{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:09:39Z","timestamp":1790978979845,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":70,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bone has a high capacity for self-renewal and repair. Prolonged local secretion of interleukin 1\u03b2 (IL-1\u03b2), however, is known to be associated with severe bone loss and delayed fracture healing. Since induction of bone resorption by IL-1\u03b2 may not sufficiently explain these pathologic processes, we investigated,\n                    <jats:italic>in vitro<\/jats:italic>\n                    , if and how IL-1\u03b2 affects migration of multipotent mesenchymal stromal cells (MSC) or osteoblasts. We found that homogenous exposure to IL-1 \u03b2 significantly diminished both nondirectional migration and site-directed migration toward the chemotactic factors platelet-derived growth factor (PDGF)-BB and insulinlike growth factor 1 (IGF-1) in osteoblasts. Exposure to a concentration gradient of IL-1\u03b2 induced an even stronger inhibition of migration and completely abolished the migratory response of osteoblasts toward PDGF-BB, IGF-1, vascular endothelial growth factor A (VEGF-A) and the complement factor C5a. IL-1\u03b2 induced extracellular signal-regulated kinases 1 and 2 (ERK1\/2) and c-Jun N-terminal kinases (JNK) activation and inhibition of these signaling pathways suggested an involvement in the IL-1\u03b2 effects on osteoblast migration. In contrast, basal migration of MSC and their migratory activity toward PDGF-BB was found to be unaffected by IL-1\u03b2. These results indicate that the presence of IL-1\u03b2 leads to impaired recruitment of osteoblasts which might influence early stages of fracture healing and could have pathological relevance for bone remodeling in inflammatory bone disease.\n                  <\/jats:p>","DOI":"10.2119\/molmed.2012.00058","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T15:43:26Z","timestamp":1372779806000},"page":"36-42","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["IL-1\u03b2 Inhibits Human Osteoblast Migration"],"prefix":"10.1186","volume":"19","author":[{"given":"Nina-Emily","family":"Hengartner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Fiedler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Ignatius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf E.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"1901036_CR1","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1302\/0301-620X.60B2.350882","volume":"60-B","author":"B McKibbin","year":"1978","unstructured":"McKibbin B. 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