{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:52:49Z","timestamp":1747205569569,"version":"3.40.5"},"posted":{"date-parts":[[2020,9,23]]},"group-title":"In Review","reference-count":0,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2020,8,31]]},"abstract":"<title>Abstract<\/title>\n        <p>To investigate prevalence of ongoing activation of inflammation following asymptomatic SARS-CoV-2 infection we characterized immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals with few underlying health issues following a community superspreading event. Four mildly symptomatic seropositive individuals examined three weeks after infection as positive controls demonstrated immunological activation. Approximately four to six weeks following the event, the two asymptomatic groups showed no significant differences. Two seropositive patients with underlying genetic disease impacting immunological activation were included (Cystic Fibrosis (CF), Nuclear factor-kappa B Essential Modulator (NEMO) deficiency). CF, but not NEMO, associated with significant immune transcriptome differences including some associated with severe SARS-CoV-2 infection (IL1B, IL17A, respective receptors). All subjects remained in their usual state of health from event through five-month follow-up. Here, asymptomatic infection resolved without evidence of prolonged immunological activation. Inclusion of subjects with underlying genetic disease illustrated the pathophysiological importance of context on impact of immunological response.<\/p>","DOI":"10.21203\/rs.3.rs-69657\/v1","type":"posted-content","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T14:01:21Z","timestamp":1600869681000},"source":"Crossref","is-referenced-by-count":0,"title":["Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community"],"prefix":"10.21203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-5942","authenticated-orcid":false,"given":"Hye Kyung","family":"Lee","sequence":"first","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig","family":"Knabl","sequence":"additional","affiliation":[{"name":"Medical University of Innsbruck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Pipperger","sequence":"additional","affiliation":[{"name":"Medical University of Innsbruck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Volland","sequence":"additional","affiliation":[{"name":"Medical University of Innsbruck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Furth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keunsoo","family":"Kang","sequence":"additional","affiliation":[{"name":"Dankook University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3517-5973","authenticated-orcid":false,"given":"Harold","family":"Smith","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig","family":"Knabl","sequence":"additional","affiliation":[{"name":"Krankenhaus St.Vinzenz Zams"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romuald","family":"Bellmann","sequence":"additional","affiliation":[{"name":"Medical University of Innsbruck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Bernhard","sequence":"additional","affiliation":[{"name":"Hospital Kufstein"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Bezirkskrankenhaus St. Johann in Tirol"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes","family":"G\u00e4nzer","sequence":"additional","affiliation":[{"name":"Bezirkskrankenhaus Schwaz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6623-7823","authenticated-orcid":false,"given":"Mathias","family":"Str\u00f6hle","sequence":"additional","affiliation":[{"name":"Medical University of Innsbruck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Walser","sequence":"additional","affiliation":[{"name":"Ordination (Private Practice)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothee Von","family":"Laer","sequence":"additional","affiliation":[{"name":"Medical University of Innsbruck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8319-9841","authenticated-orcid":false,"given":"Lothar","family":"Hennighausen","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.researchsquare.com\/article\/rs-69657\/v1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.researchsquare.com\/article\/rs-69657\/v1.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T14:01:22Z","timestamp":1600869682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchsquare.com\/article\/rs-69657\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.21203\/rs.3.rs-69657\/v1","relation":{},"subject":[],"published":{"date-parts":[[2020,9,23]]},"subtype":"preprint"}}