{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T18:29:47Z","timestamp":1774117787220,"version":"3.50.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T00:00:00Z","timestamp":1330473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.2119\/molmed.2011.00222","type":"journal-article","created":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T18:01:54Z","timestamp":1342029714000},"page":"647-658","source":"Crossref","is-referenced-by-count":34,"title":["Prime-Boost Vaccination with rBCG\/rAd35 Enhances CD8+ Cytolytic T-Cell Responses in Lesions from Mycobacterium Tuberculosis-Infected Primates"],"prefix":"10.1186","volume":"18","author":[{"given":"Sayma","family":"Rahman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Magalhaes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jubayer","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raija K.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donata R.","family":"Sizemore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Scanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Weichold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Verreck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanela","family":"Kondova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Sadoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rigmor","family":"Thorstensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Sp\u00e5ngberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Maeurer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Brighenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,29]]},"reference":[{"key":"1804647_CR1","first-page":"656","volume":"3","author":"P Andersen","year":"2005","unstructured":"Andersen P, Doherty TM. (2005) The success and failure of BCG: implications for a novel tuberculosis vaccine. Nat. Rev. 3:656\u201362.","journal-title":"Nat. Rev."},{"key":"1804647_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1146\/annurev.immunol.19.1.93","volume":"19","author":"JL Flynn","year":"2001","unstructured":"Flynn JL, Chan J. (2001) Immunology of tuberculosis. Annu. Rev. Immunol. 19:93\u2013129.","journal-title":"Annu. Rev. Immunol."},{"key":"1804647_CR3","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1126\/science.276.5319.1684","volume":"276","author":"S Stenger","year":"1997","unstructured":"Stenger S, et al. (1997) Differential effects of cytolytic T cell subsets on intracellular infection. Science. 276:1684\u20137.","journal-title":"Science"},{"key":"1804647_CR4","doi-asserted-by":"publisher","first-page":"8595","DOI":"10.4049\/jimmunol.181.12.8595","volume":"181","author":"JS Woodworth","year":"2008","unstructured":"Woodworth JS, Wu Y, Behar SM. (2008) Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo. J. Immunol. 181:8595\u2013603.","journal-title":"J. Immunol."},{"key":"1804647_CR5","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1126\/science.282.5386.121","volume":"282","author":"S Stenger","year":"1998","unstructured":"Stenger S, et al. (1998) An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 282:121\u20135.","journal-title":"Science"},{"key":"1804647_CR6","doi-asserted-by":"publisher","first-page":"5210","DOI":"10.1128\/IAI.00624-07","volume":"75","author":"J Andersson","year":"2007","unstructured":"Andersson J, Samarina A, Fink J, Rahman S, Grundstrom S. (2007) Impaired expression of perforin and granulysin in CD8+ T cells at the site of infection in human chronic pulmonary tuberculosis. Infect. Immun. 75:5210\u201322.","journal-title":"Infect. Immun."},{"key":"1804647_CR7","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.2353\/ajpath.2009.080941","volume":"174","author":"S Rahman","year":"2009","unstructured":"Rahman S, et al. (2009) Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory T cells in the granulomatous lesions. Am. J. Pathol. 174:2211\u201324.","journal-title":"Am. J. Pathol."},{"key":"1804647_CR8","doi-asserted-by":"publisher","first-page":"2962","DOI":"10.1128\/IAI.68.5.2962-2970.2000","volume":"68","author":"MJ Maeurer","year":"2000","unstructured":"Maeurer MJ, et al. (2000) Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice. Infect. Immun. 68:2962\u201370.","journal-title":"Infect. Immun."},{"key":"1804647_CR9","first-page":"469","volume":"4","author":"YA Skeiky","year":"2006","unstructured":"Skeiky YA, Sadoff JC. (2006) Advances in tuberculosis vaccine strategies. Nat. Rev. 4:469\u201376.","journal-title":"Nat. Rev."},{"key":"1804647_CR10","first-page":"4412","volume":"27","author":"R Sun","year":"2009","unstructured":"Sun R, et al. (2009) Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis. Vaccine. 