{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:35:52Z","timestamp":1768444552048,"version":"3.49.0"},"reference-count":44,"publisher":"Japanese Society of Toxicology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2015]]},"DOI":"10.2131\/jts.40.727","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T17:06:10Z","timestamp":1447088770000},"page":"727-738","source":"Crossref","is-referenced-by-count":13,"title":["Dose-dependent acceleration in the delayed effects of neonatal oral exposure to low-dose 17\u03b1-ethynylestradiol on reproductive functions in female Sprague-Dawley rats"],"prefix":"10.2131","volume":"40","author":[{"given":"Mariko","family":"Shirota","sequence":"first","affiliation":[{"name":"Laboratory of Comparative Toxicology, School of Veterinary Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Toxicology, School of Veterinary Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Toxicology, School of Veterinary Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Kamiie","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Azabu University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinji","family":"Shirota","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Azabu University"},{"name":"Research Institute of Biosciences, Azabu University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Asai, S., Ohta, R., Shirota, M., Sato, M., Watanabe, G. and Taya, K. (2002): Reproductive endocrinology in Hatano high- and low-avoidance rats during the estrous cycle. Endocrine, <b>18<\/b>, 161-166.","DOI":"10.1385\/ENDO:18:2:161"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Ayyanan, A., Laribi, O., Schuepbach-Mallepell, S., Schrick, C., Gutierrez, M., Tanos, T., Lefebvre, G., Rougemont, J., Yalcin-Ozuysal, O. and Brisken, C. (2011): Perinatal exposure to bisphenol A increases adult mammary gland progesterone response and cell number. Mol. Endocrinol., <b>25<\/b>, 1915-1923.","DOI":"10.1210\/me.2011-1129"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Barkhem, T., Carlsson, B., Nilsson, Y., Enmark, E., Gustafsson, J. and Nilsson, S. (1998): Differential response of estrogen receptor \u03b1 and estrogen receptor \u03b2 to partial estrogen agonists\/antagonists. Mol. Pharmacol., <b>54<\/b>, 105-112.","DOI":"10.1124\/mol.54.1.105"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Barraclough, C.A. (1961): Production of anovulatory, sterile rats by single injections of testosterone propionate. Endocrinology, <b>68<\/b>, 62-67.","DOI":"10.1210\/endo-68-1-62"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Betancourt, A.M., Eltoum, I.A., Desmond, R.A., Russo, J. and Lamartiniere, C.A. (2010): <i>In utero<\/i> exposure to bisphenol A shifts the window of susceptibility for mammary carcinogenesis in the rat. Environ. Health Perspect., <b>118<\/b>, 1614-1619.","DOI":"10.1289\/ehp.1002148"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Borges, N.C., Astigarraga, R.B., Sverdloff, C.E., Galvinas, P.R., da Silva, W.M., Rezende, V.M. and Moreno, R.A. (2009): A novel and sensitive method for ethinylestradiol quantification in human plasma by high-performance liquid chromatography coupled to atmospheric pressure photoionization (APPI) tandem mass spectrometry: Application to a comparative pharmacokinetics study. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., <b>877<\/b>, 3601-3609.","DOI":"10.1016\/j.jchromb.2009.08.048"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Bukovsky, A., Ayala, M.E., Dominguez, R., Keenan, J.A., Wimalasena, J., McKenzie, P.P. and Caudle, M.R. (2000): Postnatal androgenization induces premature aging of rat ovaries. Steroids, <b>65<\/b>, 190-205.","DOI":"10.1016\/S0039-128X(99)00101-4"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Burdick, H.O. and Whitney, R. (1941): Ovulation induced in mice by single injection of follutein or untreated human pregnancy urine. Am. J. Physiol., <b>132<\/b>, 