{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:38:00Z","timestamp":1761597480416},"reference-count":20,"publisher":"Japanese Society of Toxicology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2014]]},"DOI":"10.2131\/jts.39.109","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T23:03:40Z","timestamp":1389308620000},"page":"109-119","source":"Crossref","is-referenced-by-count":11,"title":["A 13-week subchronic toxicity study of sodium iron chlorophyllin in F344 rats"],"prefix":"10.2131","volume":"39","author":[{"given":"Takeshi","family":"Toyoda","sequence":"first","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Man","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-ichi","family":"Akagi","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"},{"name":"Division of Pharmacology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Biological Safety Research Center, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Arimoto-Kobayashi, S., Inada, N., Nakano, H., Rai, H. and Hayatsu, H. (1998): Iron-chlorophyllin-mediated conversion of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2(NHOH)) into its nitroso derivative. Mutat. Res., <b>400<\/b>, 259-269.","DOI":"10.1016\/S0027-5107(98)00033-5"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Buchner, A. and Sreebny, L.M. (1972): Enlargement of salivary glands. Review of the literature. Oral Surg. Oral Med. Oral Pathol., <b>34<\/b>, 209-222.","DOI":"10.1016\/0030-4220(72)90411-2"},{"key":"3","unstructured":"Charles River Laboratories Japan, Inc. (2009): Long-term monitoring data of F344\/DuCrlCrlj rats. [http:\/\/www.crj.co.jp\/cms\/pdf\/info_common\/137\/4004703\/OP-F-16_F344_DATA_2009.pdf accessed 2013\/11\/20]"},{"key":"4","unstructured":"Charles River Laboratories Japan, Inc. (2010): Background data of F344\/DuCrlCrlj rats. [http:\/\/www.crj.co.jp\/cms\/pdf\/info_common\/36\/8178965\/control%20data_F344_100107ca.pdf accessed 2013\/11\/20]"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Chiu, T. and Chen, H.C. (1986): Spontaneous basophilic hypertrophic foci of the parotid glands in rats and mice. Vet. Pathol., <b>23<\/b>, 606-609.","DOI":"10.1177\/030098588602300509"},{"key":"6","doi-asserted-by":"crossref","unstructured":"da Costa, G., Lamy, E., Capela e Silva, F., Andersen, J., Sales Baptista, E. and Coelho, A.V. (2008): Salivary amylase induction by tannin-enriched diets as a possible countermeasure against tannins. J. Chem. Ecol., <b>34<\/b>, 376-387.","DOI":"10.1007\/s10886-007-9413-z"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Gkouvatsos, K., Papanikolaou, G. and Pantopoulos, K. (2012): Regulation of iron transport and the role of transferrin. Biochim. Biophys. Acta, <b>1820<\/b>, 188-202.","DOI":"10.1016\/j.bbagen.2011.10.013"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Greaves, P. (2012): Salivary Glands. In: Histopathology of Preclinical Toxicity Studies (Greaves, P., ed.), pp. 332-341, Academic Press, San Diego.","DOI":"10.1016\/B978-0-444-53856-7.00003-8"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Hasegawa, R., Hirose, M., Kato, T., Hagiwara, A., Boonyaphiphat, P., Nagao, M., Ito, N. and Shirai, T. (1995): Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats. Carcinogenesis, <b>16<\/b>, 2243-2246.","DOI":"10.1093\/carcin\/16.9.2243"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Hirose, M., Nishikawa, A., Shibutani, M., Imai, T. and Shirai, T. (2002): Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats. Environ. Mol. Mutagen., <b>39<\/b>, 271-278.","DOI":"10.1002\/em.10066"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Inoue, K., Morikawa, T., Takahashi, M., Yoshida, M. and Ogawa, K. (2013): A 13-week subchronic toxicity study of grape skin extract in F344 rats. J. Toxicol. Sci., <b>38<\/b>, 559-570.","DOI":"10.2131\/jts.38.559"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Ishidate, M. Jr., Sofuni, T., Yoshikawa, K., Hayashi, M., Nohmi, T., Sawada, M. and Matsuoka, A. (1984): Primary mutagenicity screening of food additives currently used in Japan. Food Chem. Toxicol., <b>22<\/b>, 623-636.","DOI":"10.1016\/0278-6915(84)90271-0"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Jackson, C.D. and Blackwell, B.N. (1988): Subchronic studies of doxylamine in Fischer 344 rats. Fundam. Appl. Toxicol., <b>10<\/b>, 243-253.","DOI":"10.1016\/0272-0590(88)90308-9"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Kato, T., Ohno, O., Nagoshi, T., Ichinose, Y. and Igarashi, S. (2005): Determination of small amounts of L-ascorbic acid using the chemiluminescence of an iron-chlorophyllin complex. Anal. Sci., <b>21<\/b>, 579-581.","DOI":"10.2116\/analsci.21.579"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Marino, D.J. (2012): Age-specific absolute and relative organ weight distributions for Fischer 344 rats. J. Toxicol. Environ. Health A, <b>75<\/b>, 1484-1516.","DOI":"10.1080\/15287394.2012.722520"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Nagoshi, T., Ohno, O., Kotake, T. and Igarashi, S. (2005): Chemiluminescence of iron-chlorophyllin. Luminescence, <b>20<\/b>, 401-404.","DOI":"10.1002\/bio.862"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Nashida, T., Yoshie, S., Imai, A. and Shimomura, H. (2009): Transferrin secretory pathways in rat parotid acinar cells. Arch. Biochem. Biophys., <b>487<\/b>, 131-138.","DOI":"10.1016\/j.abb.2009.05.010"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Wells, D.J. and Humphreys-Beher, M.G. (1985): Analysis of protein synthesis in rat salivary glands after chronic treatment with beta-receptor agonists and phosphodiesterase inhibitors. Biochem. Pharmacol., <b>34<\/b>, 4229-4237.","DOI":"10.1016\/0006-2952(85)90277-1"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Yu, J.W., Yang, R. and Kim, Y.S. (2010): Differential cytoprotective effect of copper- and iron-containing chlorophyllins against oxidative stress-mediated cell death. Free Radic. Res., <b>44<\/b>, 655-667.","DOI":"10.3109\/10715761003733893"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Zhang, J., Wang, W., Yang, F., Zhou, X., Jin, H. and Yang, P.Y. (2012): Comparative proteomic analysis of drug sodium iron chlorophyllin addition to Hep 3B cell line. Analyst, <b>137<\/b>, 4287-4294.","DOI":"10.1039\/c2an35436e"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/39\/1\/39_109\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T03:39:25Z","timestamp":1620963565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/39\/1\/39_109\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.39.109","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}