{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:57:30Z","timestamp":1779206250479,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.2119\/molmed.2017.00022","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T09:32:46Z","timestamp":1494667966000},"page":"83-91","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["IL-37 Suppresses MyD88-mediated Inflammatory Responses in Human Aortic Valve Interstitial Cells"],"prefix":"10.1186","volume":"23","author":[{"given":"Qiong","family":"Zhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingchun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Fullerton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Dinarello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"2301083_CR1","first-page":"e6","volume":"127","author":"AS Go","year":"2013","unstructured":"Go AS, et al. (2013) Heart disease and stroke statistics\u20142013 update: a report from the American Heart Association. Circulation. 127: e6\u2013e245.","journal-title":"Circulation"},{"key":"2301083_CR2","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nrcardio.2014.1","volume":"11","author":"JD Hutcheson","year":"2014","unstructured":"Hutcheson JD, Aikawa E, Merryman WD. (2014) Potential drug targets for calcific aortic valve disease. Nat. Rev. Cardiol. 11:218\u201331.","journal-title":"Nat. Rev. Cardiol."},{"key":"2301083_CR3","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1161\/CIRCULATIONAHA.110.006767","volume":"124","author":"NM Rajamannan","year":"2011","unstructured":"Rajamannan NM, et al. (2011) Calcific Aortic Valve Disease: Not Simply a Degenerative Process. A Review and Agenda for Research From the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive Summary: Calcific Aortic Valve Disease-2011 Update. Circulation. 124:1783\u201391.","journal-title":"Circulation"},{"key":"2301083_CR4","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1161\/CIRCRESAHA.110.234138","volume":"108","author":"JD Miller","year":"2011","unstructured":"Miller JD, Weiss RM, Heistad DD. (2011) Calcific aortic valve stenosis: methods, models, and mechanisms. Circ. Res. 108:1392\u20131412.","journal-title":"Circ. Res."},{"key":"2301083_CR5","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1161\/CIRCRESAHA.110.234278","volume":"109","author":"KI Bostr\u00f6m","year":"2011","unstructured":"Bostr\u00f6m KI, Rajamannan NM, Towler DA. (2011) The regulation of valvular and vascular sclerosis by osteogenic morphogens. Circ. Res. 109:564\u201377.","journal-title":"Circ. Res."},{"key":"2301083_CR6","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1161\/CIRCULATIONAHA.111.051052","volume":"125","author":"MR Dweck","year":"2012","unstructured":"Dweck MR, et al. (2012) Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis. Circulation. 125:76\u201386.","journal-title":"Circulation"},{"key":"2301083_CR7","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1093\/eurheartj\/ehq237","volume":"31","author":"J Hjortnaes","year":"2010","unstructured":"Hjortnaes J, et al. (2010) Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation. Eur. Heart J. 31:1975\u201384.","journal-title":"Eur. Heart J."},{"key":"2301083_CR8","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1161\/CIRCULATIONAHA.106.654913","volume":"115","author":"E Aikawa","year":"2007","unstructured":"Aikawa E, et al. (2007) Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation. 115:377\u201386.","journal-title":"Circulation"},{"key":"2301083_CR9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1161\/CIRCRESAHA.113.300153","volume":"113","author":"RM Weiss","year":"2013","unstructured":"Weiss RM, Miller JD, Heistad DD. (2013) Fibrocalcific Aortic Valve Disease: Opportunity to Understand Disease Mechanisms Using Mouse Models. Circ. Res. 113:209\u201322.","journal-title":"Circ. Res."},{"key":"2301083_CR10","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ijcard.2008.10.014","volume":"139","author":"A Alexopoulos","year":"2010","unstructured":"Alexopoulos A, et al. (2010) Bone regulatory factors NFATc1 and Osterix in human calcific aortic valves. Int. J. Cardiol. 139:142\u20139.","journal-title":"Int. J. Cardiol."},{"key":"2301083_CR11","first-page":"841","volume":"13","author":"E Rabkin-Aikawa","year":"2004","unstructured":"Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ. (2004) Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves. J. Heart Valve Dis. 13:841\u20137.","journal-title":"J. Heart Valve Dis."},{"key":"2301083_CR12","doi-asserted-by":"publisher","first-page":"C29","DOI":"10.1152\/ajpcell.00137.2007","volume":"294","author":"X Meng","year":"2008","unstructured":"Meng X, et al. (2008) Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis. Am. J. Physiol. Cell Physiol. 294: C29\u2013C35.","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2301083_CR13","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1161\/ATVBAHA.112.300116","volume":"32","author":"R Song","year":"2012","unstructured":"Song R, et al. (2012) Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like receptor-2. Arterioscler. Thromb. Vasc. Biol. 32:2711\u201320.","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2301083_CR14","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri1391","volume":"4","author":"S Akira","year":"2004","unstructured":"Akira S, Takeda K. (2004) Toll-like receptor signalling. Nat. Rev. Immunol. 