{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:17:21Z","timestamp":1787163441421,"version":"build-2736575974"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.2119\/molmed.2015.00232","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T15:49:24Z","timestamp":1456156164000},"page":"769-781","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Genome-Wide Association Study of Late-Onset Myasthenia Gravis: Confirmation of TNFRSF11A and Identification of ZBTB10 and Three Distinct HLA Associations"],"prefix":"10.1186","volume":"21","author":[{"given":"Michael F.","family":"Seldin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar K.","family":"Alkhairy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette T.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine A.","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Sussman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritva","family":"Pirskanen-Matell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Piehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J. G. M.","family":"Verschuuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kostera-Pruszczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Szczudlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McKee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina H.","family":"Maniaol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne F.","family":"Harbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicte A.","family":"Lie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Melms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri-Jean","family":"Garchon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Willcox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Gregersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Hammarstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,10]]},"reference":[{"key":"2101769_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000279334","volume":"34","author":"A McGrogan","year":"2010","unstructured":"McGrogan A, Sneddon S, de Vries CS. (2010) The incidence of myasthenia gravis: a systematic literature review. Neuroepidemiology. 34:171\u201383.","journal-title":"Neuroepidemiology"},{"key":"2101769_CR2","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S1474-4422(09)70063-8","volume":"8","author":"MN Meriggioli","year":"2009","unstructured":"Meriggioli MN, Sanders DB. (2009) Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity. Lancet. 8:475\u201390.","journal-title":"Lancet"},{"key":"2101769_CR3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1471-2377-10-46","volume":"10","author":"AS Carr","year":"2010","unstructured":"Carr AS, Cardwell CR, McCarron PO, McConville J. (2010) A systematic review of population based epidemiological studies in Myasthenia Gravis. BMC Neurol. 10:46.","journal-title":"BMC Neurol."},{"key":"2101769_CR4","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1212\/WNL.26.11.1054","volume":"26","author":"JM Lindstrom","year":"1976","unstructured":"Lindstrom JM, Seybold ME, Lennon VA, Whittingham S, Duane DD. (1976) Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value. Neurology. 26:1054\u20139.","journal-title":"Neurology"},{"key":"2101769_CR5","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jaut.2013.12.006","volume":"52","author":"WY Chuang","year":"2014","unstructured":"Chuang WY, et al. (2014) Late-onset myasthenia gravis-CTLA4(low) genotype association and low-for-age thymic output of naive T cells. J. Autoimmun. 52:122\u20139.","journal-title":"J. Autoimmun."},{"key":"2101769_CR6","doi-asserted-by":"publisher","first-page":"e36603","DOI":"10.1371\/journal.pone.0036603","volume":"7","author":"AH Maniaol","year":"2012","unstructured":"Maniaol AH, et al. (2012) Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population. PLoS One. 7:e36603.","journal-title":"PLoS One"},{"key":"2101769_CR7","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1093\/brain\/103.3.579","volume":"103","author":"DA Compston","year":"1980","unstructured":"Compston DA, Vincent A, Newsom-Davis J, Batchelor JR. (1980) Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain. 103:579\u2013601.","journal-title":"Brain"},{"key":"2101769_CR8","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1111\/j.1532-5415.2000.tb02635.x","volume":"48","author":"A Evoli","year":"2000","unstructured":"Evoli A, Batocchi AP, Minisci C, Di Schino C, Tonali P. (2000) Clinical characteristics and prognosis of myasthenia gravis in older people. J. Am. Geriatr. Soc. 48:1442\u20138.","journal-title":"J. Am. Geriatr. Soc."