{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T05:25:16Z","timestamp":1736227516838,"version":"3.32.0"},"posted":{"date-parts":[[2024,7,29]]},"group-title":"In Review","reference-count":40,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,7,1]]},"abstract":"<title>Abstract<\/title>\n        <p><bold>Objectives: <\/bold>This study evaluates the clinical utility of the Patient-Reported Outcomes Measurement Information System (PROMIS\u00ae) by comparing it with objective clinical data and validated health-related quality of life (HRQOL) measures in pediatric Crohn\u2019s disease (CD) patients.\n<bold>Study Design: <\/bold>Cross-sectional study. Pediatric CD patients (aged 8-17 years) were enrolled prospectively over eight months from an outpatient pediatric gastroenterology center. We assessed the associations between PROMIS\u00ae Pediatric short-form measures, demographic and disease-related data, global clinical assessments, and HRQOL measures. A sub-analysis according to PCDAI score (remission versus active disease) was also conducted.\n<bold>Results: <\/bold>31 patients included (mean age: 15.3; 58% female) with a mean disease duration of 2.7 years; 80.6% were in remission or with mild disease. PROMIS\u00ae scores showed significant correlations with several factors: age negatively correlated with PROMIS\u00ae Global Health (r=-0.399; p=0.026) and Life Satisfaction (r=-0.359; p=0.047); gender was associated with PROMIS\u00ae Cognitive Function (t=2.20; p=0.038), favoring males; and school level inversely influenced PROMIS\u00ae Peer Relationships (F=3.90; p=0.003). Clinical assessments also revealed significant correlations: hemoglobin with PROMIS\u00ae Global Health (r=0.356; p=0.049) and Pain Interference (r=-0.360; p=0.046); ferritin with PROMIS\u00ae Meaning and Purpose (r=0.435; p=0.016) and Cognitive Function (r=0.450; p=0.011). Disease activity assessments correlated significantly with multiple PROMIS\u00ae measures, with better scores in remission patients. Treatment changes, particularly corticosteroids, negatively impacted PROMIS\u00ae Anxiety and Life Satisfaction scores. IMPACT-III scores correlated positively with PROMIS\u00ae Global Health, Meaning and Purpose, Life Satisfaction, peer relationships and negatively with Depression, Anxiety, Pain interference, and Fatigue. Group analysis indicated better PROMIS\u00ae scores and HRQOL scores in remission, as compared to active disease.\n<bold>Conclusion: <\/bold>Consistent with recent evidence, PROMIS\u00ae scores reliably reflect disease activity and HRQOL. The meaningful associations with clinical assessment and treatment efficacy, reinforce the clinical relevance and utility of PROs in the patient-centered management of pediatric IBD and highlight the importance of self-reporting as a gold standard tool for assessing health status.<\/p>","DOI":"10.21203\/rs.3.rs-4668853\/v1","type":"posted-content","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T07:12:05Z","timestamp":1722237125000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical Usefulness of Patient-Reported-Outcome-Measurement Information System in Pediatric Crohn\u2019s Disease: A Cross-Sectional Study"],"prefix":"10.21203","author":[{"given":"Sara","family":"Azevedo","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Pediatric Department, Santa Maria University Hospital - CHLN, Academic Medical Centre of Lisbon"}]},{"given":"Maria Miguel","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Medical School, University of Lisbon"}]},{"given":"Paulo","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Medical School, University of Lisbon"}]},{"given":"Ana Isabel","family":"Lopes","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Pediatric Department, Santa Maria University Hospital - CHLN, Academic Medical Centre of Lisbon"}]}],"member":"297","reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1053\/j.gastro.2021.12.282","article-title":"Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review","volume":"162","author":"Kuenzig ME","year":"2022","unstructured":"Kuenzig ME, Fung SG, Marderfeld L, Mak JWY, Kaplan GG, Ng SC, et al. 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Gastroenterol Clin North Am. 2023;52(3):483\u201396.","journal-title":"Gastroenterol Clin North Am"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ajg.2017.228","article-title":"Dramatic Increase in Incidence of Ulcerative Colitis and Crohn's Disease (1988\u20132011): A Population-Based Study of French Adolescents","volume":"113","author":"Ghione S","year":"2018","unstructured":"Ghione S, Sarter H, Fumery M, Armengol-Debeir L, Savoye G, Ley D, et al. Dramatic Increase in Incidence of Ulcerative Colitis and Crohn's Disease (1988\u20132011): A Population-Based Study of French Adolescents. Am J Gastroenterol. 