{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:10:19Z","timestamp":1716423019171},"reference-count":61,"publisher":"The Nencki Institute of Experimental Biology, Polish Academy of Sciences","issue":"3","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurobiol. Exp."],"abstract":"<jats:p>Decreased cerebral blood flow (CBF) in aging is known to induce aging\u2011related cerebral deteriorations, such as neuronal degeneration, white matter (WM) alterations, and vascular deformations. However, the effects of cerebral hypoperfusion on WM alterations remain unclear. This study investigates the relationship between cerebral hypoperfusion and WM total volume changes by assessing the trends in CBF and WM changes by meta\u2011analysis. In this meta\u2011analysis, the differences in CBF were compared according to cerebral hypoperfusion type and the effect of cerebral hypoperfusion on the total volume of WM changes in rodents. Using subgroup analysis, 13 studies were evaluated for comparing CBF according to the type of cerebral hypoperfusion; 12 studies were evaluated for comparing the effects of cerebral hypoperfusion on the total volume of WM changes. Our meta\u2011analysis shows that the total volume of WM decreases with a decrease in CBF. However, the reduction in\\r\\nthe total volume of WM was greater in normal aging mice than in the cerebral hypoperfusion model mice. These results suggest that the reduction of cerebral WM volume during the aging process is affected by other factors in addition to a decrease in CBF.<\/jats:p>","DOI":"10.21307\/ane-2021-029","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T23:31:27Z","timestamp":1634081487000},"page":"295-306","source":"Crossref","is-referenced-by-count":1,"title":["Effects of cerebral hypoperfusion on the cerebral white matter: a meta\u2011analysis"],"prefix":"10.55782","volume":"81","author":[{"given":"Juyeon","family":"Mun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyang","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34635","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"key2021101217_bib1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/ana.25129","article-title":"Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter","volume":"83","year":"2018","journal-title":"Ann Neurol"},{"key":"key2021101217_bib2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.10.017","article-title":"White matter hyperintensity associations with cerebral blood flow in elderly subjects stratified by cerebrovascular risk","volume":"26","year":"2017","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"key2021101217_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuroscience.2013.11.026","article-title":"Disconnected aging: cerebral white matter integrity and age-related differences in cognition","volume":"276","year":"2014","journal-title":"Neuroscience"},{"key":"key2021101217_bib4","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1038\/jcbfm.2013.140","article-title":"Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition","volume":"33","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"key2021101217_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.pscychresns.2008.11.006","article-title":"Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging","volume":"172","year":"2009","journal-title":"Psychiatry Res"},{"key":"key2021101217_bib6","first-page":"159","article-title":"Venous collagenosis and arteriolar tortuosity in leukoaraiosis","volume":"203\u2013204","year":"2002","journal-title":"J Neurol Sci"},{"key":"key2021101217_bib7","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.neuroimage.2010.12.032","article-title":"Age-associated reductions in cerebral blood flow are independent from regional atrophy","volume":"55","year":"2011","journal-title":"Neuroimage"},{"key":"key2021101217_bib8","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1227\/01.NEU.0000341908.48173.EB","article-title":"Local chronic hypoperfusion secondary to sinus high pressure seems to be mainly responsible for the formation of intracranial dural arteriovenous fistula","volume":"64","year":"2009","journal-title":"Neurosurgery"},{"key":"key2021101217_bib9","first-page":"131","article-title":"Gray matter blood flow and volume are reduced in association with white matter hyperintensity lesion burden: a cross-sectional MRI study","volume":"7","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"key2021101217_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/jnnp.70.1.9","article-title":"Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study","volume":"70","year":"2001","journal-title":"The Rotterdam Scan Study. 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