{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T18:48:48Z","timestamp":1649011728152},"reference-count":25,"publisher":"Japanese Society of Toxicology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2013]]},"DOI":"10.2131\/jts.38.759","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T23:10:18Z","timestamp":1380150618000},"page":"759-773","source":"Crossref","is-referenced-by-count":4,"title":["Combined repeated-dose and reproductive\/developmental toxicity screening test of 3-amino-5-mercapto-1,2,4-triazole in rats"],"prefix":"10.2131","volume":"38","author":[{"given":"Junichi","family":"Kikuchi","sequence":"first","affiliation":[{"name":"CERI Hita, Chemicals Evaluation and Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunao","family":"Aso","sequence":"additional","affiliation":[{"name":"CERI Hita, Chemicals Evaluation and Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Koga","sequence":"additional","affiliation":[{"name":"CERI Hita, Chemicals Evaluation and Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Miyata","sequence":"additional","affiliation":[{"name":"CERI Hita, Chemicals Evaluation and Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satsuki","family":"Hoshuyama","sequence":"additional","affiliation":[{"name":"CERI Hita, Chemicals Evaluation and Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kusune","sequence":"additional","affiliation":[{"name":"CERI Hita, Chemicals Evaluation and Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"CERI Kurume"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"CERI, Chemical Biotesting Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Ajimi","sequence":"additional","affiliation":[{"name":"CERI Hita, Chemicals Evaluation and Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Furukawa","sequence":"additional","affiliation":[{"name":"CERI Hita, Chemicals Evaluation and Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"898","reference":[{"key":"1","unstructured":"Alexander, N.M. (1959): Iodide peroxidase in rat thyroid and salivary glands and its inhibition by anti-thyroid compounds. Fed. Proc., <b>18<\/b>,<b> <\/b>1530-1533."},{"key":"2","unstructured":"Capen, C.C. (2008): 21 Toxic Responses of the Endocrine System. pp.807-879. In: Casarett &amp; Doull&rsquo;s Toxicology The Basic Science of Poisons 7<sup>th<\/sup> edition (Curtis D, Klaassen ed.), McGraw Hill Medical, New York."},{"key":"3","doi-asserted-by":"crossref","unstructured":"Davidson, B., Soodak, M., Neary, J.T., Strout, H.V., Kieffer, J.D., Mover, H. and Maloof, F. (1978): The irreversible inactivation of thyroid peroxidase by methylmercaptoimidazole, thiouracil, and propylthiouracil <i>in vitro<\/i> and its relationship to in vivo findings. Endocrinology, <b>103<\/b>, 871-882.","DOI":"10.1210\/endo-103-3-871"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Doerge, D.R. (1986): Mechanism-based inhibition of lactoperoxidase by thiocarbamide goitrogens. Biochemistry, <b>25<\/b>, 4724-4728.","DOI":"10.1021\/bi00364a041"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Doerge, D.R. and Takazawa, R.S. (1990): Mechanism of thyroid peroxidase inhibition by ethylenethiourea. Chem. Res. Toxicol., <b>3<\/b>, 98-101.","DOI":"10.1021\/tx00014a003"},{"key":"6","unstructured":"EHC (1994): Environmental Health Criteria No.158 Amitrole, International Programme on Chemical Safety."},{"key":"7","doi-asserted-by":"crossref","unstructured":"Freyberger, A. and Ahr, H.J. (2006): Studies on the goitrogenic mechanism of action of N,N,N&rsquo;,N&rsquo;-tetramethylthiourea. Toxicology, <b>217<\/b>, 169-175.","DOI":"10.1016\/j.tox.2005.09.005"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Gaines, T.B., Kimbrough, R.D. and Linder, R.E. (1973): The toxicity of amitrole in the rat. Toxicol. Appl. Pharmacol., <b>26<\/b>, 118-129.","DOI":"10.1016\/0041-008X(73)90092-6"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Hamamura, M., Hirose, A., Kamata, E., Katoku, K., Kuwasaki, E., Oshikawa, T., Nakahara, Y., Ema, M. and Hasegawa, R. (2006): Semi-quantitative immunohistochemical analysis of male rat-specific &alpha;<sub>2u<\/sub>-globulin accumulation for chemical toxicity evaluation. J. Toxicol. Sci., <b>31<\/b>, 35-47.","DOI":"10.2131\/jts.31.35"},{"key":"10","unstructured":"Hatsuta, M., Abe, K., Tamura, K., Ryuno, T., Watanabe, G., Taya, K. and Kogo, H. (2004): Effects of hypothyroidism on the estrous cycle and reproductive hormones in mature female rat. Eur. J. Pharmacol., <b>486<\/b>, 343-348.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;"},{"key":"11","unstructured":"IARC (2001): IARC monographs on the evaluation of carcinogenic risks to humans, volume 79 Some thyrothropic agents, International Agency for Research on Cancer, Lyon, France."