{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:27:45Z","timestamp":1766428065261,"version":"3.30.1"},"posted":{"date-parts":[[2024,3,4]]},"group-title":"In Review","reference-count":48,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,2,15]]},"abstract":"<title>Abstract<\/title>\n        <p>Autism Spectrum Disorder (ASD) is among the most prevalent neurodevelopmental disorders, yet the current diagnostic procedures rely on behavioral analyses and interviews and lack objective screening methods. This study seeks to address this gap by integrating upper limb kinematics and deep learning methods to identify potential biomarkers that could be validated in younger age groups in the future to enhance the identification of ASD. Forty-one school-age children, with and without an ASD diagnosis (Mean age\u2009\u00b1\u2009SE\u2009=\u200910.3\u2009\u00b1\u20090.4; 12 Females), participated in the study. A single Inertial Measurement Unit (IMU) was affixed to the child\u2019s wrist as they engaged in a continuous reaching and placing task. Deep learning techniques were employed to classify children with and without ASD. Our findings suggest delays in motor planning and control in school-age children compared to healthy adults. Compared to TD children, children with ASD exhibited poor motor planning and control as seen by greater number of movement units, more movement overshooting, and prolonged time to peak velocity\/acceleration. Compensatory movement strategies such as greater velocity and acceleration were also seen in the ASD group. More importantly, using Multilayer Perceptron (MLP) model, we demonstrated an accuracy of ~\u200978.1% in classifying children with and without ASD. These findings underscore the potential use of studying upper limb movement kinematics during goal-directed arm movements and deep learning methods as valuable tools for classifying and, consequently, aiding in the diagnosis and early identification of ASD upon further validation in younger children.<\/p>","DOI":"10.21203\/rs.3.rs-3959596\/v1","type":"posted-content","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T18:57:03Z","timestamp":1709578623000},"source":"Crossref","is-referenced-by-count":2,"title":["Developmental Differences in Reaching-and-Placing Movement and Its Potential in Classifying Children with and without Autism Spectrum Disorder: Deep Learning Approach"],"prefix":"10.21203","author":[{"given":"Wan-Chun","family":"Su","sequence":"first","affiliation":[{"name":"National Institutes of Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Mutersbaugh","sequence":"additional","affiliation":[{"name":"National Institutes of Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Lun","family":"Huang","sequence":"additional","affiliation":[{"name":"National Institutes of Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjana","family":"Bhat","sequence":"additional","affiliation":[{"name":"University of Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Gandjbakhche","sequence":"additional","affiliation":[{"name":"National Institutes of Health"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7202a1","article-title":"Prevalence and characteristics of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2020","volume":"72","author":"Maenner MJ","year":"2023","unstructured":"Maenner, M. 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A further study of relations between motor impairment and social communication, cognitive, language, functional impairments, and repetitive behavior severity in children with ASD using the SPARK study dataset. Autism Res.15(6), 1156\u20131178 (2022).","journal-title":"Autism Res"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/aur.2870","article-title":"Multidimensional motor performance in children with autism mostly remains stable with age and predicts social communication delay, language delay, functional delay, and repetitive behavior severity after accounting for intellectual disability or cognitive delay: A SPARK dataset analysis","volume":"16","author":"Bhat A","year":"2023","unstructured":"Bhat, A. Multidimensional motor performance in children with autism mostly remains stable with age and predicts social communication delay, language delay, functional delay, and repetitive behavior severity after accounting for intellectual disability or cognitive delay: A SPARK dataset analysis. Autism Res. 16(1), 208\u2013229 (2023).","journal-title":"Autism Res."