27:4412\u201323.","journal-title":"Mycobacterium tuberculosis. Vaccine."},{"key":"1804647_CR11","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1172\/JCI24617","volume":"115","author":"L Grode","year":"2005","unstructured":"Grode L, et al. (2005) Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin. J. Clin. Invest. 115:2472\u20139.","journal-title":"J. Clin. Invest."},{"key":"1804647_CR12","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.cell.2007.05.059","volume":"129","author":"N Wel van der","year":"2007","unstructured":"van der Wel N, et al. (2007) M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell. 129:1287\u201398.","journal-title":"Cell"},{"key":"1804647_CR13","doi-asserted-by":"publisher","first-page":"e3790","DOI":"10.1371\/journal.pone.0003790","volume":"3","author":"I Magalhaes","year":"2008","unstructured":"Magalhaes I, et al. (2008) rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector. PloS One. 3:e3790.","journal-title":"PloS One."},{"key":"1804647_CR14","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0022-1759(94)90363-8","volume":"175","author":"L Bjork","year":"1994","unstructured":"Bjork L, Andersson U, Chauvet JM, Skansen-Saphir U, Andersson J. (1994) Quantification of superantigen induced IFN-gamma production by computerised image analysis\u2014inhibition of cytokine production and blast transformation by pooled human IgG. J. Immunol. Methods. 175:201\u201313.","journal-title":"J. Immunol. Methods."},{"key":"1804647_CR15","first-page":"16","volume":"83","author":"J Andersson","year":"1994","unstructured":"Andersson J, et al. (1994) Concomitant in vivo production of 19 different cytokines in human tonsils. Immunol. 83:16\u201324.","journal-title":"Immunol"},{"key":"1804647_CR16","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1097\/00002030-199907300-00005","volume":"13","author":"J Andersson","year":"1999","unstructured":"Andersson J, et al. (1999) Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection. AIDS (London, England) 13:1295\u2013303.","journal-title":"AIDS (London, England)"},{"key":"1804647_CR17","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3109\/00016489609137876","volume":"116","author":"K Agren","year":"1996","unstructured":"Agren K, et al. (1996) The production of immunoregulatory cytokines is localized to the extrafollicular area of human tonsils. Acta Otolaryngol. 116:477\u201385.","journal-title":"Acta Otolaryngol."},{"key":"1804647_CR18","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1097\/00126334-200010010-00009","volume":"25","author":"H Behbahani","year":"2000","unstructured":"Behbahani H, et al. (2000) Normalization of immune activation in lymphoid tissue following highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 25:150\u20136.","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"1804647_CR19","doi-asserted-by":"publisher","first-page":"3808","DOI":"10.1182\/blood-2006-05-021576","volume":"108","author":"J Nilsson","year":"2006","unstructured":"Nilsson J, et al. (2006) HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV\/AIDS. Blood. 108:3808\u201317.","journal-title":"Blood"},{"key":"1804647_CR20","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1600-0684.2003.00053.x","volume":"33","author":"J Soderlund","year":"2004","unstructured":"Soderlund J, et al. (2004) Dichotomy between CD1a+ and CD83+ dendritic cells in lymph nodes during SIV infection of macaques. J. Med. Primatol. 33:16\u201324.","journal-title":"J. Med. Primatol."},{"key":"1804647_CR21","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/BF00184787","volume":"70","author":"J Westermann","year":"1992","unstructured":"Westermann J, Pabst R. (1992) Distribution of lymphocyte subsets and natural killer cells in the human body. Clin. Invest. 70:539\u201344.","journal-title":"Clin. Invest."},{"key":"1804647_CR22","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1099\/vir.0.81956-0","volume":"87","author":"M Havenga","year":"2006","unstructured":"Havenga M, et al. (2006) Novel replication-incompetent adenoviral B-group vectors: high vector stability and yield in PER.C6 cells. J. Gen. Virol. 87:2135\u201343.","journal-title":"J. Gen. Virol."},{"key":"1804647_CR23","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0046-8177(80)80031-1","volume":"11","author":"JA Madri","year":"1980","unstructured":"Madri JA, Furthmayr H. (1980) Collagen polymorphism in the lung: an immunochemical study of pulmonary fibrosis. Hum. Pathol. 11:353\u201366.","journal-title":"Hum. Pathol."