{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:42:08Z","timestamp":1747204928513,"version":"3.40.5"},"posted":{"date-parts":[[2023,11,21]]},"group-title":"In Review","reference-count":69,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,11,1]]},"abstract":"<title>Abstract<\/title>\n        <p>Growing evidence suggests that long-term air pollution exposure is a risk factor for cardiovascular mortality and morbidity. However, few studies have investigated air pollution below current regulatory limits, and causal evidence is limited. We used a double negative control approach to examine the association between long-term exposure to air pollution at low concentrations and three major cardiovascular events among Medicare beneficiaries aged\u2009\u2265\u200965 years across the contiguous United States between 2000 and 2016. We derived ZIP code-level estimates of ambient fine particulate matter (PM<sub>2.5<\/sub>), nitrogen dioxide (NO<sub>2<\/sub>), and warm-season ozone (O<sub>3<\/sub>) from high-resolution spatiotemporal models. The outcomes of interest were hospitalizations for stroke, heart failure (HF), and atrial fibrillation and flutter (AF). The analyses were restricted to areas with consistently low pollutant levels on an annual basis (PM<sub>2.5<\/sub> &lt;10 \u00b5g\/m\u00b3, NO<sub>2<\/sub>\u2009&lt;\u200945 or 40 ppb, warm-season O<sub>3<\/sub>\u2009&lt;\u200945 or 40 ppb). For each 1 \u00b5g\/m<sup>3<\/sup> increase in PM<sub>2.5<\/sub>, the hospitalization rates increased by 2.25% (95% confidence interval (CI): 1.96%, 2.54%) for stroke and 3.14% (95% CI: 2.80%, 3.94%) for HF. Each ppb increase in NO<sub>2<\/sub> increased hospitalization rates for stroke, HF, and AF by 0.28% (95% CI: 0.25%, 0.31%), 0.56% (95% CI: 0.52%, 0.60%), and 0.45% (95% CI: 0.41%, 0.49%), respectively. For each ppb increase in warm-season O<sub>3<\/sub>, there was a 0.32% (95% CI: 0.21%, 0.44%) increase in hospitalization rate for stroke. The associations for NO<sub>2<\/sub> and warm-season O<sub>3<\/sub> became stronger under a more restrictive upper threshold. Using an approach robust to omitted confounders, we concluded that long-term exposure to low-level PM<sub>2.5<\/sub>, NO<sub>2<\/sub>, and warm-season O<sub>3<\/sub> was associated with increased risks of cardiovascular diseases in the US elderly. Stricter national air quality standards should be considered.<\/p>","DOI":"10.21203\/rs.3.rs-3530201\/v1","type":"posted-content","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T16:18:57Z","timestamp":1700583537000},"source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Exposure to Air Pollution Below Regulatory Standards and Cardiovascular Diseases Among US Medicare Beneficiaries: A Double Negative Control Approach"],"prefix":"10.21203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3949-8996","authenticated-orcid":false,"given":"Yichen","family":"Wang","sequence":"first","affiliation":[{"name":"Harvard T.H. Chan School of Public Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danesh Yazdi","family":"Mahdieh","sequence":"additional","affiliation":[{"name":"Stony Brook University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaguang","family":"Wei","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association","volume":"121","author":"Brook RD","year":"2010","unstructured":"Brook, R. D. et al. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation 121, 2331\u20132378 (2010).","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrcardio.2015.152","article-title":"D. Environmental factors in cardiovascular disease","volume":"12","author":"Cosselman KE","year":"2015","unstructured":"Cosselman, K. E., Navas-Acien, A. & Kaufman, J. D. Environmental factors in cardiovascular disease. Nat Rev Cardiol 12, 627\u2013642 (2015).","journal-title":"Nat Rev Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e239","DOI":"10.1016\/S2214-109X(13)70095-0","article-title":"The global and regional burden of stroke","volume":"1","author":"Hankey GJ","year":"2013","unstructured":"Hankey, G. J. The global and regional