},{"key":"ref7","article-title":"N. Fewer children with autism spectrum disorder with motor challenges receive physical and recreational therapies compared to standard therapies: A SPARK data set analysis","volume":"13623613231193196","author":"Bhat A","year":"2023","unstructured":"Bhat A. N. Fewer children with autism spectrum disorder with motor challenges receive physical and recreational therapies compared to standard therapies: A SPARK data set analysis. Autism. 13623613231193196. Advance online publication (2023).","journal-title":"Autism."},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s11689-018-9259-4","article-title":"The reach-to-grasp movement in infants later diagnosed with autism spectrum disorder: a high-risk sibling cohort study","volume":"10","author":"Sacrey LR","year":"2018","unstructured":"Sacrey, L. R., Zwaigenbaum, L., Bryson, S., Brian, J., & Smith, I. M. The reach-to-grasp movement in infants later diagnosed with autism spectrum disorder: a high-risk sibling cohort study. J Neurodev Disord. 10(1), 41 (2018).","journal-title":"J Neurodev Disord."},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.infbeh.2005.03.001","article-title":"Toy-oriented changes in hand and joint kinematics during the emergence of purposeful reaching","volume":"28","author":"Bhat A","year":"2005","unstructured":"Bhat, A., Heathcock, J., Galloway, J.C. 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PloS one. 13(6), e0198524 (2018).","journal-title":"PloS one."},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.2522\/ptj.20100294","article-title":"Current perspectives on motor functioning in infants, children, and adults with autism spectrum disorders","volume":"91","author":"Bhat AN","year":"2011","unstructured":"Bhat, A. N., Landa, R. J., & Galloway, J. C. Current perspectives on motor functioning in infants, children, and adults with autism spectrum disorders. Phys. Ther. 91(7), 1116\u20131129 (2011).","journal-title":"Phys. Ther."},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/aur.2904","article-title":"Cross-replicating findings on unique motor impairments of children with ASD using confirmatory factor analysis and a novel SPARK study sample","volume":"16","author":"Bhat A","year":"2023","unstructured":"Bhat, A., Tulsky, D. S., & Boulton, A. J. 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Postural control and interceptive skills in children with autism spectrum disorder. Phys. Ther. 99(9), 1231\u20131241 (2019).","journal-title":"Phys. Ther."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-psych-010418-102836","article-title":"Motor development: embodied, embedded, enculturated, and enabling","volume":"70","author":"Adolph KE","year":"2019","unstructured":"Adolph, K. E., & Hoch, J. E. Motor development: embodied, embedded, enculturated, and enabling. Annu. Rev. Psychol. 70, 141\u2013164 (2019).","journal-title":"Annu. Rev. Psychol."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000511511","article-title":"The importance of motor skills for development","volume":"95","author":"Adolph KE","year":"2020","unstructured":"Adolph, K. E., & Hoch, J. E. The importance of motor skills for development. Nestle Nutr. Inst. Workshop Ser. 95, 136\u2013144 (2020).","journal-title":"Nestle Nutr. Inst. Workshop Ser"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/bs.acdb.2022.11.001","article-title":"Infants exploring objects: A cascades perspective","volume":"64","author":"Malachowski LG","year":"2023","unstructured":"Malachowski, L. G., & Needham, A. W. Infants exploring objects: A cascades perspective. Adv. Child Dev. Behav. 64, 39\u201368 (2023).","journal-title":"Adv. Child Dev. Behav."},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/wcs.109","article-title":"Embodiment in early development","volume":"2","author":"Needham A","year":"2011","unstructured":"Needham, A., & Libertus, K. Embodiment in early development. Wiley Interdiscip. Rev. Cogn. Sci. 2(1), 117\u2013123 (2011).","journal-title":"Wiley Interdiscip. Rev. Cogn. Sci."},{"key":"ref27","first-page":"100","article-title":"General movements in infants with autism spectrum disorders","volume":"156","author":"Phagava H","year":"2008","unstructured":"Phagava, H., Muratori, F., Einspieler, C., Maestro, S., Apicella, F., Guzzetta, A., Prechtl, H. F., & Cioni, G. General movements in infants with autism spectrum disorders. Georgian Med. News. 156, 100\u2013105 (2008).","journal-title":"Georgian Med. News"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.nicl.2017.08.017","article-title":"Identification of autism spectrum disorder using deep learning and the ABIDE dataset","volume":"17","author":"Heinsfeld AS","year":"2017","unstructured":"Heinsfeld, A. S., Franco, A. R., Craddock, R. C., Buchweitz, A., & Meneguzzi, F. Identification of autism spectrum disorder using deep learning and the ABIDE dataset. Neuroimage Clin. 17, 16\u201323 (2017).","journal-title":"Neuroimage Clin."