{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:52:41Z","timestamp":1792507961309,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.2119\/molmed.2014.00264","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T17:28:13Z","timestamp":1438104493000},"page":"233-241","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Loss of Allograft Inflammatory Factor-1 Ameliorates Experimental Autoimmune Encephalomyelitis by Limiting Encephalitogenic CD4 T-Cell Expansion"],"prefix":"10.1186","volume":"21","author":[{"given":"Prameladevi","family":"Chinnasamy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario F.","family":"Riascos-Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Jeganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Casimiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia F.","family":"Brosnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas E. S.","family":"Sibinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,6]]},"reference":[{"key":"2101233_CR1","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1056\/NEJMra052130","volume":"354","author":"EM Frohman","year":"2006","unstructured":"Frohman EM, Racke MK, Raine CS. (2006) Multiple sclerosis: the plaque and its pathogenesis. N. Engl. J. Med. 354:942\u201355.","journal-title":"N. Engl. J. Med."},{"key":"2101233_CR2","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/ana.410380202","volume":"38","author":"R Martin","year":"1995","unstructured":"Martin R, McFarland HF. (1995) Multiple sclerosis: are HLA class I molecules involved in disease pathogenesis? Ann. Neurol. 38:137\u20139.","journal-title":"Ann. Neurol."},{"key":"2101233_CR3","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","volume":"372","author":"A Compston","year":"2008","unstructured":"Compston A, Coles A. (2008) Multiple sclerosis. Lancet. 372:1502\u201317.","journal-title":"Lancet"},{"key":"2101233_CR4","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1002\/ana.410360714","volume":"36","author":"H Wekerle","year":"1994","unstructured":"Wekerle H, Kojima K, Lannes-Vieira J, Lassmann H, Linington C. (1994) Animal models. Ann. Neurol. 36 (Suppl.):S47\u201353.","journal-title":"Ann. Neurol."},{"key":"2101233_CR5","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/0167-5699(94)90173-2","volume":"15","author":"SD Miller","year":"1994","unstructured":"Miller SD, Karpus WJ. (1994) The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases. Immunol. Today. 15:356\u201361.","journal-title":"Immunol. Today."},{"key":"2101233_CR6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1084\/jem.20041257","volume":"201","author":"CL Langrish","year":"2005","unstructured":"Langrish CL, et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201:233\u201340.","journal-title":"J. Exp. Med."},{"key":"2101233_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12031-010-9483-1","volume":"44","author":"R Zhang","year":"2011","unstructured":"Zhang R, et al. (2011) Amelioration of experimental autoimmune encephalomyelitis by beta-elemene treatment is associated with Th17 and Treg cell balance. J. Mol. Neurosci. 44:31\u201340.","journal-title":"J. Mol. Neurosci."},{"key":"2101233_CR8","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.it.2005.08.014","volume":"26","author":"L Steinman","year":"2005","unstructured":"Steinman L, Zamvil SS. (2005) Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis. Trends Immunol. 26:565\u201371.","journal-title":"Trends Immunol."},{"key":"2101233_CR9","doi-asserted-by":"publisher","first-page":"e15531","DOI":"10.1371\/journal.pone.0015531","volume":"5","author":"HS Domingues","year":"2010","unstructured":"Domingues HS, Mues M, Lassmann H, Wekerle H, Krishnamoorthy G. (2010) Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS One. 5:e15531.","journal-title":"PLoS One"},{"key":"2101233_CR10","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.expneurol.2009.04.024","volume":"225","author":"I Napoli","year":"2010","unstructured":"Napoli I, Neumann H. (2010) Protective effects of microglia in multiple sclerosis. Exp. Neurol. 225:24\u20138.","journal-title":"Exp. Neurol."},{"key":"2101233_CR11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.imlet.2014.03.006","volume":"160","author":"Z Jiang","year":"2014","unstructured":"Jiang Z, Jiang JX, Zhang GX. (2014) Macrophages: a double-edged sword in experimental autoimmune encephalomyelitis. Immunol. Lett. 160:17\u201322.","journal-title":"Immunol. Lett."},{"key":"2101233_CR12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/ng0293-137","volume":"3","author":"FJ Iris","year":"1993","unstructured":"Iris FJ, et al. (1993) Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. Nat. Genet. 3:137\u201345.","journal-title":"Nat. Genet."},{"key":"2101233_CR13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0014-5793(02)02430-4","volume":"514","author":"MH Deininger","year":"2002","unstructured":"Deininger MH, Meyermann R, Schluesener HJ. (2002) The allograft inflammatory factor-1 family of proteins. FEBS Lett. 514:115\u201321.","journal-title":"FEBS Lett."},{"key":"2101233_CR14","first-page":"1453","volume":"7","author":"MV Autieri","year":"1996","unstructured":"Autieri MV, Haines DS, Romanic AM, Ohlstein EH. (1996) Expression of 14-3-3 gamma in injured arteries and growth factor- and cytokinestimulated human vascular smooth muscle cells. Cell Growth Differ. 