burden of stroke. The Lancet Global Health 1, e239\u2013e240 (2013).","journal-title":"The Lancet Global Health"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1161\/STROKEAHA.122.035498","article-title":"Ambient Air Pollution and Stroke: An Updated Review","volume":"54","author":"Kulick ER","year":"2023","unstructured":"Kulick, E. R., Kaufman, J. D. & Sack, C. Ambient Air Pollution and Stroke: An Updated Review. Stroke 54, 882\u2013893 (2023).","journal-title":"Stroke"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10741-014-9420-4","article-title":"Atrial fibrillation in heart failure: stroke risk stratification and anticoagulation","volume":"19","author":"Abraham JM","year":"2014","unstructured":"Abraham, J. M. & Connolly, S. J. Atrial fibrillation in heart failure: stroke risk stratification and anticoagulation. Heart Fail Rev 19, 305\u2013313 (2014).","journal-title":"Heart Fail Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/EDE.0b013e318276ccb8","article-title":"Long-Term Exposure to Outdoor Air Pollution and Incidence of Cardiovascular Diseases","volume":"24","author":"Atkinson RW","year":"2013","unstructured":"Atkinson, R. W. et al. Long-Term Exposure to Outdoor Air Pollution and Incidence of Cardiovascular Diseases. Epidemiology 24, 44\u201353 (2013).","journal-title":"Epidemiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"105004","DOI":"10.1016\/j.envint.2019.105004","article-title":"Exposure to ambient air pollution and the incidence of congestive heart failure and acute myocardial infarction: A population-based study of 5.1 million Canadian adults living in Ontario","volume":"132","author":"Bai L","year":"2019","unstructured":"Bai, L. et al. Exposure to ambient air pollution and the incidence of congestive heart failure and acute myocardial infarction: A population-based study of 5.1 million Canadian adults living in Ontario. Environment International 132, 105004 (2019).","journal-title":"Environment International"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/eurheartj\/ehaa1031","article-title":"Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank","volume":"42","author":"Wang M","year":"2021","unstructured":"Wang, M. et al. Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank. European Heart Journal 42, 1582\u20131591 (2021).","journal-title":"European Heart Journal"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1161\/CIRCULATIONAHA.120.050252","article-title":"Long-Term Association of Air Pollution and Hospital Admissions Among Medicare Participants Using a Doubly Robust Additive Model","volume":"143","author":"Danesh Yazdi M","year":"2021","unstructured":"Danesh Yazdi, M. et al. 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Proceedings of the National Academy of Sciences 115, 9592\u20139597 (2018)."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.envres.2018.06.021","article-title":"The concentration-response between long-term PM2.5 exposure and mortality; A meta-regression approach","volume":"166","author":"Vodonos A","year":"2018","unstructured":"Vodonos, A., Awad, Y. A. & Schwartz, J. The concentration-response between long-term PM2.5 exposure and mortality; A meta-regression approach. Environmental Research 166, 677\u2013689 (2018).","journal-title":"Environmental Research"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"107594","DOI":"10.1016\/j.envint.2022.107594","article-title":"Associations between long-term air pollution exposure and the incidence of cardiovascular diseases among American older adults","volume":"170","author":"Jin T","year":"2022","unstructured":"Jin, T. et al. Associations between long-term air pollution exposure and the incidence of cardiovascular diseases among American older adults. Environment International 170, 107594 (2022).","journal-title":"Environment International"},{"year":"2023","author":"Wang Y","key":"ref14","unstructured":"Wang, Y., Qiu, X., Wei, Y. & Schwartz, J. D. Long-Term Exposure to Ambient PM 2.5 and Hospitalizations for Myocardial Infarction Among US Residents: A Difference\u2010in\u2010Differences Analysis. JAHA 12, e029428 (2023)."