{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:52:54Z","timestamp":1747205574492,"version":"3.40.5"},"posted":{"date-parts":[[2020,8,20]]},"group-title":"In Review","reference-count":0,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2020,8,19]]},"abstract":"<title>Abstract<\/title>\n        <p>Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a \u201cOne Health\u201d perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (<italic>ACE2<\/italic>, <italic>ANPEP<\/italic> and <italic>DPP4<\/italic> encoding for host receptors of the viral spike proteins and <italic>TMPRSS2 <\/italic>encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian <italic>Sus scrofa<\/italic> populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a \u201cOne Health\u201d perspective that should consider conservation programmes of pig genetic resources with twofold objectives: i) genetic resources could be reservoirs of host gene variability useful to design selection programmes to increase resistance to coronaviruses; ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources.<\/p>","DOI":"10.21203\/rs.3.rs-62420\/v1","type":"posted-content","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T16:33:04Z","timestamp":1597941184000},"source":"Crossref","is-referenced-by-count":0,"title":["Describing variability in pig genes involved in coronavirus infections: towards a One Health perspective in conservation of animal genetic resources"],"prefix":"10.21203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5712-8211","authenticated-orcid":false,"given":"Samuele","family":"Bovo","sequence":"first","affiliation":[{"name":"Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127 Bologna, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3497-1337","authenticated-orcid":false,"given":"Giuseppina","family":"Schiavo","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127 Bologna, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6778-1938","authenticated-orcid":false,"given":"Anisa","family":"Ribani","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127 Bologna, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-4216","authenticated-orcid":false,"given":"Valerio Joe","family":"Utzeri","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127 Bologna, Italy"}]},{"given":"Valeria","family":"Taurisano","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127 Bologna, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-7502","authenticated-orcid":false,"given":"Mohamad","family":"Ballan","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127 Bologna, Italy"}]},{"given":"Maria","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento Mejora Gen\u00e9tica Animal, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria (INIA), Crta. de la Coru\u00f1a, km. 7,5, 28040, Madrid, Spain"}]},{"given":"Estefania","family":"Alves","sequence":"additional","affiliation":[{"name":"Departamento Mejora Gen\u00e9tica Animal, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria (INIA), Crta. de la Coru\u00f1a, km. 7,5, 28040, Madrid, Spain"}]},{"given":"Jose P.","family":"Araujo","sequence":"additional","affiliation":[{"name":"Centro de Investigac\u0327a\u0303o de Montanha (CIMO), Instituto Polit\u00e9cnico de Viana do Castelo, Escola Superior Agra\u0301ria, Ref\u00f3ios do Lima, 4990-706 Ponte de Lima Portugal"}]},{"given":"Riccardo","family":"Bozzi","sequence":"additional","affiliation":[{"name":"DAGRI \u2013 Animal Science Section, University of Florence, Via delle Cascine 5, 50144 Firenze, Italy"}]},{"given":"Rui","family":"Charneca","sequence":"additional","affiliation":[{"name":"MED \u2013 Mediterranean Institute for Agriculture, Environment and Development & Universidade de \u00c9vora, P\u00f3lo da Mitra, Apartado 94, 7006-554 \u00c9vora, Portugal"}]},{"given":"Federica Di","family":"Palma","sequence":"additional","affiliation":[{"name":"Biodiversity School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR47UH Norfolk, United Kingdom"}]},{"given":"Ivona","family":"Djurkin","sequence":"additional","affiliation":[{"name":"Faculty of Agrobiotechnical Sciences Osijek, University of Osijek, Vladimira Preloga 1, 31000, Osijek, Croatia"}]},{"given":"Graham","family":"Etherington","sequence":"additional","affiliation":[{"name":"Earlham Institute, Norwich Research Park, Colney Lane, Norwich, NR47UZ Norfolk, United Kingdom"}]},{"given":"Ana I.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Departamento Mejora Gen\u00e9tica Animal, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria (INIA), Crta. de la Coru\u00f1a, km. 7,5, 28040, Madrid, Spain"}]},{"given":"Fabi\u00e1n","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento Mejora Gen\u00e9tica Animal, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria (INIA), Crta. de la Coru\u00f1a, km. 7,5, 28040, Madrid, Spain"}]},{"given":"Juan","family":"Garc\u00eda-Casco","sequence":"additional","affiliation":[{"name":"Departamento Mejora Gen\u00e9tica Animal, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria (INIA), Crta. de la Coru\u00f1a, km. 7,5, 28040, Madrid, Spain"}]},{"given":"Danijel","family":"Karolyi","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture, University of Zagreb, Sveto\u0161imunska c. 25, 10000 Zagreb, Croatia"}]},{"given":"Maurizio","family":"Gallo","sequence":"additional","affiliation":[{"name":"Associazione Nazionale Allevatori Suini (ANAS), Via Nizza 53, 00198 Roma, Italy"}]},{"given":"Jos\u00e9 Manuel","family":"Martins","sequence":"additional","affiliation":[{"name":"MED \u2013 Mediterranean Institute for Agriculture, Environment and Development & Universidade de \u00c9vora, P\u00f3lo da Mitra, Apartado 94, 7006-554 \u00c9vora, Portugal"}]},{"given":"Marie-Jos\u00e9","family":"Mercat","sequence":"additional","affiliation":[{"name":"IFIP Institut du porc, La Motte au Vicomte, BP 35104, 35651, Le Rheu Cedex, France"}]},{"given":"Yolanda","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Departamento Mejora Gen\u00e9tica Animal, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria (INIA), Crta. de la Coru\u00f1a, km. 7,5, 28040, Madrid, Spain"}]},{"given":"Raquel","family":"Quintanilla","sequence":"additional","affiliation":[{"name":"Programa de Gen\u00e9tica y Mejora Animal, Institute for Research and Technology in Food and Agriculture (IRTA) , Torre Marimon, 08140 Caldes de Montbui, Barcelona, 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