7:1453\u201360.","journal-title":"Cell Growth Differ."},{"key":"2101233_CR15","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1515\/BC.1999.170","volume":"380","author":"H Hara","year":"1999","unstructured":"Hara H, et al. (1999) Isolation of two novel alternative splicing variants of allograft inflammatory factor-1. Biol. Chem. 380:1333\u20136.","journal-title":"Biol. Chem."},{"key":"2101233_CR16","doi-asserted-by":"publisher","first-page":"3478","DOI":"10.1002\/art.22877","volume":"56","author":"F Galdo Del","year":"2007","unstructured":"Del Galdo F, Jimenez SA. (2007) T cells expressing allograft inflammatory factor 1 display increased chemotaxis and induce a profibrotic phenotype in normal fibroblasts in vitro. Arthritis Rheum. 56:3478\u201388.","journal-title":"Arthritis Rheum."},{"key":"2101233_CR17","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0002-9440(10)63003-9","volume":"167","author":"SE Kelemen","year":"2005","unstructured":"Kelemen SE, Autieri MV. (2005) Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies. Am. J. Pathol. 167:619\u201326.","journal-title":"Am. J. Pathol."},{"key":"2101233_CR18","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1097\/00007890-199605150-00018","volume":"61","author":"U Utans","year":"1996","unstructured":"Utans U, et al. (1996) Allograft inflammatory factory-1: a cytokine-responsive macrophage molecule expressed in transplanted human hearts. Transplantation. 61:1387\u201392.","journal-title":"Transplantation"},{"key":"2101233_CR19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cellimm.2013.07.008","volume":"284","author":"YY Zhao","year":"2013","unstructured":"Zhao YY, Yan DJ, Chen ZW. (2013) Role of AIF-1 in the regulation of inflammatory activation and diverse disease processes. Cell. Immunol. 284:75\u201383.","journal-title":"Cell. Immunol."},{"key":"2101233_CR20","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1002\/(SICI)1098-1136(199810)24:2<244::AID-GLIA9>3.0.CO;2-3","volume":"24","author":"HJ Schluesener","year":"1998","unstructured":"Schluesener HJ, Seid K, Kretzschmar J, Meyermann R. (1998) Allograft-inflammatory factor-1 in rat experimental autoimmune encephalomyelitis, neuritis, and uveitis: expression by activated macrophages and microglial cells. Glia. 24:244\u201351.","journal-title":"Glia."},{"key":"2101233_CR21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/1742-2094-9-233","volume":"9","author":"J Lu","year":"2012","unstructured":"Lu J, et al. (2012) Pain in experimental autoimmune encephalitis: a comparative study between different mouse models. J. Neuroinflammation. 9:233.","journal-title":"J. Neuroinflammation."},{"key":"2101233_CR22","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1046\/j.1365-2567.2001.01301.x","volume":"104","author":"K Watano","year":"2001","unstructured":"Watano K, et al. (2001) Allograft inflammatory factor-1 augments production of interleukin-6, \u221210 and \u221212 by a mouse macrophage line. Immunology. 104:307\u201316.","journal-title":"Immunology"},{"key":"2101233_CR23","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1242\/jcs.113.17.3073","volume":"113","author":"K Ohsawa","year":"2000","unstructured":"Ohsawa K, Imai Y, Kanazawa H, Sasaki Y, Kohsaka S. (2000) Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages\/microglia. J. Cell Sci. 113:3073\u201384.","journal-title":"J. Cell Sci."},{"key":"2101233_CR24","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1002\/dvg.22424","volume":"51","author":"I Casimiro","year":"2013","unstructured":"Casimiro I, Chinnasamy P, Sibinga NE. (2013) Genetic inactivation of the allograft inflammatory factor-1 locus. Genesis. 51:734\u201340.","journal-title":"Genesis"},{"key":"2101233_CR25","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"Committee for the Update of the Guide for the CareUse of Laboratory Animals, Institute for Laboratory Animal Research, Division on EarthLife Studies, National Research Council of the National Academies.","year":"2011","unstructured":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Research Council of the National Academies. (2011) Guide for the Care and Use of Laboratory Animals. 8th edition. Washington (DC): National Academies Press.","edition":"8"},{"key":"2101233_CR26","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jneuroim.2012.01.007","volume":"245","author":"SE Lutz","year":"2012","unstructured":"Lutz SE, Raine CS, Brosnan CF. (2012) Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice. J. Neuroimmunol. 245:8\u201314.","journal-title":"J. Neuroimmunol."},{"key":"2101233_CR27","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW. (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e45.","journal-title":"Nucleic Acids Res."},{"key":"2101233_CR28","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S0896-6273(00)81107-1","volume":"24","author":"L Steinman","year":"1999","unstructured":"Steinman L. (1999) Assessment of animal models for MS and demyelinating disease in the design of rational therapy. Neuron. 24:511\u20134.","journal-title":"Neuron"},{"key":"2101233_CR29","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature10907","volume":"484","author":"NC Derecki","year":"2012","unstructured":"Derecki NC, et al. (2012) Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature. 