{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T23:55:27Z","timestamp":1649202927069},"posted":{"date-parts":[[2021,8,12]]},"group-title":"In Review","reference-count":0,"publisher":"Research Square Platform LLC","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p><jats:bold>Background: <\/jats:bold>Congenital hypothyroidism (CH) has severe and irreversible neurological consequences for the child if treatment is not readily initiated, which justifies fast diagnosis. Screening of CH is a universal procedure well established in Portugal. It is based on measuring the pituitary thyroid stimulating hormone. The physiology of maturation of the pituitary-thyroid axis is incomplete at delivery in preterm and very-low birth weight babies (VLBW), which raises concerns with respect to the standard timing of CH diagnosis.The Portuguese Neonatal Screening Program recommends testing preterm\/VLBW babies at three time points. The purpose of this study was to assess compliance of these guidelines.<jats:bold>Methods: <\/jats:bold>Questionnaires were sent to neonatal care units (NCU) and to general practitioner community health units in two time periods.<jats:bold>Results: <\/jats:bold>All NCU have written guidelines and the great majority follows the recommendations. Few NCU still postpone the first collection for newborns with protein intake restrictions, some retest new-borns in special circumstances, and a great number still use iodine disinfectants.<jats:bold>Conclusions:<\/jats:bold> This study shows that performing the metabolic screening is a well standardized procedure that can still be improved: not delaying the first collection, retesting sick and medicated babies, and avoiding iodine disinfectants.<\/jats:p>","DOI":"10.21203\/rs.3.rs-689419\/v1","type":"posted-content","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T16:16:10Z","timestamp":1628784970000},"source":"Crossref","is-referenced-by-count":0,"title":["Neonatal Screening Program of Congenital Hypothyroidism: How Can We (Still) Improve?"],"prefix":"10.21203","author":[{"given":"Maria Jos\u00e9","family":"Costeira","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit- Hospital Senhora da Oliveira- Guimar\u00e3es"}]},{"given":"Andreia","family":"Martins","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit- Hospital Senhora da Oliveira- Guimar\u00e3es"}]},{"given":"Raquel","family":"Reis","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit- Hospital Senhora da Oliveira- Guimar\u00e3es"}]},{"given":"Laura","family":"Vilarinho","sequence":"additional","affiliation":[{"name":"Newborn Screening, Metabolism & Genetics Unit, National Institute of Health Dr Ricardo Jorge, Porto"}]},{"given":"Joana","family":"Palha","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga"}]}],"member":"8761","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.researchsquare.com\/article\/rs-689419\/v1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.researchsquare.com\/article\/rs-689419\/v1.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T10:14:27Z","timestamp":1632478467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchsquare.com\/article\/rs-689419\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.21203\/rs.3.rs-689419\/v1","relation":{},"subject":[],"published":{"date-parts":[[2021,8,12]]},"subtype":"preprint"}}