},{"key":"1804647_CR24","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1097\/PAI.0b013e31816c3f79","volume":"16","author":"K Baba","year":"2008","unstructured":"Baba K, et al. (2008) Rapid and specific diagnosis of tuberculous pleuritis with immunohistochemistry by detecting Mycobacterium tuberculosis complex specific antigen MPT64 in patients from a HIV endemic area. Appl. Immunohistochem. Mol. Morphol. 16:554\u201361.","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"1804647_CR25","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.jmb.2006.11.039","volume":"366","author":"Z Wang","year":"2007","unstructured":"Wang Z, et al. (2007) The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a new family of beta-grasp proteins. J. Mol. Biol. 366:375\u201381.","journal-title":"J. Mol. Biol."},{"key":"1804647_CR26","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.4049\/jimmunol.154.6.2775","volume":"154","author":"PA Sieling","year":"1995","unstructured":"Sieling PA, et al. (1995) IL-7 in the cell-mediated immune response to a human pathogen. J. Immunol. 154:2775\u201383.","journal-title":"J. Immunol."},{"key":"1804647_CR27","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1086\/426139","volume":"40","author":"KA Wilkinson","year":"2005","unstructured":"Wilkinson KA, et al. (2005) Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. Clin. Infect. Dis. 40:184\u20137.","journal-title":"Clin. Infect. Dis."},{"key":"1804647_CR28","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.4049\/jimmunol.142.4.1114","volume":"142","author":"PF Barnes","year":"1989","unstructured":"Barnes PF, et al. (1989) Compartmentalization of a CD4+ T lymphocyte subpopulation in tuberculous pleuritis. J. Immunol. 142:1114\u20139.","journal-title":"J. Immunol."},{"key":"1804647_CR29","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1183\/09031936.00096707","volume":"31","author":"C Jafari","year":"2008","unstructured":"Jafari C, et al. (2008) Local immunodiagnosis of pulmonary tuberculosis by enzyme-linked immunospot. Eur. Respir. J. 31:261\u20135.","journal-title":"Eur. Respir. J."},{"key":"1804647_CR30","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1086\/314454","volume":"178","author":"SK Schwander","year":"1998","unstructured":"Schwander SK, et al. (1998) Enhanced responses to Mycobacterium tuberculosis antigens by human alveolar lymphocytes during active pulmonary tuberculosis. J. Infect. Dis. 178:1434\u201345.","journal-title":"J. Infect. Dis."},{"key":"1804647_CR31","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1365-2796.2008.02012.x","volume":"265","author":"J Nemeth","year":"2009","unstructured":"Nemeth J, et al. (2009) Recruitment of Mycobacterium tuberculosis specific CD4+ T cells to the site of infection for diagnosis of active tuberculosis. J. Intern. Med. 265:163\u20138.","journal-title":"J. Intern. Med."},{"key":"1804647_CR32","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1084\/jem.20041378","volume":"201","author":"C Lurquin","year":"2005","unstructured":"Lurquin C, et al. (2005) Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen. J. Exp. Med. 201:249\u201357.","journal-title":"J. Exp. Med."},{"key":"1804647_CR33","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1016\/S0140-6736(08)61592-5","volume":"372","author":"MJ McElrath","year":"2008","unstructured":"McElrath MJ, et al. (2008) HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. Lancet. 372:1894\u2013905.","journal-title":"Lancet"},{"key":"1804647_CR34","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nm1592","volume":"13","author":"PA Darrah","year":"2007","unstructured":"Darrah PA, et al. (2007) Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat. Med. 13:843\u201350.","journal-title":"Nat. Med."},{"key":"1804647_CR35","doi-asserted-by":"publisher","first-page":"4955","DOI":"10.4049\/jimmunol.181.7.4955","volume":"181","author":"EK Forbes","year":"2008","unstructured":"Forbes EK, et al. (2008) Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice. J. Immunol. 181:4955\u201364.","journal-title":"J. Immunol."},{"key":"1804647_CR36","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1164\/rccm.200910-1484OC","volume":"181","author":"B Abel","year":"2010","unstructured":"Abel B, et al. (2010) The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adults. Am. J. Respir. Crit. Care Med. 181:1407\u201317.","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"1804647_CR37","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1128\/IAI.67.10.5223-5230.1999","volume":"67","author":"SM Smith","year":"1999","unstructured":"Smith SM, et al. (1999) Characterization of human Mycobacterium bovis bacille Calmette-Guerin-reactive CD8+ T cells. Infect. Immun. 