{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:47:33Z","timestamp":1747205253573,"version":"3.40.5"},"posted":{"date-parts":[[2024,6,5]]},"group-title":"In Review","reference-count":52,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,4,26]]},"abstract":"<title>Abstract<\/title>\n        <p>Kadsuric acid, a major triterpenoid isolated from the leaves of Vietnamese <italic>Kadsura coccinea<\/italic>, exhibited potent cytotoxic effects in some human cancer cells. In this study, the effects of kadsuric acid on pancreatic cancer cells PANC-1 were investigated. The results showed that kadsuric acid exhibited dose-dependent cytotoxicity against PANC-1 with an IC50 value of 14.5\u2009\u00b1\u20090.8 \u00b5M. Kadsuric acid effectively activated caspase-3 by increasing the level of enzyme cleavage by 1\u20132 times after 12 and 24 h, and by more than 3\u20134 times compared to the negative control. In addition, this compound enhanced both two types of cysteine-aspartic acid proteases, including caspase-3 and caspase-9 through protein expressions. Western blot analysis also indicated that kadsuric acid reduced Poly [ADP-ribose] polymerase 1 (PARP1) expression in PANC-1 cells. For underlying mechanism insights, molecular modeling methods were applied to investigate the binding interaction between kadsuric acid and PARP1. Compared to the co-crystallized ligand, kadsuric acid displayed a stronger binding affinity (-9.3 kcal\/mol). A molecular dynamics simulation showed that the complex is stable over 200 ns. Taken together, it can be determined that kadsuric acid can interact with the DNA of human pancreatic cancer cells through the intrinsic caspase\/PARP-1 pathway. This study can guide future research on kadsuric acid as PARP1 inhibitor for cancer treatment.<\/p>","DOI":"10.21203\/rs.3.rs-4328289\/v1","type":"posted-content","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T15:05:23Z","timestamp":1717599923000},"source":"Crossref","is-referenced-by-count":0,"title":["Apoptosis induction of kadsuric acid from Vietnamese Kadsura coccinea (Lem.) A. C. Smith in human pancreatic cancer cells: in vitro and in silico approach"],"prefix":"10.21203","author":[{"given":"Tan Khanh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Dong A University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manh Hung","family":"Tran","sequence":"additional","affiliation":[{"name":"The University of Danang"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tan Trung","family":"Truong","sequence":"additional","affiliation":[{"name":"Dong Nai University of Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long-Hung Dinh","family":"Pham","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy at Ho Chi Minh City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phu Chi Hieu","family":"Truong","sequence":"additional","affiliation":[{"name":"The University of Danang"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4359-4924","authenticated-orcid":false,"given":"Phu Tran Vinh","family":"Pham","sequence":"additional","affiliation":[{"name":"VN UK Institute for Research and Executive Education"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SOFTX.2015.06.001","author":"Abraham MJ","year":"2015","unstructured":"Abraham MJ, Murtola T, Schulz R, P\u00e1ll S, Smith JC, Hess B, Lindah E (2015) GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX, 1\u20132, 19\u201325. https:\/\/doi.org\/10.1016\/J.SOFTX.2015.06.001"},{"issue":"8","key":"ref2","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1093\/NAR\/GKZ120","article-title":"Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins","volume":"47","author":"Alemasova EE","year":"2019","unstructured":"Alemasova EE, Lavrik OI (2019) Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins. Nucleic