},{"year":"2021","author":"Brunekreef B","key":"ref15","unstructured":"Brunekreef, B. et al. Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PM2.5, BC, NO2, and O3: An Analysis of European Cohorts in the ELAPSE Project. Res Rep Health Eff Inst 2021, 208 (2021)."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/S2542-5196(21)00277-1","article-title":"Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project","volume":"6","author":"Stafoggia M","year":"2022","unstructured":"Stafoggia, M. et al. Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project. The Lancet Planetary Health 6, e9\u2013e18 (2022).","journal-title":"The Lancet Planetary Health"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/EDE.0b013e3181d61eeb","article-title":"Negative Controls: A Tool for Detecting Confounding and Bias in Observational Studies","volume":"21","author":"Lipsitch M","year":"2010","unstructured":"Lipsitch, M., Tchetgen, E. T. & Cohen, T. Negative Controls: A Tool for Detecting Confounding and Bias in Observational Studies. Epidemiology 21, 383\u2013388 (2010).","journal-title":"Epidemiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/rssb.12361","article-title":"Multiply Robust Causal Inference with Double-Negative Control Adjustment for Categorical Unmeasured Confounding","volume":"82","author":"Shi X","year":"2020","unstructured":"Shi, X., Miao, W., Nelson, J. C. & Tchetgen Tchetgen, E. J. Multiply Robust Causal Inference with Double-Negative Control Adjustment for Categorical Unmeasured Confounding. Journal of the Royal Statistical Society Series B: Statistical Methodology 82, 521\u2013540 (2020).","journal-title":"Journal of the Royal Statistical Society Series B: Statistical Methodology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/aje\/kwx013","article-title":"A New Method for Partial Correction of Residual Confounding in Time-Series and Other Observational Studies","volume":"185","author":"Flanders WD","year":"2017","unstructured":"Flanders, W. D., Strickland, M. J. & Klein, M. A New Method for Partial Correction of Residual Confounding in Time-Series and Other Observational Studies. American Journal of Epidemiology 185, 941\u2013949 (2017).","journal-title":"American Journal of Epidemiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/EDE.0b013e3181fdcabe","article-title":"A Method for Detection of Residual Confounding in Time-Series and Other Observational Studies","volume":"22","author":"Flanders WD","year":"2011","unstructured":"Flanders, W. D. et al. A Method for Detection of Residual Confounding in Time-Series and Other Observational Studies. Epidemiology (Cambridge, Mass.) 22, 59 (2011).","journal-title":"Epidemiology (Cambridge, Mass.)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1289\/EHP232","article-title":"Estimating Causal Effects of Local Air Pollution on Daily Deaths: Effect of Low Levels","volume":"125","author":"Schwartz J","year":"2017","unstructured":"Schwartz, J., Bind, M.-A. & Koutrakis, P. Estimating Causal Effects of Local Air Pollution on Daily Deaths: Effect of Low Levels. Environ Health Perspect 125, 23\u201329 (2017).","journal-title":"Environ Health Perspect"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/aje\/kwaa172","article-title":"Identification and Estimation of Causal Effects Using a Negative-Control Exposure in Time-Series Studies With Applications to Environmental Epidemiology","volume":"190","author":"Yu Y","year":"2021","unstructured":"Yu, Y. et al. Identification and Estimation of Causal Effects Using a Negative-Control Exposure in Time-Series Studies With Applications to Environmental Epidemiology. American Journal of Epidemiology 190, 468\u2013476 (2021).","journal-title":"American Journal of Epidemiology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00001648-199901000-00006","article-title":"Effects of Ambient Air Pollution on Nonelderly Asthma Hospital Admissions in Seattle, Washington, 1987\u20131994","volume":"10","author":"Sheppard L","year":"1999","unstructured":"Sheppard, L., Levy, D., Norris, G., Larson, T. V. & Koenig, J. Q. Effects