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(1997): Perforin, Fas\/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL. J. Immunol., 158<\/b>, 5283-5291.","DOI":"10.4049\/jimmunol.158.11.5283"},{"key":"2","unstructured":"Atakisi, O., Atakisi, E., Ozcan, A., Karapehlivan, M. and Kart, A. (2013): Protective effect of omega-3 fatty acids on diethylnitrosamine toxicity in rats. Eur. Rev. Med. Pharmacol. Sci., 17<\/b>, 467-471."},{"key":"3","unstructured":"Ayata, C.K., Ganal, S.C., Hockenjos, B., Willim, K., Vieira, R.P., Grimm, M., Robaye, B., Boeynaems, J.M., Di Virgilio, F., Pellegatti, P., Diefenbach, A., Idzko, M. and Hasselblattm, P. (2012): Purinergic P2Y(2) receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury. Gastroenterology, <\/i>143<\/b>, 1620-1629 e1624."},{"key":"4","doi-asserted-by":"crossref","unstructured":"Badovinac, V.P., Tvinnereim, A.R. and Harty, J.T. (2000): Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science, <\/i>290<\/b>, 1354-1358.","DOI":"10.1126\/science.290.5495.1354"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Bonder, C.S., Ajuebor, M.N., Zbytnuik, L.D., Kubes, P. and Swain, M.G. (2004). Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis. J. Immunol., <\/i>172<\/b>, 45-53.","DOI":"10.4049\/jimmunol.172.1.45"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Calder, P.C. (2007): Immunomodulation by omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids, <\/i>77<\/b>, 327-335.","DOI":"10.1016\/j.plefa.2007.10.015"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Cao, Q., Batey, R., Pang, G., Russell, A. and Clancy, R. (1998): IL-6, IFN-gamma and TNF-alpha production by liver-associated T cells and acute liver injury in rats administered concanavalin A. Immunol. 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