Acids Res 47(8):3811. https:\/\/doi.org\/10.1093\/NAR\/GKZ120","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/BIB\/BBAA161","article-title":"MolAICal: a soft tool for 3D drug design of protein targets by artificial intelligence and classical algorithm","volume":"22","author":"Bai Q","year":"2021","unstructured":"Bai Q, Tan S, Xu T, Liu H, Huang J, Yao X (2021) MolAICal: a soft tool for 3D drug design of protein targets by artificial intelligence and classical algorithm. Brief Bioinform 22(3). https:\/\/doi.org\/10.1093\/BIB\/BBAA161","journal-title":"Brief Bioinform"},{"issue":"11","key":"ref4","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1055\/S-0029-1185537","article-title":"Dibenzocyclooctadiene lignans and lanostane derivatives from the roots of kadsura coccinea and their protective effects on primary rat hepatocyte injury induced by t-butyl hydroperoxide","volume":"75","author":"Ban NK","year":"2009","unstructured":"Ban NK, Van Thanh B, Van Kiem P, Van Minh C, Cuong NX, Nhiem NX, Huong HT, Anh HT, Park EJ, Sohn DH, Kim YH (2009) Dibenzocyclooctadiene lignans and lanostane derivatives from the roots of kadsura coccinea and their protective effects on primary rat hepatocyte injury induced by t-butyl hydroperoxide. Planta Med 75(11):1253\u20131257. https:\/\/doi.org\/10.1055\/S-0029-1185537","journal-title":"Planta Med"},{"issue":"7","key":"ref5","doi-asserted-by":"publisher","first-page":"5648","DOI":"10.1063\/1.464913","article-title":"Density-functional thermochemistry. III. The role of exact exchange","volume":"98","author":"Becke AD","year":"1993","unstructured":"Becke AD (1993) Density-functional thermochemistry. III. The role of exact exchange. J Chem Phys 98(7):5648\u20135652. https:\/\/doi.org\/10.1063\/1.464913","journal-title":"J Chem Phys"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/07391102.2023.2187218","article-title":"Investigating the antibacterial mechanism of Ampelopsis cantoniensis extracts against methicillin-resistant Staphylococcus aureus via in vitro and in silico analysis","author":"Bich VNT","year":"2023","unstructured":"Bich VNT, Nguyen TK, Thu TDT, Tran LTT, Nguyen SVD, Han H, Le, Pham L-HD, Thanh TH, Duong VH, Trieu TA, Tran MH, Pham PTV (2023) Investigating the antibacterial mechanism of Ampelopsis cantoniensis extracts against methicillin-resistant Staphylococcus aureus via in vitro and in silico analysis. J Biomol Struct Dynamics 1\u201312. https:\/\/doi.org\/10.1080\/07391102.2023.2187218","journal-title":"J Biomol Struct Dynamics"},{"issue":"1","key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-14-32","article-title":"Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis","volume":"14","author":"Brentnall M","year":"2013","unstructured":"Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH (2013) Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol 14(1). https:\/\/doi.org\/10.1186\/1471-2121-14-32","journal-title":"BMC Cell Biol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"842376","DOI":"10.3389\/fphar.2022.842376","article-title":"Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics","volume":"13","author":"Chaudhry G-E-S","year":"2022","unstructured":"Chaudhry G-E-S, Akim M, Sung A, Y. Y., Sifzizul TMT (2022) Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics. Front Pharmacol 13:842376. https:\/\/doi.org\/10.3389\/fphar.2022.842376","journal-title":"Front Pharmacol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1201\/B11185\/","article-title":"Anticancer agents from natural products","author":"Cragg GM","year":"2005","unstructured":"Cragg GM, Kingston DGI, Newman DJ (2005) Anticancer agents from natural products. Anticancer Agents Nat Prod 