of Ambient Air Pollution on Nonelderly Asthma Hospital Admissions in Seattle, Washington, 1987\u20131994. Epidemiology 10, 23 (1999).","journal-title":"Epidemiology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e052","DOI":"10.1097\/EE9.0000000000000052","article-title":"Estimating the causal effect of annual PM2.5 exposure on mortality rates in the Northeastern and mid-Atlantic states","volume":"3","author":"Yitshak-Sade M","year":"2019","unstructured":"Yitshak-Sade, M., Kloog, I., Zanobetti, A. & Schwartz, J. D. Estimating the causal effect of annual PM2.5 exposure on mortality rates in the Northeastern and mid-Atlantic states. Environmental Epidemiology 3, e052 (2019).","journal-title":"Environmental Epidemiology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12940-022-00886-4","article-title":"Short term exposure to air pollution and mortality in the US: a double negative control analysis","volume":"21","author":"Liu RA","year":"2022","unstructured":"Liu, R. A., Wei, Y., Qiu, X., Kosheleva, A. & Schwartz, J. D. Short term exposure to air pollution and mortality in the US: a double negative control analysis. Environmental Health 21, 81 (2022).","journal-title":"Environmental Health"},{"year":"2018","author":"Miao W","key":"ref26","unstructured":"Miao W., Shi X. & Tchetgen E. T. A Confounding Bridge Approach for Double Negative Control Inference on Causal Effects. arXiv.org https:\/\/arxiv.org\/abs\/1808.04945v3 (2018)."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"116203","DOI":"10.1016\/j.envres.2023.116203","article-title":"Effects of low-level air pollution exposures on hospital admission for myocardial infarction using multiple causal models","volume":"232","author":"Schwartz J","year":"2023","unstructured":"Schwartz, J., Wei, Y., Dominici, F. & Yazdi, M. D. Effects of low-level air pollution exposures on hospital admission for myocardial infarction using multiple causal models. Environmental Research 232, 116203 (2023).","journal-title":"Environmental Research"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1021\/acs.est.9b03358","article-title":"Assessing NO2 Concentration and Model Uncertainty with High Spatiotemporal Resolution across the Contiguous United States Using Ensemble Model Averaging","volume":"54","author":"Di Q","year":"2020","unstructured":"Di, Q. et al. Assessing NO2 Concentration and Model Uncertainty with High Spatiotemporal Resolution across the Contiguous United States Using Ensemble Model Averaging. Environ. Sci. Technol. 54, 1372\u20131384 (2020).","journal-title":"Environ. Sci. Technol."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"104909","DOI":"10.1016\/j.envint.2019.104909","article-title":"An ensemble-based model of PM2.5 concentration across the contiguous United States with high spatiotemporal resolution","volume":"130","author":"Di Q","year":"2019","unstructured":"Di, Q. et al. An ensemble-based model of PM2.5 concentration across the contiguous United States with high spatiotemporal resolution. Environment International 130, 104909 (2019).","journal-title":"Environment International"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"11037","DOI":"10.1021\/acs.est.0c01791","article-title":"An Ensemble Learning Approach for Estimating High Spatiotemporal Resolution of Ground-Level Ozone in the Contiguous United States","volume":"54","author":"Requia WJ","year":"2020","unstructured":"Requia, W. J. et al. An Ensemble Learning Approach for Estimating High Spatiotemporal Resolution of Ground-Level Ozone in the Contiguous United States. Environ. Sci. Technol. 54, 11037\u201311047 (2020).","journal-title":"Environ. Sci. Technol."