{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:31:20Z","timestamp":1787506280928,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.2119\/molmed.2014.00140","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T13:36:49Z","timestamp":1554471409000},"page":"720-728","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An Entity Evolving into a Community: Defining the Common Ancestor and Evolutionary Trajectory of Chronic Lymphocytic Leukemia Stereotyped Subset #4"],"prefix":"10.1186","volume":"20","author":[{"given":"Lesley-Ann","family":"Sutton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgos","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Hadzidimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efterpi","family":"Kostareli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Rosenquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tzovaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Stamatopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"2001720_CR1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1182\/blood-2006-03-012948","volume":"109","author":"K Stamatopoulos","year":"2007","unstructured":"Stamatopoulos K, et al. (2007) Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations. Blood. 109:259\u201370.","journal-title":"Blood"},{"key":"2001720_CR2","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1016\/S2352-3026(14)00005-2","volume":"1","author":"P Baliakas","year":"2014","unstructured":"Baliakas P, et al. (2014) Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study. Lancet Haematol. 1:e74\u201384.","journal-title":"Lancet Haematol."},{"key":"2001720_CR3","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1182\/blood-2007-07-099564","volume":"111","author":"F Murray","year":"2008","unstructured":"Murray F, et al. (2008) Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood. 111:1524\u201333.","journal-title":"Blood"},{"key":"2001720_CR4","doi-asserted-by":"publisher","first-page":"4467","DOI":"10.1182\/blood-2011-11-393694","volume":"119","author":"A Agathangelidis","year":"2012","unstructured":"Agathangelidis A, et al. (2012) Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood. 119:4467\u201375.","journal-title":"Blood"},{"key":"2001720_CR5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1158\/1078-0432.CCR-13-1993","volume":"20","author":"A Vardi","year":"2014","unstructured":"Vardi A, et al. (2014) IgG-switched CLL has a distinct immunogenetic signature from the common MD variant: ontogenetic implications. Clin. Cancer Res. 20:323\u201330.","journal-title":"Clin. Cancer Res."},{"key":"2001720_CR6","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.4049\/jimmunol.157.6.2430","volume":"157","author":"MR Krishnan","year":"1996","unstructured":"Krishnan MR, Jou NT, Marion TN. (1996) Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies. J. Immunol. 157:2430\u20139.","journal-title":"J. Immunol"},{"key":"2001720_CR7","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1002\/1521-4141(200007)30:7<2015::AID-IMMU2015>3.0.CO;2-5","volume":"30","author":"Z Li","year":"2000","unstructured":"Li Z, Schettino EW, Padlan EA, Ikematsu H, Casali P. (2000) Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double- and single-stranded DNA. Eur. J. Immunol. 30:2015\u201326.","journal-title":"Eur. J. Immunol"},{"key":"2001720_CR8","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s000180300026","volume":"60","author":"YJ Jang","year":"2003","unstructured":"Jang YJ, Stollar BD. (2003) Anti-DNA antibodies: aspects of structure and pathogenicity. Cell. Mol. Life Sci. 60:309\u201320.","journal-title":"Cell. Mol. Life Sci."},{"key":"2001720_CR9","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1182\/blood-2008-07-166868","volume":"113","author":"A Hadzidimitriou","year":"2009","unstructured":"Hadzidimitriou A, et al. (2009) Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia. Blood. 113:403\u201311.","journal-title":"Blood"},{"key":"2001720_CR10","doi-asserted-by":"publisher","first-page":"4460","DOI":"10.1182\/blood-2009-05-221309","volume":"114","author":"LA Sutton","year":"2009","unstructured":"Sutton LA, et al. (2009) Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen. Blood. 