{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:02:53Z","timestamp":1789405373385,"version":"build-2803163510"},"posted":{"date-parts":[[2026,7,8]]},"group-title":"In Review","reference-count":15,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,30]]},"abstract":"<title>Abstract<\/title>\n                <p>Cerebellar ataxia results in debilitating impairments in balance, gait, and cognition, with no established effective treatments. Kilohertz transcranial magnetic perturbation (kTMP) is a novel subthreshold non-invasive brain stimulation (NIBS) method that delivers strong, subthreshold electric fields to the cerebellar cortex without discomfort. We present the case of a 78-year-old patient with cerebellar ataxia following hemorrhagic stroke who underwent amplitude-modulated kTMP (AM-kTMP) targeted to vermal and paravermal cerebellar regions. Active AM-kTMP produced improvements on clinical scales of ataxia alongside enhanced gait stability and cognitive performance, with no device-related adverse reactions, representing a promising NIBS intervention for cerebellar disorders.<\/p>","DOI":"10.21203\/rs.3.rs-10199168\/v1","type":"posted-content","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:03:43Z","timestamp":1783523023000},"source":"Crossref","is-referenced-by-count":0,"title":["Motor and Cognitive Improvements Following Non-Invasive Brain Stimulation with kTMP: A Case Study of Cerebellar Stroke"],"prefix":"10.21203","author":[{"given":"Amanda","family":"Chirino-P\u00e9rez","sequence":"first","affiliation":[{"name":"University of California, Berkeley"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Merrick","sequence":"additional","affiliation":[{"name":"Magnetic Tides Inc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredy","family":"Miranda-Casasola","sequence":"additional","affiliation":[{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Labruna","sequence":"additional","affiliation":[{"name":"Magnetic Tides Inc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Ivry","sequence":"additional","affiliation":[{"name":"University of California, Berkeley"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"4","key":"ref1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s12311-025-01873-4","article-title":"Characteristics of adverse events and clinical risks of omaveloxolone based on FAERS data","volume":"24","author":"Liu H","year":"2025","unstructured":"Liu H, Fan D, Tao H, Shen Z, Yao K. Characteristics of adverse events and clinical risks of omaveloxolone based on FAERS data. Cerebellum. 2025;24(4):119. 10.1007\/s12311-025-01873-4.","journal-title":"Cerebellum"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"105899","DOI":"10.1016\/j.nbd.2022.105899","article-title":"Cerebellar deep brain stimulation for movement disorders","volume":"175","author":"Tai CH","year":"2022","unstructured":"Tai CH, Tseng SH. Cerebellar deep brain stimulation for movement disorders. Neurobiol Dis. 2022;175:105899. 10.1016\/j.nbd.2022.105899.","journal-title":"Neurobiol Dis"},{"issue":"11","key":"ref3","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1002\/mdc3.14205","article-title":"Effects of non-invasive brain stimulation for degenerative cerebellar ataxia: a systematic review and meta-analysis","volume":"11","author":"Matsugi A","year":"2024","unstructured":"Matsugi A, Ohtsuka H, Bando K, Kondo Y, Kikuchi Y. Effects of non-invasive brain stimulation for degenerative cerebellar ataxia: a systematic review and meta-analysis. Mov Disord Clin Pract. 2024;11(11):1323\u201334. 10.1002\/mdc3.14205.","journal-title":"Mov Disord Clin Pract"},{"issue":"1","key":"ref4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.2174\/1570159X15666171114142422","article-title":"Noninvasive cerebellar stimulation as a complement tool to pharmacotherapy","volume":"17","author":"Ferrucci R","year":"2019","unstructured":"Ferrucci R, Bocci T, Cortese F, Ruggiero F, Priori A. Noninvasive cerebellar stimulation as a complement tool to pharmacotherapy. 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