1\u2013593. https:\/\/doi.org\/10.1201\/B11185\/. ANTICANCER-AGENTS-NATURAL-PRODUCTS-DAVID-NEWMAN-DAVID-KINGSTON-GORDON-CRAGG","journal-title":"Anticancer Agents Nat Prod"},{"issue":"1","key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25405-w","article-title":"Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation","volume":"12","author":"Dadheech N","year":"2022","unstructured":"Dadheech N, Srivastava A, Shah RG, Shah GM, Gupta S (2022) Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation. Sci Rep 12(1). https:\/\/doi.org\/10.1038\/s41598-022-25405-w","journal-title":"Sci Rep"},{"issue":"7","key":"ref11","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.1002\/ptr.7114","article-title":"Anti-gastric cancer activity and mechanism of natural compound Heilaohulignan C isolated from Kadsura coccinea","volume":"35","author":"Daniyal M","year":"2021","unstructured":"Daniyal M, Liu Y, Yang Y, Xiao F, Fan J, Yu H, Qiu Y, Liu B, Wang W, Yuhui Q (2021) Anti-gastric cancer activity and mechanism of natural compound Heilaohulignan C isolated from Kadsura coccinea. Phytother Res 35(7):3977\u20133987. https:\/\/doi.org\/10.1002\/ptr.7114","journal-title":"Phytother Res"},{"year":"2016","author":"Dennington R","key":"ref12","unstructured":"Dennington R (2016) T. K. and J. G. M. GaussView, version 6.0. 16"},{"issue":"8","key":"ref13","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1021\/ACS.JCIM.1C00203\/SUPPL_FILE\/CI1C00203_SI_002.ZIP","article-title":"AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings","volume":"61","author":"Eberhardt J","year":"2021","unstructured":"Eberhardt J, Santos-Martins D, Tillack AF, Forli S (2021) AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings. J Chem Inf Model 61(8):3891\u20133898. https:\/\/doi.org\/10.1021\/ACS.JCIM.1C00203\/SUPPL_FILE\/CI1C00203_SI_002.ZIP","journal-title":"J Chem Inf Model"},{"year":"2016","author":"Frisch MJ","key":"ref14","unstructured":"Frisch MJ (2016) T. G. W., S. H. B., S. G. E., R. M. A., C. J. R. ; S. G. ; B. V. ; P. Gaussian 16"},{"issue":"12","key":"ref15","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/S12094-007-0138-9","article-title":"Natural products as leads to anticancer drugs","volume":"9","author":"Gordaliza M","year":"2007","unstructured":"Gordaliza M (2007) Natural products as leads to anticancer drugs. Clin Transl Oncol 9(12):767\u2013776. https:\/\/doi.org\/10.1007\/S12094-007-0138-9","journal-title":"Clin Transl Oncol"},{"issue":"3","key":"ref16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.carrev.2006.02.002","article-title":"A concise review of DNA damage checkpoints and repair in mammalian cells","volume":"7","author":"Houtgraaf JH","year":"2006","unstructured":"Houtgraaf JH, Versmissen J, van der Giessen WJ (2006) A concise review of DNA damage checkpoints and repair in mammalian cells. Cardiovasc Revascularization Med 7(3):165\u2013172. https:\/\/doi.org\/10.1016\/j.carrev.2006.02.002","journal-title":"Cardiovasc Revascularization Med"},{"issue":"10","key":"ref17","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1021\/acs.jnatprod.6b00508","article-title":"Rearranged 6\/6\/5\/6-fused triterpenoid acids from the stems of Kadsura coccinea","volume":"79","author":"Hu ZX","year":"2016","unstructured":"Hu ZX, Hu K, Shi YM, Wang WG, Du X, Li Y, Zhang YH, Pu JX, Sun HD (2016) Rearranged 6\/6\/5\/6-fused triterpenoid acids from the stems of Kadsura coccinea. J Nat Prod 79(10):2590\u20132598. https:\/\/doi.org\/10.1021\/acs.jnatprod.6b00508","journal-title":"J Nat Prod"},{"issue":"18","key":"ref18","doi-asserted-by":"publisher","first-page":"4616","DOI":"10.1021\/ACS.ORGLETT.5B02360","article-title":"Kadcoccinones A-F, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons from Kadsura coccinea","volume":"17","author":"Hu