{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T16:38:23Z","timestamp":1649090303218},"posted":{"date-parts":[[2021,10,18]]},"group-title":"In Review","reference-count":0,"publisher":"Research Square Platform LLC","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Background: Recently, leptin\/adiponectin (L\/A) ratio has been suggested as a novel predictor of cardio-metabolic and other chronic disease.Aim: to evaluate the ability of leptin (L), adiponectin (A) and the L\/A ratio in identifying high risk of IR in adolescents adjusted by cardiorespiratory fitness, adherence to the Mediterranean diet and body fat percentage. Subjects and methods: This is a cross-sectional analysis with 529 adolescents aged 12<jats:bold>-<\/jats:bold>18 years-old. Blood samples were taken to analyze glucose, insulin, leptin, and adiponectin levels. IR (homeostasis model assessment of insulin resistance [HOMA\u2010IR] was estimated from fasting serum insulin and glucose). Results: Adiponectin, leptin, and L\/A ratio were accurate to predict of IR among adolescents. The optimal L\/A cut-off value to indicate risk of IR development was &gt;0.35 in boys and &gt;0.97 in girls. Logistic analyses showed that the suggested cut points for adiponectin (girls: OR:2.87 (1.1.26-6.53); p=0.012); leptin (boys: OR:5.23 (1.16-7.14) p = 0.006; girls: OR:2.99 (1.10-8.09) p=0.031) and the L\/A ratio (boys: OR:8.38 (2.6-26.8) p&lt;0.001; girls: OR:6.1 (2.1-17.0) p&lt;0.001), were significant predictors of IR, after adjustments for age, pubertal stage, adherence to the Mediterranean diet, cardiorespiratory fitness and body fat percentage. Conclusion: Leptin and L\/A ratio were associated with IR risk, after adjustments for confounders in both sexes and adiponectin in girls. L\/A ratio seems to have a higher diagnostic accuracy to identify IR risk than adiponectin or leptin, in both sexes.<\/jats:p>","DOI":"10.21203\/rs.3.rs-950095\/v1","type":"posted-content","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T03:23:16Z","timestamp":1634613796000},"source":"Crossref","is-referenced-by-count":0,"title":["Adipocytokines on Insulin Resistance in Adolescents"],"prefix":"10.21203","author":[{"given":"C\u00e9sar","family":"Agostinis-Sobrinho","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Klaip\u0117da University, Lithuania"}]},{"given":"Sofia E. de Castro Ferreira","family":"Vicente","sequence":"additional","affiliation":[{"name":"Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Portugal"}]},{"given":"Sigute","family":"Norkiene","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Klaip\u0117da University, Lithuania"}]},{"given":"Alona","family":"Rauckien\u0117-Michaelsson","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Klaip\u0117da University, Lithuania"}]},{"given":"Justina","family":"Kievi\u0161ien\u0117","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Klaip\u0117da University, Lithuania"}]},{"given":"Viney Prakash","family":"Dubey","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Klaip\u0117da University, Lithuania"}]},{"given":"Arturas","family":"Razbadauskas","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Klaip\u0117da University, Lithuania"}]},{"given":"Lu\u00eds","family":"Lopes","sequence":"additional","affiliation":[{"name":"Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Portugal"}]},{"given":"Rute","family":"Santos","sequence":"additional","affiliation":[{"name":"Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Portugal"}]}],"member":"8761","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.researchsquare.com\/article\/rs-950095\/v1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.researchsquare.com\/article\/rs-950095\/v1.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T06:14:19Z","timestamp":1647843259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchsquare.com\/article\/rs-950095\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,18]]},"references-count":0,"URL":"https:\/\/doi.org\/10.21203\/rs.3.rs-950095\/v1","relation":{},"subject":[],"published":{"date-parts":[[2021,10,18]]},"subtype":"preprint"}}