{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T21:02:48Z","timestamp":1748466168680},"reference-count":17,"publisher":"Japanese Society of Toxicology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2016]]},"DOI":"10.2131\/jts.41.739","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T17:09:12Z","timestamp":1479229752000},"page":"739-744","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac safety profile of sildenafil: chronotropic, inotropic and coronary vasodilator effects in the canine isolated, blood-perfused heart preparations"],"prefix":"10.2131","volume":"41","author":[{"given":"Nur Jaharat","family":"Lubna","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Toho University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Toho University"},{"name":"Yamanashi Research Center of Clinical Pharmacology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Toho University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Toho University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Izumi-Nakaseko","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Toho University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Toho University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Toho University"},{"name":"Yamanashi Research Center of Clinical Pharmacology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Beca, S., Aschars-Sobbi, R., Panama, B.K. and Backx, P.H. (2011): Regulation of murine cardiac function by phosphodiesterases type 3 and 4. Curr. Opin. Pharmacol., <b>11<\/b>, 714-719.","DOI":"10.1016\/j.coph.2011.10.017"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Bischoff, E. (2004): Potency, selectivity, and consequences of nonselectivity of PDE inhibition. Int. J. Impot. Res., <b>16<\/b>, 11-14.","DOI":"10.1038\/sj.ijir.3901208"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Chew, K.K., Earle, C.M., Stuckey, B.G., Jamrozik, K. and Keogh, E.J. (2000): Erectile dysfunction in general medicine practice: prevalence and clinical correlates. Int. J. Impot. Res., <b>12<\/b>, 41-45.","DOI":"10.1038\/sj.ijir.3900457"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Chrysant, S.G. (2013): Effectiveness and safety of phosphodiesterase 5 inhibitors in patients with cardiovascular disease and hypertension. Curr. Hypertens. Rep., <b>15<\/b>, 475-483.","DOI":"10.1007\/s11906-013-0377-9"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Cremers, B., Scheler, M., Maack, C., Wendler, O., Sch\u00e4fers, H.J., S\u00fcdkamp, M. and B\u00f6hm, M. (2003): Effects of sildenafil (viagra) on human myocardial contractility,<i> in vitro<\/i> arrhythmias, and tension of internal mammaria arteries and saphenous veins. J. Cardiovasc. Pharmacol., <b>41<\/b>, 734-743.","DOI":"10.1097\/00005344-200305000-00010"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Goldstein, I., Lue, T.F., Padma-Nathan, H., Rosen, R.C., Steers, W.D. and Wicker, P.A. (1998): Oral sildenafil in the treatment erectile dysfunction: Sildenafil study group. N. Engl. J. Med., <b>338<\/b>, 1397-1404.","DOI":"10.1056\/NEJM199805143382001"},{"key":"7","unstructured":"Katzung, B.G. (2015): Vasodilators &amp; the treatment of angina pectoris. In: Basic &amp; Clinical Pharmacology. 13th Edition (Katzung, B.G. and Trevor A.J., eds.), pp.191-208, McGraw-Hill Education, New York."},{"key":"8","doi-asserted-by":"crossref","unstructured":"Kaumann, A.J., Galindo-Tovar, A., Escudero, E. and Vargas, M.L. (2009): Phosphodiesterases do not limit \u00df1-adrenoceptor-mediated sinoatrial tachycardia: evidence with PDE3 and PDE4 in rabbits and PDE1-5 in rats. Naunyn Schmiedebergs Arch. Pharmacol., <b>380<\/b>, 421-430.","DOI":"10.1007\/s00210-009-0445-5"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Kloner, R.A. (2000): Cardiovascular risk and sildenafil. Am. J. Cardiol., <b>86<\/b>, 57F-61F.","DOI":"10.1016\/S0002-9149(00)00895-X"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Knight, W.E. and Yan, C. (2012): Cardiac cyclic nucleotide phosphodiesterases: function, regulation, and therapeutic prospects. Horm. Metab. Res., <b>44<\/b>, 766-775.","DOI":"10.1055\/s-0032-1321870"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Sakuma, I., Akaishi, Y., Tomioka, H., Sato, A., Kitabatake, A. and Hattori, Y. (2002): Interactions of sildenafil with various coronary vasodilators in isolated porcine coronary artery. Eur. J. Pharmacol., <b>437<\/b>, 155-163.","DOI":"10.1016\/S0014-2999(01)01622-3"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Sugiyama, A., Motomura, S. and Hashimoto, K. (1991): Comparison of cardiovascular effects of a novel class Ic antiarrhythmic agent, NIK-244, with those of flecainide in isolated canine heart preparations cross-circulated with a donor dog. Jpn. J. Pharmacol., <b>56<\/b>, 1-12.","DOI":"10.1254\/jjp.56.1"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Sugiyama, A., Motomura, S., Tamura, K. and Hashimoto, K. (1990): Comparison of cardiovascular effects of pirmenol with those of disopyramide in isolated canine heart preparations cross-circulated with a donor dog. Jpn. J. Pharmacol., <b>53<\/b>, 97-110.","DOI":"10.1254\/jjp.53.97"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Sugiyama, A., Satoh, Y., Shiina, H., Takahara, A., Yoneyama, M. and Hashimoto, K. (2001): Cardiac electrophysiologic and hemodynamic effects of sildenafil, a PDE5 inhibitor, in anesthetized dogs. J. Cardiovasc. Pharmacol., <b>38<\/b>, 940-946.","DOI":"10.1097\/00005344-200112000-00016"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Sugiyama, A., Takeuchi, N., Saegusa Y., Sugita, M. and Hashimoto, K. (2002): Molecular mechanisms of cardiostimulatory effects of sildenafil. Jpn. J. Pharmacol., <b>88<\/b>, 362-364.","DOI":"10.1254\/jjp.88.362"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Wallis, R.M., Corbin, J.D., Francic, S.H. and Ellis, P. (1999): Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings<i> in vitro<\/i>. Am. J. Cardiol., <b>83<\/b>, 3C-12C.","DOI":"10.1016\/S0002-9149(99)00042-9"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Zusman, R.M., Morales, A., Glasser, D.B., and Osterloh, I.H. (1999): Overall cardiovascular profile of sildenafil citrate. Am. J. Cardiol., <b>83<\/b>, 35C-44C.","DOI":"10.1016\/S0002-9149(99)00046-6"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/41\/6\/41_739\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T23:38:37Z","timestamp":1498347517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/41\/6\/41_739\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.41.739","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}