ZX","year":"2015","unstructured":"Hu ZX, Shi YM, Wang WG, Li XN, Du X, Liu M, Li Y, Xue YB, Zhang YH, Pu JX, Sun HD (2015) Kadcoccinones A-F, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons from Kadsura coccinea. Org Lett 17(18):4616\u20134619. https:\/\/doi.org\/10.1021\/ACS.ORGLETT.5B02360","journal-title":"Org Lett"},{"issue":"11","key":"ref19","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1002\/JCC.20945","article-title":"CHARMM-GUI: A web-based graphical user interface for CHARMM","volume":"29","author":"Jo S","year":"2008","unstructured":"Jo S, Kim T, Iyer VG, Im W (2008) CHARMM-GUI: A web-based graphical user interface for CHARMM. J Comput Chem 29(11):1859\u20131865. https:\/\/doi.org\/10.1002\/JCC.20945","journal-title":"J Comput Chem"},{"issue":"2","key":"ref20","first-page":"189","article-title":"Discovery of Natural Product Anticancer Agents from Biodiverse Organisms","volume":"12","author":"Kinghorn AD","year":"2009","unstructured":"Kinghorn AD, Chin YW, Swanson SM (2009) Discovery of Natural Product Anticancer Agents from Biodiverse Organisms. Curr Opin Drug Discov Devel 12(2):189. \/pmc\/articles\/PMC2877274\/","journal-title":"Curr Opin Drug Discov Devel"},{"issue":"1","key":"ref21","first-page":"11","article-title":"Tran Phi Long, Jeong Hyung Lee, Phuong Thien Thuong, Tran Luu Phuong Thuy, & Tran Manh Hung","volume":"23","author":"Nguyen BT","year":"2018","unstructured":"Le Nguyen BT, Linh LM, Dang NH, Thao TP (2018) Tran Phi Long, Jeong Hyung Lee, Phuong Thien Thuong, Tran Luu Phuong Thuy, & Tran Manh Hung. T\u1ea1p Ch\u00ed D\u01b0\u1ee3c Li\u1ec7u 23(1):11\u201317S\u00e0ng l\u1ecdc ho\u1ea1t t\u00ednh \u0111\u1ed9c t\u1ebf b\u00e0o c\u1ee7a d\u1ecbch chi\u1ebft c\u1ed3n t\u1eeb c\u00e1c d\u01b0\u1ee3c li\u1ec7u thu h\u00e1i t\u1ea1i Qu\u1ea3ng Nam, \u0110\u00e0 N\u1eb5ng tr\u00ean d\u00f2ng t\u1ebf b\u00e0o ung th\u01b0 tuy\u1ebfn t\u1ee5y","journal-title":"T\u1ea1p Ch\u00ed D\u01b0\u1ee3c Li\u1ec7u"},{"issue":"1","key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/S12943-020-01227-0","article-title":"PARP inhibitor resistance: The underlying mechanisms and clinical implications","volume":"19","author":"Li H","year":"2020","unstructured":"Li H, Liu ZY, Wu N, Chen YC, Cheng Q, Wang J (2020) PARP inhibitor resistance: The underlying mechanisms and clinical implications. Mol Cancer 19(1). https:\/\/doi.org\/10.1186\/S12943-020-01227-0","journal-title":"Mol Cancer"},{"issue":"12","key":"ref23","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1021\/NP400546Z","article-title":"Kadcotriones A-C: Tricyclic triterpenoids from kadsura coccinea","volume":"76","author":"Liang CQ","year":"2013","unstructured":"Liang CQ, Shi YM, Li XY, Luo RH, Li Y, Zheng YT, Zhang H, Bin, Xiao WL, Sun HD (2013) Kadcotriones A-C: Tricyclic triterpenoids from kadsura coccinea. J Nat Prod 76(12):2350\u20132354. https:\/\/doi.org\/10.1021\/NP400546Z","journal-title":"J Nat Prod"},{"issue":"8\u20139","key":"ref24","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.phymed.2014.01.015","article-title":"Genus Kadsura, a good source with considerable characteristic chemical constituents and potential bioactivities","volume":"21","author":"Liu J","year":"2014","unstructured":"Liu J, Qi Y, Lai H, Zhang J, Jia X, Liu H, Zhang B, Xiao P (2014) Genus Kadsura, a good source with considerable characteristic chemical constituents and potential bioactivities. Phytomedicine 21(8\u20139):1092\u20131097. https:\/\/doi.org\/10.1016\/j.phymed.2014.01.015","journal-title":"Phytomedicine"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/FNUT.2022.903218","author":"Long H","year":"2022","unstructured":"Long H, Xia X, Liao S, Wu T, Wang L, Chen Q, Wei S, Gu X, Zhu Z (2022) Physicochemical Characterization