114:4460\u20138.","journal-title":"Blood"},{"key":"2001720_CR11","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1038\/leu.2010.90","volume":"24","author":"E Kostareli","year":"2010","unstructured":"Kostareli E, et al. (2010) Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution. Leukemia. 24:1317\u201324.","journal-title":"Leukemia"},{"key":"2001720_CR12","doi-asserted-by":"publisher","first-page":"230","DOI":"10.2119\/molmed.2013.00042","volume":"19","author":"LA Sutton","year":"2013","unstructured":"Sutton LA, et al. (2013) Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34\/IGKV2-30 antigen receptors: longitudinal immunogenetic evidence. Mol. Med. 19:230\u20136.","journal-title":"Mol. Med."},{"key":"2001720_CR13","doi-asserted-by":"publisher","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","volume":"111","author":"M Hallek","year":"2008","unstructured":"Hallek M, et al. (2008) Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 111:5446\u201356.","journal-title":"Blood"},{"key":"2001720_CR14","doi-asserted-by":"crossref","unstructured":"Dang QT, Phan TH. (2010) Determining Restricted Damerau-Levenshtein Edit-Distance of Two Languages by Extended Automata [Internet]. In: Computing and Communication Technologies, Research, Innovation, and Vision for the Future (RIVF), 2010 IEEE RIVF International Conference on; 2010 Nov 1\u20134; Hanoi. [cited 2015 Mar 31]. Available from: https:\/\/doi.org\/ieeexplore.ieee.org\/xpl\/articleDetails.jsp?tp=&arnumber=5632914&queryText%3DDetermining+Restricted+Damerau-Levenshtein.","DOI":"10.1109\/RIVF.2010.5632914"},{"key":"2001720_CR15","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/978-3-540-88269-5_13","volume-title":"Modeling Decisions for Artificial Intelligence: 5th International Conference, MDAI 2008, Sabadell, Spain, October 30\u201331, 2008, Proceedings","author":"C Gomez-Alonso","year":"2008","unstructured":"Gomez-Alonso C, Valls A. (2008) A Similarity Measure for Sequences of Categorical Data Based on the Ordering of Common Elements. In: Modeling Decisions for Artificial Intelligence: 5th International Conference, MDAI 2008, Sabadell, Spain, October 30\u201331, 2008, Proceedings. Torra V, Narukawa Y (eds.) Springer, Berlin, pp. 134\u201345."},{"key":"2001720_CR16","doi-asserted-by":"publisher","first-page":"e41531","DOI":"10.1371\/journal.pone.0041531","volume":"7","author":"MA Schulz","year":"2012","unstructured":"Schulz MA, Schmalbach B, Brugger P, Witt K. (2012) Analysing humanly generated random number sequences: a pattern-based approach. PloS One. 7:e41531.","journal-title":"PloS One"},{"key":"2001720_CR17","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1086\/282802","volume":"106","author":"JS Farris","year":"1972","unstructured":"Farris JS. (1972) Estimating phylogenetic trees from distance matrices. Am. Nat. 106:645\u201368.","journal-title":"Am. Nat."},{"key":"2001720_CR18","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1089\/cmb.2012.0042","volume":"19","author":"LJ Helmkamp","year":"2012","unstructured":"Helmkamp LJ, Jewett EM, Rosenberg NA. (2012) Improvements to a class of distance matrix methods for inferring species trees from gene trees. J. Comput. Biol. 19:632\u201349.","journal-title":"Comput. Biol."},{"key":"2001720_CR19","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/9781118600788.ch9","volume-title":"Mathematical morphology: From theory to applications","author":"F Meyer","year":"2013","unstructured":"Meyer F, Najman L. (2013) Segmentation, minimum spanning tree and hierarchies. In: Mathematical morphology: From theory to applications. L N, H T (eds.) John Wiley & Sons, Hoboken, New Jersey, USA, pp. 229\u201361."},{"key":"2001720_CR20","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1128\/JCM.01315-09","volume":"48","author":"JW Marsh","year":"2010","unstructured":"Marsh JW, et al. (2010) Multilocus variable-number tandem-repeat analysis and multilocus sequence typing reveal genetic relationships among Clostridium difficile isolates genotyped by restriction endonuclease analysis. J. Clin. Microbiol. 