{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:16:54Z","timestamp":1791274614721,"version":"4.1.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.2119\/molmed.2016.00131","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T12:00:15Z","timestamp":1472817615000},"page":"338-348","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia"],"prefix":"10.1186","volume":"22","author":[{"given":"Brian S","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadia B","family":"Dib-Hajj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Morisset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Tate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G","family":"Waxman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulayman D","family":"Dib-Hajj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"2201338_CR1","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S0072-9752(10)97056-5","volume":"97","author":"G Cruccu","year":"2010","unstructured":"Cruccu G, Bonamico LH, Zakrzewska JM. (2010) Cranial neuralgias. Handb. Clin. Neurol. 97:663\u201378.","journal-title":"Handb. Clin. Neurol."},{"key":"2201338_CR2","doi-asserted-by":"publisher","first-page":"532","DOI":"10.3171\/jns.2002.96.3.0532","volume":"96","author":"M Devor","year":"2002","unstructured":"Devor M, Govrin-Lippmann R, Rappaport ZH. (2002) Mechanism of trigeminal neuralgia: an ultrastructural analysis of trigeminal root specimens obtained during microvascular decompression surgery. J. Neurosurg. 96:532\u201343.","journal-title":"J. Neurosurg."},{"key":"2201338_CR3","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1093\/brain\/awu349","volume":"138","author":"S Maarbjerg","year":"2015","unstructured":"Maarbjerg S, Wolfram F, Gozalov A, Olesen J, Bendtsen L. (2015) Significance of neurovascular contact in classical trigeminal neuralgia. Brain. 138:311\u201319.","journal-title":"Brain"},{"key":"2201338_CR4","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/j.pain.2014.04.020","volume":"155","author":"G Antonini","year":"2014","unstructured":"Antonini G, et al. (2014) Magnetic resonance imaging contribution for diagnosing symptomatic neurovascular contact in classical trigeminal neuralgia: a blinded case-control study and meta-analysis. Pain. 155:1464\u201371.","journal-title":"Pain"},{"key":"2201338_CR5","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.3171\/2014.1.JNS131410","volume":"120","author":"A Lee","year":"2014","unstructured":"Lee A, McCartney S, Burbidge C, Raslan AM, Burchiel KJ. (2014) Trigeminal neuralgia occurs and recurs in the absence of neurovascular compression. J. Neurosurg. 120:1048\u201354.","journal-title":"J. Neurosurg."},{"key":"2201338_CR6","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.3171\/2014.11.JNS141741","volume":"123","author":"AL Ko","year":"2015","unstructured":"Ko AL, et al. (2015) Trigeminal neuralgia without neurovascular compression presents earlier than trigeminal neuralgia with neurovascular compression. J. Neurosurg. 123:1519\u201327.","journal-title":"J. Neurosurg."},{"key":"2201338_CR7","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00701-012-1311-7","volume":"154","author":"M Bozkurt","year":"2012","unstructured":"Bozkurt M, et al. (2012) Management of bilateral trigeminal neuralgia with trigeminal radiofrequency rhizotomy: a treatment strategy for the life-long disease. Acta. Neurochir. (Wien.) 154: 785\u201391; discussion 791\u20132.","journal-title":"Acta. Neurochir. (Wien.)"