and Antioxidant and Hypolipidaemic Activities of a Polysaccharide From the Fruit of Kadsura coccinea (Lem.) A. C. Smith. Frontiers in Nutrition, 9. https:\/\/doi.org\/10.3389\/FNUT.2022.903218"},{"issue":"4","key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/FOODS11040556","article-title":"Phenolics Profile and Protective Effect on Injuried HUVEC Cells of Epicarp Extracts from Kadsura coccinea","volume":"11","author":"Lu J","year":"2022","unstructured":"Lu J, Zheng Y, Yang Z, Cheng J, Luo F (2022) Phenolics Profile and Protective Effect on Injuried HUVEC Cells of Epicarp Extracts from Kadsura coccinea. Foods 11(4). https:\/\/doi.org\/10.3390\/FOODS11040556","journal-title":"Foods"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114425","author":"Medoro A","year":"2023","unstructured":"Medoro A, Jafar TH, Ali S, Trung TT, Sorrenti V, Intrieri M, Scapagnini G, Davinelli S (2023) In silico evaluation of geroprotective phytochemicals as potential sirtuin 1 interactors. Biomedicine and Pharmacotherapy, 161. https:\/\/doi.org\/10.1016\/j.biopha.2023.114425"},{"issue":"16","key":"ref28","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/JCC.21256","article-title":"AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility","volume":"30","author":"Morris GM","year":"2009","unstructured":"Morris GM, Ruth H, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ (2009) AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility. J Comput Chem 30(16):2785. https:\/\/doi.org\/10.1002\/JCC.21256","journal-title":"J Comput Chem"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133627","author":"Nguyen TK","year":"2022","unstructured":"Nguyen TK, Nguyen TN, Le, Nguyen K, Nguyen HVT, Tran LTT, Ngo TXT, Pham PTV, Tran MH (2022) Machine learning-based screening of MCF-7 human breast cancer cells and molecular docking analysis of essential oils from Ocimum basilicum against breast cancer. Journal of Molecular Structure, 1268. https:\/\/doi.org\/10.1016\/j.molstruc.2022.133627"},{"issue":"7","key":"ref30","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X221117310\/ASSET\/IMAGES\/LARGE\/10.1177_1934578X221117310-FIG1.JPEG","article-title":"Deep Learning Model to Identify Potential Acetylcholinesterase Inhibitors: A Case Study of Isolated Compounds From Pongamia pinnata (L.) Pierre","volume":"17","author":"Nguyen TK","year":"2022","unstructured":"Nguyen TK, Tran TH, Nguyen K, Ho DV, Nguyen HT, Tran LTT (2022) Deep Learning Model to Identify Potential Acetylcholinesterase Inhibitors: A Case Study of Isolated Compounds From Pongamia pinnata (L.) Pierre. Nat Prod Commun 17(7). https:\/\/doi.org\/10.1177\/1934578X221117310\/ASSET\/IMAGES\/LARGE\/10.1177_1934578X221117310-FIG1.JPEG","journal-title":"Nat Prod Commun"},{"key":"ref31","unstructured":"Pham Hoang Ho (2006) C\u00e2y C\u00f3 V\u1ecb Thu\u1ed1c \u1ede Vi\u1ec7t Nam - T\u00e1i b\u1ea3n 12\/06\/2006, NXB Tr\u1ebb (Medicinal plants in Vietnam, 2006 Edition. Youth Publishing House, Vietnam)),"},{"issue":"7","key":"ref32","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/BIOINFORMATICS\/BTT055","article-title":"GROMACS 4.5: A high-throughput and highly parallel open source molecular simulation toolkit","volume":"29","author":"Pronk S","year":"2013","unstructured":"Pronk S, P\u00e1ll S, Schulz R, Larsson P, Bjelkmar P, Apostolov R, Shirts MR, Smith JC, Kasson PM, Van Der Spoel D, Hess B, Lindahl E (2013) GROMACS 4.5: A high-throughput and highly parallel open source molecular simulation toolkit. Bioinformatics 29(7):845\u2013854. https:\/\/doi.org\/10.1093\/BIOINFORMATICS\/BTT055","journal-title":"Bioinformatics"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/J.YMETH.2017.09.008","article-title":"In silico methods for design of biological