67:5223\u201330.","journal-title":"Infect. Immun."},{"key":"1804647_CR38","doi-asserted-by":"publisher","first-page":"e1000392","DOI":"10.1371\/journal.ppat.1000392","volume":"5","author":"CY Chen","year":"2009","unstructured":"Chen CY, et al. (2009) A critical role for CD8 T cells in a nonhuman primate model of tuberculosis. PLoS Pathog. 5:e1000392.","journal-title":"PLoS Pathog."},{"key":"1804647_CR39","doi-asserted-by":"publisher","first-page":"12013","DOI":"10.1073\/pnas.89.24.12013","volume":"89","author":"JL Flynn","year":"1992","unstructured":"Flynn JL, Goldstein MM, Triebold KJ, Koller B, Bloom BR. (1992) Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. U. S. A. 89:12013\u20137.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"1804647_CR40","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.vaccine.2008.10.053","volume":"27","author":"AE Hogg","year":"2009","unstructured":"Hogg AE, Worth A, Beverley P, Howard CJ, Villarreal-Ramos B. (2009) The antigen-specific memory CD8+ T-cell response induced by BCG in cattle resides in the CD8+gamma\/deltaTCR-CD45RO+ T-cell population. Vaccine. 27:270\u20139.","journal-title":"Vaccine"},{"key":"1804647_CR41","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1084\/jem.20041690","volume":"200","author":"AB Kamath","year":"2004","unstructured":"Kamath AB, et al. (2004) Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection. J. Exp. Med. 200:1479\u201389.","journal-title":"J. Exp. Med."},{"key":"1804647_CR42","doi-asserted-by":"publisher","first-page":"3689","DOI":"10.1002\/1521-4141(200012)30:12<3689::AID-IMMU3689>3.0.CO;2-4","volume":"30","author":"LA Pinxteren van","year":"2000","unstructured":"van Pinxteren LA, Cassidy JP, Smedegaard BH, Agger EM, Andersen P. (2000) Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cells. Eur. J. Immunol. 30:3689\u201398.","journal-title":"Eur. J. Immunol."},{"key":"1804647_CR43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/IAI.65.1.127-132.1997","volume":"65","author":"P Laochumroonvorapong","year":"1997","unstructured":"Laochumroonvorapong P, et al. (1997) Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice. Infect. Immun. 65:127\u201332.","journal-title":"Infect. Immun."},{"key":"1804647_CR44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1189\/jlb.72.1.115","volume":"72","author":"Y Tsunetsugu-Yokota","year":"2002","unstructured":"Tsunetsugu-Yokota Y, et al. (2002) Selective expansion of perforin-positive CD8+ T cells by immature dendritic cells infected with live Bacillus Calmette-Guerin mycobacteria. J. Leukoc. Biol. 72:115\u201324.","journal-title":"J. Leukoc. Biol."},{"key":"1804647_CR45","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/j.1865-1682.2008.01058.x","volume":"56","author":"CF Capinos Scherer","year":"2009","unstructured":"Capinos Scherer CF, et al. (2009) Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with Mycobacterium bovis BCG or M. bovisDeltaRD1. Transbound. Emerg. Dis. 56:228\u201339.","journal-title":"Transbound. Emerg. Dis."},{"key":"1804647_CR46","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/84620","volume":"7","author":"MT Ochoa","year":"2001","unstructured":"Ochoa MT, et al. (2001) T-cell release of granulysin contributes to host defense in leprosy. Nat. Med. 7:174\u20139.","journal-title":"Nat. Med."},{"key":"1804647_CR47","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1086\/323600","volume":"184","author":"F Dieli","year":"2001","unstructured":"Dieli F, et al. (2001) Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9\/Vdelta2 T lymphocytes. J. Infect. Dis. 184:1082\u20135.","journal-title":"J. Infect. Dis."},{"key":"1804647_CR48","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.tube.2007.01.002","volume":"87","author":"E Sahiratmadja","year":"2007","unstructured":"Sahiratmadja E, et al. (2007) Plasma granulysin levels and cellular interferon-gamma production correlate with curative host responses in tuberculosis, while plasma interferon-gamma levels correlate with tuberculosis disease activity in adults. Tuberculosis. 87:312\u201321.","journal-title":"Tuberculosis"},{"key":"1804647_CR49","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1172\/JCI38482","volume":"119","author":"H Bruns","year":"2009","unstructured":"Bruns H, et al. (2009) Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans. J. Clin. Invest. 119:1167\u201377.","journal-title":"J. Clin. Invest."