},{"key":"2101769_CR9","doi-asserted-by":"publisher","first-page":"e106757","DOI":"10.1371\/journal.pone.0106757","volume":"9","author":"T Akaishi","year":"2014","unstructured":"Akaishi T, et al. (2014) Insights into the classification of myasthenia gravis. PLoS One. 9:e106757.","journal-title":"PLoS One"},{"key":"2101769_CR10","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/S0198-8859(99)00062-2","volume":"60","author":"M Janer","year":"1999","unstructured":"Janer M, et al. (1999) A susceptibility region for myasthenia gravis extending into the HLA-class I sector telomeric to HLA-C. Hum. Immunol. 60:909\u201317.","journal-title":"Hum. Immunol."},{"key":"2101769_CR11","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jaut.2013.12.001","volume":"52","author":"N Avidan","year":"2014","unstructured":"Avidan N, Le Panse R, Berrih-Aknin S, Miller A. (2014) Genetic basis of myasthenia gravis: a comprehensive review. J. Autoimmun. 52:146\u201353.","journal-title":"J. Autoimmun."},{"key":"2101769_CR12","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1212\/WNL.57.9.1555","volume":"57","author":"M Giraud","year":"2001","unstructured":"Giraud M, et al. (2001) Linkage of HLA to myasthenia gravis and genetic heterogeneity depending on anti-titin antibodies. Neurology. 57:1555\u201360.","journal-title":"Neurology"},{"key":"2101769_CR13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/mus.20950","volume":"37","author":"D Grob","year":"2008","unstructured":"Grob D, Brunner N, Namba T, Pagala M. (2008) Lifetime course of myasthenia gravis. Muscle Nerve. 37:141\u20139.","journal-title":"Muscle Nerve"},{"key":"2101769_CR14","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/ana.20751","volume":"59","author":"C Vandiedonck","year":"2006","unstructured":"Vandiedonck C, et al. (2006) Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis. Ann. Neurol. 59:404\u20137.","journal-title":"Ann. Neurol."},{"key":"2101769_CR15","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/ana.23691","volume":"72","author":"PK Gregersen","year":"2012","unstructured":"Gregersen PK, et al. (2012) Risk for myasthenia gravis maps to a (151) Pro\u2014>Ala change in TNIP1 and to human leukocyte antigen-B*08. Ann Neurol 72:927\u2013935.","journal-title":"Ann Neurol"},{"key":"2101769_CR16","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1001\/jamaneurol.2014.4103","volume":"72","author":"AE Renton","year":"2015","unstructured":"Renton AE, et al. (2015) A genome-wide association study of myasthenia gravis. JAMA Neurol. 72:396\u2013404.","journal-title":"JAMA Neurol."},{"key":"2101769_CR17","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81:559\u201375.","journal-title":"Am. J. Hum. Genet."},{"key":"2101769_CR18","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/genetics\/155.2.945","volume":"155","author":"JK Pritchard","year":"2000","unstructured":"Pritchard JK, Stephens M, Donnelly P. (2000) Inference of population structure using multilocus genotype data. Genetics. 155:945\u201359.","journal-title":"Genetics"},{"key":"2101769_CR19","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/genetics\/164.4.1567","volume":"164","author":"D Falush","year":"2003","unstructured":"Falush D, Stephens M, Pritchard JK. (2003) Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics. 164:1567\u201387.","journal-title":"Genetics"},{"key":"2101769_CR20","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/humu.20822","volume":"30","author":"R Kosoy","year":"2009","unstructured":"Kosoy R, et al. (2009) Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America. Hum. Mutat. 30:69\u201378.","journal-title":"Hum. Mutat."},{"key":"2101769_CR21","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"AL Price","year":"2006","unstructured":"Price AL, et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38:904\u20139.","journal-title":"Nat. Genet."},{"key":"2101769_CR22","doi-asserted-by":"publisher","first-page":"e1004234","DOI":"10.1371\/journal.pgen.1004234","volume":"10","author":"J O\u2019Connell","year":"2014","unstructured":"O\u2019Connell J, et al. (2014) A general approach for haplotype phasing across the full spectrum of relatedness. PLoS Genet. 10:e1004234.","journal-title":"PLoS Genet."},{"key":"2101769_CR23","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1093\/bioinformatics\/btu704","volume":"31","author":"C Fuchsberger","year":"2014","unstructured":"Fuchsberger C, Abecasis GR, Hinds DA. (2014) minimac2: faster genotype imputation. Bioinformatics. 31:782\u20134.","journal-title":"Bioinformatics"},{"key":"2101769_CR24","doi-asserted-by":"publisher","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","volume":"5","author":"BN Howie","year":"2009","unstructured":"Howie BN, Donnelly P, Marchini J. (2009) A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5:e1000529.","journal-title":"PLoS Genet."