{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T16:40:03Z","timestamp":1745858403080,"version":"3.40.4"},"posted":{"date-parts":[[2025,1,1]]},"group-title":"In Review","reference-count":37,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,12,17]]},"abstract":"<title>Abstract<\/title>\n        <p>Crosstalk mechanisms between retinas were never documented in humans despite being documented for several other species, including non-human primates. Here, we report the results of the first-in-human study that documents the crosstalk between retinas by measuring the vascular response in one retina to the photic stimulation of the contralateral eye in health and disease. We developed a stimulation apparatus and integrated it into an adaptive-optics fundus camera to image 32 healthy control (HC) subjects and 20 type 1 diabetes mellitus (DM) patients. We documented both the ipsilateral and the contralateral neurovascular coupling effect and established criteria to consider an actual response to find positive and negative responses. Ten (31.2%) and two (6.2%) subjects of the HC group presented contralateral positive and negative responses, respectively, and three (15.0%) positive and four (20.0%) negative responses were found for the DM group. Also, statistically significant differences in the ipsilateral and contralateral responses were found for the HC group, rejecting the null (non-response) hypothesis. This finding raises the need to revisit the current knowledge of neurovascular coupling mechanisms and the association between its dysregulation and neurological disorders. Further studies involving distinct populations and imaging centers are necessary to validate the findings herein.<\/p>","DOI":"10.21203\/rs.3.rs-5661001\/v1","type":"posted-content","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T16:52:03Z","timestamp":1735750323000},"source":"Crossref","is-referenced-by-count":0,"title":["Direct crosstalk between adult human retinas as suggested by interocular transfer of neurovascular coupling through photic stimulation"],"prefix":"10.21203","author":[{"given":"Jo\u00e3o","family":"Jord\u00e3o","sequence":"first","affiliation":[{"name":"University of Coimbra, Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra"}]},{"given":"Jo\u00e3o","family":"Figueira","sequence":"additional","affiliation":[{"name":"University of Coimbra, Faculty of Medicine, Clinical and Academic Centre of Coimbra (CACC), Coimbra"}]},{"given":"Miguel","family":"Morgado","sequence":"additional","affiliation":[{"name":"University of Coimbra, Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra"}]},{"given":"Pedro","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"University of Coimbra, Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra"}]},{"given":"Pedro","family":"Serranho","sequence":"additional","affiliation":[{"name":"University of Coimbra, Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra"}]},{"given":"Daniela","family":"Castro-Far\u00edas","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, Paris Eye Imaging, Paris"}]},{"given":"Delia Cabrera","family":"DeBuc","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University Miami Miller School of Medicine, Miami, Florida"}]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[{"name":"University of Coimbra, Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra"}]},{"given":"Michel","family":"Paques","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, Paris Eye Imaging, Paris"}]},{"given":"Rui","family":"Bernardes","sequence":"additional","affiliation":[{"name":"University of Coimbra, Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra"}]}],"member":"297","reference":[{"issue":"1","key":"ref1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease","volume":"96","author":"Iadecola C","year":"2017","unstructured":"Iadecola, C. 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