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"100073","DOI":"10.1016\/j.gloepi.2022.100073","article-title":"Long-term air pollution exposure and incident stroke in American older adults: A national cohort study","volume":"4","author":"Ma T","year":"2022","unstructured":"Ma, T. et al. Long-term air pollution exposure and incident stroke in American older adults: A national cohort study. Global Epidemiology 4, 100073 (2022).","journal-title":"Global Epidemiology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1606328","DOI":"10.3389\/ijph.2023.1606328","article-title":"Sex Associations Between Air Pollution and Estimated Atherosclerotic Cardiovascular Disease Risk Determination","volume":"68","author":"Vall\u00e9e A","year":"2023","unstructured":"Vall\u00e9e, A. Sex Associations Between Air Pollution and Estimated Atherosclerotic Cardiovascular Disease Risk Determination. Int J Public Health 68, 1606328 (2023).","journal-title":"Int J Public Health"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1056\/NEJMsb2011009","article-title":"The Need for a Tighter Particulate-Matter Air-Quality Standard","volume":"383","author":"Independent Particulate Matter Review Panel","year":"2020","unstructured":"Independent Particulate Matter Review Panel. The Need for a Tighter Particulate-Matter Air-Quality Standard. New England Journal of Medicine 383, 680\u2013683 (2020).","journal-title":"New England Journal of Medicine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1289\/ehp.8816","article-title":"The Exposure\u2013Response Curve for Ozone and Risk of Mortality and the Adequacy of Current Ozone Regulations","volume":"114","author":"Bell ML","year":"2006","unstructured":"Bell, M. L., Peng, R. D. & Dominici, F. The Exposure\u2013Response Curve for Ozone and Risk of Mortality and the Adequacy of Current Ozone Regulations. Environmental Health Perspectives 114, 532\u2013536 (2006).","journal-title":"Environmental Health Perspectives"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.chest.2019.03.017","article-title":"Impact of Long-Term Exposures to Ambient PM2.5 and Ozone on ARDS Risk for Older Adults in the United States","volume":"156","author":"Rhee J","year":"2019","unstructured":"Rhee, J. et al. Impact of Long-Term Exposures to Ambient PM2.5 and Ozone on ARDS Risk for Older Adults in the United States. Chest 156, 71\u201379 (2019).","journal-title":"Chest"},{"year":"2020","author":"Bureau USC","key":"ref36","unstructured":"Bureau, U. S. C. Behavioral Risk Factor Surveillance System (2005\u20132019). (2020)."},{"key":"ref37","volume-title":"The Dartmouth Atlas of Health Care in the United States: The Center for the Evaluative Clinical Sciences","author":"Wennberg JE","year":"1996","unstructured":"Wennberg, J. E. & Cooper, M. M. The Dartmouth Atlas of Health Care in the United States: The Center for the Evaluative Clinical Sciences. (American Hospital Publishing, Inc., 1996)."},{"key":"ref38","unstructured":"ESRI Data and Maps & United States Geological Survey. USA Hospitals. (2010)."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/nclimate2704","article-title":"Impacts of Temperature and its Variability on Mortality in New England","volume":"5","author":"Shi L","year":"2015","unstructured":"Shi, L., Kloog, I., Zanobetti, A., Liu, P. & Schwartz, J. D. Impacts of Temperature and its Variability on Mortality in New England. Nat Clim Chang 5, 988\u2013991 (2015).","journal-title":"Nat Clim Chang"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrcardio.2017.76","article-title":"J. V. Seasonal variations in cardiovascular disease","volume":"14","author":"Stewart S","year":"2017","unstructured":"Stewart, S., Keates, A. K., Redfern, A. & McMurray, J. J. V. Seasonal variations in cardiovascular disease. Nat Rev Cardiol 14, 654\u2013664 (2017).","journal-title":"Nat Rev Cardiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/joc.3413","article-title":"Development of gridded surface meteorological data for ecological applications and modelling","volume":"33","author":"Abatzoglou JT","year":"2013","unstructured":"Abatzoglou, J. T. Development of gridded surface meteorological data for ecological applications and modelling. Int. J. Climatol. 33, 121\u2013131 (2013).","journal-title":"Int. J. Climatol."