2018;113(2):265\u201372.","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12876-016-0455-y","article-title":"Clinical course and outcomes of diagnosing Inflammatory Bowel Disease in children 10 years and under: retrospective cohort study from two tertiary centres in the United Kingdom and in Italy","volume":"16","author":"Gasparetto M","year":"2016","unstructured":"Gasparetto M, Guariso G, Pozza LVD, Ross A, Heuschkel R, Zilbauer M. Clinical course and outcomes of diagnosing Inflammatory Bowel Disease in children 10 years and under: retrospective cohort study from two tertiary centres in the United Kingdom and in Italy. BMC Gastroenterol. 2016;16(1):35.","journal-title":"BMC Gastroenterol"},{"issue":"41","key":"ref5","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.3748\/wjg.v18.i41.5862","article-title":"Crohn's and colitis in children and adolescents","volume":"18","author":"Day AS","year":"2012","unstructured":"Day AS, Ledder O, Leach ST, Lemberg DA. Crohn's and colitis in children and adolescents. World J Gastroenterol. 2012;18(41):5862\u20139.","journal-title":"World J Gastroenterol"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/j.1365-2036.2011.04628.x","article-title":"The changing pattern of Crohn's disease incidence in northern France: a continuing increase in the 10- to 19-year-old age bracket (1988\u20132007)","volume":"33","author":"Chouraki V","year":"2011","unstructured":"Chouraki V, Savoye G, Dauchet L, Vernier-Massouille G, Dupas JL, Merle V, et al. 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Inflamm Bowel Dis. 2021;27(3):344\u201351.","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/MPG.0000000000003101","article-title":"Validity and Responsiveness of the Patient-reported Outcomes Measurement Information System in Children With Ulcerative Colitis","volume":"73","author":"Brenner EJ","year":"2021","unstructured":"Brenner EJ, Long MD, Mann CM, Lin L, Chen W, Reyes C, et al. Validity and Responsiveness of the Patient-reported Outcomes Measurement Information System in Children With Ulcerative Colitis. J Pediatr Gastroenterol Nutr. 2021;73(1):67\u201372.","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/01.mpg.0000183350.46795.42","article-title":"Evaluation of the pediatric crohn disease activity index: a prospective multicenter experience","volume":"41","author":"Hyams J","year":"2005","unstructured":"Hyams J, Markowitz J, Otley A, Rosh J, Mack D, Bousvaros A, et al. Evaluation of the pediatric crohn disease activity index: a prospective multicenter experience. J Pediatr Gastroenterol Nutr. 2005;41(4):416\u201321.","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"4","key":"ref21","first-page":"439","article-title":"Development and validation of a pediatric Crohn's disease activity index","volume":"12","author":"Hyams JS","year":"1991","unstructured":"Hyams JS, Ferry GD, Mandel FS, Gryboski JD, Kibort PM, Kirschner BS, et al. Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr. 1991;12(4):439\u201347.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref22","unstructured":"Union OJotE. International Standard Classification of Education (ISCED): Commission Regulation (EU) 2013 [."},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/ibd.21493","article-title":"Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification","volume":"17","author":"Levine A","year":"2011","unstructured":"Levine A, Griffiths A, Markowitz J, Wilson DC, Turner D, Russell RK, et al. Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification. Inflamm Bowel Dis. 2011;17(6):1314\u201321.","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0016-5107(04)01878-4","article-title":"Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD","volume":"60","author":"Daperno M","year":"2004","unstructured":"Daperno M, D'Haens G, Van Assche G, Baert F, Bulois P, Maunoury V, et al. Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD. Gastrointest Endosc. 2004;60(4):505\u201312.","journal-title":"Gastrointest Endosc"},{"issue":"4","key":"ref25","first-page":"557","article-title":"The IMPACT questionnaire: a valid measure of health-related quality of life in pediatric inflammatory bowel disease","volume":"35","author":"Otley A","year":"2002","unstructured":"Otley A, Smith C, Nicholas D, Munk M, Avolio J, Sherman PM, et al. 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J Crohns Colitis. 2012;6(5):507\u201317.","journal-title":"J Crohns Colitis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"670902","DOI":"10.3389\/fpsyg.2021.670902","article-title":"Passive Coping Associations With Self-Esteem and Health-Related Quality of Life in Youth With Inflammatory Bowel Disease","volume":"12","author":"Reed B","year":"2021","unstructured":"Reed B, Rea KE, Claar RL, van Tilburg MAL, Levy RL. Passive Coping Associations With Self-Esteem and Health-Related Quality of Life in Youth With Inflammatory Bowel Disease. Front Psychol. 