},{"key":"2201338_CR8","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s10194-011-0350-4","volume":"12","author":"Y Wang","year":"2011","unstructured":"Wang Y, Yu CY, Huang L, Riederer F, Ettlin D. (2011) Familial neuralgia of occipital and inter-medius nerves in a Chinese family. J. Headache Pain. 12:497\u2013500.","journal-title":"J. Headache Pain"},{"key":"2201338_CR9","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s10194-010-0207-2","volume":"11","author":"F Riederer","year":"2010","unstructured":"Riederer F, Sandor PS, Linnebank M, Ettlin DA. (2010) Familial occipital and nervus intermedius neuralgia in a Swiss family. J Headache Pain 11:335\u20138.","journal-title":"J Headache Pain"},{"key":"2201338_CR10","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.neurol.2007.10.010","volume":"164","author":"H Otmani El","year":"2008","unstructured":"El Otmani H, Moutaouakil F, Fadel H, Slassi I. (2008) [Familial trigeminal neuralgia]. Rev. Neurol. (Paris) 164:384\u20137.","journal-title":"Rev. Neurol. (Paris)"},{"key":"2201338_CR11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0304-3959(94)90086-8","volume":"56","author":"ZH Rappaport","year":"1994","unstructured":"Rappaport ZH, Devor M. (1994) Trigeminal neuralgia: the role of self-sustaining discharge in the trigeminal ganglion. Pain. 56:127\u201338.","journal-title":"Pain"},{"key":"2201338_CR12","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/00002508-200201000-00002","volume":"18","author":"M Devor","year":"2002","unstructured":"Devor M, Amir R, Rappaport ZH. (2002) Pathophysiology of trigeminal neuralgia: the ignition hypothesis. Clin. J. Pain. 18:4\u201313.","journal-title":"Clin. J. Pain."},{"key":"2201338_CR13","doi-asserted-by":"publisher","first-page":"872","DOI":"10.3171\/jns.2004.101.5.0872","volume":"101","author":"KJ Burchiel","year":"2004","unstructured":"Burchiel KJ, Baumann TK. (2004) Pathophysiology of trigeminal neuralgia: new evidence from a trigeminal ganglion intraoperative microneurographic recording. Case report. J. Neurosurg. 101:872\u20133.","journal-title":"J. Neurosurg."},{"key":"2201338_CR14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrn3404","volume":"14","author":"SD Dib-Hajj","year":"2013","unstructured":"Dib-Hajj SD, Yang Y, Black JA, Waxman SG. (2013) The NaV1.7 sodium channel: from molecule to man. Nat. Rev. Neurosci. 14:49\u201362.","journal-title":"Nat. Rev. Neurosci."},{"key":"2201338_CR15","first-page":"249sr244","volume":"6","author":"SD Dib-Hajj","year":"2014","unstructured":"Dib-Hajj SD, Waxman SG. (2014) Translational pain research: Lessons from genetics and genomics. Sci. Transi. Med. 6:249sr244.","journal-title":"Sci. Transi. Med."},{"key":"2201338_CR16","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nrn3977","volume":"16","author":"SD Dib-Hajj","year":"2015","unstructured":"Dib-Hajj SD, Black JA, Waxman SG. (2015) NaV1.9: a sodium channel linked to human pain. Nat. Rev. Neurosci. 16:511\u201319.","journal-title":"Nat. Rev. Neurosci."},{"key":"2201338_CR17","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1136\/jmedgenet-2014-102813","volume":"52","author":"MG Blanchard","year":"2015","unstructured":"Blanchard MG, et al. (2015) De novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsy. J. Med. Genet. 52:330\u20137.","journal-title":"J. Med. Genet."},{"key":"2201338_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.nbd.2014.05.017","volume":"69","author":"M Estacion","year":"2014","unstructured":"Estacion M, et al. (2014) A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy. Neurobiol. Dis. 69:117\u201323.","journal-title":"Neurobiol. Dis."},{"key":"2201338_CR19","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.ajhg.2012.01.006","volume":"90","author":"KR Veeramah","year":"2012","unstructured":"Veeramah KR, et al. (2012) De Novo Pathogenic SCN8A Mutation Identified by Whole-Genome Sequencing of a Family Quartet Affected by Infantile Epileptic Encephalopathy and SUDEP. Am. J. Hum. Genet. 90:502\u201310.","journal-title":"Am. J. Hum. Genet."},{"key":"2201338_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.pain.2004.08.015","volume":"113","author":"LC Stirling","year":"2005","unstructured":"Stirling LC, et al. (2005) Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice. Pain. 113:27\u201336.","journal-title":"Pain"},{"key":"2201338_CR21","doi-asserted-by":"publisher","first-page":"6765","DOI":"10.1523\/JNEUROSCI.1628-04.2004","volume":"24","author":"EK Wittmack","year":"2004","unstructured":"Wittmack EK, et al. (2004) Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. J. Neurosci. 