},{"key":"ref42","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1214\/16-STS558","article-title":"Tchetgen Tchetgen, E. J. On negative outcome control of unobserved confounding as a generalization of difference-in-differences","volume":"31","author":"Sofer T","year":"2016","unstructured":"Sofer, T., Richardson, D. B., Colicino, E., Schwartz, J. & Tchetgen Tchetgen, E. J. On negative outcome control of unobserved confounding as a generalization of difference-in-differences. Stat Sci 31, 348\u2013361 (2016).","journal-title":"Stat Sci"},{"key":"ref43","article-title":"Extended Follow-Up and Spatial Analysis of the American Cancer Society Study Linking Particulate Air Pollution and Mortality","author":"Krewski D","year":"2009","unstructured":"Krewski, D. et al. Extended Follow-Up and Spatial Analysis of the American Cancer Society Study Linking Particulate Air Pollution and Mortality. (2009)."},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1056\/NEJMoa1702747","article-title":"Air Pollution and Mortality in the Medicare Population","volume":"376","author":"Di Q","year":"2017","unstructured":"Di, Q. et al. Air Pollution and Mortality in the Medicare Population. New England Journal of Medicine 376, 2513\u20132522 (2017).","journal-title":"New England Journal of Medicine"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1289\/ehp.1409111","article-title":"Low-Concentration PM2.5 and Mortality: Estimating Acute and Chronic Effects in a Population-Based Study","volume":"124","author":"Shi L","year":"2016","unstructured":"Shi, L. et al. Low-Concentration PM2.5 and Mortality: Estimating Acute and Chronic Effects in a Population-Based Study. Environmental Health Perspectives 124, 46\u201352 (2016).","journal-title":"Environmental Health Perspectives"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1161\/STROKEAHA.115.009913","article-title":"Long-Term Exposure to Particulate Matter Air Pollution Is a Risk Factor for Stroke: Meta-Analytical Evidence","volume":"46","author":"Scheers H","year":"2015","unstructured":"Scheers, H., Jacobs, L., Casas, L., Nemery, B. & Nawrot, T. S. Long-Term Exposure to Particulate Matter Air Pollution Is a Risk Factor for Stroke: Meta-Analytical Evidence. Stroke 46, 3058\u20133066 (2015).","journal-title":"Stroke"},{"year":"2021","author":"Alexeeff SE","key":"ref47","unstructured":"Alexeeff, S. E., Liao, N. S., Liu, X., Van Den Eeden, S. K. & Sidney, S. Long-Term PM 2.5 Exposure and Risks of Ischemic Heart Disease and Stroke Events: Review and Meta\u2010Analysis. JAHA 10, e016890 (2021)."},{"key":"ref48","doi-asserted-by":"crossref","first-page":"087002","DOI":"10.1289\/EHP8090","article-title":"Long-Term Exposure to Road Traffic Noise and Air Pollution, and Incident Atrial Fibrillation in the Danish Nurse Cohort","volume":"129","author":"Andersen ZJ","year":"2021","unstructured":"Andersen, Z. J. et al. Long-Term Exposure to Road Traffic Noise and Air Pollution, and Incident Atrial Fibrillation in the Danish Nurse Cohort. Environ Health Perspect 129, 087002 (2021).","journal-title":"Environ Health Perspect"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1097\/EDE.0000000000001034","article-title":"Long-term Exposure to Low Air Pollutant Concentrations and the Relationship with All-Cause Mortality and Stroke in Older Men","volume":"30","author":"Dirgawati M","year":"2019","unstructured":"Dirgawati, M. et al. Long-term Exposure to Low Air Pollutant Concentrations and the Relationship with All-Cause Mortality and Stroke in Older Men. Epidemiology 30, S82\u2013S89 (2019).","journal-title":"Epidemiology"},{"year":"2015","author":"Hart JE","key":"ref50","unstructured":"Hart, J. E., Puett, R. C., Rexrode, K. M., Albert, C. M. & Laden, F. Effect Modification of Long-Term Air Pollution Exposures and the Risk of Incident Cardiovascular Disease in US Women. JAHA 4, e002301 (2015)."