405-410.","DOI":"10.1152\/ajplegacy.1941.132.2.405"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Chen, Y., Breen, K. and Pepling, M.E. (2009): Estrogen can signal through multiple pathways to regulate oocyte cyst breakdown and primordial follicle assembly in the neonatal mouse ovary. J. Endocrinol., <b>202<\/b>, 407-417.","DOI":"10.1677\/JOE-09-0109"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Chung, W.C. and Auger, A.P. (2013): Gender differences in neurodevelopment and epigenetics. Pflugers Arch., <b>465<\/b>, 573-584.","DOI":"10.1007\/s00424-013-1258-4"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Cimafranca, M.A., Davila, J., Ekman, G.C., Andrews, R.N., Neese, S.L., Peretz, J., Woodling, K.A., Helferich, W.G., Sarkar, J., Flaws, J.A., Schantz, S.L., Doerge, D.R. and Cooke, P.S. (2010): Acute and chronic effects of oral genistein administration in neonatal mice. Biol. Reprod., <b>83<\/b>, 114-121.","DOI":"10.1095\/biolreprod.109.080549"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Coldham, N.G., Dave, M., Sivapathasundaram, S., McDonnell, D.P., Connor, C. and Sauer, M. J. (1997): Evaluation of a recombinant yeast cell estrogen screening assay. Environ. Health Perspect., <b>105<\/b>, 734-742.","DOI":"10.1289\/ehp.97105734"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Downsa, J.L. and Wise, P.M. (2009): The role of the brain in female reproductive aging. Mol. Cell. Endocrinol., <b>299<\/b>, 32-38.","DOI":"10.1016\/j.mce.2008.11.012"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Fang, H., Tong, W., Perkins, R., Soto, A.M., Precht, N.V. and Sheehan, D.M. (2000): Quantitative comparisons of <i>in vitro<\/i> assays for estrogenic activities. Environ. Health Perspect., <b>108<\/b>, 723-729.","DOI":"10.1289\/ehp.00108723"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Freyberge, A., Wilson, V., Weimer, M., Tan, S., Tran, H.-S. and Ahr, H.-J. (2010): Assessment of a robust model protocol with accelerated throughput for a human recombinant full length estrogen receptor-\u03b1 binding assay: Protocol optimization and intralaboratory assay performance as initial steps towards validation. Reprod. Toxicol., <b>30<\/b>, 50-59.","DOI":"10.1016\/j.reprotox.2010.01.001"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Frye, C.A., Bo, E., Calamandrei, G., Calz\u00e0, L., Dess\u00ec-Fulgheri, F., Fern\u00e1ndez, M., Fusani, L., Kah, O., Kajta, M., Le Page, Y., Patisaul, H.B., Venerosi, A., Wojtowicz, A.K. and Panzica, G.C. (2012): Endocrine disrupters: a review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems. J. Neuroendocrinol., <b>24<\/b>, 144-159.","DOI":"10.1111\/j.1365-2826.2011.02229.x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Gitlin, D. and Boesman, M. (1967): Sites of serum \u03b1-fetoprotein synthesis in the human and in the rat. J. Clin. Invest., <b>46<\/b>, 1010-1016.","DOI":"10.1172\/JCI105590"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Gore, A.C., Martien, K.M., Gagnidze, K. and Pfaff, D. (2014): Implications of prenatal steroid perturbations for neurodevelopment, behavior, and autism. Endocr. Rev., <b>35<\/b>, 961-991.","DOI":"10.1210\/er.2013-1122"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Gorski, R.A. (1968): Influence of age on the response to paranatal administration of a low dose of androgen. Endocrinology, <b>82<\/b>, 1001-1004.","DOI":"10.1210\/endo-82-5-1001"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Hong, H., Branham, W.S., Dial, S.L., Moland, C.L., Fang, H., Shen, J., Perkins, R., Sheehan, D. and Tong, W. (2012): Rat \u03b1-fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities. Chem. Res. Toxicol., <b>25<\/b>, 2553-2566.","DOI":"10.1021\/tx3003406"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Ichimura, R., Takahashi, M., Morikawa, T., Inouea, K., Maeda, J., Usuda, K., Yokosuka, M., Watanabe, G. and Yoshida, M. (2015): Prior attenuation of KiSS1\/GPR54 