{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:37:24Z","timestamp":1747204644885,"version":"3.40.5"},"posted":{"date-parts":[[2021,3,18]]},"group-title":"In Review","reference-count":0,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,3,4]]},"abstract":"<title>Abstract<\/title>\n        <p><bold>Background: <\/bold>Dilated cardiomyopathy (DCM) is the third most common cause of heart failure. The multidisciplinary nature of testing, -involving genetics, imaging, or cardiovascular techniques-, makes its diagnosis challenging. Novel and reliable biomarkers are needed for early identification and tailored personalized management. Peripheral circular RNAs (circRNAs), a leading research topic, remain mostly unexplored in DCM. We aimed to assess whether peripheral circRNAs are expressed differentially among etiology-based DCM. The study was based on a case-control multicentric study. <bold>Methods:<\/bold> We enrolled 130 subjects: healthy controls (n=20), idiopathic DCM (n=30), ischemic DCM (n=20) and familial DCM patients which included pathogen variants of i) <italic>LMNA<\/italic> gene (n=30) and ii) BCL2-associated athanogene 3 (<italic>BAG3<\/italic>) gene (n=30). Differentially expressed circRNAs were analyzed in plasma samples by quantitative RT-PCR and correlated to relevant systolic and diastolic parameters. The pathophysiological implications were explored through bioinformatics tools. <bold>Results: <\/bold>Four circRNAs were overexpressed compared to controls: hsa_circ_0003258, hsa_circ_0051238, and hsa_circ_0051239 in <italic>LMNA<\/italic>-related DCM; and hsa_circ_0089762 in the ischemic DCM cohort. The obtained areas under the curve confirm the discriminative capacity of circRNAs. <bold>Conclusions:<\/bold> The circRNAs correlated with some diastolic and systolic echocardiographic parameters with notable diagnostic potential in DCM. Circulating circRNAs may be helpful for the etiology-based diagnosis of DCM as a non-invasive biomarker.<\/p>","DOI":"10.21203\/rs.3.rs-298067\/v1","type":"posted-content","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T19:20:49Z","timestamp":1616095249000},"source":"Crossref","is-referenced-by-count":0,"title":["Circulating circRNA as Biomarkers For Dilated Cardiomyopathy Etiology"],"prefix":"10.21203","author":[{"given":"Marina","family":"Costa*","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular: Universidade de Lisboa Instituto de Medicina Molecular Joao Lobo Antunes"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-3450","authenticated-orcid":false,"given":"Maria","family":"Calderon-Dominguez*","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of Cadiz"}]},{"given":"Alipio","family":"Mangas","sequence":"additional","affiliation":[{"name":"University of Cadiz Faculty of Medicine: Universidad de Cadiz Facultad de Medicina"}]},{"given":"Oscar","family":"Campuzano","sequence":"additional","affiliation":[{"name":"University of Girona Faculty of Medicine: Universitat de Girona Facultat de Medicina"}]},{"given":"Georgia","family":"Sarquella-Brugada","sequence":"additional","affiliation":[{"name":"University of Girona Faculty of Medicine: Universitat de Girona Facultat de Medicina"}]},{"given":"Monica","family":"Ramos","sequence":"additional","affiliation":[{"name":"Universidad Alfonso X El Sabio"}]},{"given":"Maribel","family":"Quezada-Feijoo","sequence":"additional","affiliation":[{"name":"Universidad Alfonso X El Sabio"}]},{"given":"Jos\u00e9 Manuel Garc\u00eda","family":"Pinilla","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Victoria"}]},{"given":"Ainhoa","family":"Robles-Mezcua","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Victoria"}]},{"given":"Thalia","family":"Belmonte","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of Cadiz"}]},{"given":"Francisco J","family":"Enguita","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular: Universidade de Lisboa Instituto de Medicina Molecular Joao Lobo Antunes"}]},{"given":"Rocio","family":"Toro","sequence":"additional","affiliation":[{"name":"University of Cadiz Faculty of Medicine: Universidad de Cadiz Facultad de Medicina"}]}],"member":"297","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.researchsquare.com\/article\/rs-298067\/v1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.researchsquare.com\/article\/rs-298067\/v1.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T01:28:53Z","timestamp":1659058133000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchsquare.com\/article\/rs-298067\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":0,"URL":"https:\/\/doi.org\/10.21203\/rs.3.rs-298067\/v1","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1007\/s00109-021-02119-6","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2021,3,18]]},"subtype":"preprint"}}