},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1177\/2047487319835984","article-title":"Association of short- and long-term exposure to air pollution with atrial fibrillation","volume":"26","author":"Kwon OK","year":"2019","unstructured":"Kwon, O. K. et al. Association of short- and long-term exposure to air pollution with atrial fibrillation. Eur J Prev Cardiolog 26, 1208\u20131216 (2019).","journal-title":"Eur J Prev Cardiolog"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1182\/blood-2011-04-343111","article-title":"Thrombogenicity and cardiovascular effects of ambient air pollution","volume":"118","author":"Franchini M","year":"2011","unstructured":"Franchini, M. & Mannucci, P. M. Thrombogenicity and cardiovascular effects of ambient air pollution. Blood 118, 2405\u20132412 (2011).","journal-title":"Blood"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.acvd.2017.05.003","article-title":"Cardiovascular effects of air pollution","volume":"110","author":"Bourdrel T","year":"2017","unstructured":"Bourdrel, T., Bind, M.-A., B\u00e9jot, Y., Morel, O. & Argacha, J.-F. Cardiovascular effects of air pollution. Arch Cardiovasc Dis 110, 634\u2013642 (2017).","journal-title":"Arch Cardiovasc Dis"},{"key":"ref54","first-page":"E8","article-title":"Air particulate matter and cardiovascular disease: the epidemiological, biomedical and clinical evidence","volume":"8","author":"Du Y","year":"2016","unstructured":"Du, Y., Xu, X., Chu, M., Guo, Y. & Wang, J. Air particulate matter and cardiovascular disease: the epidemiological, biomedical and clinical evidence. J Thorac Dis 8, E8\u2013E19 (2016).","journal-title":"J Thorac Dis"},{"key":"ref55","first-page":"61","article-title":"Medicaid, and the Elderly Poor","volume":"18","author":"Rowland D","year":"1996","unstructured":"Rowland, D. & Lyons, B. Medicare, Medicaid, and the Elderly Poor. Health Care Financ Rev 18, 61\u201385 (1996).","journal-title":"Health Care Financ Rev"},{"key":"ref56","article-title":"Individual and Neighborhood Socioeconomic Status and the Association between Air Pollution and Cardiovascular Disease","volume":"124","author":"Chi G","year":"2016","unstructured":"Chi, G. et al. Individual and Neighborhood Socioeconomic Status and the Association between Air Pollution and Cardiovascular Disease. Environmental Health Perspectives 124, (2016).","journal-title":"Environmental Health Perspectives"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/EDE.0b013e3181773476","article-title":"Who is More Vulnerable to Die From Ozone Air Pollution?","volume":"19","author":"Medina-Ram\u00f3n M","year":"2008","unstructured":"Medina-Ram\u00f3n, M. & Schwartz, J. Who is More Vulnerable to Die From Ozone Air Pollution? Epidemiology 19, 672\u2013679 (2008).","journal-title":"Epidemiology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/jcdd6020019","article-title":"Cardiovascular Risks Associated with Gender and Aging","volume":"6","author":"Rodgers JL","year":"2019","unstructured":"Rodgers, J. L. et al. Cardiovascular Risks Associated with Gender and Aging. Journal of Cardiovascular Development and Disease 6, 19 (2019).","journal-title":"Journal of Cardiovascular Development and Disease"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1536\/ihj.20-523","article-title":"The Association Between Ambient Air Pollution and Atrial Fibrillation: A Systematic Review and Meta-Analysis","volume":"62","author":"Chen M","year":"2021","unstructured":"Chen, M., Zhao, J., Zhuo, C. & Zheng, L. The Association Between Ambient Air Pollution and Atrial Fibrillation: A Systematic Review and Meta-Analysis. Int. Heart J. 62, 290\u2013297 (2021).","journal-title":"Int. Heart J."},{"key":"ref60","doi-asserted-by":"crossref","first-page":"132255","DOI":"10.1016\/j.chemosphere.2021.132255","article-title":"Acute effects of ambient nitrogen oxides and interactions with temperature on cardiovascular mortality in Shenzhen, China","volume":"287","author":"Gao P","year":"2022","unstructured":"Gao, P. et al. Acute effects of ambient nitrogen oxides and interactions with temperature on cardiovascular mortality in Shenzhen, China. Chemosphere 287, 132255 (2022).","journal-title":"Chemosphere"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1476-069X-12-43","article-title":"Long-term air pollution exposure and cardio- respiratory mortality: a review","volume":"12","author":"Hoek G","year":"2013","unstructured":"Hoek, G. et al. Long-term air pollution exposure and cardio- respiratory mortality: a review. Environmental