48:412\u20138.","journal-title":"J. Clin. MicroBiol."},{"key":"2001720_CR21","doi-asserted-by":"crossref","unstructured":"Erciyes K. (2013) Minimum spanning trees. In: Distributed graph algorithms for computer networks. Sammes AJ (ed.) Springer, pp. 69\u201382.","DOI":"10.1007\/978-1-4471-5173-9_6"},{"key":"2001720_CR22","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1006\/bcmd.1996.0020","volume":"22","author":"LE Silberstein","year":"1996","unstructured":"Silberstein LE, George A, Durdik JM, Kipps TJ. (1996) The V4\u201334 encoded anti-i autoantibodies recognize a large subset of human and mouse B-cells. Blood Cells Mol. Dis. 22:126\u201338.","journal-title":"Blood Cells Mol. Dis."},{"key":"2001720_CR23","doi-asserted-by":"publisher","first-page":"3777","DOI":"10.4049\/jimmunol.169.7.3777","volume":"169","author":"KN Potter","year":"2002","unstructured":"Potter KN, Hobby P, Klijn S, Stevenson FK, Sutton BJ. (2002) Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen. J. Immunol. 169:3777\u201382.","journal-title":"J. Immunol"},{"key":"2001720_CR24","doi-asserted-by":"publisher","first-page":"665","DOI":"10.2119\/2008-00102.Catera","volume":"14","author":"R Catera","year":"2008","unstructured":"Catera R, et al. (2008) Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol. Med. 14:665\u201374.","journal-title":"Mol. Med."},{"key":"2001720_CR25","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1182\/blood.V108.11.2813.2813","volume":"108","author":"R Catera","year":"2006","unstructured":"Catera R, et al. (2006) Polyreactive monoclonal antibodies synthesized by some B-CLL cells recognize specific antigens on viable and apoptotic T cells. Blood. 108:2813.","journal-title":"Blood"},{"key":"2001720_CR26","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1172\/JCI200112462","volume":"108","author":"AE Pugh-Bernard","year":"2001","unstructured":"Pugh-Bernard AE, et al. (2001) Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J. Clin. Invest. 108:1061\u201370.","journal-title":"J. Clin. Invest"},{"key":"2001720_CR27","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.4049\/jimmunol.172.7.4298","volume":"172","author":"AJ Cappione","year":"2004","unstructured":"Cappione AJ, Pugh-Bernard AE, Anolik JH, Sanz I. (2004) Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45\/B220 on the surface of human B lymphocytes. J. Immunol. 172:4298\u2013307.","journal-title":"J. Immunol"},{"key":"2001720_CR28","doi-asserted-by":"publisher","first-page":"13826","DOI":"10.1073\/pnas.241510698","volume":"98","author":"BA Cocca","year":"2001","unstructured":"Cocca BA, et al. (2001) Structural basis for auto-antibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells. Proc. Natl. Acad. Sci. U. S. A. 98:13826\u201331.","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"2001720_CR29","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1084\/jem.20021560","volume":"196","author":"Y Li","year":"2002","unstructured":"Li Y, Li H, Ni D, Weigert M. (2002) Anti-DNA B cells in MRL\/lpr mice show altered differentiation and editing pattern. J. Exp. Med. 196:1543\u201352.","journal-title":"J. Exp. Med."},{"key":"2001720_CR30","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1046\/j.1365-2249.2003.02026.x","volume":"131","author":"M Behrendt","year":"2003","unstructured":"Behrendt M, et al. (2003) The role of somatic mutation in determining the affinity of anti-DNA antibodies. Clin. Exp. Immunol. 131:182\u20139.","journal-title":"Clin. Exp. Immunol"},{"key":"2001720_CR31","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/leu.2008.379","volume":"23","author":"E Kostareli","year":"2009","unstructured":"Kostareli E, et al. (2009) Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Leukemia. 