24:6765\u201375.","journal-title":"J. Neurosci."},{"key":"2201338_CR22","doi-asserted-by":"publisher","first-page":"6621","DOI":"10.1523\/JNEUROSCI.0541-05.2005","volume":"25","author":"EK Wittmack","year":"2005","unstructured":"Wittmack EK, Rush AM, Hudmon A, Waxman SG, Dib-Hajj SD. (2005) Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase. J. Neurosci. 25:6621\u201330.","journal-title":"J. Neurosci."},{"key":"2201338_CR23","doi-asserted-by":"publisher","first-page":"26149","DOI":"10.1074\/jbc.M109.098681","volume":"285","author":"A Gasser","year":"2010","unstructured":"Gasser A, et al. (2010) Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK. J. Biol. Chem. 285:26149\u201361.","journal-title":"J. Biol. Chem."},{"key":"2201338_CR24","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/1744-8069-7-92","volume":"7","author":"M Estacion","year":"2011","unstructured":"Estacion M, et al. (2011) Intra- and interfamily phenotypic diversity in pain syndromes associated with a gain-of-function variant of NaV1.7. Mol. Pain. 7:92.","journal-title":"Mol. Pain"},{"key":"2201338_CR25","doi-asserted-by":"publisher","first-page":"4517","DOI":"10.1523\/JNEUROSCI.17-12-04517.1997","volume":"17","author":"IM Raman","year":"1997","unstructured":"Raman IM, Bean BP. (1997) Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. J. Neurosci. 17:4517\u201326.","journal-title":"J. Neurosci."},{"key":"2201338_CR26","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/nprot.2009.90","volume":"4","author":"SD Dib-Hajj","year":"2009","unstructured":"Dib-Hajj SD, et al. (2009) Transfection of rat or mouse neurons by biolistics or electroporation. Nat. Protoc. 4:1118\u201326.","journal-title":"Nat. Protoc."},{"key":"2201338_CR27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/1745-6215-14-402","volume":"14","author":"JM Zakrzewska","year":"2013","unstructured":"Zakrzewska JM, et al. (2013) Novel design for a phase IIa placebo-controlled, double-blind randomized withdrawal study to evaluate the safety and efficacy of CNV1014802 in patients with trigeminal neuralgia. Trials. 14:402.","journal-title":"Trials"},{"key":"2201338_CR28","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S0896-6273(00)80969-1","volume":"19","author":"IM Raman","year":"1997","unstructured":"Raman IM, Sprunger LK, Meisler MH, Bean BP. (1997) Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron. 19:881\u201391.","journal-title":"Neuron."},{"key":"2201338_CR29","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1016\/j.febslet.2005.03.009","volume":"579","author":"TR Cummins","year":"2005","unstructured":"Cummins TR, Dib-Hajj SD, Herzog RI, Waxman SG. (2005) Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons. FEBS Letters. 579:2166\u201370.","journal-title":"FEBS Letters"},{"key":"2201338_CR30","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1172\/JCI40801","volume":"120","author":"BW Jarecki","year":"2010","unstructured":"Jarecki BW, Piekarz AD, Jackson JO 2nd, Cummins TR. (2010) Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents. J. Clin. Invest. 120:369\u201378.","journal-title":"J. Clin. Invest."},{"key":"2201338_CR31","doi-asserted-by":"publisher","first-page":"18177","DOI":"10.1073\/pnas.0506818102","volume":"102","author":"M Mantegazza","year":"2005","unstructured":"Mantegazza M, et al. (2005) Identification of an Nav1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures. Proc. Natl. Acad. Sci. U.S.A. 102: 18177\u2013182.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2201338_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1744-8069-4-1","volume":"4","author":"X Cheng","year":"2008","unstructured":"Cheng X, Dib-Hajj SD, Tyrrell L, Waxman SG. (2008) Mutation I136V alters electrophysiological properties of the NaV1.7 channel in a family with onset of erythromelalgia in the second decade. Mol. Pain. 4:1.","journal-title":"Mol. Pain"},{"key":"2201338_CR33","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1212\/01.wnl.0000335168.86248.55","volume":"71","author":"S Petitprez","year":"2008","unstructured":"Petitprez S, et al. (2008) A novel dominant mutation of the Nav1.4 alpha-subunit domain I leading to sodium channel myotonia. Neurology. 