},{"key":"1804647_CR50","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.4049\/jimmunol.177.3.1780","volume":"177","author":"N Caccamo","year":"2006","unstructured":"Caccamo N, et al. (2006) Phenotypical and functional analysis of memory and effector human CD8 T cells specific for mycobacterial antigens. J. Immunol. 177:1780\u20135.","journal-title":"J. Immunol."},{"key":"1804647_CR51","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/35065118","volume":"410","author":"P Champagne","year":"2001","unstructured":"Champagne P, et al. (2001) Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 410:106\u201311.","journal-title":"Nature"},{"key":"1804647_CR52","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1084\/jem.192.1.63","volume":"192","author":"V Appay","year":"2000","unstructured":"Appay V, et al. (2000) HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med. 192:63\u201375.","journal-title":"J. Exp. Med."},{"key":"1804647_CR53","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1182\/blood-2002-11-3577","volume":"101","author":"J Geginat","year":"2003","unstructured":"Geginat J, Lanzavecchia A, Sallusto F. (2003) Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. Blood. 101:4260\u20136.","journal-title":"Blood"},{"key":"1804647_CR54","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.4049\/jimmunol.145.8.2415","volume":"145","author":"CJ Hickman","year":"1990","unstructured":"Hickman CJ, Crim JA, Mostowski HS, Siegel JP. (1990) Regulation of human cytotoxic T lymphocyte development by IL-7. J. Immunol. 145:2415\u201320.","journal-title":"J. Immunol."},{"key":"1804647_CR55","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/0008-8749(91)90163-6","volume":"138","author":"MJ Smyth","year":"1991","unstructured":"Smyth MJ, Norihisa Y, Gerard JR, Young HA, Ortaldo JR. (1991) IL-7 regulation of cytotoxic lymphocytes: pore-forming protein gene expression, interferon-gamma production, and cytotoxicity of human peripheral blood lymphocytes subsets. Cell. Immunol. 138:390\u2013403.","journal-title":"Cell. Immunol."},{"key":"1804647_CR56","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1086\/653827","volume":"202","author":"V Singh","year":"2010","unstructured":"Singh V, et al. (2010) Coadministration of interleukins 7 and 15 with Bacille Calmette-Guerin mounts enduring T cell memory response against Mycobacterium tuberculosis. J. Infect. Dis. 202:480\u20139.","journal-title":"J. Infect. Dis."},{"key":"1804647_CR57","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/nm906","volume":"9","author":"UE Schaible","year":"2003","unstructured":"Schaible UE, et al. (2003) Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. Nat. Med. 9:1039\u201346.","journal-title":"Nat. Med."},{"key":"1804647_CR58","doi-asserted-by":"publisher","first-page":"11497","DOI":"10.1073\/pnas.201404898","volume":"98","author":"JA Langermans","year":"2001","unstructured":"Langermans JA, Andersen P, van Soolingen D, et al. (2001) Divergent effect of bacillus Calmette-Guerin (BCG) vaccination on Mycobacterium tuberculosis infection in highly related macaque species: implications for primate models in tuberculosis vaccine research. Proc. Natl. Acad. Sci. U S A. 98:11497\u2013502.","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"1804647_CR59","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1128\/IAI.61.9.4008-4012.1993","volume":"61","author":"A Gessner","year":"1993","unstructured":"Gessner A, Vieth M, Will A, Schroppel K, Rollinghoff M. (1993) Interleukin-7 enhances antimicrobial activity against Leishmania major in murine macrophages. Infect. Immun. 61:4008\u201312.","journal-title":"Infect. Immun."},{"key":"1804647_CR60","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/path.1628","volume":"204","author":"T Ulrichs","year":"2004","unstructured":"Ulrichs T, et al. (2004) Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung. J. Pathol. 204:217\u201328.","journal-title":"J. Pathol."}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2011.00222.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.2119\/molmed.2011.00222\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.crossref.org\/molmed.2011.00222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2011.00222.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T06:54:45Z","timestamp":1687589685000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.2119\/molmed.2011.00222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,29]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["1804647"],"URL":"https:\/\/doi.org\/10.2119\/molmed.2011.00222","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,29]]}}}