unstructured":"Carlson CG, Samadi A, Siegel A. (2005) Chronic treatment with agents that stabilize cytosolic IkappaB-alpha enhances survival and improves resting membrane potential in MDX muscle fibers subjected to chronic passive stretch. Neurobiol. Dis. 20:719\u201330.","journal-title":"Neurobiol. Dis."},{"key":"1705508_CR18","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.2353\/ajpath.2008.071009","volume":"172","author":"K Hnia","year":"2008","unstructured":"Hnia K, et al. (2008) L-arginine decreases inflammation and modulates the nuclear factor-kappaB\/matrix metalloproteinase cascade in mdx muscle fibers. Am. J. Pathol. 172:1509\u201319.","journal-title":"Am. J. Pathol."},{"key":"1705508_CR19","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S1016-8478(23)17614-X","volume":"25","author":"Y Pan","year":"2008","unstructured":"Pan Y, et al. (2008) Curcumin alleviates dystrophic muscle pathology in mdx mice. Mol. Cells. 25:531\u20137.","journal-title":"Mol. Cells"},{"key":"1705508_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.nmd.2008.10.006","volume":"19","author":"AL Siegel","year":"2009","unstructured":"Siegel AL, et al. (2009) Treatment with inhibitors of the NF-kappaB pathway improves whole body tension development in the mdx mouse. Neuromuscul. Disord. 19:131\u20139.","journal-title":"Neuromuscul. Disord."},{"key":"1705508_CR21","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.nbd.2005.02.010","volume":"20","author":"V Voisin","year":"2005","unstructured":"Voisin V, et al. (2005) L-arginine improves dys-trophic phenotype in mdx mice. Neurobiol. Dis. 20:123\u201330.","journal-title":"Neurobiol. Dis."},{"key":"1705508_CR22","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/352536a0","volume":"352","author":"HH Stedman","year":"1991","unstructured":"Stedman HH, et al. (1991) The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy. Nature. 352:536\u20139.","journal-title":"Nature"},{"key":"1705508_CR23","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1126\/science.289.5484.1550","volume":"289","author":"MJ May","year":"2000","unstructured":"May MJ, et al. (2000) Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science. 289:1550\u20134.","journal-title":"Science"},{"key":"1705508_CR24","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1161\/01.RES.65.5.1441","volume":"65","author":"LA Mulieri","year":"1989","unstructured":"Mulieri LA, Hasenfuss G, Ittleman F, Blanchard EM, Alpert NR. (1989) Protection of human left ventricular myocardium from cutting injury with 2,3-butanedione monoxime. Circ. Res. 65:1441\u20139.","journal-title":"Circ. Res."},{"key":"1705508_CR25","doi-asserted-by":"publisher","first-page":"42ra54","DOI":"10.1126\/scitranslmed.3000692","volume":"2","author":"K Chandrasekharan","year":"2010","unstructured":"Chandrasekharan K, et al. (2010) A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy. Sci. Transl. Med. 2:42ra54.","journal-title":"Sci. Transl. Med."},{"key":"1705508_CR26","doi-asserted-by":"publisher","first-page":"H2373","DOI":"10.1152\/ajpheart.00448.2005","volume":"289","author":"PML Janssen","year":"2005","unstructured":"Janssen PML, Hiranandani N, Mays TA, Rafael-Fortney JA. (2005) Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice. Am. J. Physiol. Heart Circ. Physiol. 289:H2373\u20138.","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"1705508_CR27","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1152\/jappl.1994.77.5.2434","volume":"77","author":"PT Diaz","year":"1994","unstructured":"Diaz PT, Brownstein E, Clanton TL. (1994) Effects of N-acetylcysteine on in vitro diaphragm function are temperature dependent. J. Appl. Physiol. 77:2434\u20139.","journal-title":"J. Appl. Physiol."},{"key":"1705508_CR28","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1152\/jappl.1990.69.5.1740","volume":"69","author":"DJ Prezant","year":"1990","unstructured":"Prezant DJ, et al. (1990) Temperature dependence of rat diaphragm muscle contractility and fatigue. J. Appl. Physiol. 69:1740\u20135.","journal-title":"J. Appl. Physiol."},{"key":"1705508_CR29","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1242\/dev.01169","volume":"131","author":"M Rucker","year":"2004","unstructured":"Rucker M, et al. (2004) Rescue of enzyme deficiency in embryonic diaphragm in a mouse model of metabolic myopathy: Pompe disease. Development. 