{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:30:06Z","timestamp":1759530606374},"reference-count":38,"publisher":"Japanese Society of Toxicology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2014]]},"DOI":"10.2131\/jts.39.437","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T23:05:07Z","timestamp":1400713507000},"page":"437-445","source":"Crossref","is-referenced-by-count":7,"title":["Repeated dose liver micronucleus assay using adult mice with multiple genotoxicity assays concurrently performed as a combination test"],"prefix":"10.2131","volume":"39","author":[{"given":"Soichiro","family":"Hagio","sequence":"first","affiliation":[{"name":"Biological Research Laboratories, Nissan Chemical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Biological Research Laboratories, Nissan Chemical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Abe","sequence":"additional","affiliation":[{"name":"Biological Research Laboratories, Nissan Chemical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Biological Research Laboratories, Nissan Chemical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seigo","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Biological Research Laboratories, Nissan Chemical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Biological Research Laboratories, Nissan Chemical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Aggarwal, S.K. (1993): A histochemical approach to the mechanism of action of cisplatin and its analogues. J. Histochem.&nbsp; Cytochem.,&nbsp;<b>41<\/b>, 1053-1073.","DOI":"10.1177\/41.7.8515048"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Braithwaite, I. and Ashby, J. (1988): A non-invasive micronucleus assay in the rat liver. Mutat. Res.,&nbsp;<b>203<\/b>, 23-32.","DOI":"10.1016\/0165-1161(88)90004-0"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Cliet, I., Fournier, E., Melcion, C. and Cordier, A. (1989):&nbsp;In vivo&nbsp;micronucleus test using mouse hepatocytes. Mutat. Res.,&nbsp;<b>216<\/b>, 321-326.","DOI":"10.1016\/0165-1161(89)90042-3"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Cliet, I., Melcion, C. and Cordier, A. (1993): Lack of predictivity of bone marrow micronucleus test versus testis micronucleus test: comparison with four carcinogens. Mutat. Res.,&nbsp;<b>292<\/b>, 105-111.","DOI":"10.1016\/0165-1161(93)90137-O"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Collins, M.A., Lake, B.G., Evans, J.G., Walker, R., Gangolli, S.D. and Conning, D.M. (1984): Sustained induction of hepatic xenobiotic metabolising enzyme activities by phenobarbitone in C3H\/He mice: relevance to nodule formation. Toxicology,&nbsp;<b>33<\/b>, 129-144.","DOI":"10.1016\/0300-483X(84)90068-4"},{"key":"6","unstructured":"CSGMT\/JEMS.MMS No authors listed. (1992): Micronucleus test with mouse peripheral blood erythrocytes by acridine orange supravital staining: the summary report of the 5th collaborative study by CSGMT\/JEMS.MMS. The Collaborative Study Group for the Micronucleus Test. Mutat. Res.,&nbsp;<b>278<\/b>, 83-98."},{"key":"7","doi-asserted-by":"crossref","unstructured":"Dertinger, S.D., Phonethepswath, S., Franklin, D., Weller, P., Torous, D.K., Bryce, S.M., Avlasevich, S., Bemis, J.C., Hyrien, O., Palis, J. and MacGregor, J.T. (2010): Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies. Toxicol. Sci.,&nbsp;<b>115<\/b>, 401-411.","DOI":"10.1093\/toxsci\/kfq070"},{"key":"8","unstructured":"Dostalek, M., Brooks, J.D., Hardy, K.D., Milne, G.L., Moore, M.M., Sharma, S., Morrow, J.D. and Guengerich, F.P. (2007):&nbsp;<i>In vivo<\/i>&nbsp;oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers. Mol.&nbsp; Pharmacol.,&nbsp;<b>72<\/b>, 1419-1424."},{"key":"9","unstructured":"Dybing, E. and Huitfeldt, H.S. (1992): Species differences in carcinogen metabolism and interspecies extrapolation. IARC Sci. Publ.,&nbsp;<b>116<\/b>, 501-522."},{"key":"10","doi-asserted-by":"crossref","unstructured":"Hamada, S., Sutou, S., Morita, T., Wakata, A., Asanami, S., Hosoya, S., Ozawa, S., Kondo, K., Nakajima, M., Shimada, H., Osawa, K., Kondo, Y., Asano, N., Sato, S., Tamura, H., Yajima, N., Marshall, R., Moore, C., Blakey, D.H., Schechtman, L.M., Weaver, J.L., Torous, D.K., Proudlock. R., Ito, S., Namiki, C. and Hayashi, M. (2001): Evaluation of the rodent micronucleus assay by a 28-day treatment protocol: Summary of the 13th Collaborative Study by the Collaborative Study Group for the Micronucleus Test (CSGMT)\/Environmental Mutagen Society of Japan (JEMS)-Mammalian Mutagenicity Study Group (MMS). Environ. Mol. Mutagen.,&nbsp;<b>37<\/b>, 93-110.","DOI":"10.1002\/em.1017"},{"key":"11","unstructured":"IARC (1978):&nbsp;<i>N<\/i>-Nitrosodiethylamine, in: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 17, IARC, Lyon (France), pp. 83."