{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:02:04Z","timestamp":1788447724496,"version":"build-2803163510"},"reference-count":45,"publisher":"Japanese Society of Toxicology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2012]]},"DOI":"10.2131\/jts.37.773","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T22:31:22Z","timestamp":1343773882000},"page":"773-790","source":"Crossref","is-referenced-by-count":11,"title":["Methamphetamine causes anorexia in &lt;i&gt;Drosophila melanogaster&lt;\/i&gt;, exhausting metabolic reserves and contributing to mortality"],"prefix":"10.2131","volume":"37","author":[{"given":"Kent R.","family":"Walters, Jr.","sequence":"first","affiliation":[{"name":"Department of Entomology, 516\/518 Morrill Hall, University of Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Indu","family":"Rupassara","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology, University of Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Cody Markelz","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, University of Illinois, USA"},{"name":"Institute for Genomic Biology, 1402 Institute for Genomic Biology, 1206 W Gregory Dr, University of Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.B.","family":"Leakey","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, University of Illinois, USA"},{"name":"Institute for Genomic Biology, 1402 Institute for Genomic Biology, 1206 W Gregory Dr, University of Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Muir","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Room G405, Lily Hall, Purdue University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry R.","family":"Pittendrigh","sequence":"additional","affiliation":[{"name":"Department of Entomology, 516\/518 Morrill Hall, University of Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5461.2185"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Al-Anzi, B. and Zinn, K. (2010): Colorimetric measurement of triglycerides cannot provide an accurate measure of stored fat content in <i>Drosophila<\/i>. PLoS ONE, <b>5<\/b>, e12353.doi:10.1371\/journal.pone.0012353.","DOI":"10.1371\/journal.pone.0012353"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Aravich, P.F. and Sclafani, A. (1980): Dietary preference behavior in rats fed bitter tasting quinine and sucrose octa acetate adulterated diets. Physiol. Behav., <b>25<\/b>, 157-160.","DOI":"10.1016\/0031-9384(80)90200-0"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Barron, A.B. (2000): Anaesthetising <i>Drosophila<\/i> for behavioural studies. J. Insect Physiol., <b>46<\/b>, 439-442.","DOI":"10.1016\/S0022-1910(99)00129-8"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Bedford, J.J. (1977): The carbohydrate levels of insect haemolymph. Comp. Biochem. Physiol. A, <b>54<\/b>, 83-86.","DOI":"10.1016\/0300-9629(77)90354-1"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Berrigan, D. and Partridge, L. (1997) Influence of temperature and activity on the metabolic rate of adult <i>Drosophila melanogaster<\/i>. Comp. Biochem. Physiol. A, <b>118<\/b>, 1301-1307.","DOI":"10.1016\/S0300-9629(97)00030-3"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Bjerke, R. and Zachariassen, K.E. (1997):<b> <\/b>Effects of dehydration on water content, metabolism, and body fluid solutes of a carabid beetle from dry savanna in East Africa. Comp. Biochem. Physiol.<b> <\/b>A, <b>118<\/b>, 779-787.","DOI":"10.1016\/S0300-9629(97)00060-1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Brosemer, R.W. and Veerabhadrappa, P.S. (1965): Pathway of proline oxidation in insect flight muscle. Biochim. Biophys. Acta, <b>110<\/b>, 102-112.","DOI":"10.1016\/S0926-6593(65)80099-6"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Bursell, E. (1960): Free amino-acids of the tsetse fly (<i>Glossina<\/i>). Nature,<i> <\/i><b>187<\/b>, 778.","DOI":"10.1038\/187778a0"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Celniker, S.E., Dillon, L.A., Gerstein, M.B., Gunsalus, K.C., Henikoff, S., Karpen, G.H., Kellis, M., Lai, E.C., Lieb, J.D., MacAlpine, D.M., Micklem, G., Piano, F., Snyder, M., Stein, L., White, K.P., Waterston, R.H. and modENCODE Consortium (2009): Unlocking the secrets of the genome. Nature, <b>459<\/b>, 927-930.","DOI":"10.1038\/459927a"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Cole, S.O. (1967): Experimental effects of amphetamine: A review. Psychol. Bull., <b>68<\/b>, 81-90.