4:499\u2013511.","journal-title":"Nat. Rev. Immunol."},{"key":"2301083_CR15","doi-asserted-by":"publisher","first-page":"672395","DOI":"10.1155\/2010\/672395","volume":"2010","author":"A Piccinini","year":"2010","unstructured":"Piccinini A, Midwood K. (2010) DAMPening inflammation by modulating TLR signalling. Mediators Inflamm. 2010:672395.","journal-title":"Mediators Inflamm."},{"key":"2301083_CR16","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","volume":"124","author":"S Akira","year":"2006","unstructured":"Akira S, Uematsu S, Takeuchi O. (2006) Pathogen recognition and innate immunity. Cell. 124:783\u2013801.","journal-title":"Cell"},{"key":"2301083_CR17","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.jaci.2006.02.023","volume":"117","author":"T Kaisho","year":"2006","unstructured":"Kaisho T, Akira S. (2006) Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 117:979\u201387.","journal-title":"J. Allergy Clin. Immunol."},{"key":"2301083_CR18","doi-asserted-by":"publisher","first-page":"RA100","DOI":"10.12659\/MSM.881709","volume":"17","author":"Y Fang","year":"2011","unstructured":"Fang Y, Hu J. (2011) Toll-like receptor and its roles in myocardial ischemic\/reperfusion injury. Med. Sci. Monit. 17: RA100\u201309.","journal-title":"Med. Sci. Monit."},{"key":"2301083_CR19","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1097\/01.mol.0000245258.25387.ec","volume":"17","author":"H Bj\u00f6rkbacka","year":"2006","unstructured":"Bj\u00f6rkbacka H. (2006) Multiple roles of Toll-like receptor signaling in atherosclerosis. Curr. Opin. Lipidol. 17:527\u201333.","journal-title":"Curr. Opin. Lipidol."},{"key":"2301083_CR20","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1161\/ATVBAHA.112.300912","volume":"33","author":"Q Zeng","year":"2013","unstructured":"Zeng Q, et al. (2013) Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1\/2 and nuclear factor-\u03baB activation. Arterioscler. Thromb. Vasc. Biol. 33:1580\u201390.","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2301083_CR21","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1002\/eji.201545828","volume":"46","author":"CA Dinarello","year":"2016","unstructured":"Dinarello CA, et al. (2016) Suppression of innate inflammation and immunity by interleukin-37. Eur. J. Immunol. 46:1067\u201381.","journal-title":"Eur. J. Immunol."},{"key":"2301083_CR22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1684\/ecn.2011.0288","volume":"22","author":"D Boraschi","year":"2011","unstructured":"Boraschi D, et al. (2011) IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur. Cytokine Netw. 22:127\u201347.","journal-title":"Eur. Cytokine Netw."},{"key":"2301083_CR23","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1073\/pnas.1619667114","volume":"114","author":"Q Zeng","year":"2017","unstructured":"Zeng Q, et al. (2017) Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice. Proc. Natl. Acad. Sci. USA. 114:1631\u20136.","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2301083_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/jsre.1994.1102","volume":"57","author":"RH Messier","year":"1994","unstructured":"Messier RH, et al. (1994) Dual structural and functional phenotypes of the porcine aortic valve interstitial population: characteristics of the leaflet myofibroblast. J. Surg. Res. 57:1\u201321.","journal-title":"J. Surg. Res."},{"key":"2301083_CR25","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1130\/0091-7613(1992)020<0375:NCAICB>2.3.CO;2","volume":"20","author":"MM Pimentel","year":"1992","unstructured":"Pimentel MM, Fuck RA. (1992) Neoproterozoic crustal accretion in central Brazil. Geology. 20:375\u20139.","journal-title":"Geology"},{"key":"2301083_CR26","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/ni.3103","volume":"16","author":"CA Nold-Petry","year":"2015","unstructured":"Nold-Petry CA, et al. (2015) IL-37 requires the receptors IL-18R [alpha] and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat. Immunol. 16:354\u201365.","journal-title":"Nat. Immunol."},{"key":"2301083_CR27","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1161\/01.CIR.103.11.1522","volume":"103","author":"ER Mohler","year":"2001","unstructured":"Mohler ER, et al. (2001) Bone formation and inflammation in cardiac valves. Circulation. 103:1522\u201328.","journal-title":"Circulation"},{"key":"2301083_CR28","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1253\/circj.CJ-11-0395","volume":"75","author":"SE New","year":"2011","unstructured":"New SE, Aikawa E. (2011) Cardiovascular calcification: an inflammatory disease. Circ. J. 75:1305\u201313.","journal-title":"Circ. J."},{"key":"2301083_CR29","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.jacc.2008.09.052","volume":"53","author":"X Yang","year":"2009","unstructured":"Yang X, Fullerton DA, Su X, Ao L, Meng X. (2009) Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2. J. Am. Coll. Cardiol. 53:491\u2013500.","journal-title":"J. Am. Coll. Cardiol."