},{"key":"12","unstructured":"IARC (1981): Cisplatin, in: Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Some Antineoplastic and Immunosuppressive Agents, Volume 26, IARC, Lyon (France), pp. 150."},{"key":"13","unstructured":"IARC (1987): Cisplatin, in: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Supplement 7, Overall Evaluations of Carcinogenicity, An Updating of IARC Monographs, Volumes 1 to 42, IARC, Lyon (France), pp. 170."},{"key":"14","unstructured":"IARC (2001): Phenobarbital and its sodium salt, in: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 79, IARC, Lyon (France), pp. 161."},{"key":"15","unstructured":"ICH (2011): Harmonized Tripartite Guideline, Guidance on Genotoxicity Testing and Data Interpretation for Pharmaceutical Intended for Human Use, S2(R1), step 4 version"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Igarashi, M. and Shimada, H. (1997): An improved method for the mouse liver micronucleus test. Mutat. Res.,&nbsp;<b>391<\/b>, 49-55.","DOI":"10.1016\/S0165-1218(97)00031-1"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Igarashi, M., Nagata, M., Itoh, S., Yamoto, T. and Tsuda, S. (2010): Relationship between DNA damage and micronucleus in mouse liver. J. Toxicol. Sci.,&nbsp;<b>35<\/b>, 881-889.","DOI":"10.2131\/jts.35.881"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Kastenbaum, M.A. and Bowman, K.O. (1970): Tables for determining the statistical significance of mutation frequencies. Mutat. Res.,&nbsp;<b>9<\/b>, 527-549.","DOI":"10.1016\/0027-5107(70)90038-2"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Krishna, G., Urda, G. and Paulissen, J. (2000): Historical vehicle and positive control micronucleus data in mice and rats. Mutat. Res.,&nbsp;<b>453<\/b>, 45-50.","DOI":"10.1016\/S0027-5107(00)00074-9"},{"key":"20","unstructured":"Macdonald, R.A. (1961): &ldquo;Lifespan&rdquo; of liver cells. Autoradio-graphic study using tritiated thymidine in normal, cirrhotic and partially hepatectomized rats. Arch. Intern. Med.,&nbsp;<b>107<\/b>, 335-343."},{"key":"21","doi-asserted-by":"crossref","unstructured":"Merk, O. and Speit, G. (1999): Detection of crosslinks with the comet assay in relationship to genotoxicity and cytotoxicity. Environ. Mol. Mutagen.,&nbsp;<b>33<\/b>, 167-172.","DOI":"10.1002\/(SICI)1098-2280(1999)33:2<167::AID-EM9>3.0.CO;2-D"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Miyamae, Y., Iwasaki, K., Kinae, N., Tsuda, S., Murakami, M., Tanaka, M. and Sasaki, Y.F. (1997): Detection of DNA lesions induced by chemical mutagens using the single-cell gel electrophoresis (comet) assay. 2. Relationship between DNA migration and alkaline condition. Mutat. Res.,&nbsp;<b>393<\/b>, 107-113.","DOI":"10.1016\/S1383-5718(97)00091-0"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Morita, T., Asano, N.T. Awogi, T. Sasaki, Y., Sato, S., Shimada,&nbsp; H., Sutou, S., Suzuki, T., Wakata, A., Sofuni, T. and Hayashi,&nbsp; M. (1997): Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (Groups 1, 2A and 2B) The summary report of the 6th collaborative study by CSGMT\/JEMS&#8226;MMS. Mutat. Res.,&nbsp;<b>389<\/b>, 3-122.","DOI":"10.1016\/S1383-5718(96)00070-8"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Morita, T., MacGregor, J.T. and Hayashi, M. (2011): Micronucleus assays in rodent tissues other than bone marrow. Mutagenesis,&nbsp; <b>26<\/b>, 223-230.","DOI":"10.1093\/mutage\/geq066"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Mughal, A., Vikram, A., Ramarao, P. and Jena, G.B. (2010): Micronucleus and comet assay in the peripheral blood of juvenile rat: establishment of assay feasibility, time of sampling and the induction of DNA damage. Mutat. Res.,&nbsp;<b>700<\/b>, 86-94.","DOI":"10.1016\/j.mrgentox.2010.05.014"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Narumi, K., Ashizawa, K., Takashima, R., Takasawa, H., Katayama,&nbsp; S., Tsuzuki, Y., Tatemoto, H., Morita, T., Hayashi, M. and&nbsp; Hamada, S. (2012): Development of a repeated-dose liver micronucleus assay using adult rats: an investigation of diethylnitrosamine and 2,4-diaminotoluene. Mutat. Res.,&nbsp;<b>747<\/b>, 234-239.","DOI":"10.1016\/j.mrgentox.2012.05.012"},{"key":"27","unstructured":"Natarajan, A.T., Tates, A.D., Van Buul, P.P., Meijers, M. and De Vogel, N. (1976): Cytogenetic effects of mutagens\/carcinogens after activation in a microsomal system&nbsp;<i>in vitro<\/i>&nbsp;I. Induction of chromosome aberrations and sister chromatid exchanges by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in CHO cells in the presence of rat-liver microsomes. Mutat. Res.,&nbsp;<b>37<\/b>, 83-90."