&nbsp;","DOI":"10.1037\/h0020185"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Cubells, J.F., Rayport, S., Rajendran, G. and Sulzer, D. (1994): Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress. J. Neurosci., <b>14<\/b>, 2260-2271.","DOI":"10.1523\/JNEUROSCI.14-04-02260.1994"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Davidson, C., Gow, A.J., Lee, T.H. and Ellinwood, E.H. (2001):<b> <\/b>Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment. Brain Res. Rev.,<b> 36<\/b>, 1-22.","DOI":"10.1016\/S0165-0173(01)00054-6"},{"key":"14","unstructured":"Duchateau, G., Florkin, M. (1959): Blood trehalose level in insects and its significance. Arch. Intern. Physiol. Biochim., <b>67<\/b>, 306-314."},{"key":"15","unstructured":"EMCDDA-<i> <\/i>Europol joint publication (2009) Methamphetamine: a European Union perspective in the global context. European Monitoring Center for Drugs and Drug Addiction, Lisbon, Portugal DOI: 10.2810\/16021."},{"key":"16","doi-asserted-by":"crossref","unstructured":"England, K., O&rsquo;Driscoll, C. and Cotter, T.G. (2004):<i> <\/i>Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis. Cell Death and Differ., <b>11<\/b>, 252-260.","DOI":"10.1038\/sj.cdd.4401338"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Evans, H.L. (1971): Behavioral effects of methamphetamine and<b> <\/b>&alpha;-methyltyrosine in the rat. J. Pharmacol. Exp. Ther.,<b> 176<\/b>, 244-254.","DOI":"10.1016\/S0022-3565(25)28779-1"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Fantegrossi, W.E., Ciullo, J.R., Wakabayashi, K.T., De La Garza II, R., Traynor, J.R. and Woods, J.H. (2008): A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse. Neurosci.,<i> <\/i><b>151<\/b>, 533-543.","DOI":"10.1016\/j.neuroscience.2007.11.007"},{"key":"19","unstructured":"Ferraris R.P. and Diamond, J. (1992): Crypt-villus site of glucose transporter induction by dietary carbohydrate in mouse intestine. Am. J. Physiol., <b>262<\/b>, G1069-G1073."},{"key":"20","doi-asserted-by":"crossref","unstructured":"Glendinning, J.I. (2002): How do herbivorous insects cope with noxious secondary plant compounds in their diet? Entomol. Exp. Appl., <b>104<\/b>, 15-25.","DOI":"10.1046\/j.1570-7458.2002.00986.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Hammarqvist, F., Andersson, K., Luo, J.L. and Wernerman, J. (2005): Free amino acid and glutathione concentrations in muscle during short-term starvation and refeeding. Clin. Nutr., <b>24<\/b>, 236-243.","DOI":"10.1016\/j.clnu.2004.10.004"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Hanzal, R., Bjerke, R., Lundheim, R. and Zachariassen, K.E. (1992): Concentration of sodium and free amino acids in the haemolymph and other fluid compartments in an adephagous and a polyphagous species of beetle. Comp. Biochem. Physiol. A, <b>102<\/b>, 741-744.","DOI":"10.1016\/0300-9629(92)90734-8"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2007.06.003"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Jones, D., Jones, G. and Bhaskaran, G. (1981): Dietary sugars, hemolymph trehalose levels, and supernumerary molting of <i>Manduca sexta<\/i> larvae. Physiol. Zool., <b>54<\/b>, 260-266.","DOI":"10.1086\/physzool.54.2.30155828"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2048-05.2005"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Lee, G., Park, J.H. (2004): Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in <i>Drosophila melanogaster.<\/i> Genetics, <b>167<\/b>, 311-323.","DOI":"10.1534\/genetics.167.1.311"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Madden, L.J., Flynn, C.T., Zandonatti, M.A., May, M., Parsons, L.H., Katner, S.N., Henriksen, S.J. and Fox, H.S. (2005): Modeling human methamphetamine exposure in nonhuman primates: chronic dosing in the rhesus macaque leads to behavioral and physiological abnormalities.<i> <\/i>Neuropsychopharmacology, <b>30<\/b>, 350-359.","DOI":"10.1038\/sj.npp.1300575"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Mcmahon, E.M., Andersen, D.K., Feldman, J.M. and Schanberg, S.M. (1971): Methamphetamine-induced insulin release. Science, <b>174<\/b>, 66-68.","DOI":"10.1126\/science.174.4004.66"},{"key":"29","unstructured":"National Institute on Drug Abuse (NIDA). (2010): DrugFacts series: methamphetamine. Available online at http:\/\/www.drugabuse.gov\/publications\/drugfacts\/methamphetamine."