{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:51:55Z","timestamp":1747205515939,"version":"3.40.5"},"posted":{"date-parts":[[2021,7,14]]},"group-title":"In Review","reference-count":0,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,6,20]]},"abstract":"<title>Abstract<\/title>\n        <p>Background\n\nThe clinical associations and prognostic implications of the 6-minute walk test (6MWT) distance in patients with rheumatoid arthritis (RA) is yet to be explored.\nAims\n\nTo identify the clinical features and prognostic implications associated with the 6MWT in patients with RA.\nMethods\n\nCohort study including 387 RA patients who underwent 6MWT. Regression models (linear and logistic) were built to identify independent predictors of shorter 6MWT distance. Cox proportional models were used to study the association of 6MWT distance with cardiovascular outcomes.\nResults\n\nPatients were subdivided according to 6MWT tertiles: 126 patients walked\u2009&gt;\u2009405m, 129 walked 345-405m, and 132 walked\u2009&lt;\u2009345m. Older age (&gt;\u200955 year), elevated waist circumference, NT-pro BNP\u2009&gt;\u2009125pg\/mL, anemia, C-reactive protein\u2009\u2265\u20093mg\/dL, and troponin T\u2009\u2265\u200914pg\/mL were independent predictors of walking shorter distances. Patients walking less than 345m had higher risk of a subsequent cardiovascular hospitalisation or cardiovascular death compared with patients walking 345m or more (adjusted HR: 2.98, 95%CI: 1.37\u20136.51, p\u2009=\u20090.006).\nConclusions\n\nOlder age, abdominal obesity, anemia, cardiac dysfunction, and inflammation were associated with walking shorter distances in patients with RA. Walking less than 345m in the 6MWT was associated with a poor cardiovascular prognosis. The 6MWT is simple, reproducible and inexpensive, easily performed in routine practice, and provides important information regarding the patients\u00b4 status and outcomes, enabling the monitorization of the therapeutic optimization of the various domains of the RA.<\/p>","DOI":"10.21203\/rs.3.rs-643214\/v1","type":"posted-content","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T14:31:43Z","timestamp":1626273103000},"source":"Crossref","is-referenced-by-count":0,"title":["6-Minute Walking Test in Rheumatoid Arthritis: Clinical Associations and Prognostic Implications"],"prefix":"10.21203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5818-1025","authenticated-orcid":false,"given":"Maria Bet\u00e2nia","family":"Ferreira","sequence":"first","affiliation":[{"name":"Luz Hospital: Hospital da Luz Lisboa"}]},{"given":"Francisca A.","family":"Saraiva","sequence":"additional","affiliation":[{"name":"University of Porto: Universidade Do Porto"}]},{"given":"Tom\u00e1s","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto: Centro Hospitalar Universitario do Porto EPE"}]},{"given":"Rita","family":"Costa","sequence":"additional","affiliation":[{"name":"Centro Hospitalar de Entre o Douro e Vouga EPE"}]},{"given":"Ant\u00f3nio","family":"Marinho","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto: Centro Hospitalar Universitario do Porto EPE"}]},{"given":"Jos\u00e9 Carlos","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto: Centro Hospitalar Universitario do Porto EPE"}]},{"given":"Henrique Cyrne","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade do Porto Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar: Universidade do Porto Instituto de Ciencias Biomedicas Abel Salazar"}]},{"given":"Patr\u00edcia","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto: Centro Hospitalar Universitario do Porto EPE"}]},{"given":"Jo\u00e3o Pedro","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centre d'Investigation Clinique Plurith\u00e9matique de Nancy: Centre d'Investigation Clinique Plurithematique de Nancy"}]}],"member":"297","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.researchsquare.com\/article\/rs-643214\/v1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.researchsquare.com\/article\/rs-643214\/v1.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T16:25:32Z","timestamp":1635092732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchsquare.com\/article\/rs-643214\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,14]]},"references-count":0,"URL":"https:\/\/doi.org\/10.21203\/rs.3.rs-643214\/v1","relation":{},"subject":[],"published":{"date-parts":[[2021,7,14]]},"subtype":"preprint"}}