},{"key":"2101769_CR25","doi-asserted-by":"publisher","first-page":"e64683","DOI":"10.1371\/journal.pone.0064683","volume":"8","author":"X Jia","year":"2013","unstructured":"Jia X, et al. (2013) Imputing amino acid polymorphisms in human leukocyte antigens. PLoS One. 8:e64683.","journal-title":"PLoS One"},{"key":"2101769_CR26","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.ajhg.2009.01.005","volume":"84","author":"BL Browning","year":"2009","unstructured":"Browning BL, Browning SR. (2009) A unified approach to genotype imputation and haplotypephase inference for large data sets of trios and unrelated individuals. Am. J. Hum. Genet. 84:210\u201323.","journal-title":"Am. J. Hum. Genet."},{"key":"2101769_CR27","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1101\/gr.137323.112","volume":"22","author":"AP Boyle","year":"2012","unstructured":"Boyle AP, et al. (2012) Annotation of functional variation in personal genomes using RegulomeDB. Genome Res.22:1790\u20137.","journal-title":"Genome Res"},{"key":"2101769_CR28","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","volume":"26","author":"RJ Pruim","year":"2010","unstructured":"Pruim RJ, et al. (2010) LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics. 26:2336\u20137.","journal-title":"Bioinformatics"},{"key":"2101769_CR29","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/nature10808","volume":"482","author":"JF Degner","year":"2012","unstructured":"Degner JF, et al. (2012) DNase I sensitivity QTLs are a major determinant of human expression variation. Nature. 482:390\u20134.","journal-title":"Nature"},{"key":"2101769_CR30","doi-asserted-by":"publisher","first-page":"e1002805","DOI":"10.1371\/journal.pgen.1002805","volume":"8","author":"AD Coviello","year":"2012","unstructured":"Coviello AD, et al. (2012) A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genet. 8:e1002805.","journal-title":"PLoS Genet."},{"key":"2101769_CR31","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.jaci.2013.10.030","volume":"133","author":"MA Ferreira","year":"2014","unstructured":"Ferreira MA, et al. (2014) Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. J. Allergy Clin. Immunol. 133:1564\u201371.","journal-title":"J. Allergy Clin. Immunol."},{"key":"2101769_CR32","doi-asserted-by":"publisher","first-page":"e34442","DOI":"10.1371\/journal.pone.0034442","volume":"7","author":"N Eriksson","year":"2012","unstructured":"Eriksson N, et al. (2012) Novel associations for hypothyroidism include known autoimmune risk loci. PLoS One. 7:e34442.","journal-title":"PLoS One"},{"key":"2101769_CR33","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/ng.1017","volume":"44","author":"L Paternoster","year":"2011","unstructured":"Paternoster L, et al. (2011) Meta-analysis of genomewide association studies identifies three new risk loci for atopic dermatitis. Nat. Genet. 44:187\u201392.","journal-title":"Nat. Genet."},{"key":"2101769_CR34","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/ng.2686","volume":"45","author":"DA Hinds","year":"2013","unstructured":"Hinds DA, et al. (2013) A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. Nat. Genet. 45:907\u201311.","journal-title":"Nat. Genet."},{"key":"2101769_CR35","doi-asserted-by":"publisher","first-page":"8123","DOI":"10.1074\/jbc.274.12.8123","volume":"274","author":"LG Tillotson","year":"1999","unstructured":"Tillotson LG. (1999) RIN ZF, a novel zinc finger gene, encodes proteins that bind to the CACC element of the gastrin promoter. J. Biol. Chem. 274:8123\u20138.","journal-title":"J. Biol. Chem."},{"key":"2101769_CR36","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1210\/en.2009-1150","volume":"151","author":"X Li","year":"2010","unstructured":"Li X, et al. (2010) MicroRNA-27a indirectly regulates estrogen receptor \u03b1 expression and hormone responsiveness in MCF-7 breast cancer cells. Endocrinology. 151:2462\u201373.","journal-title":"Endocrinology"},{"key":"2101769_CR37","doi-asserted-by":"publisher","first-page":"286","DOI":"10.4049\/jimmunol.165.1.286","volume":"165","author":"M Tone","year":"2000","unstructured":"Tone M, Powell MJ, Tone Y, Thompson SA, Waldmann H. (2000) IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3. J. Immunol. 165:286\u201391.","journal-title":"J. Immunol."},{"key":"2101769_CR38","doi-asserted-by":"publisher","first-page":"8890","DOI":"10.1074\/jbc.M109889200","volume":"277","author":"M Tone","year":"2002","unstructured":"Tone M, Tone Y, Babik JM, Lin CY, Waldmann H. (2002) The role of Sp1 and NF-kappa B in regulating CD40 gene expression. J. Biol. Chem. 277:8890\u20137.","journal-title":"J. Biol. Chem."