{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:16:10Z","timestamp":1791141370974,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.2119\/molmed.2011.00034","type":"journal-article","created":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T17:27:06Z","timestamp":1318008426000},"page":"901-909","source":"Crossref","is-referenced-by-count":32,"title":["B-Cell Subsets in the Joint Compartments of Seropositive and Seronegative Rheumatoid Arthritis (RA) and No-RA Arthritides Express Memory Markers and ZAP70 and Characterize the Aggregate Pattern Irrespectively of the Autoantibody Status"],"prefix":"10.1186","volume":"17","author":[{"given":"Alessandro","family":"Michelutti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Gremese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Morassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Petricca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Arena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Tolusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Alivernini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusy","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Laura","family":"Bosello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Ferraccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,5,13]]},"reference":[{"key":"1709901_CR1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1097\/BOR.0b013e3283369cb8","volume":"22","author":"B Marston","year":"2010","unstructured":"Marston B, Palanichamy A, Anolik JH. (2010) B cells in the pathogenesis and treatment of rheumatoid arthritis. Curr. Opin. Rheumatol. 22:307\u201315.","journal-title":"Curr. Opin. Rheumatol."},{"key":"1709901_CR2","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nrrheum.2010.68","volume":"6","author":"I Sanz","year":"2010","unstructured":"Sanz I, Lee FE, Medscape B. (2010) B cells as therapeutic targets in SLE. Nat. Rev. Rheumatol. 6:326\u201337.","journal-title":"Nat. Rev. Rheumatol."},{"key":"1709901_CR3","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1053\/j.seminhematol.2010.01.010","volume":"47","author":"R Stasi","year":"2010","unstructured":"Stasi R. (2010) Rituximab in autoimmune hematologic diseases: not just a matter of B cells. Semin. Hematol. 47:170\u20139.","journal-title":"Semin. Hematol."},{"key":"1709901_CR4","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1002\/art.23902","volume":"58","author":"S Dass","year":"2008","unstructured":"Dass S, et al. (2008) Highly sensitive B cell analysis predicts response to rituximab therapy in rheumatoid arthritis. Arthritis Rheum. 58:2993\u20139.","journal-title":"Arthritis Rheum."},{"key":"1709901_CR5","doi-asserted-by":"publisher","first-page":"R131","DOI":"10.1186\/ar2798","volume":"11","author":"M Nakou","year":"2009","unstructured":"Nakou M, et al. (2009) Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response. Arthritis Res. Ther. 11:R131.","journal-title":"Arthritis Res. Ther."},{"key":"1709901_CR6","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.1002\/art.24141","volume":"58","author":"A Palanichamy","year":"2008","unstructured":"Palanichamy A, Roll P, Theiss R, D\u00f6rner T, Tony HP. (2008) Modulation of molecular imprints in the antigen-experienced B cell repertoire by rituximab. Arthritis Rheum. 58:3665\u201374.","journal-title":"Arthritis Rheum."},{"key":"1709901_CR7","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1136\/ard.2007.080960","volume":"67","author":"RM Thurlings","year":"2008","unstructured":"Thurlings RM, et al. (2008) Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of response. Ann. Rheum. Dis. 67:917\u201325.","journal-title":"Ann. Rheum. Dis."},{"key":"1709901_CR8","doi-asserted-by":"crossref","unstructured":"Anolik JH, Looney RJ, Lund FE, Randall TD, Sanz I. (2009) Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets. Immunol Res. 7 April 2009 [Epub ahead of print]","DOI":"10.1007\/s12026-009-8096-7"},{"key":"1709901_CR9","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1002\/art.24722","volume":"60","author":"K Muhammad","year":"2009","unstructured":"Muhammad K, Roll P, Einsele H, D\u00f6rner T, Tony HP. (2009) Delayed acquisition of somatic hypermutations in repopulated IGD+CD27+ memory B cell receptors after rituximab treatment. Arthritis Rheum. 60:2284\u201393.","journal-title":"Arthritis Rheum."},{"key":"1709901_CR10","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/ar2852","volume":"11","author":"MJ Boumans","year":"2009","unstructured":"Boumans MJ, Tak PP. (2009) Rituximab treatment in rheumatoid arthritis: how does it work? Arthritis Res. Ther. 11:134.","journal-title":"Arthritis Res. Ther."},{"key":"1709901_CR11","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1136\/ard.2007.074229","volume":"67","author":"A Kavanaugh","year":"2008","unstructured":"Kavanaugh A, et al. (2008) Assessment of rituximab\u2019s immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results. Ann. Rheum. Dis. 67:402\u20138.","journal-title":"Ann. Rheum. Dis."},{"key":"1709901_CR12","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1136\/ard.2007.080960","volume":"67","author":"RM Thurlings","year":"2008","unstructured":"Thurlings RM, et al. (2008) Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of response. Ann. Rheum. Dis. 67:917\u201325.","journal-title":"Ann. Rheum. Dis."