{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T23:59:22Z","timestamp":1772236762138,"version":"3.50.1"},"posted":{"date-parts":[[2021,11,5]]},"group-title":"In Review","reference-count":0,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["771714, 679368"],"award-info":[{"award-number":["771714, 679368"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["839960"],"award-info":[{"award-number":["839960"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["LT000047\/2019-L"],"award-info":[{"award-number":["LT000047\/2019-L"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 1048-2016"],"award-info":[{"award-number":["ALTF 1048-2016"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["CEECIND\/03322\/2018, CEECIND\/00697\/2018, CEECIND\/04251\/2017, IF\/00412\/2012, EXPL\/BEX- BCM\/2258\/2013, PRECISE-LISBOA-01-0145-FEDER-016394, PTDC\/MED-PAT\/31639\/2017, PTDC\/BIA-CEL\/32180\/2017"],"award-info":[{"award-number":["CEECIND\/03322\/2018, CEECIND\/00697\/2018, CEECIND\/04251\/2017, IF\/00412\/2012, EXPL\/BEX- BCM\/2258\/2013, PRECISE-LISBOA-01-0145-FEDER-016394, PTDC\/MED-PAT\/31639\/2017, PTDC\/BIA-CEL\/32180\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["17CVD03"],"award-info":[{"award-number":["17CVD03"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,11,4]]},"abstract":"<title>Abstract<\/title>\n                <p>\n                  <italic>Trypanosoma congolense<\/italic>\n                  causes a syndrome of variable severity in animals in sub-Saharan Africa. Cerebral trypanosomiasis is an acute form, but the mechanism underlying this severity remains unknown\n                  <italic>.<\/italic>\n                  We developed a mouse model of cerebral trypanosomiasis with\n                  <italic>T. congolense<\/italic>\n                  strain 1\/148 and characterized the cellular, behavioral and physiological consequences of this infection. Using\n                  <italic>in vivo<\/italic>\n                  imaging, we show large parasite sequestration in the brain vasculature for long periods of time (up to 8 hours), that results in extensive brain damage partly caused by ICAM1-mediated recruitment and accumulation of T cells. Antibody-mediated ICAM1 blocking and lymphocyte absence reduce parasite sequestration in the brain and prevent the onset of cerebral trypanosomiasis. Here, we establish a new mouse model of cerebral trypanosomiasis and we propose a mechanism whereby parasite sequestration, host ICAM1, and T cells play a pivotal role.\n                <\/p>","DOI":"10.21203\/rs.3.rs-1050698\/v1","type":"posted-content","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T09:19:15Z","timestamp":1636103955000},"source":"Crossref","is-referenced-by-count":0,"title":["Immunopathology and parasite sequestration cause severe cerebral trypanosomiasis in animals"],"prefix":"10.21203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-6626","authenticated-orcid":false,"given":"Sara Silva","family":"Pereira","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular Joao Lobo Antunes"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-6789","authenticated-orcid":false,"given":"Mariana","family":"De Niz","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Joao Lobo Antunes"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9152-4739","authenticated-orcid":false,"given":"Karine","family":"Serre","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Joao Lobo Antunes"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4724-4363","authenticated-orcid":false,"given":"Marie","family":"Ouarn\u00e9","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Joao Lobo Antunes"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-3883","authenticated-orcid":false,"given":"Claudio A","family":"Franco","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Joao Lobo Antunes"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-6586","authenticated-orcid":false,"given":"Luisa M","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Joao Lobo Antunes"}]}],"member":"297","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.researchsquare.com\/article\/rs-1050698\/v1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.researchsquare.com\/article\/rs-1050698\/v1.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T09:19:21Z","timestamp":1636103961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchsquare.com\/article\/rs-1050698\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.21203\/rs.3.rs-1050698\/v1","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.7554\/eLife.77440","asserted-by":"object"}]},"subject":[],"published":{"date-parts":[[2021,11,5]]},"subtype":"preprint"}}