},{"key":"12","doi-asserted-by":"crossref","unstructured":"Kawasaki, Y., Umemura, T., Saito, M., Momma, J., Matsushima, Y., Sekiguchi, H., Matsumoto, M., Sakemi, K., Isama, K., Inoue, T., Kurokawa, Y. and Tsuda, M. (1998): Toxicity study of a rubber antioxidant, 2-mercaptobenzimidazole, by repeated oral administration to rats. J. Toxicol. Sci., <b>23<\/b>, 53-68.","DOI":"10.2131\/jts.23.53"},{"key":"13","unstructured":"MHLW (1997): Twenty-eight-day repeated dose oral toxicity test of 3,5-dimethylaniline in rats. In Toxicity Testing Reports of Environmental Chemicals (Ministry of Health, Labor and Welfare ed.), Vol. 5, pp 391-402, Chemicals Investigation Promoting Council, Japan. http:\/\/dra4.nihs.go.jp\/mhlw_data\/home\/pdf\/PDF108-69-0b.pdf (in Japanese)."},{"key":"14","unstructured":"MHLW (2000): Ninety-day repeated dose oral toxicity test of dicyclopentan-1-ylsilanediol in rats, consigned by Ministry of Health, Labour and Welfare, Japan. http:\/\/dra4.nihs.go.jp\/mhlw_data\/home\/pdf\/PDF211495-85-1h.pdf (in Japanese)."},{"key":"15","unstructured":"MHLW (2004): Twenty-eight-day repeated dose oral toxicity test of 2-imizolidinethione in rats, consigned by Ministry of Health, Labour and Welfare, Japan. http:\/\/dra4.nihs.go.jp\/mhlw_data\/home\/pdf\/PDF96-45-7b.pdf (in Japanese)."},{"key":"16","unstructured":"MHLW (2005): Twenty-eight-day repeated dose oral toxicity test of 2-imidazolidinethione in rats. In Toxicity Testing Reports of Environmental Chemicals (Ministry of Health, Labor and Welfare ed.), Vol. 12, pp 155-170, Chemicals Investigation Promoting Council, Japan."},{"key":"17","unstructured":"MHLW (2007a): Final report of combined repeated dose and reproductive\/developmental toxicity screening test of trithiocyanuric acid in rats, consigned by Ministry of Health, Labour and Welfare, Japan. http:\/\/dra4.nihs.go.jp\/mhlw_data\/home\/pdf\/PDF638-16-4d.pdf (in Japanese)."},{"key":"18","unstructured":"MHLW (2007b): Final report of combined repeated dose and reproductive\/developmental toxicity screening test of 4-methyl-2,4-diphenylpent-1-ene in rats, consigned by Ministry of Health, Labour and Welfare, Japan.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; http:\/\/dra4.nihs.go.jp\/mhlw_data\/home\/pdf\/PDF6362-80-7d.pdf (in Japanese)."},{"key":"19","unstructured":"OECD (1996): OECD Guideline For Testing of Chemicals, No. 422, Combined Repeated Dose Toxicity Study with the Reproduction\/Developmental Toxicity Screening Test (Original Guideline, adopted 22 March 1996)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"Parks, R.E.Jr., Kidder, G.W. and Dewey, V.C. (1952): Thiosemicarbazide toxicity in mice. Proc. Soc. Exp. Biol. Med., <b>79<\/b>, 287-289.","DOI":"10.3181\/00379727-79-19354"},{"key":"21","unstructured":"Rao, P.M. and Panda, J.N. (1980): Effects of hypothyroidism on pregnancy of rats. Indian J. Physiol. Pharmacol., <b>24<\/b>, 126-130."},{"key":"22","doi-asserted-by":"crossref","unstructured":"Takaoka, M., Manabe, S., Yamoto, T., Teranishi, M., Matsunuma, N., Masuda, H. and Goto, N. (1994) : Comparative study of goitrogenic actions of 3-substituted 1,2,4-triazoles in rats. J. Vet. Med. Sci., <b>56<\/b>, 341-346.","DOI":"10.1292\/jvms.56.341"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Taurog, A. and Dorris, M.L. (1989): A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil. Endocrinology, <b>124<\/b>, 3038-3042.","DOI":"10.1210\/endo-124-6-3038"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Yamada, T., Hasegawa, R., Nishikawa, S., Sakuratani, Y., Yamada, J., Yamashita, T., Yoshinari, K., Yamazoe, Y., Kamata, E., Ono, A., Hirose, A. and Hayashi, M. (2013): A new parameter that supports speculation on the possible mechanism of hypothyroidism induced by chemical substances in repeated-dose toxicity studies. J. Toxicol. Sci., <b>38<\/b>, 291-299.","DOI":"10.2131\/jts.38.291"},{"key":"25","unstructured":"Yamasaki, K., Tago, Y., Nagai, K., Sawaki, M., Noda, S. and Takatsuki, M. (2002): Comparison of toxicity studies based on the draft protocol for the &lsquo;Enhanced OECD Test Guideline no. 407&rsquo; and the research protocol of &lsquo;Pubertal Development and Thyroid Function in Immature Male Rats&rsquo; with 6-n-propyl-2-thiouracil. Arch. Toxicol., <b>76<\/b>, 495-501."}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/38\/5\/38_759\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T03:39:09Z","timestamp":1620963549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/38\/5\/38_759\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.38.759","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}