},{"key":"2101769_CR39","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/sj.gene.6364458","volume":"9","author":"KK Bynote","year":"2008","unstructured":"Bynote KK, et al. (2008) Estrogen receptor-alpha deficiency attenuates autoimmune disease in (NZB x NZW)F1 mice. Genes Immun. 9:137\u201352.","journal-title":"Genes Immun."},{"key":"2101769_CR40","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1172\/JCI78082","volume":"125","author":"K Rubtsova","year":"2015","unstructured":"Rubtsova K, Marrack P, Rubtsov AV. (2015) Sexual dimorphism in autoimmunity. J. Clin. Invest. 125:2187\u201393.","journal-title":"J. Clin. Invest."},{"key":"2101769_CR41","doi-asserted-by":"publisher","first-page":"e104760","DOI":"10.1371\/journal.pone.0104760","volume":"9","author":"GA Kaya","year":"2014","unstructured":"Kaya GA, et al. (2014) The association of PTPN22 R620W polymorphism is stronger with late-onset AChR-myasthenia gravis in Turkey. PLoS One. 9:e104760.","journal-title":"PLoS One"},{"key":"2101769_CR42","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/ng1323","volume":"36","author":"N Bottini","year":"2004","unstructured":"Bottini N, et al. (2004) A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat. Genet. 36:337\u20138.","journal-title":"Nat. Genet."},{"key":"2101769_CR43","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1086\/422827","volume":"75","author":"AB Begovich","year":"2004","unstructured":"Begovich AB, et al. (2004) A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am. J. Hum. Genet. 75:330\u20137.","journal-title":"Am. J. Hum. Genet."},{"key":"2101769_CR44","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1086\/423790","volume":"75","author":"C Kyogoku","year":"2004","unstructured":"Kyogoku C, et al. (2004) Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am. J. Hum. Genet. 75:504\u20137.","journal-title":"Am. J. Hum. Genet."},{"key":"2101769_CR45","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1146\/annurev-immunol-032713-120249","volume":"32","author":"N Bottini","year":"2014","unstructured":"Bottini N, Peterson EJ. (2014) Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. Ann. Rev. Immunol. 32:83\u2013119.","journal-title":"Ann. Rev. Immunol."},{"key":"2101769_CR46","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/71667","volume":"24","author":"AE Hughes","year":"2000","unstructured":"Hughes AE, et al. (2000) Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nat. Genet. 24:45\u20138.","journal-title":"Nat. Genet."},{"key":"2101769_CR47","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ajhg.2008.06.015","volume":"83","author":"MM Guerrini","year":"2008","unstructured":"Guerrini MM, et al. (2008) Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am. J. Hum. Genet. 83:64\u201376.","journal-title":"Am. J. Hum. Genet."},{"key":"2101769_CR48","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/ng.562","volume":"42","author":"OM Albagha","year":"2010","unstructured":"Albagha OM, et al. (2010) Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget\u2019s disease of bone. Nat. Genet. 42:520\u20134.","journal-title":"Nat. Genet."},{"key":"2101769_CR49","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/ng.2249","volume":"44","author":"K Estrada","year":"2012","unstructured":"Estrada K, et al. (2012) Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat. Genet. 44:491\u2013501.","journal-title":"Nat. Genet."},{"key":"2101769_CR50","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.immuni.2012.01.016","volume":"36","author":"NA Roberts","year":"2012","unstructured":"Roberts NA, et al. (2012) Rank signaling links the development of invariant gammadelta T cell progenitors and Aire(+) medullary epithelium. Immunity. 36:427\u201337.","journal-title":"Immunity"},{"key":"2101769_CR51","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/36593","volume":"390","author":"DM Anderson","year":"1997","unstructured":"Anderson DM, et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature. 390:175\u20139.","journal-title":"Nature"},{"key":"2101769_CR52","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1101\/gad.13.18.2412","volume":"13","author":"WC Dougall","year":"1999","unstructured":"Dougall WC, et al. (1999) RANK is essential for osteoclast and lymph node development. Genes Dev. 13:2412\u201324.","journal-title":"Genes Dev."},{"key":"2101769_CR53","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/sj.gene.6364339","volume":"7","author":"D Mewar","year":"2006","unstructured":"Mewar D, et al. (2006) Haplotype-specific gene expression profiles in a telomeric major histocompatibility complex gene cluster and susceptibility to autoimmune diseases. Genes Immun. 7:625\u201331.","journal-title":"Genes Immun."