signaling in the anteroventral periventricular nucleus is a trigger for the delayed effect induced by neonatal exposure to 17alpha-ethynylestradiol in female rats. Reprod. Toxicol., <b>51<\/b>, 145-156.","DOI":"10.1016\/j.reprotox.2015.01.004"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Iguchi, T., Fukazawa, Y., Uesugi, Y. and Takasugi, N. (1990): Polyovular follicles in mouse ovaries exposed neonatally to diethylstilbestrol <i>in vivo<\/i> and<i> in vitro<\/i>. Biol. Reprod., <b>43<\/b>, 478-484.","DOI":"10.1095\/biolreprod43.3.478"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Jefferson, W.N., Patisaul, H.B. and Williams, C.J. (2012): Reproductive consequences of developmental phytoestrogen exposure. Reproduction, <b>143<\/b>, 247-260.","DOI":"10.1530\/REP-11-0369"},{"key":"24","doi-asserted-by":"crossref","unstructured":"McLachlan, J.A., Tilghman, S.L., Burow, M.E. and Bratton, M.R. (2012): Environmental signaling and reproduction: a comparative biological and chemical perspective. Mol. Cell. Endocrinol., <b>354<\/b>, 60-62.","DOI":"10.1016\/j.mce.2011.11.028"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Mogi, K., Takanashi, H., Nagasawa, M. and Kikusui, T. (2015): Sex differences in spatiotemporal expression of AR, ER\u03b1, and ER\u03b2 mRNA in the perinatal mouse brain. Neuroscie. Lett., <b>584<\/b>, 88-92.","DOI":"10.1016\/j.neulet.2014.10.028"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Moral, R., Santucci-Pereira, J., Wang, R., Russo, I.H., Lamartiniere, C.A. and Russo, J. (2011): In utero exposure to butyl benzyl phthalate induces modifications in the morphology and the gene expression profile of the mammary gland: an experimental study in rats. Environ. Health, <b>10<\/b>, 5.","DOI":"10.1186\/1476-069X-10-5"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Nakamuro, K., Ueno, H., Okuno, T., Sakazaki, H., Kawai, H., Kamei, T. and Ugawa, M. (2002): Contribution of endocrine-disrupting chemicals to estrogenicity of environmental water. J. Jpn. Soc. Water Environ., <b>125<\/b>, 355-360. [Japanease, Abstract in English]","DOI":"10.2965\/jswe.25.355"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Nishihara, T., Nishikawa, J., Kanayama, T., Utsumi, H., Dakeyama, F., Saito, K., Imagawa, M., Takatori, S., Kitagawa, Y. and Hori, S. (2000): Estrogenic activities of 517 chemicals by yeast two-hybrid assay. J. Health Sci., <b>46<\/b>, 282-298.","DOI":"10.1248\/jhs.46.282"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Nozawa, K., Nagaoka, K., Zhang, H., Usuda, K., Okazaki, S., Taya, K., Yoshida, M. and Waranabe, G. (2014): Neonatal exposure to 17\u03b1-ethynyl estradiol affects ovarian geneexpression and disrupts reproductive cycles in female rats. Reprod. Toxicol., <b>46<\/b>, 77-84.","DOI":"10.1016\/j.reprotox.2014.03.001"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Ohta, R., Ohmukai, H., Marumo, H., Shindo, T., Nagata, T. and Ono, H. (2012): Delayed reproductive dysfunction in female rats induced by early life exposure to low-dose diethylstilbestrol. Reprod. Toxicol., <b>34<\/b>, 323-330.","DOI":"10.1016\/j.reprotox.2012.04.014"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Prins, G.S., Ye, S.-H., Birch, L., Ho, S.M. and Kannan, K. (2011): Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague\u2013Dawley rats. Reprod. Toxicol., <b>31<\/b>, 1-9.","DOI":"10.1016\/j.reprotox.2010.09.009"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez, H., A., Santambrosio, N., Santamar\u00eda, C.G., Mu\u00f1oz-de-Toro, M. and Luque, E.H. (2010): Neonatal exposure to bisphenol A reduces the pool of primordial follicles in the rat ovary. Reprod. Toxicol., <b>30<\/b>, 550-557.","DOI":"10.1016\/j.reprotox.2010.07.008"},{"key":"33","unstructured":"Safe, S.H. (2000): Endocrine disruptors and human health - is there a problem? An update. Environ. Health Perspect., <b>1098<\/b>, 487-493."