71:1669\u201375.","journal-title":"Neurology"},{"key":"2201338_CR34","doi-asserted-by":"publisher","first-page":"5616","DOI":"10.1073\/pnas.090034797","volume":"97","author":"JH Caldwell","year":"2000","unstructured":"Caldwell JH, Schaller KL, Lasher RS, Peles E, Levinson SR. (2000) Sodium channel Nav1.6 is localized at nodes of ranvier, dendrites, and synapses. Proc. Natl. Acad. Sci. U.S.A. 97:5616\u201320.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2201338_CR35","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1017\/S1740925X06000093","volume":"2","author":"DP Schafer","year":"2006","unstructured":"Schafer DP, Custer AW, Shrager P, Rasband MN. (2006) Early events in node of Ranvier formation during myelination and remyelination in the PNS. Neuron Glia Biol. 2:69\u201379.","journal-title":"Neuron Glia Biol."},{"key":"2201338_CR36","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0169-328X(96)00163-5","volume":"43","author":"JA Black","year":"1996","unstructured":"Black JA, et al. (1996) Spinal sensory neurons express multiple sodium channel alpha-subunit mRNAs. Mol. Brain Res. 43:117\u201331.","journal-title":"Mol. Brain Res."},{"key":"2201338_CR37","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1146\/annurev-neuro-060909-153234","volume":"33","author":"SD Dib-Hajj","year":"2010","unstructured":"Dib-Hajj SD, Cummins TR, Black JA, Waxman SG. (2010) Sodium channels in normal and pathological pain. Annu. Rev. Neurosci. 33:325\u201347.","journal-title":"Annu. Rev. Neurosci."},{"key":"2201338_CR38","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0169-328X(02)00385-6","volume":"105","author":"JA Black","year":"2002","unstructured":"Black JA, Renganathan M, Waxman SG. (2002) Sodium channel Nav1.6 is expressed along nonmyelinated axons and it contributes to conduction. Mol. Brain Res. 105:19\u201328.","journal-title":"Mol. Brain Res."},{"key":"2201338_CR39","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1111\/j.1460-9568.1995.tb01105.x","volume":"7","author":"X Chen","year":"1995","unstructured":"Chen X, Gallar J, Pozo MA, Baeza M, Belmonte C. (1995) CO2 stimulation of the cornea: a comparison between human sensation and nerve activity in polymodal nociceptive afferents of the cat. Eur. J. Neurosci. 7:1154\u201363.","journal-title":"Eur. J. Neurosci."},{"key":"2201338_CR40","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1471-2202-8-56","volume":"8","author":"MA Henry","year":"2007","unstructured":"Henry MA, Freking AR, Johnson LR, Levinson SR. (2007) Sodium channel Nav1.6 accumulates at the site of infraorbital nerve injury. BMC Neurosci. 8:56.","journal-title":"BMC Neurosci."},{"key":"2201338_CR41","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/j.pain.2013.05.032","volume":"154","author":"JR Deuis","year":"2013","unstructured":"Deuis JR, et al. (2013) An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na1.6 in peripheral pain pathways. Pain. 154:1749\u201357.","journal-title":"Pain"},{"key":"2201338_CR42","doi-asserted-by":"publisher","first-page":"6704","DOI":"10.1073\/pnas.1118058109","volume":"109","author":"R Sittl","year":"2012","unstructured":"Sittl R, et al. (2012) Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype NaV1.6-resurgent and persistent current. Proc. Natl. Acad. Sci. U.S.A. 109:6704\u20139.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2201338_CR43","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.pain.2013.02.027","volume":"154","author":"W Xie","year":"2013","unstructured":"Xie W, Strong JA, Ye L, Mao JX, Zhang JM. (2013) Knockdown of sodium channel Na1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia. Pain. 154:1170\u201380.","journal-title":"Pain"},{"key":"2201338_CR44","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.neuroscience.2015.02.010","volume":"291","author":"W Xie","year":"2015","unstructured":"Xie W, Strong JA, Zhang JM. (2015) Local knockdown of the Na1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain. Neuroscience. 