{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:45:41Z","timestamp":1747205141264,"version":"3.40.5"},"posted":{"date-parts":[[2024,4,1]]},"group-title":"In Review","reference-count":0,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,3,29]]},"abstract":"<title>Abstract<\/title>\n        <p>A hallmark of autoimmune diseases like multiple sclerosis (MS) is an imbalance between CD4<sup>+<\/sup> T cell subsets, namely pro-inflammatory T helper 1 (Th)1 and Th17 cells, and anti-inflammatory Foxp3<sup>+<\/sup> regulatory cells (Treg). Here we investigated which and how microRNAs (miRNAs) regulate these CD4<sup>+<\/sup> T cell subsets in a pre-clinical model of MS. We established a triple reporter mouse for <italic>Ifng<\/italic>, <italic>Il17<\/italic> and <italic>Foxp3<\/italic>, subjected it to experimental autoimmune encephalomyelitis (EAE), and identified the miRNomes of purified Th1, Th17 and Treg cells. We found that miR-122-5p and miR-1247 target specific sets of mRNAs to restrain Th17 cell proliferation and Th1 cell differentiation, respectively, thus impacting on the course or severity of EAE. Cytokine-regulated miR-122-5p and miR-1247 expression levels inversely associated with pathogenic gene signatures between lymphoid and central nervous systems, indicating that these miRNAs act as peripheral brakes to CD4<sup>+<\/sup> T cell pathogenicity that are subverted in the inflamed target organ.<\/p>","DOI":"10.21203\/rs.3.rs-4187285\/v1","type":"posted-content","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T03:53:30Z","timestamp":1711943610000},"source":"Crossref","is-referenced-by-count":0,"title":["MicroRNAs -122 and -1247 restrain the pathogenicity of effector CD4+ T cells in autoimmune inflammation"],"prefix":"10.21203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4141-9302","authenticated-orcid":false,"given":"Bruno","family":"Silva-Santos","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular - Jo\u00e3o Lobo Antunes, Universidade de Lisboa"}]},{"given":"Carolina","family":"Cunha","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular"}]},{"given":"Paula","family":"Romero","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular"}]},{"given":"Daniel","family":"In\u00e1cio","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular"}]},{"given":"Ana","family":"Pais","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular"}]},{"given":"Catarina","family":"Pelicano","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular"}]},{"given":"Marina","family":"Costa","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular"}]},{"given":"Sofia","family":"Mensurado","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa"}]},{"given":"Natacha","family":"Gon\u00e7alves-Sousa","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa"}]},{"given":"Pedro","family":"Papotto","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular"}]},{"given":"Daniel","family":"Neves","sequence":"additional","affiliation":[{"name":"SGS Global Biosciences Center"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3955-0117","authenticated-orcid":false,"given":"Daniel","family":"Sobral","sequence":"additional","affiliation":[{"name":"National Institute of Health Doutor Ricardo Jorge"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-8557","authenticated-orcid":false,"given":"Francisco","family":"Enguita","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Universidade de Lisboa"}]},{"given":"Anita","family":"Gomes","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular"}]}],"member":"297","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.researchsquare.com\/article\/rs-4187285\/v1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.researchsquare.com\/article\/rs-4187285\/v1.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T16:30:46Z","timestamp":1712680246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchsquare.com\/article\/rs-4187285\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.21203\/rs.3.rs-4187285\/v1","relation":{},"subject":[],"published":{"date-parts":[[2024,4,1]]},"subtype":"preprint"}}