},{"key":"2101769_CR54","doi-asserted-by":"publisher","first-page":"2972","DOI":"10.2337\/db10-0699","volume":"59","author":"JA Noble","year":"2010","unstructured":"Noble JA, et al. (2010) HLA class I and genetic susceptibility to type 1 diabetes: results from the type 1 Diabetes Genetics Consortium. Diabetes. 59:2972\u20139.","journal-title":"Diabetes"},{"key":"2101769_CR55","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng.1076","volume":"44","author":"S Raychaudhuri","year":"2012","unstructured":"Raychaudhuri S, et al. (2012) Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat. Genet. 44:291\u20136.","journal-title":"Nat. Genet."},{"key":"2101769_CR56","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1086\/342407","volume":"71","author":"D Jawaheer","year":"2002","unstructured":"Jawaheer D, et al. (2002) Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis. Am. J. Hum. Genet. 71:585\u201394.","journal-title":"Am. J. Hum. Genet."},{"key":"2101769_CR57","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.ajhg.2012.08.026","volume":"91","author":"DL Morris","year":"2012","unstructured":"Morris DL, et al. (2012) Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans. Am. J. Hum. Genet. 91:778\u201393.","journal-title":"Am. J. Hum. Genet."},{"key":"2101769_CR58","first-page":"741","volume":"35","author":"A Quinones-Lombrana","year":"2008","unstructured":"Quinones-Lombrana A, et al. (2008) BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility. J. Rheumatol. 35:741\u20134.","journal-title":"J. Rheumatol."},{"key":"2101769_CR59","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/ng.3029","volume":"46","author":"I Gockel","year":"2014","unstructured":"Gockel I, et al. (2014) Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia. Nat. Genet. 46:901\u20134.","journal-title":"Nat. Genet."},{"key":"2101769_CR60","doi-asserted-by":"publisher","first-page":"9194","DOI":"10.1073\/pnas.85.23.9194","volume":"85","author":"AJ McMichael","year":"1988","unstructured":"McMichael AJ, Gotch FM, Santos-Aguado J, Strominger JL. (1988) Effect of mutations and variations of HLA-A2 on recognition of a virus peptide epitope by cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. U. S. A. 85:9194\u20138.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2101769_CR61","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1002\/eji.200636449","volume":"37","author":"B Tackenberg","year":"2007","unstructured":"Tackenberg B, et al. (2007) Clonal expansions of CD4+ B helper T cells in autoimmune myasthenia gravis. Eur. J. Immunol. 37:849\u201363.","journal-title":"Eur. J. Immunol."},{"key":"2101769_CR62","doi-asserted-by":"publisher","first-page":"A531","DOI":"10.1016\/j.autrev.2011.11.024","volume":"11","author":"C Selmi","year":"2012","unstructured":"Selmi C, Brunetta E, Raimondo MG, Meroni PL. (2012) The X chromosome and the sex ratio of autoimmunity. Autoimmun. Rev. 11:A531\u20137.","journal-title":"Autoimmun. Rev."},{"key":"2101769_CR63","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/S1388-2457(00)00307-2","volume":"111","author":"L Padua","year":"2000","unstructured":"Padua L, et al. (2000) SFEMG in ocular myasthenia gravis diagnosis. Clin. Neurophysiol. 111:1203\u20137.","journal-title":"Clin. Neurophysiol."},{"key":"2101769_CR64","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/mus.21156","volume":"39","author":"ME Farrugia","year":"2009","unstructured":"Farrugia ME, Jacob S, Sarrigiannis PG, Kennett RP. (2009) Correlating extent of neuromuscular instability with acetylcholine receptor antibodies. Muscle Nerve. 39:489\u201393.","journal-title":"Muscle Nerve"},{"key":"2101769_CR65","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1016\/j.clinph.2011.02.026","volume":"122","author":"R Witoonpanich","year":"2011","unstructured":"Witoonpanich R, Dejthevaporn C, Sriphrapradang A, Pulkes T. (2011) Electrophysiological and immunological study in myasthenia gravis: diagnostic sensitivity and correlation. Clin. Neurophysiol. 122:1873\u20137.","journal-title":"Clin. Neurophysiol."}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2015.00232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.2119\/molmed.2015.00232\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.crossref.org\/molmed.2015.00232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2015.00232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T17:41:55Z","timestamp":1654364515000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.2119\/molmed.2015.00232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["2101769"],"URL":"https:\/\/doi.org\/10.2119\/molmed.2015.00232","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"4 November 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}