291:317\u201330.","journal-title":"Neuroscience"},{"key":"2201338_CR45","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1113\/jphysiol.2003.047357","volume":"551","author":"RI Herzog","year":"2003","unstructured":"Herzog RI, Cummins TR, Ghassemi F, Dib-Hajj SD, Waxman SG. (2003) Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons. J. Physiol. (Lond.) 551:741\u201350.","journal-title":"J. Physiol. (Lond.)"},{"key":"2201338_CR46","doi-asserted-by":"publisher","first-page":"14805","DOI":"10.1074\/jbc.272.23.14805","volume":"272","author":"L Sangameswaran","year":"1997","unstructured":"Sangameswaran L, et al. (1997) A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia. J. Biol. Chem. 272:14805\u20139.","journal-title":"J. Biol. Chem."},{"key":"2201338_CR47","doi-asserted-by":"publisher","first-page":"6093","DOI":"10.1523\/JNEUROSCI.18-16-06093.1998","volume":"18","author":"MR Smith","year":"1998","unstructured":"Smith MR, Smith RD, Plummer NW, Meisler MH, Goldin AL. (1998) Functional analysis of the mouse Scn8a sodium channel. J. Neurosci. 18:6093\u2013102.","journal-title":"J. Neurosci."},{"key":"2201338_CR48","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1113\/jphysiol.2005.083089","volume":"564","author":"AM Rush","year":"2005","unstructured":"Rush AM, Dib-Hajj SD, Waxman SG. (2005) Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurons. J. Physiol. (Lond.) 564:803\u201315.","journal-title":"J. Physiol. (Lond.)"},{"key":"2201338_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1113\/jphysiol.2006.121483","volume":"579","author":"AM Rush","year":"2007","unstructured":"Rush AM, Cummins TR, Waxman SG. (2007) Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. J. Physiol. (Lond.) 579(Pt 1):1\u201314.","journal-title":"J. Physiol. (Lond.)"},{"key":"2201338_CR50","doi-asserted-by":"publisher","first-page":"4825","DOI":"10.1113\/jphysiol.2014.277582","volume":"592","author":"AH Lewis","year":"2014","unstructured":"Lewis AH, Raman IM. (2014) Resurgent current of voltage-gated Na(+) channels. J. Physiol. 592:4825\u201338.","journal-title":"J. Physiol."},{"key":"2201338_CR51","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/ana.22485","volume":"71","author":"CG Faber","year":"2012","unstructured":"Faber CG, et al. (2012a) Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy. Ann. Neurol. 71:26\u201339.","journal-title":"Ann. Neurol."},{"key":"2201338_CR52","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1093\/brain\/aws187","volume":"135","author":"C Han","year":"2012","unstructured":"Han C, et al. (2012b) Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy. Brain. 135:2613\u201328.","journal-title":"Brain"},{"key":"2201338_CR53","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1097\/j.pain.0000000000000453","volume":"157","author":"W Xie","year":"2016","unstructured":"Xie W, et al. (2016) Upregulation of the sodium channel NaVbeta4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local DRG inflammation. Pain. 157:879\u201391.","journal-title":"Pain"},{"key":"2201338_CR54","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1212\/WNL.34.4.418","volume":"34","author":"VK Nielsen","year":"1984","unstructured":"Nielsen VK. (1984) Pathophysiology of hemifacial spasm: I. Ephaptic transmission and ectopic excitation. Neurology. 34:418\u201326.","journal-title":"Neurology"},{"key":"2201338_CR55","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1002\/mus.880120810","volume":"12","author":"DB Sanders","year":"1989","unstructured":"Sanders DB. (1989) Ephaptic transmission in hemifacial spasm: a single-fiber EMG study. Muscle Nerve. 12:690\u20134.","journal-title":"Muscle Nerve."