},{"key":"28","doi-asserted-by":"crossref","unstructured":"Nesslany, F., Zennouche, N., Simar-Meinti&egrave;res, S., Talahari, I.,&nbsp; Nkili-Mboui, E.N. and Marzin, D. (2007):&nbsp;<i>In vivo<\/i>&nbsp;Comet assay on isolated kidney cells to distinguish genotoxic carcinogens from epigenetic carcinogens or cytotoxic compounds. Mutat. Res.,&nbsp;<b>630<\/b>, 28-41.","DOI":"10.1016\/j.mrgentox.2007.02.010"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Pfuhler, S. and Wolf, H.U. (1996): Detection of DNA-crosslinking agents with the alkaline comet assay. Environ. Mol. Mutagen.,&nbsp;<b>27<\/b>, 196-201.","DOI":"10.1002\/(SICI)1098-2280(1996)27:3<196::AID-EM4>3.0.CO;2-D"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Rothfuss, A., O&rsquo;Donovan, M., De Boeck, M., Brault, D., Czich, A., Custer, L., Hamada, S., Plappert-Helbig, U., Hayashi, M., Howe, J., Kraynak, A.R., van der Leede, B.J., Nakajima, M., Priestley,&nbsp; C., Thybaud, V., Saigo, K., Sawant, S., Shi, J., Storer, R.,&nbsp; Struwe, M., Vock, E. and Galloway, S. (2010): Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies. Mutat. Res.,&nbsp;<b>702<\/b>, 40-69.","DOI":"10.1016\/j.mrgentox.2010.07.006"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Sasaki, Y.F., Izumiyama, F., Nishidate, E., Matsusaka, N. and Tuda, S. (1997): Detection of rodent liver carcinogen genotoxicity by the alkaline single-cell gel electrophoresis (Comet) Assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow). Mutat. Res.,<b>&nbsp;391<\/b>, 201-214.","DOI":"10.1016\/S1383-5718(97)00072-7"},{"key":"32","unstructured":"Sasaki, Y.F., Sekihashi, K., Izumiyama, F., Nishidate, E., Saga, A., Ishida, K. and Tsuda, S. (2000): The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and U.S. NTP Carcinogenicity Database. Crit. Rev. Toxicol.,&nbsp;<b>30<\/b>, 629-799."},{"key":"33","doi-asserted-by":"crossref","unstructured":"Suzuki, H., Shirotori, T. and Hayashi, M. (2004): A liver micronucleus assay using young rats exposed to diethylnitrosamine: methodological establishment and evaluation. Cytogenet Genome Res.,&nbsp;<b>104<\/b>, 299-303.","DOI":"10.1159\/000077506"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Takasawa, H., Suzuki, H., Ogawa, I., Kobayashi, K., Terashima, Y., Shimada, Y., Matsumoto, H., Oshida, R., Ohata, R., Imamura,&nbsp; T., Miyazaki, A., Kawabata, M., Minowa, S., Maeda, A. and Hayashi, M. (2010): Evaluation of a liver micronucleus assay in young rats (IV): A study using a double-dosing\/single-sampling method by the Collaborative Study Group for the Micronucleus Test (CSGMT)\/Japanese Environmental Mutagen Society (JEMS)&#8211;Mammalian Mutagenicity Study Group (MMS). Mutat. Res.,&nbsp;<b>698<\/b>, 24-29.","DOI":"10.1016\/j.mrgentox.2010.02.010"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Takasawa, H., Takashima, R., Hattori, A., Narumi, K., Kawasako, K., Morita, T., Hayashi, M. and Hamada, S. (2013): Development of a repeated-dose liver micronucleus assay using adult rats (II): further investigation of 1,2-dimethylhydrazine and 2,6-diaminotoluene. Mutat. Res.,&nbsp;<b>751<\/b>, 12-18.","DOI":"10.1016\/j.mrgentox.2012.10.004"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Tates, A.D., Neuteboom, I. and Hofker, M. (1980): A micronucleus technique for detecting clastogenic effects of mutagens\/carcinogens (DEN, DMN) in hepatocytes of rat liver&nbsp;<i>in vivo<\/i>. Mutat. Res.,&nbsp;<b>74<\/b>, 11-20.","DOI":"10.1016\/0165-1161(80)90187-9"},{"key":"37","doi-asserted-by":"crossref","unstructured":"Todd, R.C. and Lippard, S.J. (2009): Inhibition of transcription by platinum antitumor compounds. Metallomics,&nbsp;<b>1<\/b>, 280-291.","DOI":"10.1039\/b907567d"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Wild, D. (1978): Cytogenetic effects in the mouse of 17 chemical mutagens and carcinogens evaluated by the micronucleus test. Mutat. Res.,&nbsp;<b>56<\/b>, 319-327.","DOI":"10.1016\/0027-5107(78)90200-2"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/39\/3\/39_437\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T03:39:47Z","timestamp":1620963587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/39\/3\/39_437\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.39.437","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}