{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:23:31Z","timestamp":1789446211691,"version":"build-2803163510"},"reference-count":44,"publisher":"Japanese Society of Toxicology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2016]]},"DOI":"10.2131\/jts.41.757","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T17:09:03Z","timestamp":1479229743000},"page":"757-763","source":"Crossref","is-referenced-by-count":4,"title":["Characteristics of hand tremor and postural sway in patients with fetal-type Minamata disease"],"prefix":"10.2131","volume":"41","author":[{"given":"Toyoto","family":"Iwata","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, Akita University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Kyouritsu Neurology and Rehabilitation Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineshi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"National Institute for Minamata Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Akita University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"National Institute for Minamata Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"National Institute for Minamata Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Akita University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"898","reference":[{"key":"1","unstructured":"ACGIH (2009): TLVs and BEIs: Based on the Documentation of the Threshold Limit Values for Chemical Substances and Physical Agents &amp; Biological Exposure Indices. ACGIH, Cincinnati."},{"key":"2","doi-asserted-by":"crossref","unstructured":"Akagi, H., Grandjean, P., Takizawa, Y. and Weihe, P. (1998): Methylmercury dose estimation from umbilical cord concentrations in patients with Minamata disease. Environ. Res., <b>77<\/b>, 98-103.","DOI":"10.1006\/enrs.1997.3822"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Ando, S., Iwata, T., Ishikawa, H., Dakeishi, M. and Murata, K. (2008): Effects of acute alcohol ingestion on neuromotor functions. Neurotoxicology, <b>29<\/b>, 735-739.","DOI":"10.1016\/j.neuro.2008.04.018"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Araki, S., Sato, H., Yokoyama, K. and Murata, K. (2000): Subclinical neurophysiological effects of lead: a review on peripheral, central, and autonomic nervous system effects in lead workers. Am. J. Ind. Med., <b>37<\/b>, 193-204.","DOI":"10.1002\/(SICI)1097-0274(200002)37:2<193::AID-AJIM5>3.0.CO;2-J"},{"key":"5","unstructured":"ATSDR (Agency for Toxic Substances and Disease Registry) (1999): Toxicological Profile for Mercury. US Department of Health and Human Services. http:\/\/www.atsdr.cdc.gov\/toxprofiles\/tp46.pdf. Accessed February 10, 2016."},{"key":"6","unstructured":"Bain, P.G. (2002): The management of tremor. J. Neurol. Neurosurg. Psychiatry, <b>75 (suppl 1)<\/b>, i3-9."},{"key":"7","doi-asserted-by":"crossref","unstructured":"Bakir, F., Rustam, H., Tikriti, S., Al-Damluji, S.F. and Shihristani, H. (1980): Clinical and epidemiological aspects of methylmercury poisoning. Postgrad. Med. J., <b>56<\/b>, 1-10.","DOI":"10.1136\/pgmj.56.651.1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Beuter, A. and Edwards, R. (1998): Tremor in Cree subjects exposed to methylmercury: a preliminary study. Neurotoxicol. Teratol., <b>20<\/b>, 581-589.","DOI":"10.1016\/S0892-0362(98)00021-X"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Cherng, R.J., Su, F.C., Chen, J.J. and Kuan, T.S. (1999): Performance of static standing balance in children with spastic diplegic cerebral palsy under altered sensory environments. Am. J. Phys. Med. Rehabil., <b>78<\/b>, 336-343.","DOI":"10.1097\/00002060-199907000-00008"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Cooley, J.W. and Tukey, J.W. (1965): An algorithm for the machine calculation of complex Fourier series. Math. Comput., <b>19<\/b>, 297-301.","DOI":"10.1090\/S0025-5718-1965-0178586-1"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Debes, F., Budtz-J\u00f8rgensen, E., Weihe, P., White, R.F. and Grandjean, P. (2006): Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol. Teratal., <b>28<\/b>, 363-375.","DOI":"10.1016\/j.ntt.2006.02.004"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Debes, F., Weihe, P. and Grandjean, P. (2016): Cognitive deficits at age 22 years associated with prenatal exposure to methylmercury. Cortex, <b>74<\/b>, 358-369.","DOI":"10.1016\/j.cortex.2015.05.017"},{"key":"13","unstructured":"Despr\u00e9s, C., Lamoureux, D. and Beuter, A. (2000): Standardization of a neuromotor test battery: the CATSYS system. Neurotoxicology, <b>21<\/b>, 725-736."