},{"key":"2201338_CR56","doi-asserted-by":"publisher","first-page":"C162","DOI":"10.1152\/ajpcell.1978.234.5.C162","volume":"234","author":"F Ramon","year":"1978","unstructured":"Ramon F, Moore JW. (1978) Ephaptic transmission in squid giant axons. Am. J. Physiol. 234: C162\u201369.","journal-title":"Am. J. Physiol."},{"key":"2201338_CR57","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1212\/WNL.29.7.1061","volume":"29","author":"Z Seltzer","year":"1979","unstructured":"Seltzer Z, Devor M. (1979) Ephaptic transmission in chronically damaged peripheral nerves. Neurology. 29:1061\u20134.","journal-title":"Neurology"},{"key":"2201338_CR58","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0022-510X(83)90043-6","volume":"59","author":"SJ Lisney","year":"1983","unstructured":"Lisney SJ, Pover CM. (1983) Coupling between fibres involved in sensory nerve neuromata in cats. J. Neurol. Sci. 59:255\u201364.","journal-title":"J. Neurol. Sci."},{"key":"2201338_CR59","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1113\/jphysiol.1980.sp013356","volume":"305","author":"M Rasminsky","year":"1980","unstructured":"Rasminsky M. (1980) Ephaptic transmission between single nerve fibres in the spinal nerve roots of dystrophic mice. J. Physiol. 305:151\u201369.","journal-title":"J. Physiol."},{"key":"2201338_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1750-3639.1998.tb00126.x","volume":"8","author":"S Love","year":"1998","unstructured":"Love S, Hilton DA, Coakham HB. (1998) Central demyelination of the Vth nerve root in trigeminal neuralgia associated with vascular compression. Brain Pathol. 8:1\u201311; discussion 11\u201312.","journal-title":"Brain Pathol."},{"key":"2201338_CR61","doi-asserted-by":"publisher","first-page":"E841","DOI":"10.1227\/01.NEU.0000367550.30165.A7","volume":"66","author":"A Lagares","year":"2010","unstructured":"Lagares A, Rivas JJ, Jimenez L, Cicuendez M, Avendano C. (2010) Central demyelination in the pathogenesis of trigeminal neuralgia associated with cerebellopontine angle tumors: case report with ultrastructural trigeminal root analysis. Neurosurgery. 66: E841\u201342.","journal-title":"Neurosurgery"},{"key":"2201338_CR62","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1083\/jcb.53.1.210","volume":"53","author":"SG Waxman","year":"1972","unstructured":"Waxman SG, Pappas GD, Bennett MV. (1972) Morphological correlates of functional differentiation of nodes of Ranvier along single fibers in the neurogenic electric organ of the knife fish Stern archus. J. Cell Biol. 53:210\u201324.","journal-title":"J. Cell Biol."},{"key":"2201338_CR63","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0006-8993(84)91314-3","volume":"294","author":"SG Waxman","year":"1984","unstructured":"Waxman SG, Wood SL. (1984) Impulse conduction in inhomogeneous axons: effects of variation in voltage-sensitive ionic conductances on invasion of demyelinated axon segments and preterminal fibers. Brain Res. 294:111\u201322.","journal-title":"Brain Res."},{"key":"2201338_CR64","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3389\/fneur.2015.00104","volume":"6","author":"JL Wagnon","year":"2015","unstructured":"Wagnon JL, Meisler MH. (2015) Recurrent and Non-Recurrent Mutations of SCN8A in Epileptic Encephalopathy. Front Neurol. 6:104.","journal-title":"Front Neurol."}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2016.00131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.2119\/molmed.2016.00131\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.crossref.org\/molmed.2016.00131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2016.00131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T01:35:24Z","timestamp":1554514524000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.2119\/molmed.2016.00131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["2201338"],"URL":"https:\/\/doi.org\/10.2119\/molmed.2016.00131","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"13 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}