},{"key":"1709901_CR13","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.clim.2008.11.011","volume":"131","author":"B Tolusso","year":"2009","unstructured":"Tolusso B, et al. (2009) Synovial B cells of rheumatoid arthritis express ZAP-70 which increases the survival and correlates with the inflammatory and autoimmune phenotype. Clin. Immunol. 131:98\u2013108.","journal-title":"Clin. Immunol."},{"key":"1709901_CR14","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, et al. (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315\u201324.","journal-title":"Arthritis Rheum."},{"key":"1709901_CR15","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1136\/ard.2010.139550","volume":"70","author":"MG Sande van de","year":"2011","unstructured":"van de Sande MG, et al. (2011) Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials. Ann. Rheum. Dis. 70:423\u20137.","journal-title":"Ann. Rheum. Dis."},{"key":"1709901_CR16","doi-asserted-by":"publisher","first-page":"785","DOI":"10.4049\/jimmunol.181.1.785","volume":"181","author":"T Cantaert","year":"2008","unstructured":"Cantaert T, et al. (2008) B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis. J. Immunol. 181: 785\u201394.","journal-title":"J. Immunol."},{"key":"1709901_CR17","first-page":"1311","volume":"151","author":"PA Klimiuk","year":"1997","unstructured":"Klimiuk PA, Goronzy JJ, Bj\u00f6rnsson J, Beckenbaugh RD, Weyand CM. (1997) Tissue cytokine patterns distinguish variants of rheumatoid synovitis. Am. J. Pathol. 151:1311\u20139.","journal-title":"Am. J. Pathol."},{"key":"1709901_CR18","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1056\/NEJMoa023143","volume":"348","author":"M Crespo","year":"2003","unstructured":"Crespo M, et al. (2003) ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N. Engl. J. Med. 348:1764\u201375.","journal-title":"N. Engl. J. Med."},{"key":"1709901_CR19","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1136\/ard.2008.096172","volume":"68","author":"A Binard","year":"2009","unstructured":"Binard A, et al. (2009) Is the blood B-cell subset profile diagnostic for Sjogren syndrome? Ann. Rheum. Dis. 68:1447\u201352.","journal-title":"Ann. Rheum. Dis."},{"key":"1709901_CR20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.smim.2007.12.006","volume":"20","author":"I Sanz","year":"2008","unstructured":"Sanz I, Wie C, Lee FE, Anolik J. (2008) Phenotypic and functional heterogeneity of human memory B cells. Semin. Immunol. 20:67\u201382.","journal-title":"Semin. Immunol."},{"key":"1709901_CR21","doi-asserted-by":"publisher","first-page":"R62","DOI":"10.1186\/ar2686","volume":"11","author":"B M\u00f6ller","year":"2009","unstructured":"M\u00f6ller B, et al. (2009) Class-switched B cells display response to therapeutic B-cell depletion in rheumatoid arthritis. Arthritis Res. Ther. 11:R62.","journal-title":"Arthritis Res. Ther."},{"key":"1709901_CR22","doi-asserted-by":"publisher","first-page":"R84","DOI":"10.1186\/ar2718","volume":"11","author":"MM Souto-Carneiro","year":"2009","unstructured":"Souto-Carneiro MM, et al. (2009) Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor. Arthritis Res. Ther. 11:R84.","journal-title":"Arthritis Res. Ther."},{"key":"1709901_CR23","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1002\/art.23498","volume":"58","author":"AM Jacobi","year":"2008","unstructured":"Jacobi AM, et al. (2008) Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95. Arthritis Rheum. 58:1762\u201373.","journal-title":"Arthritis Rheum."},{"key":"1709901_CR24","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1002\/1529-0131(200105)44:5<1022::AID-ANR181>3.0.CO;2-N","volume":"44","author":"KJ Katschke Jr.","year":"2001","unstructured":"Katschke KJ Jr, et al. (2001) Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes\/macrophages in rheumatoid arthritis. Arthritis Rheum. 44:1022\u201332.","journal-title":"Arthritis Rheum."},{"key":"1709901_CR25","doi-asserted-by":"publisher","first-page":"650","DOI":"10.4049\/jimmunol.166.1.650","volume":"166","author":"K Shi","year":"2001","unstructured":"Shi K, et al. (2001) Lymphoid chemokine B cellattracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients. J. Immunol. 166:650\u20135.","journal-title":"J. Immunol."},{"key":"1709901_CR26","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1136\/ard.2010.139287","volume":"70","author":"MGH Sande van de","year":"2011","unstructured":"van de Sande MGH, et al. (2011) Presence of lymphocytes aggregates in the synovium of patients with early arthritis in relationship to diagnosis and outcome: is it a constant feature over time? Ann. Rheum. Dis. 70:700\u20133.","journal-title":"Ann. Rheum. Dis."}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.crossref.org\/molmed.2011.00034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2011.00034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T00:50:45Z","timestamp":1554511845000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.2119\/molmed.2011.00034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,13]]},"references-count":26,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["1709901"],"URL":"https:\/\/doi.org\/10.2119\/molmed.2011.00034","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,13]]}}}