},{"key":"14","doi-asserted-by":"crossref","unstructured":"Deuschl, G. and Elble, R.J. (2000): The pathophysiology of essential tremor. Neurology, <b>54 (suppl 4)<\/b>, S14-20.","DOI":"10.1212\/WNL.54.4.14A"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Donker, S.F., Ledebt, A., Roerdink, M., Savelsbergh, G.J. and Beek, P.J. (2008): Children with cerebral palsy exhibit greater and more regular postural sway than typically developing children. Exp. Brain Res., <b>184<\/b>, 363-370.","DOI":"10.1007\/s00221-007-1105-y"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Eggert, T., Straube, A. and Schroeder, K. (1997): Visually induced motion perception and visual control of postural sway in congenital nystagmus. Behav. Brain Res., <b>88<\/b>, 161-168.","DOI":"10.1016\/S0166-4328(97)02289-4"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Ellingsen, D.G., Bast-Pettersen, R., Efskind, J., Gj\u00f8lstad, M., Olsen, R., Thomassen, Y. and Molander, P. (2006): Hand tremor related to smoking habits and the consumption of caffeine in male industrial workers. Neurotoxicology, <b>27<\/b>, 525-533.","DOI":"10.1016\/j.neuro.2006.02.004"},{"key":"18","unstructured":"Era, P. (1988): Sensory, psychomotor, and motor functions in men of different ages. Scand. J. Soc. Med. Suppl., <b>39<\/b>, 1-77."},{"key":"19","doi-asserted-by":"crossref","unstructured":"Eto, K., Oyanagi, S., Itai, Y., Tokunaga, H., Takizawa, Y. and Suda, I. (1992): A fetal type on Minanmata disease. An autopsy case report with special reference to the nervous system. Mod. Chem. Neuropathol., <b>16<\/b>, 171-186.","DOI":"10.1007\/BF03159968"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Grandjean, P., Weihe, P., White, R.F., Debes, F., Araki, S., Yokoyama, K., Murata, K., S\u00f8rensen, N., Dahl, R. and J\u00f8rgensen, P.J. (1997): Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol. Teratol., <b>19<\/b>, 417-428.","DOI":"10.1016\/S0892-0362(97)00097-4"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Grandjean, P., Satoh, H., Murata, K. and Eto, K. (2010): Adverse effects of methylmercury: environmental health research implications. Environ. Health Perspect., <b>118<\/b>, 1137-1145.","DOI":"10.1289\/ehp.0901757"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Harada, M. (1978): Congenital Minamata disease: intrauterine methylmercury poisoning. Teratology, <b>18<\/b>, 285-288.","DOI":"10.1002\/tera.1420180216"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Harada, M. (1995): Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. Crit. Rev. Toxicol., <b>25<\/b>, 1-24.","DOI":"10.3109\/10408449509089885"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Igata, A. (1993): Epidemiological and clinical features of Minamata disease. Environ. Res., <b>63<\/b>, 157-169.","DOI":"10.1006\/enrs.1993.1137"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Iki, M., Ishizaki, H., Aalto, H., Starck, J. and Pyykk\u00f6, I. (1994): Smoking habits and postural stability. Am. J. Otolaryngol., <b>15<\/b>, 124-128.","DOI":"10.1016\/0196-0709(94)90061-2"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Iwata, T., Mori, H., Dakeishi, M., Onozaki, I. and Murata, K. (2005a): Effects of mixed organic solvents on neuromotor functions among workers in Buddhist altar manufacturing factories. J. Occup. Health, <b>47<\/b>, 143-148.","DOI":"10.1539\/joh.47.143"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Iwata, T., Yano, E., Karita, K., Dakeishi, M. and Murata, K. (2005b): Critical dose of lead affecting postural balance in workers. Am. J. Ind. Med., <b>48<\/b>, 319-325.","DOI":"10.1002\/ajim.20220"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Iwata, T., Sakamoto, M., Feng, X., Yoshida, M., Liu, X.J., Dakeishi, M., Li, P., Qiu, G., Jiang, H., Nakamura, M. and Murata, K. (2007): Effects of mercury vapor exposure on neuromotor function in Chinese miners and smelters. Int. Arch. Occup. Environ. Health, <b>80<\/b>, 381-387.","DOI":"10.1007\/s00420-006-0144-1"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Koller, W.C., Vetere-Overfield, B. and Barter, R. (1989): Tremors in early Parkinson\u2019s disease. Clin. Neruopharmacol., <b>12<\/b>, 293-297.","DOI":"10.1097\/00002826-198908000-00006"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Liu, X.J., Sakamoto, M., Kato, T., Okamoto, M. and Arimura, K. (2007): Comparison of current activities of daily living (ADL) scores of fetal-type Minamata disease patients with their ADL scores 15 years ago and communication disorders of these patients. Jpn. J. Hyg., <b>62<\/b>, 905-910.","DOI":"10.1265\/jjh.62.905"},{"key":"31","unstructured":"Murata, K. and Yano, E. (2002): Medical Statistics for Evidence-based Medicine with SPBS User\u2019s Guide. Nankodo Publisher, Tokyo."