{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:16:09Z","timestamp":1770747369742,"version":"3.49.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.2119\/molmed.2015.00168","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T20:45:49Z","timestamp":1456173949000},"page":"817-823","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["BACE-1, PS-1 and sAPP\u03b2 Levels Are Increased in Plasma from Sporadic Inclusion Body Myositis Patients: Surrogate Biomarkers among Inflammatory Myopathies"],"prefix":"10.1186","volume":"21","author":[{"given":"Marc","family":"Catal\u00e1n-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gl\u00f2ria","family":"Garrabou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanza","family":"Mor\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariona","family":"Guitart-Mampel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Gonzalez-Casacuberta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Hernando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Miquel","family":"Gallego-Escuredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e8lia","family":"Yubero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Villarroya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Montero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert Selva","family":"O-Callaghan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Cardellach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep Maria","family":"Grau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,3]]},"reference":[{"key":"2101817_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.rdc.2011.01.003","volume":"37","author":"GE Solorzano","year":"2011","unstructured":"Solorzano GE, Phillips LH 2nd. (2011) Inclusion body myositis: diagnosis, pathogenesis, and treatment options. Rheum. Dis. Clin. North Am. 37:173\u201383.","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"2101817_CR2","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1002\/ana.410380504","volume":"38","author":"RC Griggs","year":"1995","unstructured":"Griggs RC, et al. (1995) Inclusion body myositis and myopathies. Ann. Neurol. 38:705\u201313.","journal-title":"Ann. Neurol."},{"key":"2101817_CR3","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S1474-4422(07)70171-0","volume":"6","author":"M Needham","year":"2007","unstructured":"Needham M, Mastaglia FL. (2007) Inclusion body myositis: current pathogenetic concepts and diagnostic and therapeutic approaches. Lancet Neurol. 6:620\u201331.","journal-title":"Lancet Neurol."},{"key":"2101817_CR4","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.autrev.2014.01.016","volume":"13","author":"M Catalan","year":"2014","unstructured":"Catalan M, Selva-O\u2019Callaghan A, Grau JM. (2014) Diagnosis and classification of sporadic inclusion body myositis (sIBM). Autoimmun. Rev. 13:363\u20136.","journal-title":"Autoimmun. Rev."},{"key":"2101817_CR5","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.1093\/brain\/awr217","volume":"134","author":"FM Cox","year":"2011","unstructured":"Cox FM, et al. (2011) A 12-year follow-up in sporadic inclusion body myositis: an end stage with major disabilities. Brain. 134:3167\u201375.","journal-title":"Brain"},{"key":"2101817_CR6","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1093\/brain\/awr213","volume":"134","author":"O Benveniste","year":"2011","unstructured":"Benveniste O, et al. (2011) Long-term observational study of sporadic inclusion body myositis. Brain. 134:3176\u201384.","journal-title":"Brain"},{"key":"2101817_CR7","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/art.1780300406","volume":"30","author":"LH Calabrese","year":"1987","unstructured":"Calabrese LH, Mitsumoto H, Chou SM. (1987) Inclusion body myositis presenting as treatment-resistant polymyositis. Arthritis Rheum. 30:397\u2013403.","journal-title":"Arthritis Rheum."},{"key":"2101817_CR8","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s00401-015-1384-5","volume":"129","author":"O Benveniste","year":"2015","unstructured":"Benveniste O, et al. (2015) Amyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: the inflammatory egg comes before the degenerative chicken. Acta Neuropathol. 129:611\u201324.","journal-title":"Acta Neuropathol."},{"key":"2101817_CR9","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1093\/brain\/awn163","volume":"132","author":"SA Greenberg","year":"2009","unstructured":"Greenberg SA. (2009) Comment on \u201cInterrelation of inflammation and APP in sIBM: IL-1beta induces accumulation of beta-amyloid in skeletal muscle.\u201d Brain. 132:e106.","journal-title":"Brain"},{"key":"2101817_CR10","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00401-009-0554-8","volume":"118","author":"WF Abdo","year":"2009","unstructured":"Abdo WF, et al. (2009) Increased plasma amyloid-beta42 protein in sporadic inclusion body myositis. Acta Neuropathol. 118:429\u201331.","journal-title":"Acta Neuropathol."},{"key":"2101817_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/mus.21386","volume":"40","author":"M Salajegheh","year":"2009","unstructured":"Salajegheh M, et al. (2009) Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis. Muscle Nerve. 40:19\u201331.","journal-title":"Muscle Nerve."