therapeutics","volume":"131","author":"Roy A","year":"2017","unstructured":"Roy A, Nair S, Sen N, Soni N, Madhusudhan MS (2017) In silico methods for design of biological therapeutics. Methods (San Diego Calif) 131:33\u201365. https:\/\/doi.org\/10.1016\/J.YMETH.2017.09.008","journal-title":"Methods (San Diego Calif)"},{"issue":"1","key":"ref34","doi-asserted-by":"publisher","DOI":"10.1186\/S13046-021-02139-7","article-title":"The role of patient-derived ovarian cancer organoids in the study of PARP inhibitors sensitivity and resistance: from genomic analysis to functional testing","volume":"40","author":"Tao M","year":"2021","unstructured":"Tao M, Wu X (2021) The role of patient-derived ovarian cancer organoids in the study of PARP inhibitors sensitivity and resistance: from genomic analysis to functional testing. J Experimental Clin Cancer Res 40(1). https:\/\/doi.org\/10.1186\/S13046-021-02139-7","journal-title":"J Experimental Clin Cancer Res"},{"issue":"10","key":"ref35","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1080\/14786419.2021.1914612","article-title":"A new triterpenoid from the stems of Kadsura coccinea with antiproliferative activity","volume":"36","author":"Tram LH","year":"2022","unstructured":"Tram LH, Huong T, Thi Thuy T, Van Thong L, Tuan Anh N, Minh NH, Ha NT, Anh Dung T, Thao D, Thuong NP, Le PT, Hiep DD, N. D., Shin HJ (2022) A new triterpenoid from the stems of Kadsura coccinea with antiproliferative activity. Nat Prod Res 36(10):2542\u20132546. https:\/\/doi.org\/10.1080\/14786419.2021.1914612","journal-title":"Nat Prod Res"},{"issue":"11","key":"ref36","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X221138435","article-title":"Phytochemicals Derived from Goniothalamus elegans Ast Exhibit Anticancer Activity by Inhibiting Epidermal Growth Factor Receptor","volume":"17","author":"Tran LTT","year":"2022","unstructured":"Tran LTT, Pham LHD, Dang NYT, Le N, Nguyen NT, H. B., Nguyen TK (2022) Phytochemicals Derived from Goniothalamus elegans Ast Exhibit Anticancer Activity by Inhibiting Epidermal Growth Factor Receptor. Nat Prod Commun 17(11). https:\/\/doi.org\/10.1177\/1934578X221138435","journal-title":"Nat Prod Commun"},{"issue":"14","key":"ref37","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24142538","article-title":"The Effects of 20,40-Dihydroxy-60-methoxy-30,50-dimethylchalcone from Cleistocalyx operculatus Buds on Human Pancreatic Cancer Cell Lines","volume":"24","author":"Tuan HN","year":"2019","unstructured":"Tuan HN, Minh BH, Tran PT, Lee JH, Van Oanh H, Ngo T, Nguyen QM, Lien YNK, P. T., Tran MH (2019) The Effects of 20,40-Dihydroxy-60-methoxy-30,50-dimethylchalcone from Cleistocalyx operculatus Buds on Human Pancreatic Cancer Cell Lines. Molecules 24(14). https:\/\/doi.org\/10.3390\/molecules24142538","journal-title":"Molecules"},{"issue":"9","key":"ref38","doi-asserted-by":"publisher","first-page":"5655","DOI":"10.1007\/s11696-022-02273-2","article-title":"Antioxidant activity and \u03b1-glucosidase inhibitability of Distichochlamys citrea M.F. Newman rhizome fractionated extracts: in vitro and in silico screenings","volume":"76","author":"Chen T","year":"2022","unstructured":"Van Chen T, Cuong TD, Quy PT, Bui TQ, Van Tuan L, Van Hue N, Triet NT, Ho DV, Bao NC, Nhung NTA (2022) Antioxidant activity and \u03b1-glucosidase inhibitability of Distichochlamys citrea M.F. Newman rhizome fractionated extracts: in vitro and in silico screenings. Chem Pap 76(9):5655\u20135675. https:\/\/doi.org\/10.1007\/s11696-022-02273-2","journal-title":"Chem Pap"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127673","author":"Vo PHT","year":"2021","unstructured":"Vo PHT, Nguyen TDT, Tran HT, Nguyen YN, Doan MT, Nguyen PH, Lien GTK, To DC, Tran MH (2021) Cytotoxic