},{"key":"32","doi-asserted-by":"crossref","unstructured":"Murata, K., Sakamoto, M., Nakai, K., Weihe, P., Dakeishi, M., Iwata, T., Liu, X.J., Ohno, T., Kurosawa, T., Kamiya, K. and Satoh, H. (2004): Effects of methylmercury on neurodevelopment in Japanese children in relation to the Madeiran study. Int. Arch. Occup. Environ. Health, <b>77<\/b>, 571-579.","DOI":"10.1007\/s00420-004-0542-1"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Murata, K., Grandjean, P. and Dakeishi, M. (2007): Neurophysiological evidence of methylmercury neurotoxicity. Am. J. Ind. Med., <b>50<\/b>, 765-771.","DOI":"10.1002\/ajim.20471"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Murata, K., Inoue, O., Akutsu, M. and Iwata, T. (2010): Neuromotor effects of short-term and long-term exposures to trichloroethylene in workers. Am. J. Ind. Med., <b>53<\/b>, 915-921.","DOI":"10.1002\/ajim.20850"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Park, J.B., Lee, K.J., Lee, K.W. and Lim, K.J. (2009): Neurotoxic effects of occupational exposure to mixed organic solvents in Korea: posturographic study. Am. J. Ind. Med., <b>52<\/b>, 429-437.","DOI":"10.1002\/ajim.20679"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Raethjen, J. and Deuschl, G. (2005): Pathophysiology of essential tremor. In Handbook of Essential Tremor and Other Tremor Disorders (Lyons, K.E. and Pahwa, R. eds.), pp. 27-49, Taylor &amp; Francis, Boca Raton.","DOI":"10.1201\/b14115-5"},{"key":"37","doi-asserted-by":"crossref","unstructured":"R\u00f8gind, H., Lykkegaard, J.J., Bliddal, H. and Danneskiold-Sams\u00f8e, B. (2003): Postural sway in normal subjects aged 20-70 years. Clin. Physiol. Funct. Imaging, <b>23<\/b>, 171-176.","DOI":"10.1046\/j.1475-097X.2003.00492.x"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Rose, J., Wolff, D.R., Jones, V.K., Bloch, D.A., Oehlert, J.W. and Gamble, J.G. (2002): Postural balance in children with cerebral palsy. Dev. Med. Child Neurol., <b>44<\/b>, 58-63.","DOI":"10.1017\/S0012162201001669"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Sakamoto, M., Murata, K., Tsuruta, K., Miyamoto, K. and Akagi, H.(2010): Retrospective study on temporal and regional variations of methylmercury concentrations in preserved umbilical cords collected from inhabitants of the Minamata area, Japan. Ecotoxicol. Environ. Saf., <b>73<\/b>, 1144-1149.","DOI":"10.1016\/j.ecoenv.2010.05.007"},{"key":"40","doi-asserted-by":"crossref","unstructured":"Seeberger, L.C. and Hauser, R.A. (2005): Cerebellar tremor. In Handbook of Essential Tremor and Other Tremor Disorders (Lyons. K.E. and Pahwa, R. eds.), pp. 227-241, Taylor &amp; Francis, Boca Raton.","DOI":"10.1201\/b14115-18"},{"key":"41","doi-asserted-by":"crossref","unstructured":"Takeuchi, T., Morikawa, N., Matsumoto, H. and Shiraishi, Y. (1962): A pathological study of Minamata disease in Japan. Acta Neuropathol., <b>2<\/b>, 40-57.","DOI":"10.1007\/BF00685743"},{"key":"42","doi-asserted-by":"crossref","unstructured":"Tokuomi, H., Uchino, M., Imamura, S., Yamanaga, H., Nakanishi, R. and Ideta, T. (1982): Minamata disease (organic mercury poisoning): neuroradiologic and electrophysiologic studies. Neurology, <b>32<\/b>, 1369-1375.","DOI":"10.1212\/WNL.32.12.1369"},{"key":"43","doi-asserted-by":"crossref","unstructured":"Yamanaga, H. (1983): Quantitative analysis of tremor in Minamata disease. Tohoku J. Exp. Med., <b>141<\/b>, 13-22.","DOI":"10.1620\/tjem.141.13"},{"key":"44","doi-asserted-by":"crossref","unstructured":"Yokoyama, K., Araki, S., Murata, K., Nishikitani, M., Nakaaki, K., Yokota, J., Ito, A. and Sakata, E. (1997): Postural sway frequency analysis in workers exposed to n-hexane, xylene, and toluene: assessment of subclinical cerebellar dysfunction. Environ. Res., <b>74<\/b>, 110-115.","DOI":"10.1006\/enrs.1997.3769"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/41\/6\/41_757\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T23:38:36Z","timestamp":1498347516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/41\/6\/41_757\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.41.757","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}