{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:28:23Z","timestamp":1719448103502},"posted":{"date-parts":[[2024,6,26]]},"group-title":"In Review","reference-count":31,"publisher":"Research Square Platform LLC","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,6,5]]},"abstract":"<title>Abstract<\/title>\n        <p><bold>Purpose <\/bold>\u2013 Although meningiomas have mostly a favourable prognosis, some have early recurrences or the need for a new treatment, irrespective of the histological grade. In this study, we aimed to characterize clinical, radiological, and molecular markers in a cohort of patients with early recurrent meningiomas.\n<bold>Methods <\/bold>\u2013 We conducted a retrospective, non-interventional study of patients with World Health Organization (WHO) grade 1 or 2 meningiomas who underwent surgical resection at Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o between 2010 and 2021, and who had tumour recurrence or needed retreatment in the subsequent 5 years. We analysed demographic, clinical, radiological, histological, treatment-associated parameters, molecular features (TERT promotor mutations and CDKN2A\/B deletion), and progression\/survival data. An analysis was conducted to determine which variables were associated with shorter time-to-progression, aiming to identify predictors with a greater impact on early and rapid recurrence.\n<bold>Results <\/bold>\u2013 We evaluated 64 patients. The median time of progression-free survival (PFS) was 26 months. Shorter PFS was associated with WHO grade 2 (11 vs 27 months, p = 0.010), mitotic index \u22658 (7 vs 26 months, p &lt;0.001), and T1-weighted image signal (T1w) hyperintensity (15 vs 26 months, p = 0.025). None of the cases showed CDKN2A\/B deletion, while TERT promoter mutations were detected in four meningiomas.\n<bold>Conclusion <\/bold>\u2013 In this study of early recurrence of meningiomas, WHO grade 2, mitotic index \u22658, and T1w hyperintensity were significantly associated with shorter PFS, while molecular biomarkers usually associated with shorter PFS (TERT promoter mutations and CDKN2A\/B deletion) were only detected in four patients.<\/p>","DOI":"10.21203\/rs.3.rs-4536290\/v1","type":"posted-content","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T19:31:20Z","timestamp":1719430280000},"source":"Crossref","is-referenced-by-count":0,"title":["Predictors of early recurrence in meningioma"],"prefix":"10.21203","author":[{"given":"Diogo Abreu","family":"Soberano","sequence":"first","affiliation":[{"name":"Faculty of Medicine of University of Porto, Porto, Portugal"}]},{"given":"Jorge","family":"Lima","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of University of Porto (Ipatimup), Porto, Portugal"}]},{"given":"Jorge","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Pathology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Maria Jos\u00e9","family":"Soares","sequence":"additional","affiliation":[{"name":"Clinical Haematology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Mafalda","family":"Pinto","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health (i3S), R. Alfredo Allen, Porto, Portugal"}]},{"given":"Anabela","family":"Ferro","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of University of Porto (Ipatimup), Porto, Portugal"}]},{"given":"Paulo","family":"Linhares","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Bruno","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]}],"member":"8761","reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"910199","DOI":"10.3389\/fonc.2022.910199","article-title":"Recent advances in the molecular prognostication of meningiomas","volume":"12","author":"Wang EJ","year":"2022","unstructured":"Wang EJ, Haddad AF, Young JS, Morshed RA, Wu JPH, Salha DM, Butowski N, Aghi MK (2022) Recent advances in the molecular prognostication of meningiomas. 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