components from the leaves of Erythrophleum fordii induce human acute leukemia cell apoptosis through caspase 3 activation and PARP cleavage. Bioorganic and Medicinal Chemistry Letters, 31. https:\/\/doi.org\/10.1016\/j.bmcl.2020.127673"},{"issue":"15","key":"ref40","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1055\/S-0032-1315260","article-title":"Five new 3,4-seco-lanostane-type triterpenoids with antiproliferative activity in human leukemia cells isolated from the roots of Kadsura coccinea","volume":"78","author":"Wang N","year":"2012","unstructured":"Wang N, Li ZL, Song DD, Li W, Pei YH, Jing YK, Hua HM (2012) Five new 3,4-seco-lanostane-type triterpenoids with antiproliferative activity in human leukemia cells isolated from the roots of Kadsura coccinea. Planta Med 78(15):1661\u20131666. https:\/\/doi.org\/10.1055\/S-0032-1315260","journal-title":"Planta Med"},{"issue":"2","key":"ref41","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s12272-020-01211-8","article-title":"Chemical constituents from the roots of Kadsura coccinea with their protein tyrosine phosphatase 1B and acetylcholinesterase inhibitory activities","volume":"43","author":"Woo MH","year":"2020","unstructured":"Woo MH, Nguyen DH, Choi JS, Park SE, Thuong PT, Min BS, Le DD (2020) Chemical constituents from the roots of Kadsura coccinea with their protein tyrosine phosphatase 1B and acetylcholinesterase inhibitory activities. Arch Pharm Res 43(2):204\u2013213. https:\/\/doi.org\/10.1007\/s12272-020-01211-8","journal-title":"Arch Pharm Res"},{"issue":"3","key":"ref42","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/S13659-019-0203-4","article-title":"Four 14(13 \u2192 12)-Abeolanostane Triterpenoids with 6\/6\/5\/6-Fused Ring System from the Roots of Kadsura coccinea","volume":"9","author":"Xu HC","year":"2019","unstructured":"Xu HC, Hu K, Sun HD, Puno PT (2019) Four 14(13 \u2192 12)-Abeolanostane Triterpenoids with 6\/6\/5\/6-Fused Ring System from the Roots of Kadsura coccinea. Nat Prod Bioprospecting 9(3):165\u2013173. https:\/\/doi.org\/10.1007\/S13659-019-0203-4","journal-title":"Nat Prod Bioprospecting"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2022.1020643\/FULL","author":"Yam CQX","year":"2022","unstructured":"Yam CQX, Lim HH, Surana U (2022) DNA damage checkpoint execution and the rules of its disengagement. Frontiers in Cell and Developmental Biology, 10. https:\/\/doi.org\/10.3389\/FCELL.2022.1020643\/FULL"},{"issue":"3","key":"ref44","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.chmed.2020.03.006","article-title":"Kadsura coccinea: A rich source of structurally diverse and biologically important compounds","volume":"12","author":"Yang Y","year":"2020","unstructured":"Yang Y, Hussain N, Zhang L, Jia Y, Jian Y, Li B, Iqbal Choudhary M, Rahman A, Wang W (2020) Kadsura coccinea: A rich source of structurally diverse and biologically important compounds. Chin Herb Med 12(3):214\u2013223. https:\/\/doi.org\/10.1016\/j.chmed.2020.03.006","journal-title":"Chin Herb Med"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105277","author":"Yang Y","year":"2021","unstructured":"Yang Y, Jian Y, Cheng S, Jia Y, Liu Y, Yu H, Cao L, Li B, Peng C, Choudhary I, Rahman M, A. ur, Wang W (2021) Dibenzocyclooctadiene lignans from Kadsura coccinea alleviate APAP-induced hepatotoxicity via oxidative stress inhibition and activating the Nrf2 pathway in vitro. Bioorganic Chemistry, 115. https:\/\/doi.org\/10.1016\/j.bioorg.2021.105277"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2021.113018","author":"Yang Y","year":"2022","unstructured":"Yang Y, Liu Y, Yu H, Xie Q, Wang B, Jiang S, Su W, Mao Y, Li B, Peng C, Jian Y, Wang W (2022) Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-\u03baB and JAK2\/STAT3 