},{"key":"2101817_CR12","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1097\/01.bor.0000434671.77891.9a","volume":"25","author":"P Machado","year":"2013","unstructured":"Machado P, Brady S, Hanna MG. (2013) Update in inclusion body myositis. Curr. Opin. Rheumatol. 25:763\u201371.","journal-title":"Curr. Opin. Rheumatol."},{"key":"2101817_CR13","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/ana.23840","volume":"73","author":"HB Larman","year":"2013","unstructured":"Larman HB, et al. (2013) Cytosolic 5\u2032-nucleotidase 1A autoimmunity in sporadic inclusion body myositis. Ann. Neurol. 73:408\u201318.","journal-title":"Ann. Neurol."},{"key":"2101817_CR14","doi-asserted-by":"publisher","first-page":"e20266","DOI":"10.1371\/journal.pone.0020266","volume":"6","author":"M Salajegheh","year":"2011","unstructured":"Salajegheh M, Lam T, Greenberg SA. (2011) Autoantibodies against a 43 KDa muscle protein in inclusion body myositis. PLoS One. 6:e20266.","journal-title":"PLoS One"},{"key":"2101817_CR15","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/acr.22600","volume":"68","author":"TE Lloyd","year":"2015","unstructured":"Lloyd TE, et al. (2015) Cytosolic 5\u2032-nucleotidase 1A is a common target of circulating autoantibodies in several autoimmune diseases. Arthritis Care Res. 68:66\u201371.","journal-title":"Arthritis Care Res."},{"key":"2101817_CR16","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1093\/intimm\/10.3.267","volume":"10","author":"S Gallucci","year":"1998","unstructured":"Gallucci S, Provenzano C, Mazzarelli P, Scuderi F, Bartoccioni E. (1998) Myoblasts produce IL-6 in response to inflammatory stimuli. Int. Immunol. 10:267\u201373.","journal-title":"Int. Immunol."},{"key":"2101817_CR17","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1365-2796.2010.02334.x","volume":"269","author":"I Loell","year":"2011","unstructured":"Loell I, Lundberg IE. (2011) Can muscle regeneration fail in chronic inflammation: a weakness in inflammatory myopathies? J. Intern. Med. 269:243\u201357.","journal-title":"J. Intern. Med."},{"key":"2101817_CR18","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature08780","volume":"464","author":"Q Zhang","year":"2010","unstructured":"Zhang Q, et al. (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 464:104\u20137.","journal-title":"Nature"},{"key":"2101817_CR19","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.mito.2011.06.005","volume":"11","author":"A Cossarizza","year":"2011","unstructured":"Cossarizza A, et al. (2011) Increased plasma levels of extracellular mitochondrial DNA during HIV infection: a new role for mitochondrial damage-associated molecular patterns during inflammation. Mitochondrion. 11:750\u20135.","journal-title":"Mitochondrion"},{"key":"2101817_CR20","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1212\/01.wnl.0000436068.43384.ef","volume":"81","author":"RL Davis","year":"2013","unstructured":"Davis RL, et al. (2013) Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease. Neurology. 81:1819\u201326.","journal-title":"Neurology"},{"key":"2101817_CR21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/2327-6924.12046","volume":"26","author":"N Littlefield","year":"2013","unstructured":"Littlefield N, Beckstrand RL, Luthy KE. (2013) Statins\u2019 effect on plasma levels of Coenzyme Q10 and improvement in myopathy with supplementation. J. Am. Assoc. Nurse Pract. 26:85\u201390.","journal-title":"J. Am. Assoc. Nurse Pract."},{"key":"2101817_CR22","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1097\/NEN.0b013e31816fc9b6","volume":"67","author":"I Santa-Mara","year":"2008","unstructured":"Santa-Mara I, et al. (2008) Coenzyme q induces tau aggregation, tau filaments, and Hirano bodies. J. Neuropathol. Exp. Neurol. 67:428\u201334.","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"2101817_CR23","doi-asserted-by":"publisher","first-page":"536231","DOI":"10.1155\/2013\/536231","volume":"2013","author":"D Levacic","year":"2013","unstructured":"Levacic D, Peddareddygari LR, Nochlin D, Sharer LR, Grewal RP. (2013) Inclusion-body myositis associated with Alzheimer\u2019s disease. Case Rep. Med. 2013:536231.","journal-title":"Case Rep. Med."},{"key":"2101817_CR24","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1212\/01.wnl.0000192108.02654.ac","volume":"66","author":"MP Murphy","year":"2006","unstructured":"Murphy MP, Golde TE. (2006) Inclusion-body myositis and Alzheimer disease: two sides of the same coin, or different currencies altogether? Neurology. 66:S65\u20138.","journal-title":"Neurology"},{"key":"2101817_CR25","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/j.1600-0404.2010.01461.x","volume":"124","author":"PM Roos","year":"2011","unstructured":"Roos PM, Vesterberg O, Nordberg M. (2011) Inclusion body myositis in Alzheimer\u2019s disease. Acta Neurol. Scand. 124:215\u20137.","journal-title":"Acta Neurol. Scand."},{"key":"2101817_CR26","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1002\/jnr.23122","volume":"90","author":"G Wu","year":"2012","unstructured":"Wu G, et al. (2012) Characterization of plasma beta-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer\u2019s disease. J. Neurosci. Res. 90:2247\u201358.","journal-title":"J. Neurosci. Res."