},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","DOI":"10.2196\/27706","article-title":"Computer-aided screening of autism spectrum disorder: eye-tracking study using data visualization and deep learning","volume":"8","author":"Cilia F","year":"2021","unstructured":"Cilia, F., Carette, R., Elbattah, M., Dequen, G., Gu\u00e9rin, J. L., Bosche, J., Vandromme, L., & Le Driant, B. Computer-aided screening of autism spectrum disorder: eye-tracking study using data visualization and deep learning. JMIR Hum. Factors, 8(4), e27706 (2021).","journal-title":"JMIR Hum. Factors"},{"key":"ref30","volume-title":"Autism Diagnostic Observation Schedule (ADOS)","author":"Lord C","year":"1989","unstructured":"Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., & Schopler, E. (1989). Autism Diagnostic Observation Schedule (ADOS). APA PsycTests."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/BF02172145","article-title":"Autism Diagnostic Interview\u2014Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders","volume":"24","author":"Lord C","year":"1994","unstructured":"Lord, C., Rutter, M., & Le Couteur, A. Autism Diagnostic Interview\u2014Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord. 24, 659\u2013685 (1994).","journal-title":"J Autism Dev Disord"},{"key":"ref32","volume-title":"Vineland adaptive behavior scales","author":"Sparrow SS","year":"2005","unstructured":"Sparrow, S.S. & Cicchetti, D.V. & Balla, D.A. Vineland adaptive behavior scales. 2nd ed. (San Antonio: NCS Pearson; 2005).","edition":"2"},{"key":"ref33","volume-title":"Social Responsiveness Scale","author":"Constantino JN","year":"2005","unstructured":"Constantino, J. N. & Gruber, C. P. Social Responsiveness Scale (Western Psychological Services, 2005)."},{"key":"ref34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fnhum.2020.00057","article-title":"Developmental differences in cortical activation during action observation, action execution and interpersonal synchrony: an fNIRS study","volume":"14","author":"Su WC","year":"2020","unstructured":"Su, W. C., Culotta, M. L., Hoffman, M. D., Trost, S. L., Pelphrey, K. A., Tsuzuki, D., & Bhat, A. N. Developmental differences in cortical activation during action observation, action execution and interpersonal synchrony: an fNIRS study. Front. Hum. Neurosci. 14, 57 (2020).","journal-title":"Front. Hum. Neurosci."},{"issue":"10","key":"ref35","article-title":"Differences in cortical activation patterns during action observation, action execution, and interpersonal synchrony between children with or without autism spectrum disorder (ASD): An fNIRS pilot study","volume":"15","author":"Su WC","year":"2020","unstructured":"Su, W. C., Culotta, M., Mueller, J., Tsuzuki, D., Pelphrey, K., & Bhat, A. Differences in cortical activation patterns during action observation, action execution, and interpersonal synchrony between children with or without autism spectrum disorder (ASD): An fNIRS pilot study. PloS one, 15(10), e0240301 (2020).","journal-title":"PloS one"},{"year":"2001","author":"Breiman L","key":"ref36","unstructured":"Breiman, L., & Forests, R. Machine Learning 45 (1) (Springer, 2001)."},{"key":"ref37","first-page":"177","article-title":"All models are wrong, but many are useful: learning a variable's importance by studying an entire class of prediction models simultaneously","volume":"20","author":"Fisher A","year":"2019","unstructured":"Fisher, A., Rudin, C., & Dominici, F. All models are wrong, but many are useful: learning a variable's importance by studying an entire class of prediction models simultaneously. J Mach Learn Res. 20, 177 (2019).","journal-title":"J Mach Learn Res"},{"year":"2022","author":"Molnar C","key":"ref38","unstructured":"Molnar, C. Interpretable Machine Learning: A guide for making black box models explainable (2nd ed. 2022)."},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.humov.2013.02.008","article-title":"The development of rapid online control in children aged 6\u201312 years: reaching performance","volume":"32","author":"Wilson PH","year":"2013","unstructured":"Wilson, P. H., & Hyde, C. The development of rapid online control in children aged 6\u201312 years: reaching performance. Hum Mov Sci. 32(5), 1138\u20131150 (2013).","journal-title":"Hum Mov Sci."