},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199601)166:1<152::AID-JCP18>3.0.CO;2-H"},{"key":"31","unstructured":"Po-Chedley, D.S. (1958): Effects of Starvation on Free Amino Acids in Larval Blood of Oriental Beetle, <i>Anomala orientalis<\/i> Waterhouse. J. N. Y. Entomol. Soc., <b>66<\/b>, 171-177."},{"key":"32","doi-asserted-by":"crossref","unstructured":"Roehrig, K.L. and Allred, J.B. (1974):<b> <\/b>Direct enzymatic procedure for the determination of liver glycogen. Anal. Biochem., <b>58<\/b>, 414-421.","DOI":"10.1016\/0003-2697(74)90210-3"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00797-3"},{"key":"34","unstructured":"Rupassara, S.I. (2008): Metabolite profiling of leaves and vascular exudates in soybean grown under free-air concentration enrichment. Ph.D. Thesis, University of Illinois at Urbana Champaign, USA."},{"key":"35","unstructured":"Sacktor, B. and Wormser-Shavit, E. (1966): Regulation of metabolism in working muscle <i>in vivo. <\/i>I. Concentrations of some glycolytic, tricarboxylic acid cycle, and amino acid intermediates in insect flight muscle during flight. J. Biol. Chem., <b>241<\/b>, 624-631."},{"key":"36","doi-asserted-by":"crossref","unstructured":"Scibelli, A.C., McKinnon, C.S., Reed, C., Burkhart-Kasch, S., Li, N., Baba, H., Wheeler, J.M. and Phillips, T.J. (2011): Selective breeding for magnitude of methamphetamine-induced sensitization alters methamphetamine consumption. Psychopharmacology, <b>214<\/b>, 791-804.","DOI":"10.1007\/s00213-010-2086-2"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.26.010181.001151"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Sun, L., Li, H.M., Seufferheld, M.J., Walters, K.R., Margam, V.M., Jannasch, A., Diaz, N., Riley, C.P., Sun, W., Li, Y.F., Muir, W.M., Xie, J., Wu, J., Zhang, F., Chen, J.Y., Barker, E.L., Adamec, J.<sup> <\/sup>and Pittendrigh, B.R. (2011): Systems-scale analysis reveals pathways involved in cellular response to methamphetamine. PLoS ONE, <b>6<\/b>, e18215. doi:10.1371\/journal.pone.0018215.","DOI":"10.1371\/journal.pone.0018215"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Virmani, A., Gaetani, F., Imam, S., Binienda, Z. and Ali, S. (2002): The protective role of l-carnitine against neurotoxicity evoked by drug of abuse, methamphetamine, could be related to mitochondrial dysfunction.<b> <\/b>Annals N. Y. Acad. Sci., <b>965<\/b>, 225-232.","DOI":"10.1111\/j.1749-6632.2002.tb04164.x"},{"key":"40","doi-asserted-by":"crossref","unstructured":"Wang, G.J., Volkow, N.D., Chang, L., Miller, E., Sedler, M., Hitzemann, R., Zhu, W., Logan, J., Ma, Y. and Fowler, J.S. (2004):<b> <\/b>Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence. Am. J. Psychiatry, <b>161<\/b>, 242-248.","DOI":"10.1176\/appi.ajp.161.2.242"},{"key":"41","doi-asserted-by":"crossref","unstructured":"Wong, R., Piper, M.D.W., Blanc, E.&nbsp;and Partridge, L. (2008): Pitfalls of measuring feeding rate in the fruit fly <i>Drosophila melanogaster<\/i>. Nat. Methods, <b>5<\/b>, 214-215.","DOI":"10.1038\/nmeth0308-214"},{"key":"42","doi-asserted-by":"crossref","unstructured":"Wong R., Piper, M.D.W., Wertheim, B., Partridge, L. (2009): Quantification of food intake in <i>Drosophila<\/i>. PLoS ONE, <b>4<\/b>, e6063.doi:10.1371\/journal.pone.0006063.","DOI":"10.1371\/journal.pone.0006063"},{"key":"43","doi-asserted-by":"crossref","unstructured":"Woodring,<b> <\/b>J.P. and Blakeney, E.W. (1980):<b> <\/b>The role of free amino acids in osmoregulation of cricket blood (<i>Acheta domesticus<\/i>). J. Insect Physiol., <b>26<\/b>, 613-618.","DOI":"10.1016\/0022-1910(80)90030-X"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.06.010161.000451"},{"key":"45","doi-asserted-by":"crossref","unstructured":"Yamamoto, B.K. and Zhu, W. (1998): The effects of methamphetamine on the production of free radicals and oxidative stress. J. Pharmacol. Exp. Ther.,<b> 287<\/b>,<b> <\/b>107-114.<b> <\/b>","DOI":"10.1016\/S0022-3565(24)37769-9"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/37\/4\/37_773\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T10:33:17Z","timestamp":1743935597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/37\/4\/37_773\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.37.773","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}