2021;12:670902.","journal-title":"Front Psychol"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/jpepsy\/jsab035","article-title":"Pediatric Global Health in Children with Very Early-Onset Inflammatory Bowel Disease","volume":"46","author":"Holbein CE","year":"2021","unstructured":"Holbein CE, Plevinsky J, Patel T, Conrad MC, Kelsen JR. 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J Pediatr Gastroenterol Nutr. 2011;52(3):295\u20139.","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s11136-015-0953-3","article-title":"PROMIS(\u00ae) pediatric self-report scales distinguish subgroups of children within and across six common pediatric chronic health conditions","volume":"24","author":"DeWalt DA","year":"2015","unstructured":"DeWalt DA, Gross HE, Gipson DS, Selewski DT, DeWitt EM, Dampier CD, et al. PROMIS(\u00ae) pediatric self-report scales distinguish subgroups of children within and across six common pediatric chronic health conditions. Qual Life Res. 2015;24(9):2195\u2013208.","journal-title":"Qual Life Res"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/01.MIB.0000217769.83142.c6","article-title":"Psychosocial functioning in pediatric inflammatory bowel disease","volume":"12","author":"Mackner LM","year":"2006","unstructured":"Mackner LM, Crandall WV, Szigethy EM. Psychosocial functioning in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2006;12(3):239\u201344.","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/jpepsy\/jsj023","article-title":"Brief report: psychosocial adjustment in adolescents with inflammatory bowel disease","volume":"31","author":"Mackner LM","year":"2006","unstructured":"Mackner LM, Crandall WV. Brief report: psychosocial adjustment in adolescents with inflammatory bowel disease. 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Scand J Gastroenterol. 2017;52(1):29\u201333.","journal-title":"Scand J Gastroenterol"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1053\/j.gastro.2021.04.063","article-title":"Approach to the Management of Recently Diagnosed Inflammatory Bowel Disease Patients: A User's Guide for Adult and Pediatric Gastroenterologists","volume":"161","author":"Agrawal M","year":"2021","unstructured":"Agrawal M, Spencer EA, Colombel JF, Ungaro RC. Approach to the Management of Recently Diagnosed Inflammatory Bowel Disease Patients: A User's Guide for Adult and Pediatric Gastroenterologists. 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Clin Exp Gastroenterol. 2021;14:123\u201331.","journal-title":"Clin Exp Gastroenterol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2147\/PRBM.S221435","article-title":"Effects of Patients' Perceptions of Physician-Patient Relational Empathy on an Inflammation Marker in Patients with Crohn's Disease: The Intermediary Roles of Anxiety, Self-Efficacy, and Sleep Quality","volume":"13","author":"Xu X","year":"2020","unstructured":"Xu X, Zhang Y, Wang W, Zhang Y, Yang N. Effects of Patients' Perceptions of Physician-Patient Relational Empathy on an Inflammation Marker in Patients with Crohn's Disease: The Intermediary Roles of Anxiety, Self-Efficacy, and Sleep Quality. Psychol Res Behav Manag. 2020;13:363\u201371.","journal-title":"Psychol Res Behav Manag"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jval.2015.12.004","article-title":"Responsiveness to Change in PROMIS(\u00ae) Measures among Children with Asthma: A Report from the PROMIS(\u00ae) Pediatric Asthma Study","volume":"19","author":"Howell CR","year":"2016","unstructured":"Howell CR, Thompson LA, Gross HE, Reeve BB, DeWalt DA, Huang IC. Responsiveness to Change in PROMIS(\u00ae) Measures among Children with Asthma: A Report from the PROMIS(\u00ae) Pediatric Asthma Study. Value Health. 2016;19(2):192\u2013201.","journal-title":"Value Health"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1477-7525-11-30","article-title":"Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study","volume":"11","author":"Gipson DS","year":"2013","unstructured":"Gipson DS, Selewski DT, Massengill SF, Wickman L, Messer KL, Herreshoff E, et al. Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study. Health Qual Life Outcomes. 2013;11:30.","journal-title":"Health Qual Life Outcomes"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/MPG.0000000000000239","article-title":"ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents","volume":"58","author":"Levine A","year":"2014","unstructured":"Levine A, Koletzko S, Turner D, Escher JC, Cucchiara S, de Ridder L, et al. ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents. 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