23:919\u201324.","journal-title":"Leukemia"},{"key":"2001720_CR32","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.2119\/molmed.2011.00480","volume":"18","author":"S Ntoufa","year":"2012","unstructured":"Ntoufa S, et al. (2012) Distinct innate immunity pathways to activation and tolerance in subgroups of chronic lymphocytic leukemia with distinct immunoglobulin receptors. Mol. Med. 18:1281\u201391.","journal-title":"Mol. Med."},{"key":"2001720_CR33","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1084\/jem.20080611","volume":"206","author":"JA Duty","year":"2009","unstructured":"Duty JA, et al. (2009) Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors. J. Exp. Med. 206:139\u201351.","journal-title":"J. Exp. Med."},{"key":"2001720_CR34","doi-asserted-by":"publisher","first-page":"4976","DOI":"10.1182\/blood-2010-03-276352","volume":"115","author":"SF Andrews","year":"2010","unstructured":"Andrews SF, Wilson PC. (2010) The anergic B cell. Blood. 115:4976\u20138.","journal-title":"Blood"},{"key":"2001720_CR35","doi-asserted-by":"publisher","first-page":"4518","DOI":"10.4049\/jimmunol.1302102","volume":"192","author":"M Chatzouli","year":"2014","unstructured":"Chatzouli M, et al. (2014) Heterogeneous functional effects of concomitant B cell receptor and TLR stimulation in chronic lymphocytic leukemia with mutated versus unmutated Ig genes. J. Immunol. 192:4518\u201324.","journal-title":"J. Immunol"},{"key":"2001720_CR36","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1172\/JCI24387","volume":"115","author":"M Herve","year":"2005","unstructured":"Herve M, et al. (2005) Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J. Clin. Invest. 115:1636\u201343.","journal-title":"J. Clin. Invest"},{"key":"2001720_CR37","doi-asserted-by":"publisher","first-page":"5122","DOI":"10.1182\/blood-2008-06-162024","volume":"112","author":"CC Chu","year":"2008","unstructured":"Chu CC, et al. (2008) Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood. 112:5122\u20139.","journal-title":"Blood"},{"key":"2001720_CR38","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.1182\/blood-2009-09-244251","volume":"115","author":"CC Chu","year":"2010","unstructured":"Chu CC, et al. (2010) Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin. Blood. 115:3907\u201315.","journal-title":"Blood"},{"key":"2001720_CR39","doi-asserted-by":"publisher","first-page":"4708","DOI":"10.1182\/blood-2012-08-447904","volume":"121","author":"C Zwick","year":"2013","unstructured":"Zwick C, et al. (2013) Autoantigenic targets of -cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells. Blood. 121:4708\u201317.","journal-title":"Blood"},{"key":"2001720_CR40","doi-asserted-by":"publisher","first-page":"9258","DOI":"10.1073\/pnas.0500132102","volume":"102","author":"U Wellmann","year":"2005","unstructured":"Wellmann U, et al. (2005) The evolution of human anti-double-stranded DNA autoantibodies. Proc. Natl. Acad. Sci. U. S. A. 102:9258\u201363.","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"2001720_CR41","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1002\/art.22743","volume":"56","author":"A Lambrianides","year":"2007","unstructured":"Lambrianides A, et al. (2007) Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome. Arthritis Rheum. 56:2392\u2013401.","journal-title":"Arthritis Rheum."},{"key":"2001720_CR42","doi-asserted-by":"publisher","first-page":"675","DOI":"10.2119\/2008-00066.Zhang","volume":"14","author":"J Zhang","year":"2008","unstructured":"Zhang J, Jacobi AM, Wang T, Diamond B. (2008) Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells. Mol. Med. 14:675\u201381.","journal-title":"Mol. Med."}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2014.00140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.2119\/molmed.2014.00140\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2014.00140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T08:52:11Z","timestamp":1694767931000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.2119\/molmed.2014.00140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["2001720"],"URL":"https:\/\/doi.org\/10.2119\/molmed.2014.00140","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"16 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}