Health 12, 43 (2013).","journal-title":"Environmental Health"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/EDE.0000000000000367","article-title":"Air Pollution, Cardiovascular Outcomes, and Social Disadvantage: The Multi-ethnic Study of Atherosclerosis","volume":"27","author":"Hicken MT","year":"2016","unstructured":"Hicken, M. T. et al. Air Pollution, Cardiovascular Outcomes, and Social Disadvantage: The Multi-ethnic Study of Atherosclerosis. Epidemiology 27, 42\u201350 (2016).","journal-title":"Epidemiology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.envres.2009.01.001","article-title":"Air pollution exposure and self-reported cardiovascular disease","volume":"109","author":"Johnson D","year":"2009","unstructured":"Johnson, D. & Parker, J. D. Air pollution exposure and self-reported cardiovascular disease. Environmental Research 109, 582\u2013589 (2009).","journal-title":"Environmental Research"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"117470","DOI":"10.1016\/j.atmosenv.2020.117470","article-title":"Spatial decomposition analysis of NO2 and PM2.5 air pollution in the United States","volume":"241","author":"Wang Y","year":"2020","unstructured":"Wang, Y. et al. Spatial decomposition analysis of NO2 and PM2.5 air pollution in the United States. Atmospheric Environment 241, 117470 (2020).","journal-title":"Atmospheric Environment"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12940-022-00901-8","article-title":"NO2 and PM2.5 air pollution co-exposure and temperature effect modification on pre-mature mortality in advanced age: a longitudinal cohort study in China","volume":"21","author":"Ji JS","year":"2022","unstructured":"Ji, J. S. et al. NO2 and PM2.5 air pollution co-exposure and temperature effect modification on pre-mature mortality in advanced age: a longitudinal cohort study in China. Environmental Health 21, 97 (2022).","journal-title":"Environmental Health"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.atmosenv.2015.03.055","article-title":"U.S. NO2 trends (2005\u20132013): EPA Air Quality System (AQS) data versus improved observations from the Ozone Monitoring Instrument (OMI)","volume":"110","author":"Lamsal LN","year":"2015","unstructured":"Lamsal, L. N. et al. U.S. NO2 trends (2005\u20132013): EPA Air Quality System (AQS) data versus improved observations from the Ozone Monitoring Instrument (OMI). Atmospheric Environment 110, 130\u2013143 (2015).","journal-title":"Atmospheric Environment"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"156855","DOI":"10.1016\/j.scitotenv.2022.156855","article-title":"The effect of long-term exposure to air pollution and seasonal temperature on hospital admissions with cardiovascular and respiratory disease in the United States: A difference-in-differences analysis","volume":"843","author":"Danesh Yazdi M","year":"2022","unstructured":"Danesh Yazdi, M. et al. The effect of long-term exposure to air pollution and seasonal temperature on hospital admissions with cardiovascular and respiratory disease in the United States: A difference-in-differences analysis. Science of The Total Environment 843, 156855 (2022).","journal-title":"Science of The Total Environment"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.jea.7500165","article-title":"The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants","volume":"11","author":"Klepeis NE","year":"2001","unstructured":"Klepeis, N. E. et al. The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants. J Expo Sci Environ Epidemiol 11, 231\u2013252 (2001).","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"077006","DOI":"10.1289\/EHP10389","article-title":"The Impact of Exposure Measurement Error on the Estimated Concentration\u2013Response Relationship between Long-Term Exposure to PM2.5 and Mortality","volume":"130","author":"Wei Y","year":"2022","unstructured":"Wei, Y. et al. The Impact of Exposure Measurement Error on the Estimated Concentration\u2013Response Relationship between Long-Term Exposure to PM2.5 and Mortality. 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