},{"key":"34","doi-asserted-by":"crossref","unstructured":"Sanseverino, J., Eldridge, M.L., Layton, A.C., Easter, J.P., Yarbrough, J., Schultz, T.W. and Sayler, G.S. (2009): Screening of potentially hormonally active chemicals using bioluminescent yeast bioreporters. Toxicol. Sci., <b>107<\/b>, 122-134.","DOI":"10.1093\/toxsci\/kfn229"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Shirota, M., Soda, S., Katoh, C., Asai, S., Sato, M., Ohta, R., Watanabe, G., Taya, K. and Shirota, K. (2003): Effects of reduction of the number of primordial follicles on follicular development to achieve puberty in female rats. Reproduction, <b>125<\/b>, 85-94.","DOI":"10.1530\/rep.0.1250085"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Shirota, M., Kawashima, J., Nakamura T., Ogawa, Y., Kamiie, J., Yasuno, K., Shirota, K. and Yoshida, M. (2012): Delayed effects of single neonatal subcutaneous exposure of low-dose 17\u03b1-ethynylestradiol on reproductive function in female rats. J. Toxicol. Sci., <b>37<\/b>, 681-690.","DOI":"10.2131\/jts.37.681"},{"key":"37","doi-asserted-by":"crossref","unstructured":"Smith, M.S., Freeman, M.E. and Neil, J.D. (1975): The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy. Endocrinology, <b>96<\/b>, 219-226.","DOI":"10.1210\/endo-96-1-219"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Soto, A.M., Sonnenschein, C., Chung, K.L., Fernandez, M.F., Olea, N. and Serrano, F.O. (1995): The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ. Health Perspect., <b>103 Suppl 7<\/b>, 113-122.","DOI":"10.1289\/ehp.95103s7113"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Takahashi, M., Inoue, K., Morikawa, T., Matsuo, S., Hayashi, S., Tamura, K., Watanabe, G., Taya, K. and Yoshida, M. (2013): Delayed effects of neonatal exposure to 17alpha-ethynylestradiol on the estrous cycle and uterine carcinogenesis in Wistar Hannover GALAS rats. Reprod. Toxicol., <b>40<\/b>, 16-23.","DOI":"10.1016\/j.reprotox.2013.05.005"},{"key":"40","doi-asserted-by":"crossref","unstructured":"Umekita, Y., Souda, M., Hatanaka, K., Hamada, T., Yoshioka, T., Kawaguchi, H. and Tanimoto, A. (2011): Gene expression profile of terminal end buds in rat mammary glands exposed to diethylstilbestrol in neonatal period. Toxicol. Lett., <b>205<\/b>, 15-25.","DOI":"10.1016\/j.toxlet.2011.04.031"},{"key":"41","doi-asserted-by":"crossref","unstructured":"Usuda, K., Nagaoka, K., Nozawa, K., Zhang, H., Taya, K., Yoshida, M. and Watanabe, G. (2014): Neonatal exposure to 17\u03b1-ethinyl estradiol affects kisspeptin expression and LH-surge level in female rats. J. Vet. Med. Sci., <b>76<\/b>, 1105-1110.","DOI":"10.1292\/jvms.14-0148"},{"key":"42","doi-asserted-by":"crossref","unstructured":"Walker, D.M., Kirson, D., Perez, L.F. and Gore, A.C. (2012): Molecular profiling of postnatal development of the hypothalamus in female and male rats. Biol. Reprod., <b>87<\/b>, 129.","DOI":"10.1095\/biolreprod.112.102798"},{"key":"43","doi-asserted-by":"crossref","unstructured":"Watanabe, C., Kuwagata, M., Yoshimura, S., Azegami, J., Kojima, K., Ono, H. and Nagao, T. (2003): An improved technique for repeated gavage administration to rat neonates. Congenit. Anom. (Kyoto), <b>43<\/b>, 177-179.","DOI":"10.1111\/j.1741-4520.2003.tb01041.x"},{"key":"44","doi-asserted-by":"crossref","unstructured":"Yasuno, K., Kobayashi, R., Mineshige, T., Sugahara, G., Nagata, M., Kamiie, J. and Shirota, K. (2013): Atypical canine mammary adenoma characterized by cystic ducts comprising a single layer of basaloid cells with myoepithelial differentiation. J. Vet. Med. Sci., <b>75<\/b>, 1095-1099.","DOI":"10.1292\/jvms.13-0016"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/40\/6\/40_727\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T06:59:59Z","timestamp":1567321199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/40\/6\/40_727\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.40.727","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}