signal pathways. Phytochemistry, 194. https:\/\/doi.org\/10.1016\/j.phytochem.2021.113018"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3389\/FCHEM.2021.808870\/FULL","author":"Yang YP","year":"2021a","unstructured":"Yang YP, Jian YQ, Liu YB, Ismail M, Xie QL, Yu HH, Wang B, Li B, Peng CY, Liu B, Man RY, Wang W (2021a) Triterpenoids From Kadsura coccinea With Their Anti-inflammatory and Inhibited Proliferation of Rheumatoid Arthritis-Fibroblastoid Synovial Cells Activities. Frontiers in Chemistry, 9. https:\/\/doi.org\/10.3389\/FCHEM.2021.808870\/FULL"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.3389\/FCHEM.2021.808870","author":"Yang YP","year":"2021b","unstructured":"Yang YP, Jian YQ, Liu YB, Ismail M, Xie QL, Yu HH, Wang B, Li B, Peng CY, Liu B, Man RY, Wang W (2021b) Triterpenoids From Kadsura coccinea With Their Anti-inflammatory and Inhibited Proliferation of Rheumatoid Arthritis-Fibroblastoid Synovial Cells Activities. Frontiers in Chemistry, 9. https:\/\/doi.org\/10.3389\/FCHEM.2021.808870"},{"issue":"4","key":"ref49","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.molcel.2018.04.019","article-title":"Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size","volume":"70","author":"Yosefzon Y","year":"2018","unstructured":"Yosefzon Y, Soteriou D, Feldman A, Kostic L, Koren E, Brown S, Ankawa R, Sedov E, Glaser F, Fuchs Y (2018) Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Mol Cell 70(4):573\u2013587e4. https:\/\/doi.org\/10.1016\/j.molcel.2018.04.019","journal-title":"Mol Cell"},{"issue":"24","key":"ref50","doi-asserted-by":"publisher","first-page":"16099","DOI":"10.1021\/ACS.JMEDCHEM.2C01352\/ASSET","article-title":"Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer Treatment","volume":"65","author":"Zhang J","year":"2022","unstructured":"Zhang J, Gao Y, Zhang Z, Zhao J, Jia W, Xia C, Wang F, Liu T (2022) Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer Treatment. J Med Chem 65(24):16099\u201316127. https:\/\/doi.org\/10.1021\/ACS.JMEDCHEM.2C01352\/ASSET. \/IMAGES\/LARGE\/JM2C01352_0028.JPEG","journal-title":"J Med Chem"},{"issue":"11","key":"ref51","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1007\/S12272-013-0186-3","article-title":"Cytotoxic dibenzocyclooctadiene lignans from Kadsura coccinea","volume":"37","author":"Zhao QJ","year":"2014","unstructured":"Zhao QJ, Song Y, Chen HS (2014) Cytotoxic dibenzocyclooctadiene lignans from Kadsura coccinea. Arch Pharm Res 37(11):1375\u20131379. https:\/\/doi.org\/10.1007\/S12272-013-0186-3","journal-title":"Arch Pharm Res"},{"issue":"20","key":"ref52","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26206259","article-title":"Chemical composition and biological activities of essential oils from the leaves, stems, and roots of kadsura coccinea","volume":"26","author":"Zhao T","year":"2021","unstructured":"Zhao T, Ma C, Zhu G (2021) Chemical composition and biological activities of essential oils from the leaves, stems, and roots of kadsura coccinea. Molecules 26(20). https:\/\/doi.org\/10.3390\/molecules26206259","journal-title":"Molecules"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.researchsquare.com\/article\/rs-4328289\/v1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.researchsquare.com\/article\/rs-4328289\/v1.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T17:15:08Z","timestamp":1726506908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchsquare.com\/article\/rs-4328289\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,5]]},"references-count":52,"URL":"https:\/\/doi.org\/10.21203\/rs.3.rs-4328289\/v1","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1007\/s43450-024-00588-7","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2024,6,5]]},"subtype":"preprint"}}