{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:55:40Z","timestamp":1747205740591,"version":"3.40.5"},"posted":{"date-parts":[[2021,10,22]]},"group-title":"In Review","reference-count":0,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,10,16]]},"abstract":"<title>Abstract<\/title>\n        <p>Heterocyclic nucleus are considered essential in medicinal chemistry and provides a model for developing several therapeutic agents such as drugs with a wide antibacterial spectrum. In an attempt to obtain a new antibacterial agent, new quinolone derivatives containing triazole and thiadiazole have prepared via a straightforward method. The newly synthesized products' chemical structures have invistigated their FT-IR, <sup>1<\/sup>H NMR, <sup>13<\/sup>C NMR, and Mass techniques. A good yield was found for all the prepared derivatives varying from 74-79%. Molecular docking studies of the synthesized compounds showed only one compound, 6c, which has the same ranking from the in vitro and silicon test results on Gram-negative bacteria. Also, several compounds have close rankings, such as compound 5 (ranks 13 and 14) and compound 6c (ranks 6 and 5) in Gram-positive bacteria, as well as compound 7a (ranks 13 and 12), compound 7c (ranks 1 and 2), and compound 7d (ranks 12 and 13) in Gram-negative bacteria. However, there is one exciting compound, 7c, which shows very high rankings (ranks 1 and 2) in Gram-negative bacteria. This suggests that the compound has potential as an antimicrobial in Gram-negative bacteria, with an ampicillin-like mechanism of action targeting the bacteria's Penicillin-binding proteins.<\/p>","DOI":"10.21203\/rs.3.rs-975354\/v1","type":"posted-content","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T17:02:25Z","timestamp":1634922145000},"source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis and Molecular Docking Study of Some Quinoline Derivatives"],"prefix":"10.21203","author":[{"given":"Dhafer Saber","family":"Zinad","sequence":"first","affiliation":[{"name":"University of Technology"}]},{"given":"Ghazwan Ali","family":"Salman","sequence":"additional","affiliation":[{"name":"Mustansiriyah University"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6977-3752","authenticated-orcid":false,"given":"Ahmed","family":"Mahal","sequence":"additional","affiliation":[{"name":"South China Botanical Garden"}]},{"given":"Mohammad Rizki Fadhil","family":"Pratama","sequence":"additional","affiliation":[{"name":"Muhammadiyah University Pontianak: Universitas Muhammadiyah Pontianak"}]},{"given":"Mohamed","family":"Yahya","sequence":"additional","affiliation":[{"name":"Ghazi University"}]},{"given":"Duan","family":"Meito","sequence":"additional","affiliation":[{"name":"Southern Medical University"}]},{"given":"Anas","family":"Alkhouri","sequence":"additional","affiliation":[{"name":"Cihan University-Erbil"}]},{"given":"Ranjan K.","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Government College of Engineering"}]}],"member":"297","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.researchsquare.com\/article\/rs-975354\/v1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.researchsquare.com\/article\/rs-975354\/v1.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T17:04:03Z","timestamp":1634922243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchsquare.com\/article\/rs-975354\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":0,"URL":"https:\/\/doi.org\/10.21203\/rs.3.rs-975354\/v1","relation":{},"subject":[],"published":{"date-parts":[[2021,10,22]]},"subtype":"preprint"}}