131:3007\u201319.","journal-title":"Development"},{"key":"1705508_CR30","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.ccr.2005.10.004","volume":"8","author":"S Acharyya","year":"2005","unstructured":"Acharyya S, et al. (2005) Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell. 8:421\u201332.","journal-title":"Cancer Cell"},{"key":"1705508_CR31","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1128\/MCB.19.8.5785","volume":"19","author":"DC Guttridge","year":"1999","unstructured":"Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS Jr. (1999) NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 19:5785\u201399.","journal-title":"Mol. Cell. Biol."},{"key":"1705508_CR32","doi-asserted-by":"publisher","first-page":"7030","DOI":"10.4049\/jimmunol.179.10.7030","volume":"179","author":"SP Chapoval","year":"2007","unstructured":"Chapoval SP, et al. (2007) Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. J. Immunol. 179:7030\u201341.","journal-title":"J. Immunol."},{"key":"1705508_CR33","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.4049\/jimmunol.173.2.1344","volume":"173","author":"S Dasgupta","year":"2004","unstructured":"Dasgupta S, et al. (2004) Antineuroinflammatory effect of NF-kappaB essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis. J. Immunol. 173:1344\u201354.","journal-title":"J. Immunol."},{"key":"1705508_CR34","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1002\/art.20960","volume":"52","author":"P Meglio di","year":"2005","unstructured":"di Meglio P, Ianaro A, Ghosh S. (2005) Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum. 52:951\u20138.","journal-title":"Arthritis Rheum."},{"key":"1705508_CR35","doi-asserted-by":"publisher","first-page":"18754","DOI":"10.1073\/pnas.0704908104","volume":"104","author":"A Ghosh","year":"2007","unstructured":"Ghosh A, et al. (2007) Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson\u2019s disease. Proc. Natl. Acad. Sci. U. S. A. 104:18754\u20139.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"1705508_CR36","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.4049\/jimmunol.179.5.2681","volume":"179","author":"W Shibata","year":"2007","unstructured":"Shibata W, et al. (2007) Cutting edge: The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis. J. Immunol. 179:2681\u20135.","journal-title":"J. Immunol."},{"key":"1705508_CR37","doi-asserted-by":"publisher","first-page":"R86","DOI":"10.1186\/ar1958","volume":"8","author":"SW Tas","year":"2006","unstructured":"Tas SW, et al. (2006) Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation. Arthritis Res. Ther. 8:R86.","journal-title":"Arthritis Res. Ther."},{"key":"1705508_CR38","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1101\/gad.1228704","volume":"18","author":"MS Hayden","year":"2004","unstructured":"Hayden MS, Ghosh S. (2004) Signaling to NF-kappaB. Genes. Dev. 18:2195\u2013224.","journal-title":"Genes. Dev."},{"key":"1705508_CR39","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1002\/jor.20184","volume":"24","author":"JC Clohisy","year":"2006","unstructured":"Clohisy JC, Yamanaka Y, Faccio R, Abu-Amer Y. (2006) Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteo-clastogenesis and calvarial inflammatory osteolysis. J. Orthop. Res. 24:1358\u201365.","journal-title":"J. Orthop. Res."},{"key":"1705508_CR40","doi-asserted-by":"publisher","first-page":"37219","DOI":"10.1074\/jbc.C400258200","volume":"279","author":"S Dai","year":"2004","unstructured":"Dai S, Hirayama T, Abbas S, Abu-Amer Y. (2004) The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. J. Biol. Chem. 279:37219\u201322.","journal-title":"J. Biol. Chem."},{"key":"1705508_CR41","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nm1054","volume":"10","author":"E Jimi","year":"2004","unstructured":"Jimi E, et al. (2004) Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat. Med. 10:617\u201324.","journal-title":"Nat. Med."}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.crossref.org\/molmed.2010.00263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2010.00263.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T05:24:47Z","timestamp":1712467487000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.2119\/molmed.2010.00263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,20]]},"references-count":41,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["1705508"],"URL":"https:\/\/doi.org\/10.2119\/molmed.2010.00263","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,20]]}}}