{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:44:16Z","timestamp":1747205056144,"version":"3.40.5"},"posted":{"date-parts":[[2024,4,22]]},"group-title":"In Review","reference-count":145,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,3,1]]},"abstract":"<title>Abstract<\/title>\n        <p>In the era of renewed space exploration, comprehending the effects of the space environment on human health, particularly for deep space missions, is crucial. While extensive research exists on the impacts of spaceflight, there is a gap regarding female reproductive risks. We hypothesize that space stressors could have enduring effects on female health, potentially increasing risks for future pregnancies upon return to Earth, particularly related to small-for-gestational-age (SGA) fetuses. To address this, we identify a shared microRNA (miRNA) signature between SGA and the space environment, conserved across humans and mice. These miRNAs target genes and pathways relevant to diseases and development. Employing a machine learning approach, we identify potential FDA-approved drugs to mitigate these risks, including estrogen and progesterone receptor antagonists, vitamin D receptor antagonists, and DNA polymerase inhibitors. This study underscores potential pregnancy-related health risks for female astronauts and proposes pharmaceutical interventions to counteract the impact of space travel on female health.<\/p>","DOI":"10.21203\/rs.3.rs-4003363\/v1","type":"posted-content","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T02:59:32Z","timestamp":1713754772000},"source":"Crossref","is-referenced-by-count":0,"title":["To boldly go where no microRNAs have gone before: Spaceflight impact on risk for small-for-gestational-age infants"],"prefix":"10.21203","author":[{"given":"Giada","family":"Corti","sequence":"first","affiliation":[{"name":"University of Rome Tor Vergata"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8733-9925","authenticated-orcid":false,"given":"JangKeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-8557","authenticated-orcid":false,"given":"Francisco","family":"Enguita","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Universidade de Lisboa"}]},{"given":"Joseph","family":"Guarnieri","sequence":"additional","affiliation":[{"name":"The Children\u2019s Hospital of Philadelphia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-9358","authenticated-orcid":false,"given":"Lawrence","family":"Grossman","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8542-2389","authenticated-orcid":false,"given":"Sylvain","family":"Costes","sequence":"additional","affiliation":[{"name":"NASA Ames Research Center"}]},{"given":"Matias","family":"Fuentealba","sequence":"additional","affiliation":[{"name":"Buck Institute for Research on Aging"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0654-5661","authenticated-orcid":false,"given":"Ryan","family":"Scott","sequence":"additional","affiliation":[{"name":"KBR, NASA Ames Research Center"}]},{"given":"Andrea","family":"Magrini","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata"}]},{"given":"Lauren","family":"Sanders","sequence":"additional","affiliation":[{"name":"NASA Ames Research Center"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3654-9519","authenticated-orcid":false,"given":"David","family":"Furman","sequence":"additional","affiliation":[{"name":"buck institute"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6369-0297","authenticated-orcid":false,"given":"Jean","family":"Calleja-Agius","sequence":"additional","affiliation":[{"name":"University of Malta"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1850-1642","authenticated-orcid":false,"given":"Christopher","family":"Mason","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1748-7148","authenticated-orcid":false,"given":"Diego","family":"Galeano","sequence":"additional","affiliation":[{"name":"Facultad de Ingenieria, Universidad Nacional de Asuncion (UNA)"}]},{"given":"Massimo","family":"Bottini","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-531X","authenticated-orcid":false,"given":"Afshin","family":"Beheshti","sequence":"additional","affiliation":[{"name":"NASA Ames Research Center"}]}],"member":"297","reference":[{"year":"2024","author":"Mason CE","unstructured":"Mason, C.E., et al.: The Second Space Age: Omics, Platforms, and Medicine Across Orbits, Nature, in press (2024)","key":"ref1"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.cell.2020.10.050","article-title":"Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration","volume":"183","author":"Afshinnekoo E","year":"2020","unstructured":"Afshinnekoo, E., et al.: Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration. 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