{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:10:07Z","timestamp":1770336607685,"version":"3.49.0"},"reference-count":22,"publisher":"Japanese Society of Toxicology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2013]]},"DOI":"10.2131\/jts.38.815","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T22:54:02Z","timestamp":1383951242000},"page":"815-820","source":"Crossref","is-referenced-by-count":28,"title":["Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells"],"prefix":"10.2131","volume":"38","author":[{"given":"Maki","family":"Tokumoto","sequence":"first","affiliation":[{"name":"Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University"},{"name":"Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University"},{"name":"Elements Chemistry Laboratory, RIKEN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Elements Chemistry Laboratory, RIKEN"},{"name":"Advanced Elements Chemistry Laboratory, Graduate School of Pharmaceutical Sciences, The University of Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Satoh","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Chen, Y.W., Huang, C.F., Yang, C.Y., Yen, C.C., Tsai, K.S. and Liu, S.H. (2010): Inorganic mercury causes pancreatic beta-cell death via the oxidative stress-induced apoptotic and necrotic pathways. Toxicol. Appl. Pharmacol., <b>243<\/b>, 323-331.","DOI":"10.1016\/j.taap.2009.11.024"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Duncan-Achanzar, K.B., Jones, J.T., Burke, M.F., Carter, D.E. and Laird, H.E. (1996): Inorganic mercury chloride-induced apoptosis in the cultured porcine renal cell line LLC-PK1. J. Pharmacol. Exp. Ther., <b>277<\/b>, 1726-1732.","DOI":"10.1016\/S0022-3565(25)13129-7"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Fricker, M., Papadia, S., Hardingham, G.E. and Tolkovsky, A.M. (2010): Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons. J. Neurochem., <b>114<\/b>, 772-783.","DOI":"10.1111\/j.1471-4159.2010.06804.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Fujiwara, Y., Lee, J.Y., Tokumoto, M. and Satoh, M. (2012): Cadmium renal toxicity via apoptotic pathways. Biol. Pharm. Bull., <b>35<\/b>, 1892-1897.","DOI":"10.1248\/bpb.b212014"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Haupt, Y., Maya, R., Kazaz, A. and Oren, M. (1997): Mdm2 promotes the rapid degradation of p53. Nature, <b>387<\/b>, 296-299.","DOI":"10.1038\/387296a0"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Homma-Takeda, S., Takenaka, Y., Kumagai, Y. and Shimojo, N. (1999): Selective induction of apoptosis of renal proximal tubular cells caused by inorganic mercury <i>in vivo<\/i>. Environ. Toxicol. Pharmacol., <b>7<\/b>, 179-187.","DOI":"10.1016\/S1382-6689(99)00012-5"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Honda, R., Tanaka, H. and Yasuda, H. (1997): Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett., <b>420<\/b>, 25-27.","DOI":"10.1016\/S0014-5793(97)01480-4"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Jimi, S., Uchiyama, M., Takaki, A., Suzumiya, J. and Hara, S. (2004): Mechanisms of cell death induced by cadmium and arsenic. Ann. N. Y. Acad. Sci., <b>1011<\/b>, 325-331.","DOI":"10.1196\/annals.1293.032"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Kanda, H., Kikushima, M., Homma-Takeda, S., Sumi, D., Endo, A., Toyama, T., Miura, N., Naganuma, A. and Kumagai, Y. (2008): Downregulation of arginase II and renal apoptosis by inorganic mercury: overexpression of arginase II reduces its apoptosis. Arch. Toxicol., <b>82<\/b>, 67-73.","DOI":"10.1007\/s00204-007-0244-z"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Kim, S.M., Kim, Y.G., Jeong, K.H., Lee, S.H., Lee, T.W., Ihm, C.G. and Moon, J.Y. (2012): Angiotensin II-induced mitochondrial Nox4 is a major endogenous source of oxidative stress in kidney