484:105\u20139.","journal-title":"Nature"},{"key":"2101233_CR30","doi-asserted-by":"publisher","first-page":"4648","DOI":"10.4049\/jimmunol.181.7.4648","volume":"181","author":"GC Furtado","year":"2008","unstructured":"Furtado GC, et al. (2008) Swift entry of myelinspecific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis. J. Immunol. 181:4648\u201355.","journal-title":"J. Immunol."},{"key":"2101233_CR31","doi-asserted-by":"publisher","first-page":"3750","DOI":"10.4049\/jimmunol.181.6.3750","volume":"181","author":"RA O\u2019Connor","year":"2008","unstructured":"O\u2019Connor RA, et al. (2008) Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J. Immunol. 181:3750\u20134.","journal-title":"J. Immunol."},{"key":"2101233_CR32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/400_2008_17","volume":"51","author":"T Korn","year":"2010","unstructured":"Korn T, Mitsdoerffer M, Kuchroo VK. (2010) Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis. Results Probl. Cell Differ. 51:43\u201374.","journal-title":"Results Probl. Cell Differ."},{"key":"2101233_CR33","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/nature01355","volume":"421","author":"DJ Cua","year":"2003","unstructured":"Cua DJ, et al. (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 421:744\u20138.","journal-title":"Nature"},{"key":"2101233_CR34","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.4049\/jimmunol.178.4.2589","volume":"178","author":"P Thakker","year":"2007","unstructured":"Thakker P, et al. (2007) IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 178:2589\u201398.","journal-title":"J. Immunol."},{"key":"2101233_CR35","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1006\/bbrc.2001.5388","volume":"286","author":"Y Sasaki","year":"2001","unstructured":"Sasaki Y, Ohsawa K, Kanazawa H, Kohsaka S, Imai Y. (2001) Iba1 is an actin-cross-linking protein in macrophages\/microglia. Biochem. Biophys. Res. Commun. 286:292\u20137.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2101233_CR36","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/glia.10149","volume":"40","author":"Y Imai","year":"2002","unstructured":"Imai Y, Kohsaka S. (2002) Intracellular signaling in M-CSF-induced microglia activation: role of Iba1. Glia. 40:164\u201374.","journal-title":"Glia."},{"key":"2101233_CR37","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1161\/01.RES.0000074000.03562.CC","volume":"92","author":"MV Autieri","year":"2003","unstructured":"Autieri MV, Kelemen SE, Wendt KW. (2003) AIF-1 is an actin-polymerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration. Circ. Res. 92:1107\u201314.","journal-title":"Circ. Res."},{"key":"2101233_CR38","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/nrm2476","volume":"9","author":"SJ Heasman","year":"2008","unstructured":"Heasman SJ, Ridley AJ. (2008) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell. Biol. 9:690\u2013701.","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"2101233_CR39","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jmb.2006.09.027","volume":"364","author":"M Yamada","year":"2006","unstructured":"Yamada M, Ohsawa K, Imai Y, Kohsaka S, Kamitori S. (2006) X-ray structures of the microglia\/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding. J. Mol. Biol. 364:449\u201357.","journal-title":"J. Mol. Biol."},{"key":"2101233_CR40","doi-asserted-by":"publisher","first-page":"4627","DOI":"10.1111\/j.1742-4658.2008.06605.x","volume":"275","author":"JO Schulze","year":"2008","unstructured":"Schulze JO, et al. (2008) Structural and functional characterization of human Iba proteins. FEBS J. 275:4627\u201340.","journal-title":"FEBS J."},{"key":"2101233_CR41","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0960-9822(98)70225-8","volume":"8","author":"LJ Holsinger","year":"1998","unstructured":"Holsinger LJ, et al. (1998) Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr. Biol. 8:563\u201372.","journal-title":"Curr. Biol."},{"key":"2101233_CR42","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.immuni.2008.08.015","volume":"29","author":"S Becart","year":"2008","unstructured":"Becart S, et al. (2008) Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation. Immunity. 29:704\u201319.","journal-title":"Immunity"},{"key":"2101233_CR43","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.bbrc.2014.04.106","volume":"448","author":"M Kadoya","year":"2014","unstructured":"Kadoya M, et al. (2014) Allograft inflammatory factor-1 stimulates chemokine production and induces chemotaxis in human peripheral blood mononuclear cells. Biochem. Biophys. Res. Comm. 448:287\u201391.","journal-title":"Biochem. Biophys. Res. Comm."}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2014.00264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.2119\/molmed.2014.00264\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.crossref.org\/molmed.2014.00264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2014.00264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T09:57:36Z","timestamp":1652954256000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.2119\/molmed.2014.00264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["2101233"],"URL":"https:\/\/doi.org\/10.2119\/molmed.2014.00264","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"30 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}