},{"key":"2101817_CR27","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.neulet.2010.03.023","volume":"474","author":"A Nogalska","year":"2010","unstructured":"Nogalska A, Engel WK, Askanas V. (2010) Increased BACE1 mRNA and noncoding BACE1-antisense transcript in sporadic inclusion-body myositis muscle fibers: possibly caused by endoplasmic reticulum stress. Neurosci. Lett. 474:140\u20133.","journal-title":"Neurosci. Lett."},{"key":"2101817_CR28","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1750-1326-8-20","volume":"8","author":"C Rosen","year":"2013","unstructured":"Rosen C, Hansson O, Blennow K, Zetterberg H. (2013) Fluid biomarkers in Alzheimer\u2019s disease-current concepts. Mol. Neurodegener. 8:20.","journal-title":"Mol. Neurodegener."},{"key":"2101817_CR29","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.nmd.2004.02.006","volume":"14","author":"JE Hoogendijk","year":"2004","unstructured":"Hoogendijk JE, et al. (2004) 119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10\u201312 October 2003, Naarden, The Netherlands. Neuromuscul. Disord. 14:337\u201345.","journal-title":"Neuromuscul. Disord."},{"key":"2101817_CR30","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.nmd.2013.08.007","volume":"3","author":"MR Rose","year":"2013","unstructured":"Rose MR, Group EIW. (2013) 188th ENMC International Workshop: Inclusion Body Myositis, 2\u20134 December 2011, Naarden, The Netherlands. Neuromuscul. Disord. 3:1044\u201355.","journal-title":"Neuromuscul. Disord."},{"key":"2101817_CR31","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/mus.20958","volume":"37","author":"CE Jackson","year":"2008","unstructured":"Jackson CE, et al. (2008) Inclusion body myositis functional rating scale: a reliable and valid measure of disease severity. Muscle Nerve. 37:473\u20136.","journal-title":"Muscle Nerve."},{"key":"2101817_CR32","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/QAD.0000000000000486","volume":"29","author":"C Moren","year":"2015","unstructured":"Moren C, et al. (2015) Mitochondrial disturbances in HIV pregnancies. Aids. 29:5\u201312.","journal-title":"Aids"},{"key":"2101817_CR33","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.metabol.2013.11.014","volume":"63","author":"E Hondares","year":"2014","unstructured":"Hondares E, et al. (2014) Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue. Metabolism. 63:312\u20137.","journal-title":"Metabolism"},{"key":"2101817_CR34","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1159\/000362390","volume":"5","author":"D Yubero","year":"2014","unstructured":"Yubero D, et al. (2014) Biochemical diagnosis of coenzyme q10 deficiency. Mol. Syndromol. 5:147\u201355.","journal-title":"Mol. Syndromol."},{"key":"2101817_CR35","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1097\/WCO.0b013e328357f211","volume":"25","author":"SA Greenberg","year":"2012","unstructured":"Greenberg SA. (2012) Pathogenesis and therapy of inclusion body myositis. Curr. Opin. Neurol. 25:630\u20139.","journal-title":"Curr. Opin. Neurol."},{"key":"2101817_CR36","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1172\/JCI23606","volume":"115","author":"A Kharitonenkov","year":"2005","unstructured":"Kharitonenkov A, et al. (2005) FGF-21 as a novel metabolic regulator. J. Clin. Invest. 115:1627\u201335.","journal-title":"J. Clin. Invest."},{"key":"2101817_CR37","doi-asserted-by":"publisher","first-page":"6495","DOI":"10.1007\/s11033-013-2767-0","volume":"40","author":"MH Salehi","year":"2013","unstructured":"Salehi MH, et al. (2013) Association of fibroblast growth factor (FGF-21) as a biomarker with primary mitochondrial disorders, but not with secondary mitochondrial disorders (Friedreich Ataxia). Mol. Biol Rep. 40:6495\u20139.","journal-title":"Mol. Biol Rep."},{"key":"2101817_CR38","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00401-008-0449-0","volume":"116","author":"V Askanas","year":"2008","unstructured":"Askanas V, Engel WK. (2008) Inclusion-body myositis: muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer\u2019s and Parkinson\u2019s disease brains. Acta Neuropathol. 116:583\u201395.","journal-title":"Acta Neuropathol."},{"key":"2101817_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jnen\/60.1.1","volume":"60","author":"V Askanas","year":"2001","unstructured":"Askanas V, Engel WK. (2001) Inclusion-body myositis: newest concepts of pathogenesis and relation to aging and Alzheimer disease. J. Neuropathol. Exp. Neurol. 60:1\u201314.","journal-title":"J. Neuropathol. Exp. Neurol."}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2015.00168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.2119\/molmed.2015.00168\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.crossref.org\/molmed.2015.00168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2015.00168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T21:41:46Z","timestamp":1654378906000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.2119\/molmed.2015.00168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["2101817"],"URL":"https:\/\/doi.org\/10.2119\/molmed.2015.00168","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"8 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}