tubular cells. PLoS One, <b>7<\/b>, e39739.","DOI":"10.1371\/journal.pone.0039739"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Kubbutat, M.H., Jones, S.N. and Vousden, K.H. (1997): Regulation of p53 stability by Mdm2. Nature, <b>387<\/b>, 299-303.","DOI":"10.1038\/387299a0"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Mills, A.A. (2005): p53: link to the past, bridge to the future. Genes Dev., <b>19<\/b>, 2091-2099.","DOI":"10.1101\/gad.1362905"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Peraza, M.A., Cromey, D.W., Carolus, B., Carter, D.E. and Gandolfi, A.J. (2006): Morphological and functional alterations in human proximal tubular cell line induced by low level inorganic arsenic: evidence for targeting of mitochondria and initiated apoptosis. J. Appl. Toxicol., <b>26<\/b>, 356-367.","DOI":"10.1002\/jat.1149"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Saville, M.K., Sparks, A., Xirodimas, D.P., Wardrop, J., Stevenson, L.F., Bourdon, J.C., Woods, Y.L. and Lane, D.P. (2004): Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B\/C <i>in vivo<\/i>. J. Biol. Chem., <b>279<\/b>, 42169-42181.","DOI":"10.1074\/jbc.M403362200"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Sharpless, N.E. and DePinho, R.A. (2002): p53: good cop\/bad cop. Cell, <b>110<\/b>, 9-12.","DOI":"10.1016\/S0092-8674(02)00818-8"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Stacchiotti, A., Morandini, F., Bettoni, F., Schena, I., Lavazza, A., Grigolato, P.G., Apostoli, P., Rezzani, R. and Aleo, M.F. (2009): Stress proteins and oxidative damage in a renal derived cell line exposed to inorganic mercury and lead. Toxicology, <b>264<\/b>, 215-224.","DOI":"10.1016\/j.tox.2009.08.014"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Taneda, S., Honda, K., Tomidokoro, K., Uto, K., Nitta, K. and Oda, H. (2010): Eicosapentaenoic acid restores diabetic tubular injury through regulating oxidative stress and mitochondrial apoptosis. Am. J. Physiol. Renal. Physiol., <b>299<\/b>, F1451-F1461.","DOI":"10.1152\/ajprenal.00637.2009"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Tokumoto, M., Ohtsu, T., Honda, A., Fujiwara, Y., Nagase, H. and Satoh, M. (2011a): DNA microarray analysis of normal rat kidney epithelial cells treated with cadmium. J. Toxicol. Sci., <b>36<\/b>, 127-129.","DOI":"10.2131\/jts.36.127"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Tokumoto, M., Fujiwara, Y., Shimada, A., Hasegawa, T., Seko, Y., Nagase, H. and Satoh, M. (2011b): Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes <i>in vitro<\/i> and <i>in vivo<\/i>. J. Toxicol. Sci., <b>36<\/b>, 191-200.","DOI":"10.2131\/jts.36.191"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Xu, F., Putt, D.A., Matherly, L.H. and Lash, L.H. (2006): Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis. J. Pharmacol. Exp. Ther., <b>316<\/b>, 1175-1186.","DOI":"10.1124\/jpet.105.094599"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Yadav, S., Shi, Y., Wang, F. and Wang, H. (2010): Arsenite induces apoptosis in human mesenchymal stem cells by altering Bcl-2 family proteins and by activating intrinsic pathway. Toxicol. Appl. Pharmacol., <b>244<\/b>, 263-272.","DOI":"10.1016\/j.taap.2010.01.001"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Yu, Y., Zhang, D., Huang, H., Li, J., Zhang, M., Wan, Y., Gao, J. and Huang, C. (2013): NF-&kappa;B1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1. Oncogene, in press.","DOI":"10.1038\/onc.2013.8"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/38\/6\/38_815\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T20:00:32Z","timestamp":1746043232000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/38\/6\/38_815\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.38.815","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}