},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00221-006-0762-6","article-title":"Age-related differences in the reaching and grasping coordination in children: unimanual and bimanual tasks","volume":"179","author":"Olivier I","year":"2007","unstructured":"Olivier, I., Hay, L., Bard, C., & Fleury, M. Age-related differences in the reaching and grasping coordination in children: unimanual and bimanual tasks. Exp. Brain Res. 179(1), 17\u201327 (2007).","journal-title":"Exp. Brain Res."},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/s41598-020-80866-1","article-title":"F. The developmental trajectories of executive function from adolescence to old age","volume":"11","author":"Ferguson HJ","year":"2021","unstructured":"Ferguson, H. J., Brunsdon, V. E. A., & Bradford, E. E. F. The developmental trajectories of executive function from adolescence to old age. Sci. Rep. 11(1), 1382 (2021).","journal-title":"Sci. Rep."},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s00221-005-0291-8","article-title":"Reaching movements in children: accuracy and reaction time development","volume":"169","author":"Favilla M","year":"2006","unstructured":"Favilla M. Reaching movements in children: accuracy and reaction time development. Exp. Brain Res.169(1), 122\u2013125 (2006).","journal-title":"Exp. Brain Res"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1207\/s15326942dn3002_4","article-title":"A comparison of the reach-to-grasp movement between children and adults: a kinematic study","volume":"30","author":"Zoia S","year":"2006","unstructured":"Zoia, S., Pezzetta, E., Blason, L., Scabar, A., Carrozzi, M., Bulgheroni, M., & Castiello, U. A comparison of the reach-to-grasp movement between children and adults: a kinematic study. Dev. Neuropsychol. 30(2), 719\u2013738 (2006).","journal-title":"Dev. Neuropsychol."},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00221-006-0704-3","article-title":"Controlling reaching movements with predictable and unpredictable target motion in 10-year-old children and adults","volume":"177","author":"Daum MM","year":"2007","unstructured":"Daum, M. M., Huber, S., & Krist, H. Controlling reaching movements with predictable and unpredictable target motion in 10-year-old children and adults. Exp. Brain Res.177(4), 483\u2013492 (2007).","journal-title":"Exp. Brain Res"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/mp.2017.75","article-title":"Autism spectrum disorders: a meta-analysis of executive function","volume":"23","author":"Demetriou EA","year":"2018","unstructured":"Demetriou, E. A., Lampit, A., Quintana, D. S., Naismith, S. L., Song, Y., Pye, J. E., Hickie, I., & Guastella, A. J. Autism spectrum disorders: a meta-analysis of executive function. Mol Psychiatry. 23(5), 1198\u20131204 (2018).","journal-title":"Mol Psychiatry."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"104779","DOI":"10.1016\/j.jecp.2019.104779","article-title":"Between- and within-person contributions of simple reaction time to executive function skills in early childhood","volume":"192","author":"Willoughby M","year":"2020","unstructured":"Willoughby, M., Hong, Y., Hudson, K., & Wylie, A. Between- and within-person contributions of simple reaction time to executive function skills in early childhood. J. Exp. Child Psychol. 192, 104779 (2020).","journal-title":"J. Exp. Child Psychol."},{"issue":"3","key":"ref47","article-title":"Delafield-Butt, JDevelopmental differences in the prospective organisation of goal-directed movement between children with autism and typically developing children: A smart tablet serious game study","volume":"25","author":"Chua YW","year":"2022","unstructured":"Chua, Y. W., Lu, S. C., Anzulewicz, A., Sobota, K., Tachtatzis, C., Andonovic, I., Rowe, P., & Delafield-Butt, JDevelopmental differences in the prospective organisation of goal-directed movement between children with autism and typically developing children: A smart tablet serious game study. Dev. Sci. 25(3), e13195 (2022).","journal-title":"Dev. Sci."},{"issue":"Pt 9","key":"ref48","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1093\/brain\/awt208","article-title":"Atypical basic movement kinematics in autism spectrum conditions","volume":"136","author":"Cook JL","year":"2013","unstructured":"Cook, J. L., Blakemore, S. J., & Press, C. Atypical basic movement kinematics in autism spectrum conditions. 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