{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T07:40:05Z","timestamp":1746344405353,"version":"3.40.4"},"posted":{"date-parts":[[2025,1,15]]},"group-title":"In Review","reference-count":0,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,1,9]]},"abstract":"<title>Abstract<\/title>\n        <p>This work showcases the first evidence of the anti-thermal quenching effect on neodymium(III) molecular thermometers working in biological windows within the physiological temperature range. A mononuclear complex, [Nd(L)(NO<sub>3<\/sub>)<sub>3<\/sub>] (<bold>1Nd<\/bold>), where L is a macrocyclic ligand, was synthesized and used as a precursor to develop two novel species: a dinuclear complex, [(Nd(L)(NO<sub>3<\/sub>))<sub>2<\/sub>(\u00b5-BDC)](NO<sub>3<\/sub>)<sub>2<\/sub>\u00b7H<sub>2<\/sub>O (<bold>2Nd<\/bold>), linked by 1,4-benzenedicarboxylate (BDC), and a hexameric complex, [(Nd(L))(\u00b5-BTC)(H<sub>2<\/sub>O)]<sub>6<\/sub>\u00b735H<sub>2<\/sub>O (<bold>6Nd<\/bold>), formed via linkage with 1,3,5-benzenetricarboxylate (BTC). The thermometric properties were studied in the physiological temperature range (292\u2013332 K), utilizing excitation with an 804 nm laser (first biological window) and monitoring emission bands in the second biological window (908, 1065, and 1340 nm) associated with the <sup>4<\/sup>F<sub>3\/2<\/sub>\u2192<sup>4<\/sup>I<sub>9\/2<\/sub>, <sup>4<\/sup>I<sub>11\/2<\/sub>, <sup>4<\/sup>I<sub>13\/2<\/sub> transitions, respectively. The thermometric performance was evaluated through deconvolution of the 1065 nm band and the 1065\/1340 nm emission ratio. Among the complexes, the hexamer <bold>6Nd<\/bold> exhibited exceptional performance, with S<sub>r<\/sub> of 2.4%K<sup>\u2212\u20091<\/sup> at 293 K, when LIR of two components was used, positioning it as a high-performance Nd<sup>III<\/sup>-based thermometer. All complexes displayed anti-thermal quenching behavior, surpassing the current molecular-based thermometers in the near-infrared region. Theoretical calculations using CASSCF and Boltzmann population models between Kramers doublets of the <sup>4<\/sup>F<sub>3\/2<\/sub> level were performed to rationalize the anti-thermal behavior.<\/p>","DOI":"10.21203\/rs.3.rs-5795718\/v1","type":"posted-content","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T08:35:53Z","timestamp":1736930153000},"source":"Crossref","is-referenced-by-count":0,"title":["Anti-Thermal Quenching in NdIII Molecular Near-Infrared Thermometers Operating at Physiological Temperatures"],"prefix":"10.21203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2432-0992","authenticated-orcid":false,"given":"Albano","family":"Neto","sequence":"first","affiliation":[{"name":"University of Aveiro"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Maldonado","sequence":"additional","affiliation":[]},{"given":"Patricia","family":"Far\u00edas-Carre\u00f1o","sequence":"additional","affiliation":[]},{"given":"Yolimar","family":"Gil","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9s","family":"Vega","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"de Santana","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Aravena","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Brites","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4747-6535","authenticated-orcid":false,"given":"Lu\u00eds","family":"Carlos","sequence":"additional","affiliation":[{"name":"University of Aveiro"}]},{"given":"Fiorenzo","family":"Vetrone","sequence":"additional","affiliation":[]},{"given":"Pablo","family":"Fuentealba","sequence":"additional","affiliation":[]}],"member":"297","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.researchsquare.com\/article\/rs-5795718\/v1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.researchsquare.com\/article\/rs-5795718\/v1.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T07:05:55Z","timestamp":1746342355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchsquare.com\/article\/rs-5795718\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,15]]},"references-count":0,"URL":"https:\/\/doi.org\/10.21203\/rs.3.rs-5795718\/v1","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1038\/s42004-025-01536-9","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2025,1,15]]},"subtype":"preprint"}}