},{"key":"2301083_CR30","doi-asserted-by":"publisher","first-page":"e95400","DOI":"10.1371\/journal.pone.0095400","volume":"9","author":"Q Zeng","year":"2014","unstructured":"Zeng Q, et al. (2014) Augmented osteogenic responses in human aortic valve cells exposed to oxLDL and TLR4 agonist: a mechanistic role of Notch1 and NF-\u03baB interaction. PLoS One. 9: e95400.","journal-title":"PLoS One"},{"key":"2301083_CR31","doi-asserted-by":"publisher","first-page":"S222","DOI":"10.1161\/CIRCULATIONAHA.111.083675","volume":"126","author":"Q Zeng","year":"2012","unstructured":"Zeng Q, et al. (2012) Cross-talk between the tolllike receptor 4 and notch1 pathways augments the inflammatory response in the interstitial cells of stenotic human aortic valves. Circulation. 126: S222\u201330.","journal-title":"Circulation"},{"key":"2301083_CR32","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1126\/science.1087262","volume":"301","author":"M Yamamoto","year":"2003","unstructured":"Yamamoto M, et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 301:640\u20133.","journal-title":"Science"},{"key":"2301083_CR33","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","volume":"16","author":"K Takeda","year":"2004","unstructured":"Takeda K, Akira S. (2004) TLR signaling pathways. Semin. Immunol. 16:3\u20139.","journal-title":"Semin. Immunol."},{"key":"2301083_CR34","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1161\/ATVBAHA.107.161224","volume":"28","author":"A Schober","year":"2008","unstructured":"Schober A. (2008) Chemokines in vascular dysfunction and remodeling. Arterioscler. Thromb. Vasc. Biol. 28:1950\u20139.","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2301083_CR35","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1161\/ATVBAHA.107.149179","volume":"27","author":"E Galkina","year":"2007","unstructured":"Galkina E, Ley K. (2007) Vascular adhesion molecules in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 27:2292\u20132301.","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2301083_CR36","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.yjmcc.2014.02.014","volume":"72","author":"D Husseini El","year":"2014","unstructured":"El Husseini D, et al. (2014) P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: implication for calcific aortic valve disease. J. Mol. Cell. Cardiol. 72:146\u201356.","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2301083_CR37","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1161\/01.CIR.90.2.844","volume":"90","author":"CM Otto","year":"1994","unstructured":"Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O\u2019Brien KD. (1994) Characterization of the early lesion of \u2018degenerative\u2019 valvular aortic stenosis. Histological and immunohistochemical studies. Circulation. 90:844\u201353.","journal-title":"Circulation"},{"key":"2301083_CR38","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1042\/bst0280551","volume":"28","author":"S Akira","year":"2000","unstructured":"Akira S. (2000) Toll-like receptors: lessons from knockout mice. Biochem. Soc. Trans. 28:551\u201356.","journal-title":"Biochem. Soc. Trans."},{"key":"2301083_CR39","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.smim.2006.12.004","volume":"19","author":"T Kawai","year":"2007","unstructured":"Kawai T, Akira S. (2007) TLR signaling. Semin. Immunol. 19:24\u201332.","journal-title":"Semin. Immunol."},{"key":"2301083_CR40","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/35099560","volume":"413","author":"L Alexopoulou","year":"2001","unstructured":"Alexopoulou L, Holt A, Medzhitov R, Flavell R. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 413:732\u20138.","journal-title":"Nature"},{"key":"2301083_CR41","doi-asserted-by":"publisher","first-page":"482","DOI":"10.7150\/ijbs.10905","volume":"11","author":"Q Zhan","year":"2015","unstructured":"Zhan Q, et al. (2015) Activation of TLR3 induces osteogenic responses in human aortic valve interstitial cells through the NF-\u03baB and ERK1\/2 pathways. Int. J. Biol. Sci. 11:482.","journal-title":"Int. J. Biol. Sci."},{"key":"2301083_CR42","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ijcard.2010.12.089","volume":"158","author":"J L\u00f3pez","year":"2012","unstructured":"L\u00f3pez J, et al. (2012) Viral and bacterial patterns induce TLR-mediated sustained inflammation and calcification in aortic valve interstitial cells. Int. J. Cardiol. 158:18\u201325.","journal-title":"Int. J. Cardiol."},{"key":"2301083_CR43","doi-asserted-by":"publisher","first-page":"C407","DOI":"10.1152\/ajpcell.00230.2016","volume":"312","author":"Q Zhan","year":"2017","unstructured":"Zhan Q, et al. (2017) Double-stranded RNA up-regulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-non-canonical NF-\u03baB pathway. Am. J. Physiol. Cell Physiol. 312:C407\u201317.","journal-title":"Am. J. Physiol. Cell Physiol."}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2017.00022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.2119\/molmed.2017.00022\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.molmed.org\/content\/pdfstore\/17_022_Zhan.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2119\/molmed.2017.00022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T16:06:50Z","timestamp":1602086810000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.2119\/molmed.2017.00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["2301083"],"URL":"https:\/\/doi.org\/10.2119\/molmed.2017.00022","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"16 February 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}