{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:44:17Z","timestamp":1747205057133,"version":"3.40.5"},"posted":{"date-parts":[[2024,2,1]]},"group-title":"In Review","reference-count":36,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,1,25]]},"abstract":"<title>Abstract<\/title>\n        <p><bold>Purpose: <\/bold><italic>Rubus idaeus<\/italic> cultivation has boosted productivity due to its high nutritional value. In consequence, waste production increased. The discarded biomass, including leaves and aerial components, can be transformed into valuable functional ingredients for industrial applications, such as cosmetics. Studying their bioactivity potential is of high relevance.\n<bold>Methods: <\/bold>According to the present idea, the research involved the extraction of phenolic compounds from raspberry plant branches and leaves by employing four different techniques, namely aqueous decoction, aqueous infusion, hydroethanolic maceration, and ultrasound-assisted extraction (UAE). Subsequently, these compounds were screened for their bioactive potential, including antioxidant, antibacterial, anti-inflammatory, and cytotoxic properties.\n<bold>Results: <\/bold>The UAE-assisted extraction has yielded extracts with more phenolic compounds, while the infusion and maceration result in higher contents of flavonols. Among the identified phenolic compounds, hydrolysable tannins, particularly galloyl-<italic>bis<\/italic>-HHDP-glucose, were found to be the most dominant ones. Regarding antioxidant potential, the decoction extract was the strongest, while the infusion showed the greatest potential for inhibiting lipid peroxidation. The UAE extract was found to be highly effective as an antibacterial agent. Both infusion and UAE extracts demonstrated the highest anti-inflammatory potential.\n<bold>Conclusion: <\/bold>The combination of these results highlights the sample's bioactive potential and the importance of exploiting bioresidues as unique, sustainable candidates for industrial applications.<\/p>","DOI":"10.21203\/rs.3.rs-3897244\/v1","type":"posted-content","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T08:03:27Z","timestamp":1706774607000},"source":"Crossref","is-referenced-by-count":0,"title":["Extraction of bioactive compounds from Rubus idaeus bioresidues: a full screening on phenolic composition and bioactive potential"],"prefix":"10.21203","author":[{"given":"Paula","family":"Plasencia","sequence":"first","affiliation":[{"name":"CIMO: Centro de Investigacao de Montanha"}]},{"given":"Tiane C.","family":"Finimundy","sequence":"additional","affiliation":[{"name":"CIMO: Centro de Investigacao de Montanha"}]},{"given":"M\u00e1rcio","family":"Carocho","sequence":"additional","affiliation":[{"name":"CIMO: Centro de Investigacao de Montanha"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-4578","authenticated-orcid":false,"given":"Ricardo","family":"Calhelha","sequence":"additional","affiliation":[{"name":"IPB CIMO: Centro de Investigacao de Montanha"}]},{"given":"Mikel","family":"A\u00f1ibarro-Ortega","sequence":"additional","affiliation":[{"name":"CIMO: Centro de Investigacao de Montanha"}]},{"given":"T\u00e2nia C.S.P.","family":"Pires","sequence":"additional","affiliation":[{"name":"CIMO: Centro de Investigacao de Montanha"}]},{"given":"Filomena","family":"Barreiro","sequence":"additional","affiliation":[{"name":"CIMO: Centro de Investigacao de Montanha"}]},{"given":"Pablo A.","family":"Garcia","sequence":"additional","affiliation":[{"name":"USAL Servicio de Bibliotecas: Universidad de Salamanca Servicio de Bibliotecas"}]},{"given":"Lillian","family":"Barros","sequence":"additional","affiliation":[{"name":"CIMO: Centro de Investigacao de Montanha"}]},{"given":"Sandrina A.","family":"Heleno","sequence":"additional","affiliation":[{"name":"CIMO: Centro de Investigacao de Montanha"}]}],"member":"297","reference":[{"year":"2007","author":"Oliveira PB","key":"ref1","unstructured":"de Oliveira, P.B., Valdiviesso, T., Esteves, A., Mota, M., Fonseca, L.L.: da: A planta de framboesa. 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